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We present a case in which the ocular findings represented a challenge in the therapeutic decision&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case Report</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 50-year-old woman with SLE was treated with a umulative dose of 365<span class="elsevierStyleHsp" style=""></span>g of hydroxychloroquine for 13 years&#44; with mild lupus nephritis and hypertension controlled 5 years prior&#59; during her screening for ocular toxicity she presented moderate loss of vision&#44; presenting a corrected visual acuity of 0&#46;7 in the right eye and 1 in the left eye&#46; In the right fundus we observed irregular areas of hyperpigmentation and depigmentation in the macula&#44; without apparent serous uprising&#44; and some arcades microhemorrhages&#46; The left fundus appeared normal&#46; 10-2 the visual field was normal in both eyes&#46; Optical coherence tomography &#40;OCT&#41; of the right eye showed hyperreflective foveal thickening and hyporreflective cavities in deep layers &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The OCT of the left eye was normal&#46; Fluorescein angiography &#40;FA&#41; showed no bull&#39;s-eye pattern&#44; but microaneurysms in both eyes &#40;not detected on fundoscopy&#41;&#44; sectoral distribution and hyper-and hypofluorescence late macular leakage &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; In the multifocal electroretinogram &#40;mfERG&#41; there were low amplitude responses in both peripheral retinas&#44; low power density in the foveal region of the right eye and normal foveolar activity in the left eye &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The alteration of the N95 wave of the electroretinogram pattern reflected a dysfunction of the ganglion cells of both retinas&#44; probably causing the disease&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The neurophysiological findings&#44; the OCT and FA suggested a vascular origin rather than a toxic effect&#44; so it toxicity was ruled out and hydroxychloroquine retinopathy was diagnosed as lupus&#44; recommending the maintenance of the antimalarial but with close monitoring of the patient to prevent maculopathy as a risk factor&#46; In subsequent visits the patient maintained her visual acuity and had improved lupus symptoms with hydroxychloroquine maintenance treatment&#44; which confirmed the suspected end diagnosis&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">In the early alterations of the visual field as a sign of cloroquine maculopathy 10-2&#44; central mfERG&#44; OCT and autofluorescence have recently been added as diagnostic tests&#44; with their use recommended for routine screening&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Central mfERG shows very early alterations&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> but its availability is scarce&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The field of view of our patient was normal in both eyes&#44; which ruled cloroquine maculopathy&#46; The mfERG showed macular dysfunction only in the right eye and asymmetry is rare in drug toxicity&#46; The results of the AGF and the rest of neurophysiological studies suggested an episode of retinal ischemia&#46; The OCT image was reminiscent of a rare form of central serous chorioretinopathy&#44; lupus<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> choroidopathy&#44; while microaneurysms in cuneiform distributions were more typical of hypertensive episodes&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Faced with a maculopathy in a patient with SLE treated with hydroxychloroquine&#44; we must not forget that they are patients exposed to thrombotic events that can generate retinal confusion&#44; so that additional tests may be necessary to make an adequate differential diagnosis&#44; because without maculopathy there is no need for drug withdrawal&#44; even to assess an increase in dosage&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><p id="par0050" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Protection of human and animal subjects&#46;</span> The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Confidentiality of Data&#46;</span> The authors declare that they have followed the protocols of their work centre on the publication of patient data and that all the patients included in the study have received sufficient information and have given their informed consent in writing to participate in that study&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Right to privacy and informed consent&#46;</span> The authors have obtained the informed consent of the patients and &#47;or subjects mentioned in the article&#46; The author for correspondence is in possession of this document&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors have no disclosures to make&#46;</p></span></span>"
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                    0 => array:2 [
                      "titulo" => "A long-term study of hydroxychloroquine withdrawal on exacerbations in systemic lupus erythematosus&#46; The Canadian Hydroxychloroquine Study Group"
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                            0 => "H&#46;N&#46; Bernstein"
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                        "tituloSerie" => "Annals of Ophthalmology"
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                        "paginaInicial" => "292"
                        "paginaFinal" => "296"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1952638"
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                ]
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                    0 => array:2 [
                      "titulo" => "Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy"
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                          "colaboracion" => "American Academy of Ophthalmology"
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                    0 => array:2 [
                      "doi" => "10.1016/j.ajo.2006.12.042"
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                        "tituloSerie" => "American Journal of Ophthalmology"
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                        "volumen" => "143"
                        "paginaInicial" => "801"
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                        "link" => array:1 [
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Case report
Maculopathy in Patient With Systemic Lupus Erythematosus Treated With Hydroxychloroquine
Maculopatía en paciente con lupus eritematoso sistémico tratado con hidroxicloroquina
Francisco Jorge Rodríguez-Hurtadoa,
Corresponding author
frhurtado@telefonica.net

Corresponding author.
, José Antonio Sáez-Morenob,c, José Manuel Rodríguez-Ferrerb
a Servicio de Oftalmología, Hospital Virgen de las Nieves, Granada, Spain
b Laboratorio de Neurociencia Visual y Cognitiva, Universidad de Granada, Granada, Spain
c Servicio de Neurofisiología Clínica, Hospital Universitario San Cecilio, Granada, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Synthetic antimalarials in the treatment of systemic lupus erythematosus &#40;SLE&#41; have been a major therapeutic advance and serve as immunomodulators and inhibitors of thrombosis&#44; with few side effects&#44; prolonging the quality of life of patients&#46; Their withdrawal leaves the patient with SLE at the mercy of the side effects of corticosteroids and immunosuppressants&#44; and increases the risk of flares&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Hydroxychloroquine can cause severe retinal toxicity&#44; requiring discontinuation of therapy&#44; although there are few cases of cloroquine retinopathy&#44; always related to very high cumulative drug dose&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Synthetic antimalarial toxicity is detected by ophthalmic screening protocols focused on development of macular pathology&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> One must not forget that the patient with SLE is predisposed to retinal ischemia that may be confused with macular damage due to cloroquine&#46; We present a case in which the ocular findings represented a challenge in the therapeutic decision&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case Report</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 50-year-old woman with SLE was treated with a umulative dose of 365<span class="elsevierStyleHsp" style=""></span>g of hydroxychloroquine for 13 years&#44; with mild lupus nephritis and hypertension controlled 5 years prior&#59; during her screening for ocular toxicity she presented moderate loss of vision&#44; presenting a corrected visual acuity of 0&#46;7 in the right eye and 1 in the left eye&#46; In the right fundus we observed irregular areas of hyperpigmentation and depigmentation in the macula&#44; without apparent serous uprising&#44; and some arcades microhemorrhages&#46; The left fundus appeared normal&#46; 10-2 the visual field was normal in both eyes&#46; Optical coherence tomography &#40;OCT&#41; of the right eye showed hyperreflective foveal thickening and hyporreflective cavities in deep layers &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The OCT of the left eye was normal&#46; Fluorescein angiography &#40;FA&#41; showed no bull&#39;s-eye pattern&#44; but microaneurysms in both eyes &#40;not detected on fundoscopy&#41;&#44; sectoral distribution and hyper-and hypofluorescence late macular leakage &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; In the multifocal electroretinogram &#40;mfERG&#41; there were low amplitude responses in both peripheral retinas&#44; low power density in the foveal region of the right eye and normal foveolar activity in the left eye &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The alteration of the N95 wave of the electroretinogram pattern reflected a dysfunction of the ganglion cells of both retinas&#44; probably causing the disease&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The neurophysiological findings&#44; the OCT and FA suggested a vascular origin rather than a toxic effect&#44; so it toxicity was ruled out and hydroxychloroquine retinopathy was diagnosed as lupus&#44; recommending the maintenance of the antimalarial but with close monitoring of the patient to prevent maculopathy as a risk factor&#46; In subsequent visits the patient maintained her visual acuity and had improved lupus symptoms with hydroxychloroquine maintenance treatment&#44; which confirmed the suspected end diagnosis&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">In the early alterations of the visual field as a sign of cloroquine maculopathy 10-2&#44; central mfERG&#44; OCT and autofluorescence have recently been added as diagnostic tests&#44; with their use recommended for routine screening&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Central mfERG shows very early alterations&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> but its availability is scarce&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The field of view of our patient was normal in both eyes&#44; which ruled cloroquine maculopathy&#46; The mfERG showed macular dysfunction only in the right eye and asymmetry is rare in drug toxicity&#46; The results of the AGF and the rest of neurophysiological studies suggested an episode of retinal ischemia&#46; The OCT image was reminiscent of a rare form of central serous chorioretinopathy&#44; lupus<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> choroidopathy&#44; while microaneurysms in cuneiform distributions were more typical of hypertensive episodes&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Faced with a maculopathy in a patient with SLE treated with hydroxychloroquine&#44; we must not forget that they are patients exposed to thrombotic events that can generate retinal confusion&#44; so that additional tests may be necessary to make an adequate differential diagnosis&#44; because without maculopathy there is no need for drug withdrawal&#44; even to assess an increase in dosage&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><p id="par0050" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Protection of human and animal subjects&#46;</span> The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Confidentiality of Data&#46;</span> The authors declare that they have followed the protocols of their work centre on the publication of patient data and that all the patients included in the study have received sufficient information and have given their informed consent in writing to participate in that study&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Right to privacy and informed consent&#46;</span> The authors have obtained the informed consent of the patients and &#47;or subjects mentioned in the article&#46; The author for correspondence is in possession of this document&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors have no disclosures to make&#46;</p></span></span>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Una mujer de 50 a&#241;os con lupus eritematoso sist&#233;mico&#44; tratada 13 a&#241;os con hidroxicloroquina y desde hace 5 a&#241;os con nefropat&#237;a e hipertensi&#243;n arterial&#44; refiri&#243; en la revisi&#243;n peri&#243;dica p&#233;rdida moderada de visi&#243;n en el ojo derecho&#46; La fundoscopia mostr&#243; solo alteraciones de la pigmentaci&#243;n macular en el ojo derecho&#46; El campo visual 10-2 fue normal en ambos ojos&#46; La tomograf&#237;a de coherencia &#243;ptica mostr&#243; en la m&#225;cula derecha un engrosamiento foveal hiperreflectivo&#44; con cavidad hiporreflectiva subyacente&#44; y fue normal en la m&#225;cula izquierda&#46; La angiograf&#237;a fluoresce&#237;nica no mostr&#243; patr&#243;n en ojo de buey&#44; sino microaneurismas en arcadas vasculares&#46; El electrorretinograma multifocal central estaba disminuido en el ojo derecho y el electrorretinograma patr&#243;n moderadamente disminuido en ambos ojos&#46; En conclusi&#243;n&#44; las alteraciones del ojo derecho fueron indicativas de maculopat&#237;a isqu&#233;mica&#44; pero no de toxicidad cloroqu&#237;nica&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Rodr&#237;guez-Hurtado FJ&#44; et al&#46; Maculopat&#237;a en paciente con lupus eritematoso sist&#233;mico tratado con hidroxicloroquina&#46; Reumatol Clin&#46; 2012&#46; <span class="elsevierStyleInterRef" href="doi:10.1016/j.reuma.2011.12.012">doi&#58;10&#46;1016&#47;j&#46;reuma&#46;2011&#46;12&#46;012</span></p>"
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    ]
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Optical coherence tomography of the right eye of the patient showing discrete thickening of the fovea&#44; with a hyporeflective space in the outer layers of the retina &#40;arrows&#41;&#46;</p>"
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                      "titulo" => "A long-term study of hydroxychloroquine withdrawal on exacerbations in systemic lupus erythematosus&#46; The Canadian Hydroxychloroquine Study Group"
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                        0 => array:2 [
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                            3 => "D&#46; Choquette"
                            4 => "J&#46;L&#46; Sen&#233;cal"
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                        "paginaInicial" => "80"
                        "paginaFinal" => "85"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9541091"
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                ]
              ]
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              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ocular safety of hydroxychloroquine"
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                        0 => array:2 [
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                          "autores" => array:1 [
                            0 => "H&#46;N&#46; Bernstein"
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                      "Revista" => array:6 [
                        "tituloSerie" => "Annals of Ophthalmology"
                        "fecha" => "1991"
                        "volumen" => "23"
                        "paginaInicial" => "292"
                        "paginaFinal" => "296"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1952638"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "American Academy of Ophthalmology"
                          "etal" => false
                          "autores" => array:5 [
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                            2 => "T&#46;Y&#46; Lai"
                            3 => "J&#46;S&#46; Lyons"
                            4 => "W&#46;F&#46; Mieler"
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                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.ophtha.2010.11.017"
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                        "tituloSerie" => "Ophthalmology"
                        "fecha" => "2011"
                        "volumen" => "118"
                        "paginaInicial" => "415"
                        "paginaFinal" => "422"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21292109"
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                      "titulo" => "Detection of early hydroxychloroquine retinal toxicity enhanced by ring ratio analysis of multifocal electroretinography"
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                        "volumen" => "143"
                        "paginaInicial" => "801"
                        "paginaFinal" => "809"
                        "link" => array:1 [
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Article information
ISSN: 21735743
Original language: English
DOI:10.1016/j.reumae.2012.04.006
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