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and another with acroosteolysis&#44; associated frequently with cyanotic congenital heart disease and which has its onset during childhood&#46; Two variants have been seen in this last pattern&#44; one in which the reabsorption of the distal phalanges makes them adopt a pyramidal form and another in which its massive destruction leads to the formation of flat surfaces&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> We present the case of a patient with primary pulmonary hypertension who developed HOA with a mixed radiological pattern&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Clinical Presentation</span><p id="par0010" class="elsevierStylePara elsevierViewall">The case is a 30-year-old male patient with a history of primary pulmonary hypertension without a shunt and followed by pediatric cardiology ever since&#46; He had no other history of importance&#44; including rheumatic disease or psoriasis&#46; At age 29 he started presenting episodes of symmetric&#44; additive polyarthritis which affected knees&#44; ankles&#44; shoulders&#44; wrists and metacarpophalangeal joints&#44; with important functional limitation&#46; Physical examination found&#44; in addition to generalized cyanosis and acropachy&#44; no skin or nail lesions suggestive of psoriasis&#46; Laboratory analysis found normal acute phase reactants&#44; negative rheumatoid factor and positive low titer anti-CCP antibodies in a single determination&#46; X-rays showed acroosteolysis of the distal phalanges of the hands and feet&#44; severest in the latter&#44; in which some of the phalanges adopted the form of a pyramid or had a flattened end&#44; with important bone neoformation in both locations&#44; especially the hands &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; Both wrists observed&#44; in addition to radiocarpal and intercarpal joint impingement&#44; especially of the left side&#44; no erosions&#46; Long bones &#40;tibia&#44; peroneal&#44; radial&#41; had a cottony cortex and periosteal separation compatible with periostitis&#46; A bone scyntigraphy showed moderate uptake in the distal phalanges of both hands&#44; as well as right wrist and radium with a theoretical zone in the left semilunar&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was diagnosed with pneumic HOA and treated with low dose steroid &#40;deflazacort 6<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41;&#44; zoledronate &#40;single 5<span class="elsevierStyleHsp" style=""></span>mg dose&#41; and calcium and vitamin D supplements&#46; He responded rapidly to treatment with remission of arthritis and steroids were suspended after a few months&#59; he only presented a single relapse which responded after 2 weeks of treatment with no further relapses&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">This case involved a patient with underlying lung pathology of pediatric onset&#44; who developed a late polyarthritis that led to the diagnosis of pneumic HOA&#46; However&#44; changes such as acro-osteolysis&#44; new bone formation and periostitis probably had a longer evolution&#44; but because these events often have a more insidious course and patients are often asymptomatic&#44; it is usually detected in an incidental radiological study&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Previous studies have reported that foot affection is more frequent and more severe than that of the hand&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a> as in our patient&#46; Solid and continuous periosteal reaction in the long bones is also a common finding&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> such as the one our patient presented on the tibial and radial bones&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The mixed pattern combining acroosteolysis and bone neoformation in the same patient was what called our attention&#44; however&#44; some studies suggest that these patterns are not mutually exclusive and constitute a continuum in which initial stages have a predominance of proliferative changes with osteolysis in late stages&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Another characteristic is that generally&#44; areas of hypertrophy&#47;osteolysis correspond with greater uptake in scyntigraphy&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> as seen in this case&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient had positive low titer anti-CCP antibodies in a single determination with no other criteria for rheumatoid arthritis nor with any compatible radiological lesions&#44; nor did he require treatment with methotrexate or any other disease modifying drug&#46; We have not found&#44; in the reviewed literature&#44; any relationship between HOA and anti-CCP positivity&#44; thus considering a false positive case&#46; The patient did not have any skin lesions or axial or enthesitic affection suggesting psoriatic arthritis&#59; however&#44; because it was a rapid onset case of polyarthritis with osteolytic and proliferative changes&#44; psoriatic arthritis must be considered in the differential diagnosis&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The mechanism that leads to bone lesions in HOA is unknown&#46; From the histological standpoint it is characterized by an excessive deposition of collagen&#44; endothelial hyperplasia&#44; edema and osteoblast proliferation in the distal parts of long bones&#44; leading to subperiostic bone neoformation&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Among the factors that intervene in these changes are endothelial vascular growth factor &#40;VEGF&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> reflex vagal hyperstimulation&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> interleukin 11&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> paraneoplasic growth factors&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> hormonal alterations&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> circulating immune complexes&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> antiphopholipid antibodies&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> alterations in platelet function<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> and endothelial activation&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Treatment of secondary HOA corresponds to that of the underlying condition &#40;for example&#44; correction of the heart defect&#44; treatment of cancer or infection&#44; etc&#46;&#41;&#46; Symptomatic management of HOA includes non steroidal antiinlammatory drugs and steroids for joint pain&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and bisphosphonates such as pamidronate<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> and zoledronate<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> which control pain due to periostitis&#44; with antiosteoclastic activity that inhibits the expression of VEGF&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Another drug employed is octeotride which has also shown activity on VEGF&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><p id="par0050" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Protection of human and animal subjects&#46;</span> The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Confidentiality of Data&#46;</span> The authors declare that they have followed the protocols of their work centre on the publication of patient data and that all the patients included in the study have received sufficient information and have given their informed consent in writing to participate in that study&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Right to privacy and informed consent&#46;</span> The authors have obtained the informed consent of the patients and &#47;or subjects mentioned in the article&#46; The author for correspondence is in possession of this document&#46;<span class="elsevierStyleVsp" style="height:0.5px"></span></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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            0 => "Osteoartropat&#237;a hipertr&#243;fica"
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            2 => "Neoformaci&#243;n &#243;sea"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hypertrophic osteoarthropathy is an entity characterized by a triad of periostitis of long bones&#44; clubbing and arthritis&#46; Radiologically there are two patterns&#44; one characterized by new bone formation which predominates in patients with pulmonary disease&#44; and another by acro-osteolysis that is most frequently associated with congenital heart disease&#46; We report the case of a 30-year-old man diagnosed with primary pulmonary hypertension for two years&#44; developing hypertrophic osteoarthropathy with a mixed radiological pattern&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La osteoartropat&#237;a hipertr&#243;fica es una entidad caracterizada por la tr&#237;ada de periostitis de huesos largos&#44; acropaquias y artritis&#46; Radiol&#243;gicamente se distinguen 2 patrones&#59; uno caracterizado por neoformaci&#243;n &#243;sea que predomina en pacientes con patolog&#237;a pulmonar&#44; y otro por acro-osteolisis que se asocia m&#225;s frecuentemente con cardiopat&#237;as cong&#233;nitas&#46; Presentamos el caso de un var&#243;n de 30 a&#241;os diagnosticado de hipertensi&#243;n arterial pulmonar primaria desde los 2 a&#241;os&#44; que desarroll&#243; una osteoartropat&#237;a hipertr&#243;fica con un patr&#243;n radiol&#243;gico mixto&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Sifuentes Giraldo WA&#44; et al&#46; Osteoartropat&#237;a hipertr&#243;fica con acro-osteolisis y neoformaci&#243;n &#243;sea en un paciente con hipertensi&#243;n pulmonar primaria&#46; Reumatol Clin&#46; 2012&#59;8&#58;208&#8211;11&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Hand X-ray &#40;A&#41; in which there is a periosteal reaction on the radius&#46; There is distal widening with hypertrophic changes and areas of osteolysis&#44; with a good example on the right fourth finger&#46; Juxtaarticular demineralization&#46; Feet X-ray &#40;B&#41; observing marked destruction of the distal phalanges&#44; some with flattened morphology and distal hypertrophy with bone proliferation&#46; There is marked deformity of the fingers&#46;</p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Comparative image of the distal phalange of the hand &#40;A&#41; and foot &#40;B&#41;&#59; the first has proliferative changes and the second destructive changes with flattened morphology&#46;</p>"
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Case Report
Hypertrophic Osteoarthropathy With Acro-osteolysis in a Patient With Primary Pulmonary Hypertension
Osteoartropatía hipertrófica con acro-osteolisis y neoformación ósea en un paciente con hipertensión pulmonar primaria
Walter Alberto Sifuentes Giraldoa,
Corresponding author
albertosifuentesg@gmail.com

Corresponding author.
, María Ahijón Lanaa, Ignacio Gallego Riverab, Francisco Javier Bachiller Corrala, María Luz Gámir Gámira
a Servicio de Reumatología, Hospital Universitario Ramón y Cajal, Madrid, Spain
b Servicio de Radiología, Hospital Universitario Ramón y Cajal, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Hypertrophic osteopathy &#40;HOA&#41; is a disease characterized by chronic proliferative periostitis of long bones&#44; acropachy and arthritis&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> It can be divided according to its etiology in primary HOA&#44; with no apparent underlying cause&#44; familial aggregation and chronic progression&#59; and secondary&#44; associated with lung&#44; cardiac&#44; hepatic or intestinal diseases&#44; with a tendency to bilateralism&#44; symmetric and rapidly progressive&#46; There are two distinct radiological patterns of HOA&#44; one characterized by hypertrophia or bone neoformation&#44; predominant in patients with lung disease &#40;pneumic HOA&#41; and which has its onset after puberty&#59; and another with acroosteolysis&#44; associated frequently with cyanotic congenital heart disease and which has its onset during childhood&#46; Two variants have been seen in this last pattern&#44; one in which the reabsorption of the distal phalanges makes them adopt a pyramidal form and another in which its massive destruction leads to the formation of flat surfaces&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> We present the case of a patient with primary pulmonary hypertension who developed HOA with a mixed radiological pattern&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Clinical Presentation</span><p id="par0010" class="elsevierStylePara elsevierViewall">The case is a 30-year-old male patient with a history of primary pulmonary hypertension without a shunt and followed by pediatric cardiology ever since&#46; He had no other history of importance&#44; including rheumatic disease or psoriasis&#46; At age 29 he started presenting episodes of symmetric&#44; additive polyarthritis which affected knees&#44; ankles&#44; shoulders&#44; wrists and metacarpophalangeal joints&#44; with important functional limitation&#46; Physical examination found&#44; in addition to generalized cyanosis and acropachy&#44; no skin or nail lesions suggestive of psoriasis&#46; Laboratory analysis found normal acute phase reactants&#44; negative rheumatoid factor and positive low titer anti-CCP antibodies in a single determination&#46; X-rays showed acroosteolysis of the distal phalanges of the hands and feet&#44; severest in the latter&#44; in which some of the phalanges adopted the form of a pyramid or had a flattened end&#44; with important bone neoformation in both locations&#44; especially the hands &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; Both wrists observed&#44; in addition to radiocarpal and intercarpal joint impingement&#44; especially of the left side&#44; no erosions&#46; Long bones &#40;tibia&#44; peroneal&#44; radial&#41; had a cottony cortex and periosteal separation compatible with periostitis&#46; A bone scyntigraphy showed moderate uptake in the distal phalanges of both hands&#44; as well as right wrist and radium with a theoretical zone in the left semilunar&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was diagnosed with pneumic HOA and treated with low dose steroid &#40;deflazacort 6<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41;&#44; zoledronate &#40;single 5<span class="elsevierStyleHsp" style=""></span>mg dose&#41; and calcium and vitamin D supplements&#46; He responded rapidly to treatment with remission of arthritis and steroids were suspended after a few months&#59; he only presented a single relapse which responded after 2 weeks of treatment with no further relapses&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">This case involved a patient with underlying lung pathology of pediatric onset&#44; who developed a late polyarthritis that led to the diagnosis of pneumic HOA&#46; However&#44; changes such as acro-osteolysis&#44; new bone formation and periostitis probably had a longer evolution&#44; but because these events often have a more insidious course and patients are often asymptomatic&#44; it is usually detected in an incidental radiological study&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Previous studies have reported that foot affection is more frequent and more severe than that of the hand&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a> as in our patient&#46; Solid and continuous periosteal reaction in the long bones is also a common finding&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> such as the one our patient presented on the tibial and radial bones&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The mixed pattern combining acroosteolysis and bone neoformation in the same patient was what called our attention&#44; however&#44; some studies suggest that these patterns are not mutually exclusive and constitute a continuum in which initial stages have a predominance of proliferative changes with osteolysis in late stages&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Another characteristic is that generally&#44; areas of hypertrophy&#47;osteolysis correspond with greater uptake in scyntigraphy&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> as seen in this case&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient had positive low titer anti-CCP antibodies in a single determination with no other criteria for rheumatoid arthritis nor with any compatible radiological lesions&#44; nor did he require treatment with methotrexate or any other disease modifying drug&#46; We have not found&#44; in the reviewed literature&#44; any relationship between HOA and anti-CCP positivity&#44; thus considering a false positive case&#46; The patient did not have any skin lesions or axial or enthesitic affection suggesting psoriatic arthritis&#59; however&#44; because it was a rapid onset case of polyarthritis with osteolytic and proliferative changes&#44; psoriatic arthritis must be considered in the differential diagnosis&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The mechanism that leads to bone lesions in HOA is unknown&#46; From the histological standpoint it is characterized by an excessive deposition of collagen&#44; endothelial hyperplasia&#44; edema and osteoblast proliferation in the distal parts of long bones&#44; leading to subperiostic bone neoformation&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Among the factors that intervene in these changes are endothelial vascular growth factor &#40;VEGF&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> reflex vagal hyperstimulation&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> interleukin 11&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> paraneoplasic growth factors&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> hormonal alterations&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> circulating immune complexes&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> antiphopholipid antibodies&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> alterations in platelet function<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> and endothelial activation&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Treatment of secondary HOA corresponds to that of the underlying condition &#40;for example&#44; correction of the heart defect&#44; treatment of cancer or infection&#44; etc&#46;&#41;&#46; Symptomatic management of HOA includes non steroidal antiinlammatory drugs and steroids for joint pain&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and bisphosphonates such as pamidronate<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> and zoledronate<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> which control pain due to periostitis&#44; with antiosteoclastic activity that inhibits the expression of VEGF&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Another drug employed is octeotride which has also shown activity on VEGF&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><p id="par0050" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Protection of human and animal subjects&#46;</span> The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Confidentiality of Data&#46;</span> The authors declare that they have followed the protocols of their work centre on the publication of patient data and that all the patients included in the study have received sufficient information and have given their informed consent in writing to participate in that study&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Right to privacy and informed consent&#46;</span> The authors have obtained the informed consent of the patients and &#47;or subjects mentioned in the article&#46; The author for correspondence is in possession of this document&#46;<span class="elsevierStyleVsp" style="height:0.5px"></span></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hypertrophic osteoarthropathy is an entity characterized by a triad of periostitis of long bones&#44; clubbing and arthritis&#46; Radiologically there are two patterns&#44; one characterized by new bone formation which predominates in patients with pulmonary disease&#44; and another by acro-osteolysis that is most frequently associated with congenital heart disease&#46; We report the case of a 30-year-old man diagnosed with primary pulmonary hypertension for two years&#44; developing hypertrophic osteoarthropathy with a mixed radiological pattern&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La osteoartropat&#237;a hipertr&#243;fica es una entidad caracterizada por la tr&#237;ada de periostitis de huesos largos&#44; acropaquias y artritis&#46; Radiol&#243;gicamente se distinguen 2 patrones&#59; uno caracterizado por neoformaci&#243;n &#243;sea que predomina en pacientes con patolog&#237;a pulmonar&#44; y otro por acro-osteolisis que se asocia m&#225;s frecuentemente con cardiopat&#237;as cong&#233;nitas&#46; Presentamos el caso de un var&#243;n de 30 a&#241;os diagnosticado de hipertensi&#243;n arterial pulmonar primaria desde los 2 a&#241;os&#44; que desarroll&#243; una osteoartropat&#237;a hipertr&#243;fica con un patr&#243;n radiol&#243;gico mixto&#46;</p>"
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Article information
ISSN: 21735743
Original language: English
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2022 December 77 42 119
2022 November 77 40 117
2022 October 80 63 143
2022 September 54 43 97
2022 August 49 69 118
2022 July 47 48 95
2022 June 55 46 101
2022 May 65 50 115
2022 April 55 50 105
2022 March 44 63 107
2022 February 72 39 111
2022 January 80 55 135
2021 December 50 36 86
2021 November 47 40 87
2021 October 62 63 125
2021 September 56 46 102
2021 August 71 47 118
2021 July 72 43 115
2021 June 49 46 95
2021 May 49 58 107
2021 April 234 118 352
2021 March 193 45 238
2021 February 147 30 177
2021 January 91 31 122
2020 December 71 30 101
2020 November 63 20 83
2020 October 59 17 76
2020 September 55 38 93
2020 August 48 28 76
2020 July 51 31 82
2020 June 64 39 103
2020 May 57 19 76
2020 April 50 31 81
2020 March 28 7 35
2020 February 2 0 2
2020 January 5 0 5
2019 October 2 0 2
2019 September 6 0 6
2019 June 2 0 2
2019 May 2 0 2
2019 March 3 0 3
2019 January 1 0 1
2018 December 2 0 2
2018 May 9 1 10
2018 April 71 17 88
2018 March 136 19 155
2018 February 59 2 61
2018 January 118 5 123
2017 December 44 8 52
2017 November 49 5 54
2017 October 47 11 58
2017 September 59 8 67
2017 August 79 20 99
2017 July 46 20 66
2017 June 90 21 111
2017 May 92 24 116
2017 April 85 14 99
2017 March 78 11 89
2017 February 65 15 80
2017 January 50 21 71
2016 December 99 26 125
2016 November 90 10 100
2016 October 145 17 162
2016 September 206 6 212
2016 August 142 15 157
2016 July 70 9 79
2015 December 2 0 2
2015 November 3 0 3
2015 October 2 0 2
2015 September 7 0 7
2015 August 1 0 1
2015 July 59 9 68
2015 June 62 21 83
2015 May 103 32 135
2015 April 74 18 92
2015 March 67 10 77
2015 February 81 13 94
2015 January 85 14 99
2014 December 89 10 99
2014 November 98 9 107
2014 October 85 10 95
2014 September 79 7 86
2014 August 60 15 75
2014 July 85 14 99
2014 June 102 10 112
2014 May 83 14 97
2014 April 102 7 109
2014 March 104 20 124
2014 February 94 11 105
2014 January 85 19 104
2013 December 81 11 92
2013 November 86 20 106
2013 October 91 19 110
2013 September 94 10 104
2013 August 90 17 107
2013 July 86 13 99
2013 June 83 21 104
2013 May 80 13 93
2013 April 86 15 101
2013 March 84 19 103
2013 February 56 18 74
2013 January 57 9 66
2012 December 74 23 97
2012 November 66 23 89
2012 October 64 15 79
2012 September 27 9 36
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