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This complication may be due to diffuse involvement of the pulmonary interstitium or the appearance of pulmonary hypertension (PHT). The latter with a prevalence estimated at 12%–26% depending on diagnostic criteria, from scanning and population estudiada.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">PHT is generally considered a late complication of SS. Previous studies found that the TIME between the diagnosis of SS and the beginning of the PHT is between 9.08±6.6<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and 14±5 years.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It is also a major cause of morbidity and mortality in patients, with a median survival of 50% at 12 months of diagnosis.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The definitive diagnosis of PHT is made with right heart catheterization; however, there are another 4 screening measurements used in most studies due to good correlation with the hemodynamic values obtained with cardiac catheterization: first, the measurement of pulmonary artery systolic pressure (sPAP); second, the speed of the tricuspid reflux (VRT), both parameters measured by transthoracic Doppler; third, considered as a predictor, the decrease of the diffusion coefficient of carbon monoxide (DLCO) calculated by means of the RFT, and finally the elevation in serum N-terminal brain natriuretic peptide (N-terminal BNP) prohormone, recently reviewed.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5–7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In this paper, we studied a population with SS and PHT with clinical, immunologic, echocardiographic and spirometry parameters, and tried to identify predictors of higher levels of sPAP. We also studied the influence of PHT in the prognosis of these patients.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Materials and Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Design</span><p id="par0025" class="elsevierStylePara elsevierViewall">The study included 331 patients with a diagnosis of SS controlled at the Systemic Autoimmune Diseases Unit of the Internal Medicine department, University Hospital Vall d’Hebron, until 2009. Of these patients, we studied 68 patients who met PHT criteria by duplex Doppler considering PHT sPAP values above 35<span class="elsevierStyleHsp" style=""></span>mmHg.</p><p id="par0030" class="elsevierStylePara elsevierViewall">We divided the population according to clinical characteristics in subtypes of SS (limited, diffuse and no SS). These patients underwent spirometry with DLCO and FVC measurements, a computed tomography (CT), an immunological profile and capillaroscopy following a study protocol used in the department.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Two patterns were considered for capillaroscopy: slow, characterized by the presence of megacapillaries, no hair loss, and a current pattern for important<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> hair loss.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Statistical Analysis</span><p id="par0040" class="elsevierStylePara elsevierViewall">Statistical analysis was performed using SPSS 11.5 for Windows. The association between variables was performed using the Pearson correlation coefficient and results were considered statistically significant if presenting <span class="elsevierStyleItalic">P</span> values of less than .05.</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0045" class="elsevierStylePara elsevierViewall">331 patients with SS were included in the study, of which 68 (20.5%) had sPAP>35<span class="elsevierStyleHsp" style=""></span>mmHg. The mean age of patients was 56.3±14.4 years), 61 were women (90%) and 7 men (10%), with a 9:1 ratio.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Raynaud's phenomenon was the first most common manifestation of SS in all subtypes studied. The average time from the first manifestation of the disease until the diagnosis of the same was 9.5±11 years. Clinical and immunological characteristics of the study population are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">The average sPAP by ECHO at rest was 54.9±18<span class="elsevierStyleHsp" style=""></span>mmHg, while the mean VRT was 3.3<span class="elsevierStyleHsp" style=""></span>m/s. With respect to respiratory function tests, we found a mean DLCO of 45.7%±34% predicted, a FVC of 59.5%+27.8% predicted, and ratio of the FVC/DLCO of 1.3±0.6.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Using chest CT we found interstitial disease in 52% (30/58) of patients, and 28% (16/58) of patients had a limited form.</p><p id="par0065" class="elsevierStylePara elsevierViewall">We calculated the Pearson correlation coefficient with the following variables FVC-sPAP (<span class="elsevierStyleItalic">r</span>=−0.040, <span class="elsevierStyleItalic">P</span>=.373), FVC/DLCO-sPAP (<span class="elsevierStyleItalic">r</span>=0.150, <span class="elsevierStyleItalic">P</span>=.149), DLCO-sPAP (<span class="elsevierStyleItalic">r</span>=−0.282, <span class="elsevierStyleItalic">P</span>=.01) and VRT-sPAP (<span class="elsevierStyleItalic">r</span>=0.658, <span class="elsevierStyleItalic">P</span>=.0001), demonstrating a linear association of moderate significance in relation to these 2 last variables (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">We also analyzed other variables such as the presence of distal ulcers (<span class="elsevierStyleItalic">P</span>=.184), the active capillaroscopy pattern (<span class="elsevierStyleItalic">P</span>=.241), the presence of antibodies to ACA (0.351) or Scl70 (<span class="elsevierStyleItalic">P</span>=.330), interstitial pulmonary involvement diagnosed by CT (<span class="elsevierStyleItalic">P</span>=.073) and its relationship to the severity of the PHT, although no statistically significant association with any of these variables was found.</p><p id="par0075" class="elsevierStylePara elsevierViewall">There were 29 deaths (42.6%), of which PHT was the fundamental cause in 12 patients (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). The years from diagnosis to death due to PHT were 1.8 years.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">In this study we observed a prevalence of PHT assessed by Doppler ultrasound of 20.5% and a correlation between increased values of pulmonary artery systolic pressure and decreased DLCO values with increasing VRT values statistically significant.</p><p id="par0085" class="elsevierStylePara elsevierViewall">The prevalence found is similar to that described in other series.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3–5</span></a> Thus, the study of Vonk et al.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> of the POEMS database found a prevalence of 9.9%; in the Launay et al.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> study it was 18.3% and in the UNCOVER study the prevalence was 26.7%. Probably, this variation is due to different diagnostic methods (Doppler and right heart catheterization), the different characteristics of the populations studied and the criteria used to define PHT.</p><p id="par0090" class="elsevierStylePara elsevierViewall">By analyzing the values of PHT and DLCO levels, we observed that a decrease of 50% predicted higher numbers of pulmonary artery pressure. This is similar to that found by other authors.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,12</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Mathai et al.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> found that the decrease in DLCO correlated PHBP in patients with interstitial lung disease, with the decrease in DLCO a marker of increased pulmonary pressure numbers. In the ItinérAIR-Sclérodermie<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> study, it has been observed that a DLCO less than 60% predicted normal lung volumes associated with the echocardiographic diagnosis of PHT and that this decline may precede by several years the appearance of PHT. These data suggest that the decline in the numbers of DLCO is a predictor of the development of PHT, even in asymptomatic patients.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Other parameters to consider are VRT and sPAP. European guidelines for the diagnosis of PHT<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> have been established arbitrarily to estimate the presence of VRT due to PHT and sPAP estimated by ECHO. Thus a VRT between 2.9 and 3.4<span class="elsevierStyleHsp" style=""></span>m/s and sPAP between 37 and 50<span class="elsevierStyleHsp" style=""></span>mmHg can be used as criteria to define a possible PHT.</p><p id="par0105" class="elsevierStylePara elsevierViewall">Currently, PHT is the leading cause of mortality in these patients.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Prior to the use of ACE inhibitors, renal crisis were the largest cause of mortality in patients with SS, but since the advent of these drugs, there has been a decrease in the number of newly affected renal patients.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">This study found a mortality of 42.6% among patients diagnosed with PHT and SS, with PHT itself the most common cause of death, followed by pulmonary fibrosis. These data are consistent with the ItenérAIR-Sclérodermie study, which showed a cumulative mortality of 3.04 per 100 patients/year with SS, with PHT the cause of death in 32.2%.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">The time elapsed from diagnosis of PHT and death found in this study was 1.8 years, similar to that found in other studies.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2,4</span></a> MacGregor et al.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> reported that an sPAP measured by Doppler greater than or equal to 30<span class="elsevierStyleHsp" style=""></span>mmHg was associated with increased mortality of 20%. Mukerjee et al.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> found that patients with sPAP>45<span class="elsevierStyleHsp" style=""></span>mmHg had a mortality 30% higher at one year than patients with sPAP<32<span class="elsevierStyleHsp" style=""></span>mmHg and that survival was 81, 63 and 56% at 1, 2, and 3 years, respectively, after the diagnosis of PHT.</p><p id="par0120" class="elsevierStylePara elsevierViewall">The influence of PHT in the survival of these patients is especially important considering that, initially, PHT goes unnoticed and the first symptoms are often attributed generally to the underlying disease, delaying diagnosis and treatment. The detection of this complication in the early stages is therefore recommended, when treatment could prevent or halt its progression.</p><p id="par0125" class="elsevierStylePara elsevierViewall">Thus sPAP and the VRT measured by Doppler echocardiograph, and DLCO values measured by spirometry, being non-lethal methods, are easily accessible, and may be useful as screening methods for PHT. However, it is important to note that the final confirmation of the diagnosis of this complication continues to be the performance of right cardiac catheterization.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,5,7,12</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">In this paper the detection of sPAP was made by echo-Doppler and not by right heart catheterization, which is a major limiting factor. However, major works, as exemplified by the EUSTAR<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> group, on the causes of death and associated risk factors in patients with SS, used the Doppler method for the diagnosis of PHT. Another limiting factor that we must note is that this is a retrospective study and we did not study brain natriuretic peptide, which is currently used as a predictor of PHT.</p><p id="par0135" class="elsevierStylePara elsevierViewall">In short, the PHT worsens the prognosis of patients with SS in the very short term. Therefore it is important to find predictors of onset, as early detection and treatment would help avoid much of both progression and the complications that this entails.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><p id="par0145" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Protection of human and animal subjects</span>. The authors declare that no experiments were performed on humans or animals for this investigation.</p><p id="par0150" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Confidentiality of Data</span>. The authors declare that they have followed the protocols of their work centre on the publication of patient data and that all the patients included in the study have received sufficient information and have given their informed consent in writing to participate in that study.</p><p id="par0155" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Right to privacy and informed consent</span>. The authors have obtained the informed consent of the patients and /or subjects mentioned in the article. The author for correspondence is in possession of this document.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of Interest</span><p id="par0140" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:2 [ "identificador" => "xres125921" "titulo" => array:5 [ 0 => "Abstract" 1 => "Objectives" 2 => "Material and methods" 3 => "Results" 4 => "Conclusions" ] ] 1 => array:2 [ "identificador" => "xpalclavsec113216" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres125922" "titulo" => array:5 [ 0 => "Resumen" 1 => "Objetivos" 2 => "Material y métodos" 3 => "Resultados" 4 => "Conclusiones" ] ] 3 => array:2 [ "identificador" => "xpalclavsec113217" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Materials and Methods" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Design" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Statistical Analysis" ] ] ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Ethical disclosures" ] 9 => array:2 [ "identificador" => "sec0035" "titulo" => "Conflict of Interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2011-11-28" "fechaAceptado" => "2012-03-08" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec113216" "palabras" => array:3 [ 0 => "Scleroderma" 1 => "Pulmonary artery hypertension" 2 => "Doppler echocardiography" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec113217" "palabras" => array:3 [ 0 => "Esclerodermia" 1 => "Hipertensión arterial pulmonar" 2 => "Ecocardiografía Doppler" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To describe the clinical–biological characteristics of patients with scleroderma (SS) and pulmonary artery hypertension (PAH).</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To establish the relationship between pulmonary functional tests (PFT), Doppler echocardiography (ECHO) and the severity of the PAH.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Retrospective study of patients with SS treated at a tertiary center. All participants received a protocol study, which included a complete analysis and additional tests: ECHO and PFT with carbon monoxide diffusing capacity (DLCO).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Overall, 331 patients were treated, including 68 (20.5%) with PAH. The limited subtype of SS was the most prevalent. The Pearson's correlation coefficient was used for the following variables: FVC-sPAP, FVC/DLCO-sPAP, DLCO-sPAP and TRV-sPAP, showed a significant moderate linear association in the relationship DLCO-sPAP and TRV-sPAP.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">29 deaths occurred, with 12 of them related to PAH. The median time between the PAH diagnosis and death was 1.8 years.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The decrease in DLCO and the increase in TRV are negative predictor factor of PAH which, at the same time, means a worsening prognosis for patients with SS.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Describir las características clínico-biológicas de pacientes con esclerodermia (ES) e hipertensión arterial pulmonar (HTAP).</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Establecer la relación entre las pruebas funcionales respiratorias (PFR), la ecocardiografía Doppler (eco-Doppler) y la gravedad de la HTAP.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo de pacientes con diagnóstico de ES seguidos en un centro de tercer nivel. Se les realizó un estudio protocolizado con analítica completa y pruebas complementarias; se estimó la presión arterial pulmonar sistólica (PAPs), la velocidad de reflujo de la válvula tricúspide (VRT), la difusión de monóxido de carbono (DLCO) y la capacidad vital forzada (CVF), por medio de la eco-Doppler y la PFR.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Se incluyó a 331 pacientes, de los cuales 68 (20,5%) tenían HTAP. El subtipo de ES más prevalente fue la limitada. Se calculó el coeficiente de correlación de Pearson a las siguientes variables: CVF-PAPs CVF/DLCO-PAPs, DLCO-PAP y VRT-PAPs, observándose una asociación lineal moderada significativa en la relación DLCO-PAPs y con VRT-PAP.</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Se constataron 29 fallecimientos, 12 relacionados a la HTAP. El tiempo medio entre el diagnóstico de HTAP y la muerte fue de 1,8 años.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">La disminución de la DLCO y el aumento de la VRT son factores predictores de HTAP, que al mismo tiempo condiciona un peor pronóstico en los pacientes con ES.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Acosta Colmán MI, et al. ¿Podemos predecir la gravedad de la hipertensión arterial pulmonar en pacientes con esclerodermia? Reumatol Clin. 2012. <span class="elsevierStyleInterRef" href="doi:10.1016/j.reuma.2012.03.007">http://dx.doi.org/10.1016/j.reuma.2012.03.007</span>.</p>" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 646 "Ancho" => 1618 "Tamanyo" => 55964 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Correlation between sPAP and DLCO (n=49). <span class="elsevierStyleItalic">r</span>=−0.282, <span class="elsevierStyleItalic">P</span>=.01.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 729 "Ancho" => 1535 "Tamanyo" => 59617 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Correlation between sPAP and VRT (n=48). <span class="elsevierStyleItalic">r</span>=0.658, <span class="elsevierStyleItalic">P</span>=.0001.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">RFT: respiratory function tests; DLCO: carbon monoxide diffusion; CVF: forced vital capacity; PAP: pulmonary arterial pressure; ACA: anticentromere antibodies; Scl70: anti sclera 70 antibodies; echo-Doppler: Doppler echocardiography; sPAP: systolic pulmonary arterial pressure; VRT: tricuspid valve reflux speed; n: number of patients with available test results.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Diffuse \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Limited \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">No Scleroderma \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">Number of patients</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16/68 (24%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41/68 (60%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11/68 (16%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:1.0px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">Clinical characteristics</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Raynaud's phenomenon</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12/16 (75%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38/41 (92%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10/11 (91%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Capillaroscopy pattern</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Slow \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10/16 (62%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">36/41 (87%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9/11 (81%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Active \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5/16 (32%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5/41 (13%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Undefined \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/16 (6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/11 (18%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Presence of ulcers</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15/16 (93%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30/41 (73%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/11 (9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Immunological</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>ACA (+) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/16 (19%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18/38 (47%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8/10 (72%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Scl70 (+) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9/16 (67%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/38 (8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/11 (9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">RFT</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>DLCO (media) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">55% (n=13) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48% (n=29) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">53% (n=7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>CVF (media) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">51% (n=14) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">63% (n=36) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61% (n=10) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">TAC</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Interstitial affection \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12/16 (75%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16/32 (50%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/10 (20%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>No interstitial affection \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4/16 (25%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16/32 (50%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8/10 (80%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">echo-Doppler</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Mean sPAP (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">62 (n=16) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">58 (n=41) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">64 (n=11) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Mean VRT (m/s) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.38 (n=12) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.33 (n=27) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.24 (n=9) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab212430.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Clinical, Immunological and Complementary Test Characteristics in Patients With SS and PTH.</p>" ] ] 3 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">PHT, pulmonary arterial hypertension; SS, scleroderma.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Cause of Death \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">No. of Patients, % \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PHT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12/29 (41%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PHT+pulmonary fibrosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5/29 (17%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pulmonary fibrosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/29 (7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PHT+renal crisis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/29 (3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Heart failure \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/29 (10%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Disseminated neoplasia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/29 (7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Liver cirrhosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/29 (10%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Renal crisis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/29 (3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab212431.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Causes of Death in Patients With SS and PHT.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 12 | 15 | 27 |
2024 October | 34 | 31 | 65 |
2024 September | 48 | 27 | 75 |
2024 August | 57 | 40 | 97 |
2024 July | 57 | 35 | 92 |
2024 June | 49 | 41 | 90 |
2024 May | 57 | 29 | 86 |
2024 April | 51 | 26 | 77 |
2024 March | 45 | 31 | 76 |
2024 February | 45 | 34 | 79 |
2024 January | 43 | 22 | 65 |
2023 December | 34 | 39 | 73 |
2023 November | 42 | 36 | 78 |
2023 October | 39 | 31 | 70 |
2023 September | 94 | 41 | 135 |
2023 August | 39 | 20 | 59 |
2023 July | 41 | 22 | 63 |
2023 June | 45 | 38 | 83 |
2023 May | 55 | 23 | 78 |
2023 April | 29 | 9 | 38 |
2023 March | 62 | 42 | 104 |
2023 February | 53 | 41 | 94 |
2023 January | 28 | 27 | 55 |
2022 December | 63 | 36 | 99 |
2022 November | 53 | 46 | 99 |
2022 October | 63 | 47 | 110 |
2022 September | 47 | 39 | 86 |
2022 August | 51 | 35 | 86 |
2022 July | 36 | 52 | 88 |
2022 June | 56 | 44 | 100 |
2022 May | 62 | 39 | 101 |
2022 April | 61 | 68 | 129 |
2022 March | 46 | 53 | 99 |
2022 February | 60 | 41 | 101 |
2022 January | 37 | 44 | 81 |
2021 December | 24 | 39 | 63 |
2021 November | 40 | 45 | 85 |
2021 October | 60 | 48 | 108 |
2021 September | 42 | 37 | 79 |
2021 August | 42 | 40 | 82 |
2021 July | 31 | 27 | 58 |
2021 June | 54 | 49 | 103 |
2021 May | 44 | 45 | 89 |
2021 April | 100 | 119 | 219 |
2021 March | 76 | 39 | 115 |
2021 February | 41 | 22 | 63 |
2021 January | 34 | 18 | 52 |
2020 December | 33 | 17 | 50 |
2020 November | 39 | 30 | 69 |
2020 October | 15 | 20 | 35 |
2020 September | 33 | 20 | 53 |
2020 August | 28 | 24 | 52 |
2020 July | 26 | 29 | 55 |
2020 June | 57 | 18 | 75 |
2020 May | 44 | 11 | 55 |
2020 April | 42 | 15 | 57 |
2020 March | 19 | 12 | 31 |
2020 February | 2 | 0 | 2 |
2019 January | 1 | 0 | 1 |
2018 May | 3 | 0 | 3 |
2018 April | 68 | 8 | 76 |
2018 March | 98 | 8 | 106 |
2018 February | 83 | 5 | 88 |
2018 January | 41 | 9 | 50 |
2017 December | 82 | 4 | 86 |
2017 November | 46 | 10 | 56 |
2017 October | 43 | 10 | 53 |
2017 September | 46 | 4 | 50 |
2017 August | 34 | 7 | 41 |
2017 July | 28 | 8 | 36 |
2017 June | 52 | 12 | 64 |
2017 May | 64 | 11 | 75 |
2017 April | 38 | 6 | 44 |
2017 March | 36 | 5 | 41 |
2017 February | 27 | 10 | 37 |
2017 January | 22 | 6 | 28 |
2016 December | 88 | 12 | 100 |
2016 November | 65 | 5 | 70 |
2016 October | 81 | 8 | 89 |
2016 September | 98 | 9 | 107 |
2016 August | 100 | 0 | 100 |
2016 July | 51 | 9 | 60 |
2016 June | 1 | 0 | 1 |
2016 May | 3 | 10 | 13 |
2015 December | 3 | 0 | 3 |
2015 October | 3 | 16 | 19 |
2015 August | 1 | 0 | 1 |
2015 July | 27 | 5 | 32 |
2015 June | 59 | 7 | 66 |
2015 May | 63 | 15 | 78 |
2015 April | 58 | 12 | 70 |
2015 March | 76 | 5 | 81 |
2015 February | 49 | 9 | 58 |
2015 January | 57 | 7 | 64 |
2014 December | 60 | 8 | 68 |
2014 November | 52 | 9 | 61 |
2014 October | 55 | 5 | 60 |
2014 September | 41 | 8 | 49 |
2014 August | 45 | 7 | 52 |
2014 July | 57 | 10 | 67 |
2014 June | 50 | 8 | 58 |
2014 May | 63 | 11 | 74 |
2014 April | 53 | 10 | 63 |
2014 March | 64 | 13 | 77 |
2014 February | 36 | 12 | 48 |
2014 January | 50 | 12 | 62 |
2013 December | 53 | 8 | 61 |
2013 November | 32 | 12 | 44 |
2013 October | 47 | 7 | 54 |
2013 September | 49 | 10 | 59 |
2013 August | 48 | 14 | 62 |
2013 July | 40 | 10 | 50 |
2013 June | 42 | 9 | 51 |
2013 May | 40 | 11 | 51 |
2013 April | 46 | 16 | 62 |
2013 March | 34 | 13 | 47 |
2013 February | 35 | 9 | 44 |
2013 January | 27 | 15 | 42 |
2012 December | 35 | 16 | 51 |
2012 November | 35 | 28 | 63 |
2012 October | 15 | 21 | 36 |