array:24 [
  "pii" => "S2173574312001554"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2012.05.006"
  "estado" => "S300"
  "fechaPublicacion" => "2013-05-01"
  "aid" => "474"
  "copyright" => "Elsevier España, S.L.. All rights reserved"
  "copyrightAnyo" => "2012"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "ssu"
  "cita" => "Reumatol Clin. 2013;9:166-71"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 9020
    "formatos" => array:3 [
      "EPUB" => 62
      "HTML" => 7771
      "PDF" => 1187
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X12001647"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2012.05.011"
      "estado" => "S300"
      "fechaPublicacion" => "2013-05-01"
      "aid" => "474"
      "copyright" => "Elsevier España, S.L."
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "ssu"
      "cita" => "Reumatol Clin. 2013;9:166-71"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 164632
        "formatos" => array:3 [
          "EPUB" => 194
          "HTML" => 159430
          "PDF" => 5008
        ]
      ]
      "es" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Revisi&#243;n</span>"
        "titulo" => "Plasma rico en plaquetas&#58; &#191;un nuevo tratamiento para el reumat&#243;logo&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "166"
            "paginaFinal" => "171"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Platelet rich plasma&#46; A new treatment tool for the rheumatologist&#63;"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Jos&#233; De La Mata"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "Jos&#233;"
                "apellidos" => "De La Mata"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574312001554"
          "doi" => "10.1016/j.reumae.2012.05.006"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574312001554?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X12001647?idApp=UINPBA00004M"
      "url" => "/1699258X/0000000900000003/v1_201305061538/S1699258X12001647/v1_201305061538/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574312001293"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2012.07.011"
    "estado" => "S300"
    "fechaPublicacion" => "2013-05-01"
    "aid" => "467"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "ssu"
    "cita" => "Reumatol Clin. 2013;9:172-7"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 3985
      "formatos" => array:3 [
        "EPUB" => 59
        "HTML" => 3127
        "PDF" => 799
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review Article</span>"
      "titulo" => "Systematic Literature Review of Biphosphonates and Osteonecrosis of the Jaw in Patients With Osteoporosis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "172"
          "paginaFinal" => "177"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Revisi&#243;n sistem&#225;tica de la literatura sobre la osteonecrosis maxilar con el uso de bisfosfonatos en pacientes con osteoporosis"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1224
              "Ancho" => 1632
              "Tamanyo" => 103202
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Article flow chart&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Eugenio Chamizo Carmona, Adela Gallego Flores, Est&#237;baliz Loza Santamar&#237;a, Aurora Herrero Olea, Mar&#237;a Piedad Rosario Lozano"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Eugenio"
              "apellidos" => "Chamizo Carmona"
            ]
            1 => array:2 [
              "nombre" => "Adela"
              "apellidos" => "Gallego Flores"
            ]
            2 => array:2 [
              "nombre" => "Est&#237;baliz"
              "apellidos" => "Loza Santamar&#237;a"
            ]
            3 => array:2 [
              "nombre" => "Aurora"
              "apellidos" => "Herrero Olea"
            ]
            4 => array:2 [
              "nombre" => "Mar&#237;a Piedad"
              "apellidos" => "Rosario Lozano"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X12001404"
        "doi" => "10.1016/j.reuma.2012.05.005"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X12001404?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574312001293?idApp=UINPBA00004M"
    "url" => "/21735743/0000000900000003/v1_201307311407/S2173574312001293/v1_201307311407/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574313000075"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2012.08.003"
    "estado" => "S300"
    "fechaPublicacion" => "2013-05-01"
    "aid" => "505"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Reumatol Clin. 2013;9:161-5"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 4144
      "formatos" => array:3 [
        "EPUB" => 62
        "HTML" => 3479
        "PDF" => 603
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Brief Report</span>"
      "titulo" => "Newborns Whose Mother Has Autoimmune Disease&#46; A Community Hospitals&#8217; Experience"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "161"
          "paginaFinal" => "165"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Reci&#233;n nacidos de madre con enfermedad autoinmunitaria&#46; Experiencia en un hospital comarcal"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Judith Sanchez-Manubens, Vera Ortiz-Santamaria, Maria Teresa Coll Sibina, Jordi Cuquet, Jorge Ren&#233; Bermudez, Xavier Sur&#237;s, Margarida Catal&#224; i Puigb&#243;"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Judith"
              "apellidos" => "Sanchez-Manubens"
            ]
            1 => array:2 [
              "nombre" => "Vera"
              "apellidos" => "Ortiz-Santamaria"
            ]
            2 => array:2 [
              "nombre" => "Maria Teresa"
              "apellidos" => "Coll Sibina"
            ]
            3 => array:2 [
              "nombre" => "Jordi"
              "apellidos" => "Cuquet"
            ]
            4 => array:2 [
              "nombre" => "Jorge Ren&#233;"
              "apellidos" => "Bermudez"
            ]
            5 => array:2 [
              "nombre" => "Xavier"
              "apellidos" => "Sur&#237;s"
            ]
            6 => array:2 [
              "nombre" => "Margarida"
              "apellidos" => "Catal&#224; i Puigb&#243;"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X12002501"
        "doi" => "10.1016/j.reuma.2012.08.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X12002501?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574313000075?idApp=UINPBA00004M"
    "url" => "/21735743/0000000900000003/v1_201307311407/S2173574313000075/v1_201307311407/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Review Article</span>"
    "titulo" => "Platelet Rich Plasma&#46; A New Treatment Tool for the Rheumatologist&#63;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "166"
        "paginaFinal" => "171"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Jos&#233; De La Mata"
        "autores" => array:1 [
          0 => array:3 [
            "nombre" => "Jos&#233;"
            "apellidos" => "De La Mata"
            "email" => array:1 [
              0 => "drdelamata&#64;frenarlartritis&#46;com"
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Servicio de Reumatolog&#237;a&#44; Cl&#237;nica Nuestra Se&#241;ora del Valle&#44; Madrid&#44; Spain"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Plasma rico en plaquetas&#58; &#191;un nuevo tratamiento para el reumat&#243;logo&#63;"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Platelet rich plasma &#40;PRP&#41; is a novel therapeutic tool of autologous nature that has emerged strongly in recent years due to successful therapeutic use in elite<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> athletes&#46; Famous professional football players&#44; Tiger Woods and Rafael Nadal attribute&#44; in part&#44; their &#8220;miraculous&#8221; recoveries to the employment of this enigmatic treatment dubbed the &#8220;PRP phenomenon&#46;&#8221; PRP treatment is little known but quite prominent in rheumatology&#44; orthopedics and sports medicine congresses in which&#44; despite the controversy surrounding it&#44; has gradually awakened growing interest because of its supposed effectiveness and apparent lack of side effects&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Its therapeutic target eminently comprises chronic tendinopathy and enthesopathy&#44; although the range of indications is constantly expanding and has been successfully used in many ailments&#44; including knee osteoarthritis&#46; Its low cost&#44; ease of use&#44; usefulness in pathological processes elusive to conventional treatments and apparent safety make it a seductive alternative to consider in the therapeutic armamentarium of the rheumatologist&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The following review attempts to analyze what has been called the &#8220;PRP phenomenon&#8217;&#59; I will review in detail the rationale for use&#44; preparation and management regimes&#46; I will also discuss and critically analyze its safety profile and the scientific evidence supporting its use and consider its possible usefulness in rheumatology&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Background</span><p id="par0015" class="elsevierStylePara elsevierViewall">PRP owes its therapeutic interest to the crucial instrumental role of platelets in the wound healing and tissue repair processes&#46; This role is not related to the repairing properties of the platelets themselves but&#44; rather&#44; to growth factors &#40;GF&#41; released by its &#945; granules&#44; which possess multiple regenerative properties &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Tissue wound repair is a complex process in which a variety of cellular functions such as chemotaxis&#44; angiogenesis&#44; cell proliferation&#44; extracellular matrix formation and the &#8220;cleansing&#8221; macrophage coexist&#44; sequentially and covertly&#46; These functions form a complex in which three relatively distinct phases are classically distinguished&#58; inflammation&#44; proliferation and remodeling&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;7</span></a> All GF content of the PRP is involved in the phases described&#44; but all of their functions are still unknown&#46; It is speculated that some of them play a role&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> but it is conceivable that each individual prominence varies depending on the type of tissue wound &#40;ruptured&#44; inflammation&#44; degeneration&#44; etc&#46;&#41; and the type of tissue &#40;tendon&#44; muscle&#44; bone&#44; etc&#46;&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Preparation and Dosing Schedules</span><p id="par0020" class="elsevierStylePara elsevierViewall">PRP is defined as a plasma fraction containing a higher concentration of platelets than the peripheral blood&#46; Some authors are more precise and consider PRP platelet concentrations to be approximately five times above normal&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Actually&#44; it is a plasma aliquot of 20&#8211;30<span class="elsevierStyleHsp" style=""></span>ml of peripheral blood centrifuged at 3200<span class="elsevierStyleHsp" style=""></span>rpm for 15<span class="elsevierStyleHsp" style=""></span>min&#46; The result is approximately 2&#8211;3<span class="elsevierStyleHsp" style=""></span>ml of platelet-rich plasma with varying concentrations&#44; usually about 1<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span> platelets&#46; Said aliquot can be activated with thrombin or calcium chloride for future therapeutic usefulness&#46; When PRP is intended to treat soft tissue injuries most authors consider prior activation not necessary&#44; because this is produced in situ in contact with the tendon collagen or fibrillar<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> breakage clot itself&#46; When PRP is used to facilitate integration of bone implants&#44; or when used for the treatment of knee osteoarthritis&#44; some activation is usually preferred giving it a gelatinous consistency that facilitates its surgical use&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The doses and administration regimes vary depending on the condition being treated&#46; In the case of chronic tendinopathy&#44; the literature seems to agree on a single administration for epicondylitis&#44; Achilles tendinitis and plantar fasciitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;11&#44;12</span></a> However&#44; it may be used on three consecutive occasions &#40;one every two weeks&#41; in the case of a chronic patellar tendinopathy or &#8220;jumper&#39;s knee&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> There are some authors who frequently use PRP for the treatment of impingement syndrome&#44; especially when it is chronic or refractory&#46; However&#44; no reliable information is available to provide evidence of a specific dosing schedule&#46; Recently the usefulness of PRP for treating osteoarthritis of the knee has been reported&#46; Most authors agree that the ideal number of infiltrations in these cases should be 3&#44; but there is no unanimity about the dosing interval&#44; with good results both on a weekly&#44; as well as triweekly basis&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Safety</span><p id="par0030" class="elsevierStylePara elsevierViewall">The autologous nature of PRP appears to be the main argument for its safe tolerance on infiltration&#44; rarely producing mild local inflammatory reactions&#46; There have also been reports of postpuncture infection data that may be able to relate to the antimicrobial effect of PRP as suggested by some authors&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> Adherents to PRP say repeatedly that no undesirable effects exist because it is an autologous product in nature&#46; The truth is that these statements are based only on their own experiences&#44; because there are neither safety studies&#44; nor authoritative information from clinical trials&#46; Conceivably&#44; the autologous nature of PRP provides therapeutic tolerance&#44; but tolerance does not mean safety&#46; The therapeutic effect is achieved by concentrating PRP&#39;s massive amounts of GF in the damaged tissues&#46; As mentioned&#44; GF promote multiple cellular functions that well modulated may result in an acceleration of tissue repair process&#46; Tissue repair is not the only process in which these factors contribute decisively&#46; The endothelial growth factor &#40;VEGF&#41;&#44; the basic fibroblast growth factor&#44; hepatocyte growth factor &#40;HGF&#41;&#44; and insulin growth factor are particularly important factors in the growth of certain tumors because of their angiogenic high potential&#46; Some GF have even exhibited oncogenic potential themselves&#44; capable of promoting clonal expansion of previously mutated cells&#44; facilitating their immortalization cycle by inhibiting apoptosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#8211;19</span></a> These properties of GF&#44; promoting the generation and perpetuation of tumors&#44; although disturbing are only described in experimental animals&#44; and there is no evidence so far linking the therapeutic use of PRP in humans with carcinomatous transformation&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">It has recently been demonstrated that certain GF favor proliferation or activation &#40;in situ and peripheral&#41; of circulating osteogenic progenitors or &#8220;COP cells&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> These recently described undifferentiated cells are known as osteochondral progenitors that are definitely involved in extraskeletal bone formation&#44; as occurs in postarthroplasty heterotopic ossification<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> or valve calcifications&#46; It seems reasonable that&#44; in the presence of a suitable microenvironment in the wound tissue&#44; exaggerated GF concentrations contained in the PRP may promote recruitment and activation of COP supranormal cells in the infiltration area with capacity to develop heterotopic calcification or intra level ossification of soft tissue&#46; To date&#44; these reflections do not stop from being mere speculation since no complications have been reported in the literature as such&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Preclinical Evidence</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Tendon and Muscle</span><p id="par0040" class="elsevierStylePara elsevierViewall">Most of the preclinical evidence supporting the benefit of PRP in tendinopathy is based on its supposed ability to stimulate tissue repair process&#46; Cell cultures provide evidence that PRP is involved in the different phases of the repair process&#46; In the inflammatory phase&#44; the GF contained in PRP can mobilize circulating inflammatory cells into the wound&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> They also stimulate tenoviocytes to secrete collagen&#44; VEGF and HGF&#44; all of them reparative<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> process accelerators&#46; In the proliferative phase&#44; PRP is capable of stimulating the proliferation and division of almost all types of mesenchymal cells &#40;osteoblasts&#44; fibroblasts&#44; chondrocytes or tenoviocytes&#41; and also multipotential<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> stem cell&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> In the final phase of remodeling&#44; PRP facilitates newly formed collagen maturation and apoptosis of excess cells&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> Taken together&#44; all of these evidences involve PRP definitely in the tissue repair process&#44; but do not clarify whether this involvement translates directly into acceleration&#44; and even less when it favors faster and more efficient healing&#44; as proposed by some authors&#46; Some of these questions have been clarified by certain animal models&#46; In murine models with partial section of the Achilles tendon&#44; PRP has been shown to be associated with a faster consolidation of the tendon callus&#44; which is also mechanically efficient&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">28&#44;29</span></a> Part of this effect could be due to its ability to accumulate circulating proinflammatory cells in the tendon wound&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> In muscle&#44; some models also have observed a benefit of PRP in the myofibrillar repair process&#46; In a model of breaking-strain of the tibialis anterior in rats&#44; PRP seems to significantly shorten recovery times in those lesions that require myogenesis for recovery&#44; directly involving them in the process of muscular neoformation&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> None of these studies have yet determined the properties that each GF individually has in these two different microenvironments&#46; The response to PRP in animal models of inflammatory tendinopathy<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> has also been described&#44; more in line with the reality of clinical rheumatologists&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Bone and Joints</span><p id="par0045" class="elsevierStylePara elsevierViewall">Historically the first PRP therapeutic applications began in the field of dental surgery for compacting maxillofacial implants and bone<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> sealant&#46; These osteointegrating properties caught the attention of some orthopedic surgeons who saw PRP as the ideal adjuvant to shorten the recovery of certain surgeries&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> This osteoinductive and sealant effect is still controversial&#44; but the most consistent and valuable for many of its advocates&#46; The truth is that the composition of PRP&#39;s many factors individually has shown a potent bone anabolic effect&#46; The osteoinductive potential of platelet derived growth has been confirmed in more than one study so some authors have speculated on its clinical use &#40;especially the BB isoform&#41; in osteoporosis and consolidation of fracture<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> calluses&#46; One of the best-known properties of the epidermal growth factor &#40;EGF&#41; is its ability to expand totipotent stem cell populations&#46; EGF is also able to differentiate these cells to the osteoblast lineage&#44; thereby favoring remarkable osteogenesis&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">35&#44;36</span></a> The fibroblast growth factor &#40;FGF&#41; is a classic and very powerful stimulator of the differentiation and activation of osteoblasts and has bone anabolic potential which is due in large measure to the Wnt<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> pathway activation&#46; In rabbits&#44; FGF has been used successfully for the treatment of hip osteonecrosis&#44; avoiding collapse not only of the femoral head&#44; but also the development of secondary<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> coxarthrosis&#46; In humans&#44; FGF significantly accelerates the formation of bone callus&#44; shortening tibial<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> osteotomy patient&#39;s time to discharge&#46; The transformative growth factor &#946; &#40;TGF &#946;&#41; is a GF widely involved in bone and chondral<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> anabolism&#46; However&#44; the TGF &#946; superfamily is a complex of factors and receptors which&#44; under various circumstances&#44; can be converted into powerful stimulators and also osteoclast determinants associated to&#44; for example&#44; myeloma bone aggressiveness and multiple skeletal<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">41&#44;42</span></a> metastases&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The set of all such evidence suggests that&#44; by virtue of its composition&#44; PRP meets the right qualities to play a powerful osteoinductive role&#44; capable of accelerating consolidation or osteointegration of fractures quickly and efficiently<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">43&#44;44</span></a> as well as of different types of implants&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a> However&#44; the literature is not unanimous in weighing these hypothetical beneficial properties of PRP&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">46&#8211;48</span></a> The relative concentrations of each GF upon activation&#44; the dosing schedule&#44; the type of injury and the microenvironment are determinants that seem to alter the osteoinductive qualities of GF which may be translated into the real clinical benefits of PRP&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The use of PRP in joints is relatively recent and has scant preclinical literature&#46; Regarding degenerative arthropathy&#44; there is only one work that analyzes the effect of PRP in knee osteoarthritis in rabbits&#46; In this study&#44; the authors histologically examined knees of rabbits treated with PRP-impregnated microspheres&#44; observing a reduction in the progression of osteoarthritis with respect to controls&#46; Using complementary cell cultures&#44; the authors concluded that this effect was due to the metabolic stimulation of chondral matrix synthesis through glucosaminglycans&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> Regarding inflammatory arthritis&#44; a paper has just recently been released&#44; of particular interest to rheumatologists&#44; which analyzes the effect of PRP in a porcine model of antigen-induced rheumatoid arthritis&#46; In this study&#44; intra-articular treatment with PRP of arthritic knees resulted&#44; histologically and immunohistochemically&#44; in a significant attenuation of the inflammatory changes characteristic of the disease&#44; both at the synovial and<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a> cartilage levels&#46; These results contrast to some extent&#44; with the recently proinflammatory effect attributed to platelets in rheumatoid arthritis and other inflammatory arthropathies&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a></p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Clinical Evidence</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Platelet Rich Plasma and Subacromial Tendonitis</span><p id="par0060" class="elsevierStylePara elsevierViewall">The use of the PRP in the subacromial syndrome and all variants lacks&#44; to date&#44; studies that evaluate it as a single treatment&#46; The only evidence mentions its use as an adjuvant in decompressive and reconstructive surgery of the rotator cuff&#46; In this type of surgery&#44; PRP improves the results of conventional reconstructive surgery and shortens recuperation time&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">52&#44;53</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Platelet Rich Plasma and Epicondylitis</span><p id="par0065" class="elsevierStylePara elsevierViewall">Epicondylitis is a limiting tendinopathy&#44; with a clear tendency to become chronic&#44; which has a random&#44; often partial response to glucocorticoid infiltrations and physiotherapy&#46; Some authors have investigated the effectiveness of PRP in this disease because of the potential remedial effect observed in animal models&#46; The pioneering essay that analyzes for the first time the effect of PRP on epicondylitis dates from 2006&#46; This is a pilot&#44; local anesthetic-controlled study&#44; performed on 19 patients with refractory epicondylitis<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> who were proposed surgery&#46; In this study&#44; the effect of a single injection of PRP on pain &#40;Visual Analog Pain Scale &#91;VAS&#93;&#41; and functional capacity &#40;Mayo Elbow Score modified&#41; was analyzed&#46; At 8 weeks&#44; patients referred an improvement of 60&#37; &#40;16&#37; in controls&#41;&#44; which after two years ended up being 93&#37;&#46; No adverse effects were reported&#46; More recently&#44; an open study with 30 patients also analyzed the role of PRP as salvage therapy in epicondylitis&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a> As in previous studies&#44; a single dose of PRP was administered and its effect was evaluated annually on pain &#40;VAS&#41; and functional capacity &#40;American Shoulder &#38; Elbow Surgeons outcome instrument&#41;&#46; It reported a 25&#37; improvement in VAS in &#8805;90&#37; of patients&#44; finding no adverse effects&#46; The findings of the two studies ponder the clinical utility of PRP in patients with refractory epicondylitis&#46; Remember that the design of both had some biases that limit the value of their findings&#46; The main limitation lies in the small number of patients treated in both cases&#44; to which the lack of randomization and blinding in a randomized controlled retrospective manner must be added&#46; At the beginning of 2010 the first quality clinical trial was published&#44; leading to less vulnerable conclusions on the role of PRP in patients with epicondylitis&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a> It was a comparative clinical trial&#44; controlled with corticosteroids&#44; randomized&#44; double-blind study on 100 patients with chronic epicondylitis who were followed one year&#46; It analyzed the effect of a single injection of PRP in pain and improvement of functional capacity of the elbow&#44; using corticosteroid infiltration as control&#46; A VAS decreased in the Disabilities of the Arm&#44; Shoulder and Hand score &#40;DASH&#41; more than 25&#37; was considered as a measure of response to treatment&#46; In the PRP group&#44; it was reported by 73&#37; of respondents&#44; while in the group of patients who received corticosteroids only 50&#37; reported the outcome&#46; In this study no adverse effect was reported&#46; The authors concluded that PRP significantly exceeded the clinical benefit obtained by corticosteroids&#46; However&#44; the clinical benefit achieved by corticosteroids in this work is directly influenced by the fact that all the patients included in the trial must have had evidence of pre refractoriness to local injections of corticosteroids&#46; This bias prevents a true comparative analysis as it greatly favors PRP in comparison with steroids&#46; Additionally&#44; the results of this study support the concept reported in the previous 2&#44; on the analgesic properties of the PRP in the treatment of epicondylitis&#44; without presenting clinically significant adverse effects&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Platelet Rich Plasma and Plantar Fasciitis</span><p id="par0070" class="elsevierStylePara elsevierViewall">Plantar fasciitis is another common problem in rheumatology and&#44; like the rest of tendinopathy&#44; also tends to chronicity&#46; The only evidence that analyzes the effect of PRP on plantar fasciitis dates from 2004 and is the first study that applies PRP to any type of tendinopathy&#46; It is a series of 9 patients&#44; followed for a year&#44; with plantar fasciitis refractory to NSAIDs&#44; immobilization&#44; physical therapy and corticosteroid infiltration&#44; given a single ultrasound-guided injection of PRP in the central and medial calcaneal fascicles&#46; It evaluated the improvement in pain and ultrasound pattern changes&#46; At follow-up&#44; 8 of the 9 patients were asymptomatic but one of them required a second dose&#46; The ultrasound thickness decreased at 3 months &#40;on average&#41; 1&#46;2<span class="elsevierStyleHsp" style=""></span>mm in the central and 2&#46;3<span class="elsevierStyleHsp" style=""></span>mm in the medial bundles&#46; The evidence provided by this work seems worthy of further study&#44; but it is still anecdotal given the small number of patients treated and the biases inherent in a retrospective design and open design&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Platelet Rich Plasma and Knee Osteoarthritis</span><p id="par0075" class="elsevierStylePara elsevierViewall">The application of PRP to treat osteoarthritis of the knee can be considered a relatively new therapeutic indication that focuses undoubtedly on the most current clinical research&#46; This new indication has led to multiple studies in the past 3 years&#44; both controlled and open&#46; Among them&#44; one highlight is a retrospective study of 60 patients with osteoarthritis of the knees&#44; followed for 5 weeks&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> This study compared the therapeutic effect of PRP with high molecular weight hyaluronic acid &#40;HMWHA&#41;&#46; The authors treated 30 patients with an infiltration weekly &#40;for 3 weeks&#41; of activated PRP and a similar number with a single dose of HMWHA&#46; Respondents were considered those who decreased the WOMAC pain score &#8805;40&#37; from baseline&#46; The authors found 33&#37; responders with PRP and 10&#37; with hyaluronic acid at the end of follow-up&#46; Such a low percentage of responders to viscosupplementation is surprising&#44; documented in the literature with much higher response rates than those in this trial&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">56</span></a> Undoubtedly&#44; a very poor response from the control group favors PRP in the comparative analysis&#46; Probably&#44; this analysis would have been more truthful and more clinically relevant if the patients had been tracked longer in order to fully develop the potential HMWHA accredited analgesic efficacy&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">57</span></a> In favor of the results of this study it should be noted that it was the first to specify the relative concentrations of GF contained in the infiltrated plasma&#44; and also it is the only paper published that explicitly uses leukocyte free PRP&#44; a very important fact for some authors&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">58</span></a> Very recently a new study&#44; with a larger number of patients&#44; again compares the effect of PRP with hyaluronic acid&#46; This is a new comparative trial on 150 patients with osteoarthritis of the knees&#44; followed for 6 months&#46; It establishes three treatment arms with 50 patients each&#58; activated PRP &#40;infiltration every 21 days&#41;&#44; HMWHA &#40;single dose&#41; and low molecular weight hyaluronic acid &#40;LMWHA&#41; &#40;single dose&#41;&#46; It analyzed the effect on the visual analogue scale of quality of life related to health status &#40;EQ VAS&#41; and knee function using the International Knee Documentation Committee index &#40;IKDC&#41;&#46; At follow-up&#44; the authors reported better response rates in PRP-treated patients than in those treated with AHAPM or AHBPM &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;005&#41;&#46; In all groups&#44; the response was better in younger patients and in those who had a more recent onset osteoarthritis&#46; As in previous studies&#44; a comparative analysis was not entirely fair and in this case&#44; the AHBPM comparison was not clear&#46; The use of infra treatment therapeutic dose control&#44; as in this case&#44; for AHBPM&#44;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a> favors the intervention to be analyzed &#40;PRP&#41;&#46; Besides this bias&#44; lack of randomization and blinding lack credibility and&#44; on the other hand&#44; employs rare outcome measures and doubtful discriminative ability for osteoarthritis of the knee&#44; such as IKDC&#44; for example&#44; as it is an index originally designed for the analysis of knee<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> ligamentous instability&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Some series of patients with osteoarthritis of the knees&#44; successfully treated with PRP have also been reported in recent years&#46; The largest number belongs to a Spanish group that included 261 patients treated with three injections of activated PRP every 15 days &#40;infiltrated volume not detailed&#41;&#44; which was followed for 6 months&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a> VAS&#44; WOMAC &#40;pain&#44; stiffness and functional class&#41;&#44; and SF-36 Lequesme &#40;baseline and 6 months&#41; were assessed&#46; In their results&#44; the authors reported improvement in all outcome measures&#44; with percentages &#40;relative to baseline&#41; ranging from 8&#46;4 in SF-36 and 30&#46;7 in the WOMAC pain subscale&#46; Another series with a longer follow-up&#44; included 100 patients with osteoarthritis of the knee treated and followed for a year&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> In this work&#44; which also employed 3 doses of activated PRP administered every three weeks&#44; the authors found a significant improvement in VAS and EQ IKDC that&#44; although more marked in the first 6 months&#44; remained for a year&#46; As in other studies of the same group&#44; patients with the most benefit were young and had a less evolved osteoarthritis&#46; Finally&#44; one last article is worth mentioning that evaluates the effect of PRP in 14 patients with refractory prosthetic gonarthrosis<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">62</span></a> proposed for replacement&#46; It included patients with osteoarthritis of the knee refractory to conservative treatment &#40;NSAIDs&#44; rehabilitation&#44; acupuncture&#44; corrective splints&#44; injections of corticosteroids or hyaluronic acid&#41; that were treated with 3 doses of activated PRP &#40;one per month&#41;&#46; An effect was observed one year after infiltration on the VAS and the Knee Injury &#38; Osteoartrhitis Outcome measure&#46; The authors observed a linear improvement of VAS and Knee Injury &#38; Osteoartrhitis Outcome in 60&#37; of patients at follow-up&#46; Although 40&#37; of patients did not improve&#44; none had to undergo surgery during the study&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Significant adverse effects were not reported in the five above mentioned studies&#44; except for local postpuncture pain&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusions</span><p id="par0090" class="elsevierStylePara elsevierViewall">PRP is a novel therapeutic tool that has arguments for and against its use in the rheumatologist&#39;s therapeutic spectrum&#46; Proponents point out to&#44; among its highest virtues&#44; its autologous nature in guaranteeing an excellent safety profile&#46; However&#44; in the reviewed literature&#44; there are no safety studies and clinical trials that can permit such conclusions to be drawn&#46; Series of patients and published works provide information about adverse local reactions&#46; While tolerance to PRP infiltration is excellent as is its short-term safety&#44; this profile in the long-term is still incomplete or at least uncertain&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The supposed effectiveness of PRP in various diseases has not been studied in clinical trials of proven quality&#46; The studies supporting its effectiveness have a level of evidence under multiple biases penalized for both design and implementation&#46; However&#44; the results reported so far are unanimous in stating that PRP&#44; if not effective&#44; is useful in the treatment of epicondylitis and knee osteoarthritis&#46; Among a number of specialists there may be sufficient evidence to justify the use of PRP&#46; They may argue that medicine &#40;until recent years&#41; has progressed and grown outside the orthodoxy of clinical trials&#44; sustained by a less demanding scientific rigor than that reviewed here&#46; They are right&#46; For another great part of clinicians&#44; this evidence will be inadequate and will not neutralize the logical suspicion that a treatment prescribed for multiple conditions that have nothing in common produces&#44; protected by an aura of safety that transcends the strictly scientific&#46; It may be more appropriate not to be seduced by fashion prejudices nor dwell on academics&#44; substantiating the value of this therapy through quality clinical trials that to date do not exist&#44; and seem indispensable to properly develop the therapeutic potential of PRP&#46; This work will require the measurement of many important aspects of the therapeutic usefulness that are still confusing such as collection&#44; processing or activation&#46; Additionally&#44; this will help formalize the doses&#44; volumes and more appropriate management schemes&#44; establish guidelines&#44; and especially more rigorously evaluate its potential safety issues&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Rheumatologists&#44; as leaders in medical pathology of the musculoskeletal system&#44; should enforce judgment and properly size up this novel treatment&#44; as other specialists in the field have already done&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><p id="par0110" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Protection of human and animal subjects&#46;</span> The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Confidentiality of Data&#46;</span> The authors declare that no patient data appears in this article&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Right to privacy and informed consent&#46;</span> The authors declare that no patient data appears in this article&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of Interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">The author declares no conflict of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:13 [
        0 => array:2 [
          "identificador" => "xres243414"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec229972"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres243413"
          "titulo" => "Resumen"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec229971"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Background"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Preparation and Dosing Schedules"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Safety"
        ]
        7 => array:3 [
          "identificador" => "sec0020"
          "titulo" => "Preclinical Evidence"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Tendon and Muscle"
            ]
            1 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Bone and Joints"
            ]
          ]
        ]
        8 => array:3 [
          "identificador" => "sec0035"
          "titulo" => "Clinical Evidence"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Platelet Rich Plasma and Subacromial Tendonitis"
            ]
            1 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Platelet Rich Plasma and Epicondylitis"
            ]
            2 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Platelet Rich Plasma and Plantar Fasciitis"
            ]
            3 => array:2 [
              "identificador" => "sec0055"
              "titulo" => "Platelet Rich Plasma and Knee Osteoarthritis"
            ]
          ]
        ]
        9 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Conclusions"
        ]
        10 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Ethical disclosures"
        ]
        11 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conflict of Interest"
        ]
        12 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2012-02-08"
    "fechaAceptado" => "2012-05-23"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec229972"
          "palabras" => array:5 [
            0 => "Platelet rich plasma"
            1 => "Impingement syndrome"
            2 => "Tennis elbow"
            3 => "Plantar fasciitis"
            4 => "Knee osteoarthritis"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec229971"
          "palabras" => array:5 [
            0 => "Plasma rico en plaquetas"
            1 => "S&#237;ndrome subacromial"
            2 => "Epicondilitis"
            3 => "Fascitis plantar"
            4 => "Osteoartritis de rodilla"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Platelet rich plasma &#40;PRP&#41; is a novel therapeutic tool that has revolutionized the world of sports medicine and trauma due to therapeutic success shown in the media&#46; Subject to ongoing debate&#44; the PRP is outlined along a spectrum of musculoskeletal therapies with many qualities that make it ideal for use in the rheumatology&#58; effectiveness&#44; safety&#44; easy handling and low cost&#46; Is PRP a product of marketing&#63; Or&#44; conversely&#44; is an interesting tool to consider in the armamentarium of the rheumatologist&#46; In the following review we will analyze in detail its principles&#44; preparation&#44; and management regimes&#46; We will reflect on potential adverse effects and&#44; finally&#44; there will be a critical analysis of the scientific evidence that supports its potential use in the rheumatology clinic&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El plasma rico en plaquetas &#40;PRP&#41; es una novedosa herramienta terap&#233;utica que ha revolucionado el mundo de la medicina deportiva y la traumatolog&#237;a debido a &#233;xitos terap&#233;uticos medi&#225;ticos en deportistas de &#233;lite&#46; Sujeto a continuo debate&#44; el PRP se perfila en el espectro de las terapias musculoesquel&#233;ticas con m&#250;ltiples cualidades que potencialmente lo hacen id&#243;neo para su uso en la consulta de reumatolog&#237;a&#58; efectividad&#44; seguridad&#44; f&#225;cil manejo y bajo coste&#46; &#191;Es el PRP un nuevo producto de la mercadotecnia&#63; o&#44; por el contrario&#44; es una herramienta con fundamento que debe incluirse en el arsenal terap&#233;utico del reumat&#243;logo&#46; En la siguiente revisi&#243;n se repasar&#225;n en detalle su fundamento&#44; preparaci&#243;n y reg&#237;menes de administraci&#243;n&#46; Se reflexionar&#225; sobre potenciales efectos adversos y&#44; por &#250;ltimo&#44; se realizar&#225; un an&#225;lisis cr&#237;tico de la evidencia cient&#237;fica que avala su posible uso en la consulta de reumatolog&#237;a&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; De La Mata J&#46; Plasma rico en plaquetas&#58; &#191;un nuevo tratamiento para el reumat&#243;logo&#63; Reumatol Clin&#46; 2012&#46; <span class="elsevierStyleInterRef" href="doi:10.1016/j.reuma.2012.05.011">http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;reuma&#46;2012&#46;05&#46;011</span>&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Growth Factor &#40;GF&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Origin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Function&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Transforming GF &#946; &#40;TGF &#946;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelets&#44; bone and cartilage matrix&#44; monocytes&#44; neutrophils&#44; &#171;natural killer&#187; cells and activated TH1 cells&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Proliferation of undifferentiated mesenchimal cells&#59; inhibition of lymphocyte and macrophage proliferation&#59; regulate&#58;- Endothelial&#44; fibroblastic and osteoblastic mitogenesis- Collagen synthesis and secretion of collagenases- Mitogenous effect on other GF&#46;- Endothelial chemotaxis and angiogenesis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Basic fibroblast GF &#40;FGFb&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelets&#44; macrophages&#44; mesenchimal cells&#44; chondrocytes and osteoblasts&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stimulates mitogenesis&#44; growth and differentiation of chondrocytes and osteoblasts and mesenchimal cell mitogenesis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelet derived GF &#40;PDGF&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelets&#44; osteoblasts&#44; endothelial cells&#44; macrophages&#44; monocytes&#44; smooth muscle cells&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stimulates mitogenesis of mesenchimal cells and osteoblasts&#59; mitogenesis and chemotaxis of fibroblastic&#44; glial&#44; smooth muscle linage cells&#59; regulates collagenase secretion and stimulates epithelial mesenchimal mitogenesis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vascular endothelial GF &#40;VEGF&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelets&#44; endothelial cells&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Increases angiogenesis&#44; vascular permeability and endothelial cell mitogenesis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Connective tissue GF &#40;CTGF&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelets&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Promotes angiogenesis&#44; chondral regeneration&#44; fibrosis and platelet adhesion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Epidermal GF &#40;EGF&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelets&#44; macrophages and monocytes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stimulates endothelial chemotaxis and angiogenesis&#59; regulates secretion of collagenases&#59; stimulates mitogenesis of mesenchimal and epithelial cells&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab351510.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Growth Factors Contained in Platelet Rich Plasma&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:62 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Schwartz A&#46; A promising treatment for athletes in blood&#46; The New York Times Website &#91;accessed 17 Feb 2009&#93;&#46; Available from&#58; <a class="elsevierStyleInterRef" href="http://www.nytimes.com/2009/02/17/sports/17blood.htlm%3Fscp=1%26sq=A">http&#58;&#47;&#47;www&#46;nytimes&#46;com&#47;2009&#47;02&#47;17&#47;sports&#47;17blood&#46;htlm&#63;scp&#61;1&#38;sq&#61;A</a>"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Musculoskeletal applications of platelet-rich plasma&#58; fad or future&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46;S&#46; Lee"
                            1 => "J&#46;J&#46; Wilson"
                            2 => "D&#46;P&#46; Rabago"
                            3 => "G&#46;S&#46; Baer"
                            4 => "J&#46;A&#46; Jacobson"
                            5 => "C&#46;G&#46; Borrero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "American Journal of Roentgenology"
                        "fecha" => "2011"
                        "volumen" => "196"
                        "paginaInicial" => "628"
                        "paginaFinal" => "636"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of platelet-rich plasma in bone reconstruction therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46; Intini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.biomaterials.2009.05.055"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biomaterials"
                        "fecha" => "2009"
                        "volumen" => "30"
                        "paginaInicial" => "4956"
                        "paginaFinal" => "4966"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19573909"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growth factors improve muscle healing in vivo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Menetrey"
                            1 => "C&#46; Kasemkijwattana"
                            2 => "C&#46;S&#46; Day"
                            3 => "P&#46; Bosch"
                            4 => "M&#46; Vogt"
                            5 => "F&#46;H&#46; Fu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Journal of Bone and Joint Surgery&#46; British Volume"
                        "fecha" => "2000"
                        "volumen" => "82"
                        "paginaInicial" => "131"
                        "paginaFinal" => "137"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Mishra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3928/01477447-20100526-13"
                      "Revista" => array:6 [
                        "tituloSerie" => "Orthopedics"
                        "fecha" => "2010"
                        "volumen" => "33"
                        "paginaInicial" => "486"
                        "paginaFinal" => "487"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20608601"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of platelets in bone remodeling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;S&#46; Sharif"
                            1 => "M&#46; Abdollahi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3305/nh.2015.31.4.8457"
                      "Revista" => array:6 [
                        "tituloSerie" => "Inflammation &#38; Allergy Drug Targets"
                        "fecha" => "2010"
                        "volumen" => "9"
                        "paginaInicial" => "393"
                        "paginaFinal" => "399"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25795948"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interaction between macrophages&#44; TGF-beta1&#44; and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "W&#46; Shen"
                            1 => "Y&#46; Li"
                            2 => "J&#46; Zhu"
                            3 => "R&#46; Schwendener"
                            4 => "J&#46; Huard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jcp.21212"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Cellular Physiology"
                        "fecha" => "2008"
                        "volumen" => "214"
                        "paginaInicial" => "405"
                        "paginaFinal" => "412"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17657727"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma&#58; growth factor enhancement for bone grafts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46;E&#46; Marx"
                            1 => "E&#46;R&#46; Carlson"
                            2 => "R&#46;M&#46; Eichstaedt"
                            3 => "S&#46;R&#46; Schimmele"
                            4 => "J&#46;E&#46; Strauss"
                            5 => "K&#46;R&#46; Georgeff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Oral Surgery&#44; Oral Medicine&#44; Oral Pathology&#44; Oral Radiology and Endodontics"
                        "fecha" => "1998"
                        "volumen" => "85"
                        "paginaInicial" => "638"
                        "paginaFinal" => "646"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of chronic elbow tendinosis with buffered platelet-rich plasma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Mishra"
                            1 => "T&#46; Pavelko"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0363546506288850"
                      "Revista" => array:6 [
                        "tituloSerie" => "American Journal of Sports Medicine"
                        "fecha" => "2006"
                        "volumen" => "34"
                        "paginaInicial" => "1774"
                        "paginaFinal" => "1778"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16735582"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Sanchez"
                            1 => "E&#46; Anitua"
                            2 => "J&#46; Azofra"
                            3 => "I&#46; Andia"
                            4 => "S&#46; Padilla"
                            5 => "I&#46; Mujika"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0363546506294078"
                      "Revista" => array:7 [
                        "tituloSerie" => "American Journal of Sports Medicine"
                        "fecha" => "2007"
                        "volumen" => "35"
                        "paginaInicial" => "245"
                        "paginaFinal" => "251"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17099241"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1542356509007745"
                          "estado" => "S300"
                          "issn" => "15423565"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma injection for chronic Achilles tendinopathy&#58; a randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; de Vos"
                            1 => "A&#46; Weir"
                            2 => "H&#46;T&#46; van Schie"
                            3 => "S&#46;M&#46; Bierma-Zeinstra"
                            4 => "J&#46;A&#46; Verhaar"
                            5 => "H&#46; Weinans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2009.1986"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2010"
                        "volumen" => "303"
                        "paginaInicial" => "144"
                        "paginaFinal" => "149"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20068208"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growth factors for chronic plantar fasciitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Barret"
                            1 => "S&#46; Erredge"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Podiatry Today"
                        "fecha" => "2004"
                        "volumen" => "17"
                        "paginaInicial" => "37"
                        "paginaFinal" => "42"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of platelet-rich plasma for the treatment of refractory jumper&#39;s knee"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Filardo"
                            1 => "E&#46; Kon"
                            2 => "S&#46; Della Villa"
                            3 => "F&#46; Vincentelli"
                            4 => "P&#46;M&#46; Fornasari"
                            5 => "M&#46; Marcacci"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "International Orthopaedics"
                        "fecha" => "2009"
                        "volumen" => "34"
                        "paginaInicial" => "909"
                        "paginaFinal" => "915"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA&#58; a retrospective cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Sanchez"
                            1 => "E&#46; Anitua"
                            2 => "J&#46; Azofra"
                            3 => "J&#46;J&#46; Aguirre"
                            4 => "I&#46; Andia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical and Experimental Rheumatology"
                        "fecha" => "2008"
                        "volumen" => "26"
                        "paginaInicial" => "910"
                        "paginaFinal" => "913"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19032827"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma&#58; intra-articular knee injections produced favorable results on degenerative cartilage lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Kon"
                            1 => "R&#46; Buda"
                            2 => "G&#46; Filardo"
                            3 => "A&#46; Di Martino"
                            4 => "A&#46; Timoncini"
                            5 => "A&#46; Cenacchi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00167-009-0940-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Knee Surgery&#44; Sports Traumatology&#44; Arthroscopy"
                        "fecha" => "2010"
                        "volumen" => "18"
                        "paginaInicial" => "472"
                        "paginaFinal" => "479"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19838676"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances&#58; an in vitro study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46;M&#46; Bielecki"
                            1 => "T&#46;S&#46; Gazdzik"
                            2 => "J&#46; Arendt"
                            3 => "T&#46; Szczepanski"
                            4 => "W&#46; Krol"
                            5 => "T&#46; Wielkoszynski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Journal of Bone and Joint Surgery&#46; British Volume"
                        "fecha" => "2007"
                        "volumen" => "89"
                        "paginaInicial" => "417"
                        "paginaFinal" => "420"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; DiGiovanni"
                            1 => "D&#46;K&#46; Bol"
                            2 => "E&#46; Wilker"
                            3 => "L&#46; Beltran"
                            4 => "S&#46; Carbajal"
                            5 => "S&#46; Moats"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Cancer Research"
                        "fecha" => "2000"
                        "volumen" => "60"
                        "paginaInicial" => "1561"
                        "paginaFinal" => "1570"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10749124"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S021056911200112X"
                          "estado" => "S300"
                          "issn" => "02105691"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of the vascular endothelial growth factor &#40;VEGF&#41; receptor gene&#44; KDR&#44; in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46; Katoh"
                            1 => "H&#46; Tauchi"
                            2 => "K&#46; Kawaishi"
                            3 => "A&#46; Kimura"
                            4 => "Y&#46; Satow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Research"
                        "fecha" => "1995"
                        "volumen" => "55"
                        "paginaInicial" => "5687"
                        "paginaFinal" => "5692"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7585655"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#191;Existen riesgos al utilizar los concentrados de Plasma Rico en Plaquetas &#40;PRP&#41; de uso ambulatorio&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;M&#46; Martinez"
                            1 => "J&#46;C&#46; Gonzalo"
                            2 => "J&#46; Campo"
                            3 => "G&#46;C&#46; Esparza"
                            4 => "J&#46;M&#46; Seoane"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Medicina Oral"
                        "fecha" => "2002"
                        "volumen" => "7"
                        "paginaInicial" => "375"
                        "paginaFinal" => "390"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12415222"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growth factor delivery methods in the management of sports injuries&#58; the state of play"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Creaney"
                            1 => "B&#46; Hamilton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bjsm.2007.040071"
                      "Revista" => array:6 [
                        "tituloSerie" => "British Journal of Sports Medicine"
                        "fecha" => "2008"
                        "volumen" => "42"
                        "paginaInicial" => "314"
                        "paginaFinal" => "320"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17984193"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Circulating osteoblast-lineage cells in humans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46;Z&#46; Eghbali-Fatourechi"
                            1 => "J&#46; Lamsam"
                            2 => "D&#46; Fraser"
                            3 => "D&#46; Nagel"
                            4 => "B&#46;L&#46; Riggs"
                            5 => "S&#46; Khosla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa044264"
                      "Revista" => array:6 [
                        "tituloSerie" => "New England Journal of Medicine"
                        "fecha" => "2005"
                        "volumen" => "352"
                        "paginaInicial" => "1959"
                        "paginaFinal" => "1966"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15888696"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Circulating osteogenic cells&#58; implications for injury&#44; repair&#44; and regeneration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;J&#46; Pignolo"
                            1 => "M&#46; Kassem"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jbmr.370"
                      "Revista" => array:7 [
                        "tituloSerie" => "Journal of Bone and Mineral Research"
                        "fecha" => "2011"
                        "volumen" => "26"
                        "paginaInicial" => "1685"
                        "paginaFinal" => "1693"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21538513"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016508510008644"
                          "estado" => "S300"
                          "issn" => "00165085"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Kajikawa"
                            1 => "T&#46; Morihara"
                            2 => "H&#46; Sakamoto"
                            3 => "K&#46; Matsuda"
                            4 => "Y&#46; Oshima"
                            5 => "A&#46; Yoshida"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jcp.21368"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Cellular Physiology"
                        "fecha" => "2008"
                        "volumen" => "215"
                        "paginaInicial" => "837"
                        "paginaFinal" => "845"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18181148"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stromal stem cells and platelet-rich plasma improve bone allograft integration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Lucarelli"
                            1 => "M&#46; Fini"
                            2 => "A&#46; Beccheroni"
                            3 => "G&#46; Giavaresi"
                            4 => "C&#46; Di Bella"
                            5 => "N&#46; Aldini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical Orthopaedics and Related Research"
                        "fecha" => "2005"
                        "volumen" => "435"
                        "paginaInicial" => "62"
                        "paginaFinal" => "68"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15930922"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Flexor tendon healing in vitro&#58; effects of TGF-beta on tendon cell collagen production"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;B&#46; Klein"
                            1 => "N&#46; Yalamanchi"
                            2 => "H&#46; Pham"
                            3 => "M&#46;T&#46; Longaker"
                            4 => "J&#46; Chang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "The Journal of Hand Surgery"
                        "fecha" => "2002"
                        "volumen" => "27"
                        "paginaInicial" => "615"
                        "paginaFinal" => "620"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12132085"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improved bone healing by angiogenic factor-enriched platelet-rich plasma and its synergistic enhancement by bone morphogenetic protein-2"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;J&#46; Park"
                            1 => "E&#46;S&#46; Kim"
                            2 => "H&#46;P&#46; Weber"
                            3 => "R&#46;F&#46; Wright"
                            4 => "D&#46;J&#46; Mooney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "International Journal of Oral and Maxillofacial Implants"
                        "fecha" => "2008"
                        "volumen" => "23"
                        "paginaInicial" => "818"
                        "paginaFinal" => "826"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19014150"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet rich plasma &#40;PRP&#41; enhances anabolic gene expression patterns in flexor digitorum superficialis tendons"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;V&#46; Schnabel"
                            1 => "H&#46;O&#46; Mohammed"
                            2 => "B&#46;J&#46; Miller"
                            3 => "W&#46;G&#46; McDermott"
                            4 => "M&#46;S&#46; Jacobson"
                            5 => "K&#46;S&#46; Santangelo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jor.20278"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Orthopaedic Research"
                        "fecha" => "2007"
                        "volumen" => "25"
                        "paginaInicial" => "230"
                        "paginaFinal" => "240"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17106885"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet concentrate injection improves Achilles tendon repair in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Aspenberg"
                            1 => "O&#46; Virchenko"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/00016470410001708190"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Orthopaedica Scandinavica"
                        "fecha" => "2004"
                        "volumen" => "75"
                        "paginaInicial" => "93"
                        "paginaFinal" => "99"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15022816"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks&#63; Interplay between early regeneration and mechanical stimulation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46; Virchenko"
                            1 => "P&#46; Aspenberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Orthopaedica"
                        "fecha" => "2006"
                        "volumen" => "77"
                        "paginaInicial" => "806"
                        "paginaFinal" => "812"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of autologous platelet-rich plasma to treat muscle strain injuries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;W&#46; Hammond"
                            1 => "R&#46;Y&#46; Hinton"
                            2 => "L&#46;A&#46; Curl"
                            3 => "J&#46;M&#46; Muriel"
                            4 => "R&#46;M&#46; Lovering"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0363546508330974"
                      "Revista" => array:7 [
                        "tituloSerie" => "American Journal of Sports Medicine"
                        "fecha" => "2009"
                        "volumen" => "37"
                        "paginaInicial" => "1135"
                        "paginaFinal" => "1142"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19282509"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1542356511009086"
                          "estado" => "S300"
                          "issn" => "15423565"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An experimental model of tennis elbow in rats&#58; a study of the contribution of the nervous system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Haker"
                            1 => "E&#46; Theodorsson"
                            2 => "T&#46; Lundeberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Inflammation"
                        "fecha" => "1998"
                        "volumen" => "22"
                        "paginaInicial" => "435"
                        "paginaFinal" => "444"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9675613"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma&#58; evidence to support its use"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;E&#46; Marx"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Oral and Maxillofacial Surgery"
                        "fecha" => "2004"
                        "volumen" => "62"
                        "paginaInicial" => "489"
                        "paginaFinal" => "496"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15085519"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich therapies in the treatment of orthopaedic sport injuries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Sanchez"
                            1 => "E&#46; Anitua"
                            2 => "G&#46; Orive"
                            3 => "I&#46; Mujika"
                            4 => "I&#46; Andia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sports Medicine"
                        "fecha" => "2009"
                        "volumen" => "39"
                        "paginaInicial" => "345"
                        "paginaFinal" => "354"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19402740"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Graham"
                            1 => "A&#46; Leonidou"
                            2 => "M&#46; Lester"
                            3 => "M&#46; Heliotis"
                            4 => "A&#46; Mantalaris"
                            5 => "E&#46; Tsiridis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1517/13543780903241607"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Opinion on Investigational Drugs"
                        "fecha" => "2009"
                        "volumen" => "18"
                        "paginaInicial" => "1633"
                        "paginaFinal" => "1654"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19747084"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermal growth factor &#40;EGF&#41; treatment on multipotential stromal cells &#40;MSCs&#41;&#46; Possible enhancement of therapeutic potential of MSC"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46; Tamama"
                            1 => "H&#46; Kawasaki"
                            2 => "A&#46; Wells"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2010/795385"
                      "Revista" => array:5 [
                        "tituloSerie" => "Journal of Biomedicine and Biotechnology"
                        "fecha" => "2010"
                        "volumen" => "2010"
                        "paginaInicial" => "795385"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20182548"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "X&#46; Zhang"
                            1 => "J&#46; Tamasi"
                            2 => "X&#46; Lu"
                            3 => "J&#46; Zhu"
                            4 => "H&#46; Chen"
                            5 => "X&#46; Tian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jbmr.295"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Bone and Mineral Research"
                        "fecha" => "2011"
                        "volumen" => "26"
                        "paginaInicial" => "1022"
                        "paginaFinal" => "1034"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21542005"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46; Fei"
                            1 => "L&#46; Xiao"
                            2 => "T&#46; Doetschman"
                            3 => "D&#46;J&#46; Coffin"
                            4 => "M&#46;M&#46; Hurley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.M111.274910"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Biological Chemistry"
                        "fecha" => "2011"
                        "volumen" => "286"
                        "paginaInicial" => "40575"
                        "paginaFinal" => "40583"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21987573"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of experimental osteonecrosis of the hip in adult rabbits with a single local injection of recombinant human FGF-2 microspheres"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46; Kuroda"
                            1 => "H&#46; Akiyama"
                            2 => "K&#46; Kawanabe"
                            3 => "Y&#46; Tabata"
                            4 => "T&#46; Nakamura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00774-010-0172-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Bone and Mineral Metabolism"
                        "fecha" => "2010"
                        "volumen" => "28"
                        "paginaInicial" => "608"
                        "paginaFinal" => "616"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20354742"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Local application of recombinant human fibroblast growth factor-2 on bone repair&#58; a dose-escalation prospective trial on patients with osteotomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Kawaguchi"
                            1 => "S&#46; Jingushi"
                            2 => "T&#46; Izumi"
                            3 => "M&#46; Fukunaga"
                            4 => "T&#46; Matsushita"
                            5 => "T&#46; Nakamura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jor.20315"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Orthopaedic Research"
                        "fecha" => "2007"
                        "volumen" => "25"
                        "paginaInicial" => "480"
                        "paginaFinal" => "487"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17205557"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transforming growth factor-beta isoforms and the induction of bone formation&#58; implications for reconstructive craniofacial surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "U&#46; Ripamonti"
                            1 => "C&#46; Ferretti"
                            2 => "J&#46; Teare"
                            3 => "L&#46; Blann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/SCS.0b013e3181b09ca6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Craniofacial Surgery"
                        "fecha" => "2009"
                        "volumen" => "20"
                        "paginaInicial" => "1544"
                        "paginaFinal" => "1555"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19816294"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TGF-beta-related mechanisms of bone destruction in multiple myeloma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Matsumoto"
                            1 => "M&#46; Abe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bone.2010.05.036"
                      "Revista" => array:6 [
                        "tituloSerie" => "Bone"
                        "fecha" => "2010"
                        "volumen" => "48"
                        "paginaInicial" => "129"
                        "paginaFinal" => "134"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20570621"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transforming growth factor-beta in osteolytic breast cancer bone metastases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46;A&#46; Guise"
                            1 => "J&#46;M&#46; Chirgwin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.blo.0000093055.96273.69"
                      "Revista" => array:7 [
                        "tituloSerie" => "Clinical Orthopaedics and Related Research"
                        "fecha" => "2003"
                        "volumen" => "415"
                        "numero" => "Suppl&#46; 10"
                        "paginaInicial" => "S32"
                        "paginaFinal" => "S38"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14600590"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma concentrate to augment bone fusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Bibbo"
                            1 => "P&#46;S&#46; Hatfield"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.fcl.2010.09.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Foot and Ankle Clinics"
                        "fecha" => "2010"
                        "volumen" => "15"
                        "paginaInicial" => "641"
                        "paginaFinal" => "649"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21056862"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mandibular reconstruction&#58; a histological and histomorphometric study on the use of autogenous scaffolds&#44; particulate cortico-cancellous bone grafts and platelet rich plasma in goats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;P&#46; Fennis"
                            1 => "P&#46;J&#46; Stoelinga"
                            2 => "J&#46;A&#46; Jansen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1054/ijom.2003.0452"
                      "Revista" => array:6 [
                        "tituloSerie" => "International Journal of Oral and Maxillofacial Surgery"
                        "fecha" => "2004"
                        "volumen" => "33"
                        "paginaInicial" => "48"
                        "paginaFinal" => "55"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14690659"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet concentration and its effect on bone formation in calvarial defects&#58; an experimental study in rabbits"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46;S&#46; Kim"
                            1 => "E&#46;J&#46; Park"
                            2 => "P&#46;H&#46; Choung"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mpr.2001.115874"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Prosthetic Dentistry"
                        "fecha" => "2001"
                        "volumen" => "86"
                        "paginaInicial" => "428"
                        "paginaFinal" => "433"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11677539"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Application of PRP gel alone or in combination with guided bone regeneration does not enhance bone healing process&#58; an experimental study in rabbits"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Kazakos"
                            1 => "D&#46;N&#46; Lyras"
                            2 => "V&#46; Thomaidis"
                            3 => "G&#46; Agrogiannis"
                            4 => "S&#46; Botaitis"
                            5 => "G&#46; Drosos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jcms.2010.03.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Cranio-Maxillo-Facial Surgery"
                        "fecha" => "2010"
                        "volumen" => "39"
                        "paginaInicial" => "49"
                        "paginaFinal" => "53"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20456969"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of platelet-rich plasma on a rabbit model of nicotine-compromised bone healing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Ma"
                            1 => "L&#46;W&#46; Zheng"
                            2 => "M&#46;H&#46; Sham"
                            3 => "C&#46;K&#46; Lam"
                            4 => "R&#46;A&#46; Zwahlen"
                            5 => "L&#46;K&#46; Cheung"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.joms.2010.05.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Oral and Maxillofacial Surgery"
                        "fecha" => "2010"
                        "volumen" => "69"
                        "paginaInicial" => "28"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20971543"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma inhibits demineralized bone matrix-induced bone formation in nude mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;M&#46; Ranly"
                            1 => "C&#46;H&#46; Lohmann"
                            2 => "D&#46; Andreacchio"
                            3 => "B&#46;D&#46; Boyan"
                            4 => "Z&#46; Schwartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2106/JBJS.F.00388"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Bone and Joint Surgery"
                        "fecha" => "2007"
                        "volumen" => "89"
                        "paginaInicial" => "139"
                        "paginaFinal" => "147"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17200321"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraarticular administration of platelet-rich plasma with biodegradable gelatin hydrogel microspheres prevents osteoarthritis progression in the rabbit knee"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Saito"
                            1 => "K&#46;A&#46; Takahashi"
                            2 => "Y&#46; Arai"
                            3 => "A&#46; Inoue"
                            4 => "K&#46; Sakao"
                            5 => "H&#46; Tonomura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical and Experimental Rheumatology"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "201"
                        "paginaFinal" => "207"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19473558"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraarticular injection of platelet-rich plasma reduces inflammation in a pig model of rheumatoid arthritis of the knee joint"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Lippross"
                            1 => "B&#46; Moeller"
                            2 => "H&#46; Haas"
                            3 => "M&#46; Tohidnezhad"
                            4 => "N&#46; Steubesand"
                            5 => "C&#46;J&#46; Wruck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.30547"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis and Rheumatism"
                        "fecha" => "2011"
                        "volumen" => "63"
                        "paginaInicial" => "3344"
                        "paginaFinal" => "3353"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21769848"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelets amplify inflammation in arthritis via collagen-dependent microparticle production"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Boilard"
                            1 => "P&#46;A&#46; Nigrovic"
                            2 => "K&#46; Larabee"
                            3 => "G&#46;F&#46; Watts"
                            4 => "J&#46;S&#46; Coblyn"
                            5 => "M&#46;E&#46; Weinblatt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1126/science.1181928"
                      "Revista" => array:7 [
                        "tituloSerie" => "Science"
                        "fecha" => "2010"
                        "volumen" => "327"
                        "paginaInicial" => "580"
                        "paginaFinal" => "583"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20110505"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1542356511003077"
                          "estado" => "S300"
                          "issn" => "15423565"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exogenous application of platelet-leukocyte gel during open subacromial decompression contributes to improved patient outcome&#58; a prospective randomized double-blind study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;A&#46; Everts"
                            1 => "R&#46;J&#46;J&#46; Devilee"
                            2 => "C&#46; Brown Mahoney"
                            3 => "A&#46; Van Erp"
                            4 => "C&#46;J&#46;M&#46; Oosterbos"
                            5 => "M&#46; Stellenboom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000110862"
                      "Revista" => array:6 [
                        "tituloSerie" => "European Surgical Research"
                        "fecha" => "2008"
                        "volumen" => "40"
                        "paginaInicial" => "203"
                        "paginaFinal" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17998780"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of platelet-rich plasma in rotator cuff repair"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46; Mei-Dan"
                            1 => "M&#46;R&#46; Carmont"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Sports Medicine and Arthroscopy"
                        "fecha" => "2011"
                        "volumen" => "19"
                        "paginaInicial" => "244"
                        "paginaFinal" => "250"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma injection reduces pain in patients with recalcitrant epicondylitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;S&#46; Hechtman"
                            1 => "J&#46;W&#46; Uribe"
                            2 => "A&#46; Botto-vanDemden"
                            3 => "G&#46;M&#46; Kiebzak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3928/01477447-20101221-05"
                      "Revista" => array:6 [
                        "tituloSerie" => "Orthopedics"
                        "fecha" => "2011"
                        "volumen" => "34"
                        "paginaInicial" => "92"
                        "paginaFinal" => "100"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21323296"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial&#58; platelet-rich plasma versus corticosteroid injection with a 1-year follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;C&#46; Peerbooms"
                            1 => "J&#46; Sluimer"
                            2 => "D&#46;J&#46; Bruijn"
                            3 => "T&#46; Gosens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0363546509355445"
                      "Revista" => array:6 [
                        "tituloSerie" => "American Journal of Sports Medicine"
                        "fecha" => "2010"
                        "volumen" => "38"
                        "paginaInicial" => "255"
                        "paginaFinal" => "262"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20448192"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hylan g-f 20&#58; review of its safety and efficacy in the management of joint pain in osteoarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Migliore"
                            1 => "F&#46; Giovannangeli"
                            2 => "M&#46; Granata"
                            3 => "B&#46; Lagana"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Journals of Clinical Medicine Insights&#58; Arthritis and Musculoskeletal Disorders"
                        "fecha" => "2010"
                        "volumen" => "3"
                        "paginaInicial" => "55"
                        "paginaFinal" => "68"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Viscosupplementation for the treatment of osteoarthritis of the knee"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46; Bellamy"
                            1 => "J&#46; Campbell"
                            2 => "V&#46; Robinson"
                            3 => "T&#46; Gee"
                            4 => "R&#46; Bourne"
                            5 => "G&#46; Wells"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Cochrane Database of Systematic Reviews"
                        "fecha" => "2005"
                        "paginaInicial" => "CD005321"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil infiltration in exercise-injured skeletal muscle&#58; how do we resolve the controversy&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46;S&#46; Schneider"
                            1 => "P&#46;M&#46; Tiidus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sports Medicine"
                        "fecha" => "2007"
                        "volumen" => "37"
                        "paginaInicial" => "837"
                        "paginaFinal" => "856"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17887810"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A prospective&#44; randomized&#44; double-blind&#44; placebo controlled study to evaluate the efficacy of intraarticular hyaluronic acid for osteoarthritis of the knee"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;J&#46; Petrella"
                            1 => "M&#46; Petrella"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Rheumatology"
                        "fecha" => "2006"
                        "volumen" => "33"
                        "paginaInicial" => "951"
                        "paginaFinal" => "956"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16652426"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Determining utility values in patients with anterior cruciate ligament tears using clinical scoring systems"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Farshad"
                            1 => "C&#46; Gerber"
                            2 => "T&#46; Szucs"
                            3 => "D&#46;C&#46; Meyer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1472-6963-11-182"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Health Services Research"
                        "fecha" => "2011"
                        "volumen" => "11"
                        "paginaInicial" => "182"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21813026"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Wang-Saegusa"
                            1 => "R&#46; Cugat"
                            2 => "O&#46; Ares"
                            3 => "R&#46; Seijas"
                            4 => "X&#46; Cusco"
                            5 => "M&#46; Garcia-Balletbo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00402-010-1167-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Archives of Orthopaedic and Trauma Surgery"
                        "fecha" => "2010"
                        "volumen" => "131"
                        "paginaInicial" => "311"
                        "paginaFinal" => "317"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20714903"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis&#58; a pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Sampson"
                            1 => "M&#46; Reed"
                            2 => "H&#46; Silvers"
                            3 => "M&#46; Meng"
                            4 => "B&#46; Mandelbaum"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/PHM.0b013e3181fc7edf"
                      "Revista" => array:6 [
                        "tituloSerie" => "American Journal of Physical Medicine and Rehabilitation"
                        "fecha" => "2010"
                        "volumen" => "89"
                        "paginaInicial" => "961"
                        "paginaFinal" => "969"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21403592"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000000900000003/v1_201307311407/S2173574312001554/v1_201307311407/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8383"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Review Article"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000900000003/v1_201307311407/S2173574312001554/v1_201307311407/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574312001554?idApp=UINPBA00004M"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Review Article
Platelet Rich Plasma. A New Treatment Tool for the Rheumatologist?
Plasma rico en plaquetas: ¿un nuevo tratamiento para el reumatólogo?
José De La Mata
Servicio de Reumatología, Clínica Nuestra Señora del Valle, Madrid, Spain
Read
18285
Times
was read the article
3342
Total PDF
14943
Total HTML
Share statistics
 array:24 [
  "pii" => "S2173574312001554"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2012.05.006"
  "estado" => "S300"
  "fechaPublicacion" => "2013-05-01"
  "aid" => "474"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;. All rights reserved"
  "copyrightAnyo" => "2012"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "ssu"
  "cita" => "Reumatol Clin. 2013;9:166-71"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 9020
    "formatos" => array:3 [
      "EPUB" => 62
      "HTML" => 7771
      "PDF" => 1187
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X12001647"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2012.05.011"
      "estado" => "S300"
      "fechaPublicacion" => "2013-05-01"
      "aid" => "474"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "ssu"
      "cita" => "Reumatol Clin. 2013;9:166-71"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 164632
        "formatos" => array:3 [
          "EPUB" => 194
          "HTML" => 159430
          "PDF" => 5008
        ]
      ]
      "es" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Revisi&#243;n</span>"
        "titulo" => "Plasma rico en plaquetas&#58; &#191;un nuevo tratamiento para el reumat&#243;logo&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "166"
            "paginaFinal" => "171"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Platelet rich plasma&#46; A new treatment tool for the rheumatologist&#63;"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Jos&#233; De La Mata"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "Jos&#233;"
                "apellidos" => "De La Mata"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574312001554"
          "doi" => "10.1016/j.reumae.2012.05.006"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574312001554?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X12001647?idApp=UINPBA00004M"
      "url" => "/1699258X/0000000900000003/v1_201305061538/S1699258X12001647/v1_201305061538/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574312001293"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2012.07.011"
    "estado" => "S300"
    "fechaPublicacion" => "2013-05-01"
    "aid" => "467"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "ssu"
    "cita" => "Reumatol Clin. 2013;9:172-7"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 3985
      "formatos" => array:3 [
        "EPUB" => 59
        "HTML" => 3127
        "PDF" => 799
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review Article</span>"
      "titulo" => "Systematic Literature Review of Biphosphonates and Osteonecrosis of the Jaw in Patients With Osteoporosis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "172"
          "paginaFinal" => "177"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Revisi&#243;n sistem&#225;tica de la literatura sobre la osteonecrosis maxilar con el uso de bisfosfonatos en pacientes con osteoporosis"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1224
              "Ancho" => 1632
              "Tamanyo" => 103202
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Article flow chart&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Eugenio Chamizo Carmona, Adela Gallego Flores, Est&#237;baliz Loza Santamar&#237;a, Aurora Herrero Olea, Mar&#237;a Piedad Rosario Lozano"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Eugenio"
              "apellidos" => "Chamizo Carmona"
            ]
            1 => array:2 [
              "nombre" => "Adela"
              "apellidos" => "Gallego Flores"
            ]
            2 => array:2 [
              "nombre" => "Est&#237;baliz"
              "apellidos" => "Loza Santamar&#237;a"
            ]
            3 => array:2 [
              "nombre" => "Aurora"
              "apellidos" => "Herrero Olea"
            ]
            4 => array:2 [
              "nombre" => "Mar&#237;a Piedad"
              "apellidos" => "Rosario Lozano"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X12001404"
        "doi" => "10.1016/j.reuma.2012.05.005"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X12001404?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574312001293?idApp=UINPBA00004M"
    "url" => "/21735743/0000000900000003/v1_201307311407/S2173574312001293/v1_201307311407/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574313000075"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2012.08.003"
    "estado" => "S300"
    "fechaPublicacion" => "2013-05-01"
    "aid" => "505"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Reumatol Clin. 2013;9:161-5"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 4144
      "formatos" => array:3 [
        "EPUB" => 62
        "HTML" => 3479
        "PDF" => 603
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Brief Report</span>"
      "titulo" => "Newborns Whose Mother Has Autoimmune Disease&#46; A Community Hospitals&#8217; Experience"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "161"
          "paginaFinal" => "165"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Reci&#233;n nacidos de madre con enfermedad autoinmunitaria&#46; Experiencia en un hospital comarcal"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Judith Sanchez-Manubens, Vera Ortiz-Santamaria, Maria Teresa Coll Sibina, Jordi Cuquet, Jorge Ren&#233; Bermudez, Xavier Sur&#237;s, Margarida Catal&#224; i Puigb&#243;"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Judith"
              "apellidos" => "Sanchez-Manubens"
            ]
            1 => array:2 [
              "nombre" => "Vera"
              "apellidos" => "Ortiz-Santamaria"
            ]
            2 => array:2 [
              "nombre" => "Maria Teresa"
              "apellidos" => "Coll Sibina"
            ]
            3 => array:2 [
              "nombre" => "Jordi"
              "apellidos" => "Cuquet"
            ]
            4 => array:2 [
              "nombre" => "Jorge Ren&#233;"
              "apellidos" => "Bermudez"
            ]
            5 => array:2 [
              "nombre" => "Xavier"
              "apellidos" => "Sur&#237;s"
            ]
            6 => array:2 [
              "nombre" => "Margarida"
              "apellidos" => "Catal&#224; i Puigb&#243;"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X12002501"
        "doi" => "10.1016/j.reuma.2012.08.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X12002501?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574313000075?idApp=UINPBA00004M"
    "url" => "/21735743/0000000900000003/v1_201307311407/S2173574313000075/v1_201307311407/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Review Article</span>"
    "titulo" => "Platelet Rich Plasma&#46; A New Treatment Tool for the Rheumatologist&#63;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "166"
        "paginaFinal" => "171"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Jos&#233; De La Mata"
        "autores" => array:1 [
          0 => array:3 [
            "nombre" => "Jos&#233;"
            "apellidos" => "De La Mata"
            "email" => array:1 [
              0 => "drdelamata&#64;frenarlartritis&#46;com"
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Servicio de Reumatolog&#237;a&#44; Cl&#237;nica Nuestra Se&#241;ora del Valle&#44; Madrid&#44; Spain"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Plasma rico en plaquetas&#58; &#191;un nuevo tratamiento para el reumat&#243;logo&#63;"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Platelet rich plasma &#40;PRP&#41; is a novel therapeutic tool of autologous nature that has emerged strongly in recent years due to successful therapeutic use in elite<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> athletes&#46; Famous professional football players&#44; Tiger Woods and Rafael Nadal attribute&#44; in part&#44; their &#8220;miraculous&#8221; recoveries to the employment of this enigmatic treatment dubbed the &#8220;PRP phenomenon&#46;&#8221; PRP treatment is little known but quite prominent in rheumatology&#44; orthopedics and sports medicine congresses in which&#44; despite the controversy surrounding it&#44; has gradually awakened growing interest because of its supposed effectiveness and apparent lack of side effects&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Its therapeutic target eminently comprises chronic tendinopathy and enthesopathy&#44; although the range of indications is constantly expanding and has been successfully used in many ailments&#44; including knee osteoarthritis&#46; Its low cost&#44; ease of use&#44; usefulness in pathological processes elusive to conventional treatments and apparent safety make it a seductive alternative to consider in the therapeutic armamentarium of the rheumatologist&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The following review attempts to analyze what has been called the &#8220;PRP phenomenon&#8217;&#59; I will review in detail the rationale for use&#44; preparation and management regimes&#46; I will also discuss and critically analyze its safety profile and the scientific evidence supporting its use and consider its possible usefulness in rheumatology&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Background</span><p id="par0015" class="elsevierStylePara elsevierViewall">PRP owes its therapeutic interest to the crucial instrumental role of platelets in the wound healing and tissue repair processes&#46; This role is not related to the repairing properties of the platelets themselves but&#44; rather&#44; to growth factors &#40;GF&#41; released by its &#945; granules&#44; which possess multiple regenerative properties &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Tissue wound repair is a complex process in which a variety of cellular functions such as chemotaxis&#44; angiogenesis&#44; cell proliferation&#44; extracellular matrix formation and the &#8220;cleansing&#8221; macrophage coexist&#44; sequentially and covertly&#46; These functions form a complex in which three relatively distinct phases are classically distinguished&#58; inflammation&#44; proliferation and remodeling&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;7</span></a> All GF content of the PRP is involved in the phases described&#44; but all of their functions are still unknown&#46; It is speculated that some of them play a role&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> but it is conceivable that each individual prominence varies depending on the type of tissue wound &#40;ruptured&#44; inflammation&#44; degeneration&#44; etc&#46;&#41; and the type of tissue &#40;tendon&#44; muscle&#44; bone&#44; etc&#46;&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Preparation and Dosing Schedules</span><p id="par0020" class="elsevierStylePara elsevierViewall">PRP is defined as a plasma fraction containing a higher concentration of platelets than the peripheral blood&#46; Some authors are more precise and consider PRP platelet concentrations to be approximately five times above normal&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Actually&#44; it is a plasma aliquot of 20&#8211;30<span class="elsevierStyleHsp" style=""></span>ml of peripheral blood centrifuged at 3200<span class="elsevierStyleHsp" style=""></span>rpm for 15<span class="elsevierStyleHsp" style=""></span>min&#46; The result is approximately 2&#8211;3<span class="elsevierStyleHsp" style=""></span>ml of platelet-rich plasma with varying concentrations&#44; usually about 1<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span> platelets&#46; Said aliquot can be activated with thrombin or calcium chloride for future therapeutic usefulness&#46; When PRP is intended to treat soft tissue injuries most authors consider prior activation not necessary&#44; because this is produced in situ in contact with the tendon collagen or fibrillar<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> breakage clot itself&#46; When PRP is used to facilitate integration of bone implants&#44; or when used for the treatment of knee osteoarthritis&#44; some activation is usually preferred giving it a gelatinous consistency that facilitates its surgical use&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The doses and administration regimes vary depending on the condition being treated&#46; In the case of chronic tendinopathy&#44; the literature seems to agree on a single administration for epicondylitis&#44; Achilles tendinitis and plantar fasciitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;11&#44;12</span></a> However&#44; it may be used on three consecutive occasions &#40;one every two weeks&#41; in the case of a chronic patellar tendinopathy or &#8220;jumper&#39;s knee&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> There are some authors who frequently use PRP for the treatment of impingement syndrome&#44; especially when it is chronic or refractory&#46; However&#44; no reliable information is available to provide evidence of a specific dosing schedule&#46; Recently the usefulness of PRP for treating osteoarthritis of the knee has been reported&#46; Most authors agree that the ideal number of infiltrations in these cases should be 3&#44; but there is no unanimity about the dosing interval&#44; with good results both on a weekly&#44; as well as triweekly basis&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Safety</span><p id="par0030" class="elsevierStylePara elsevierViewall">The autologous nature of PRP appears to be the main argument for its safe tolerance on infiltration&#44; rarely producing mild local inflammatory reactions&#46; There have also been reports of postpuncture infection data that may be able to relate to the antimicrobial effect of PRP as suggested by some authors&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> Adherents to PRP say repeatedly that no undesirable effects exist because it is an autologous product in nature&#46; The truth is that these statements are based only on their own experiences&#44; because there are neither safety studies&#44; nor authoritative information from clinical trials&#46; Conceivably&#44; the autologous nature of PRP provides therapeutic tolerance&#44; but tolerance does not mean safety&#46; The therapeutic effect is achieved by concentrating PRP&#39;s massive amounts of GF in the damaged tissues&#46; As mentioned&#44; GF promote multiple cellular functions that well modulated may result in an acceleration of tissue repair process&#46; Tissue repair is not the only process in which these factors contribute decisively&#46; The endothelial growth factor &#40;VEGF&#41;&#44; the basic fibroblast growth factor&#44; hepatocyte growth factor &#40;HGF&#41;&#44; and insulin growth factor are particularly important factors in the growth of certain tumors because of their angiogenic high potential&#46; Some GF have even exhibited oncogenic potential themselves&#44; capable of promoting clonal expansion of previously mutated cells&#44; facilitating their immortalization cycle by inhibiting apoptosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#8211;19</span></a> These properties of GF&#44; promoting the generation and perpetuation of tumors&#44; although disturbing are only described in experimental animals&#44; and there is no evidence so far linking the therapeutic use of PRP in humans with carcinomatous transformation&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">It has recently been demonstrated that certain GF favor proliferation or activation &#40;in situ and peripheral&#41; of circulating osteogenic progenitors or &#8220;COP cells&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> These recently described undifferentiated cells are known as osteochondral progenitors that are definitely involved in extraskeletal bone formation&#44; as occurs in postarthroplasty heterotopic ossification<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> or valve calcifications&#46; It seems reasonable that&#44; in the presence of a suitable microenvironment in the wound tissue&#44; exaggerated GF concentrations contained in the PRP may promote recruitment and activation of COP supranormal cells in the infiltration area with capacity to develop heterotopic calcification or intra level ossification of soft tissue&#46; To date&#44; these reflections do not stop from being mere speculation since no complications have been reported in the literature as such&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Preclinical Evidence</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Tendon and Muscle</span><p id="par0040" class="elsevierStylePara elsevierViewall">Most of the preclinical evidence supporting the benefit of PRP in tendinopathy is based on its supposed ability to stimulate tissue repair process&#46; Cell cultures provide evidence that PRP is involved in the different phases of the repair process&#46; In the inflammatory phase&#44; the GF contained in PRP can mobilize circulating inflammatory cells into the wound&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> They also stimulate tenoviocytes to secrete collagen&#44; VEGF and HGF&#44; all of them reparative<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> process accelerators&#46; In the proliferative phase&#44; PRP is capable of stimulating the proliferation and division of almost all types of mesenchymal cells &#40;osteoblasts&#44; fibroblasts&#44; chondrocytes or tenoviocytes&#41; and also multipotential<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> stem cell&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> In the final phase of remodeling&#44; PRP facilitates newly formed collagen maturation and apoptosis of excess cells&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> Taken together&#44; all of these evidences involve PRP definitely in the tissue repair process&#44; but do not clarify whether this involvement translates directly into acceleration&#44; and even less when it favors faster and more efficient healing&#44; as proposed by some authors&#46; Some of these questions have been clarified by certain animal models&#46; In murine models with partial section of the Achilles tendon&#44; PRP has been shown to be associated with a faster consolidation of the tendon callus&#44; which is also mechanically efficient&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">28&#44;29</span></a> Part of this effect could be due to its ability to accumulate circulating proinflammatory cells in the tendon wound&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> In muscle&#44; some models also have observed a benefit of PRP in the myofibrillar repair process&#46; In a model of breaking-strain of the tibialis anterior in rats&#44; PRP seems to significantly shorten recovery times in those lesions that require myogenesis for recovery&#44; directly involving them in the process of muscular neoformation&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> None of these studies have yet determined the properties that each GF individually has in these two different microenvironments&#46; The response to PRP in animal models of inflammatory tendinopathy<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> has also been described&#44; more in line with the reality of clinical rheumatologists&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Bone and Joints</span><p id="par0045" class="elsevierStylePara elsevierViewall">Historically the first PRP therapeutic applications began in the field of dental surgery for compacting maxillofacial implants and bone<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> sealant&#46; These osteointegrating properties caught the attention of some orthopedic surgeons who saw PRP as the ideal adjuvant to shorten the recovery of certain surgeries&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> This osteoinductive and sealant effect is still controversial&#44; but the most consistent and valuable for many of its advocates&#46; The truth is that the composition of PRP&#39;s many factors individually has shown a potent bone anabolic effect&#46; The osteoinductive potential of platelet derived growth has been confirmed in more than one study so some authors have speculated on its clinical use &#40;especially the BB isoform&#41; in osteoporosis and consolidation of fracture<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> calluses&#46; One of the best-known properties of the epidermal growth factor &#40;EGF&#41; is its ability to expand totipotent stem cell populations&#46; EGF is also able to differentiate these cells to the osteoblast lineage&#44; thereby favoring remarkable osteogenesis&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">35&#44;36</span></a> The fibroblast growth factor &#40;FGF&#41; is a classic and very powerful stimulator of the differentiation and activation of osteoblasts and has bone anabolic potential which is due in large measure to the Wnt<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> pathway activation&#46; In rabbits&#44; FGF has been used successfully for the treatment of hip osteonecrosis&#44; avoiding collapse not only of the femoral head&#44; but also the development of secondary<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> coxarthrosis&#46; In humans&#44; FGF significantly accelerates the formation of bone callus&#44; shortening tibial<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> osteotomy patient&#39;s time to discharge&#46; The transformative growth factor &#946; &#40;TGF &#946;&#41; is a GF widely involved in bone and chondral<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> anabolism&#46; However&#44; the TGF &#946; superfamily is a complex of factors and receptors which&#44; under various circumstances&#44; can be converted into powerful stimulators and also osteoclast determinants associated to&#44; for example&#44; myeloma bone aggressiveness and multiple skeletal<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">41&#44;42</span></a> metastases&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The set of all such evidence suggests that&#44; by virtue of its composition&#44; PRP meets the right qualities to play a powerful osteoinductive role&#44; capable of accelerating consolidation or osteointegration of fractures quickly and efficiently<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">43&#44;44</span></a> as well as of different types of implants&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a> However&#44; the literature is not unanimous in weighing these hypothetical beneficial properties of PRP&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">46&#8211;48</span></a> The relative concentrations of each GF upon activation&#44; the dosing schedule&#44; the type of injury and the microenvironment are determinants that seem to alter the osteoinductive qualities of GF which may be translated into the real clinical benefits of PRP&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The use of PRP in joints is relatively recent and has scant preclinical literature&#46; Regarding degenerative arthropathy&#44; there is only one work that analyzes the effect of PRP in knee osteoarthritis in rabbits&#46; In this study&#44; the authors histologically examined knees of rabbits treated with PRP-impregnated microspheres&#44; observing a reduction in the progression of osteoarthritis with respect to controls&#46; Using complementary cell cultures&#44; the authors concluded that this effect was due to the metabolic stimulation of chondral matrix synthesis through glucosaminglycans&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> Regarding inflammatory arthritis&#44; a paper has just recently been released&#44; of particular interest to rheumatologists&#44; which analyzes the effect of PRP in a porcine model of antigen-induced rheumatoid arthritis&#46; In this study&#44; intra-articular treatment with PRP of arthritic knees resulted&#44; histologically and immunohistochemically&#44; in a significant attenuation of the inflammatory changes characteristic of the disease&#44; both at the synovial and<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a> cartilage levels&#46; These results contrast to some extent&#44; with the recently proinflammatory effect attributed to platelets in rheumatoid arthritis and other inflammatory arthropathies&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a></p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Clinical Evidence</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Platelet Rich Plasma and Subacromial Tendonitis</span><p id="par0060" class="elsevierStylePara elsevierViewall">The use of the PRP in the subacromial syndrome and all variants lacks&#44; to date&#44; studies that evaluate it as a single treatment&#46; The only evidence mentions its use as an adjuvant in decompressive and reconstructive surgery of the rotator cuff&#46; In this type of surgery&#44; PRP improves the results of conventional reconstructive surgery and shortens recuperation time&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">52&#44;53</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Platelet Rich Plasma and Epicondylitis</span><p id="par0065" class="elsevierStylePara elsevierViewall">Epicondylitis is a limiting tendinopathy&#44; with a clear tendency to become chronic&#44; which has a random&#44; often partial response to glucocorticoid infiltrations and physiotherapy&#46; Some authors have investigated the effectiveness of PRP in this disease because of the potential remedial effect observed in animal models&#46; The pioneering essay that analyzes for the first time the effect of PRP on epicondylitis dates from 2006&#46; This is a pilot&#44; local anesthetic-controlled study&#44; performed on 19 patients with refractory epicondylitis<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> who were proposed surgery&#46; In this study&#44; the effect of a single injection of PRP on pain &#40;Visual Analog Pain Scale &#91;VAS&#93;&#41; and functional capacity &#40;Mayo Elbow Score modified&#41; was analyzed&#46; At 8 weeks&#44; patients referred an improvement of 60&#37; &#40;16&#37; in controls&#41;&#44; which after two years ended up being 93&#37;&#46; No adverse effects were reported&#46; More recently&#44; an open study with 30 patients also analyzed the role of PRP as salvage therapy in epicondylitis&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a> As in previous studies&#44; a single dose of PRP was administered and its effect was evaluated annually on pain &#40;VAS&#41; and functional capacity &#40;American Shoulder &#38; Elbow Surgeons outcome instrument&#41;&#46; It reported a 25&#37; improvement in VAS in &#8805;90&#37; of patients&#44; finding no adverse effects&#46; The findings of the two studies ponder the clinical utility of PRP in patients with refractory epicondylitis&#46; Remember that the design of both had some biases that limit the value of their findings&#46; The main limitation lies in the small number of patients treated in both cases&#44; to which the lack of randomization and blinding in a randomized controlled retrospective manner must be added&#46; At the beginning of 2010 the first quality clinical trial was published&#44; leading to less vulnerable conclusions on the role of PRP in patients with epicondylitis&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a> It was a comparative clinical trial&#44; controlled with corticosteroids&#44; randomized&#44; double-blind study on 100 patients with chronic epicondylitis who were followed one year&#46; It analyzed the effect of a single injection of PRP in pain and improvement of functional capacity of the elbow&#44; using corticosteroid infiltration as control&#46; A VAS decreased in the Disabilities of the Arm&#44; Shoulder and Hand score &#40;DASH&#41; more than 25&#37; was considered as a measure of response to treatment&#46; In the PRP group&#44; it was reported by 73&#37; of respondents&#44; while in the group of patients who received corticosteroids only 50&#37; reported the outcome&#46; In this study no adverse effect was reported&#46; The authors concluded that PRP significantly exceeded the clinical benefit obtained by corticosteroids&#46; However&#44; the clinical benefit achieved by corticosteroids in this work is directly influenced by the fact that all the patients included in the trial must have had evidence of pre refractoriness to local injections of corticosteroids&#46; This bias prevents a true comparative analysis as it greatly favors PRP in comparison with steroids&#46; Additionally&#44; the results of this study support the concept reported in the previous 2&#44; on the analgesic properties of the PRP in the treatment of epicondylitis&#44; without presenting clinically significant adverse effects&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Platelet Rich Plasma and Plantar Fasciitis</span><p id="par0070" class="elsevierStylePara elsevierViewall">Plantar fasciitis is another common problem in rheumatology and&#44; like the rest of tendinopathy&#44; also tends to chronicity&#46; The only evidence that analyzes the effect of PRP on plantar fasciitis dates from 2004 and is the first study that applies PRP to any type of tendinopathy&#46; It is a series of 9 patients&#44; followed for a year&#44; with plantar fasciitis refractory to NSAIDs&#44; immobilization&#44; physical therapy and corticosteroid infiltration&#44; given a single ultrasound-guided injection of PRP in the central and medial calcaneal fascicles&#46; It evaluated the improvement in pain and ultrasound pattern changes&#46; At follow-up&#44; 8 of the 9 patients were asymptomatic but one of them required a second dose&#46; The ultrasound thickness decreased at 3 months &#40;on average&#41; 1&#46;2<span class="elsevierStyleHsp" style=""></span>mm in the central and 2&#46;3<span class="elsevierStyleHsp" style=""></span>mm in the medial bundles&#46; The evidence provided by this work seems worthy of further study&#44; but it is still anecdotal given the small number of patients treated and the biases inherent in a retrospective design and open design&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Platelet Rich Plasma and Knee Osteoarthritis</span><p id="par0075" class="elsevierStylePara elsevierViewall">The application of PRP to treat osteoarthritis of the knee can be considered a relatively new therapeutic indication that focuses undoubtedly on the most current clinical research&#46; This new indication has led to multiple studies in the past 3 years&#44; both controlled and open&#46; Among them&#44; one highlight is a retrospective study of 60 patients with osteoarthritis of the knees&#44; followed for 5 weeks&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> This study compared the therapeutic effect of PRP with high molecular weight hyaluronic acid &#40;HMWHA&#41;&#46; The authors treated 30 patients with an infiltration weekly &#40;for 3 weeks&#41; of activated PRP and a similar number with a single dose of HMWHA&#46; Respondents were considered those who decreased the WOMAC pain score &#8805;40&#37; from baseline&#46; The authors found 33&#37; responders with PRP and 10&#37; with hyaluronic acid at the end of follow-up&#46; Such a low percentage of responders to viscosupplementation is surprising&#44; documented in the literature with much higher response rates than those in this trial&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">56</span></a> Undoubtedly&#44; a very poor response from the control group favors PRP in the comparative analysis&#46; Probably&#44; this analysis would have been more truthful and more clinically relevant if the patients had been tracked longer in order to fully develop the potential HMWHA accredited analgesic efficacy&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">57</span></a> In favor of the results of this study it should be noted that it was the first to specify the relative concentrations of GF contained in the infiltrated plasma&#44; and also it is the only paper published that explicitly uses leukocyte free PRP&#44; a very important fact for some authors&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">58</span></a> Very recently a new study&#44; with a larger number of patients&#44; again compares the effect of PRP with hyaluronic acid&#46; This is a new comparative trial on 150 patients with osteoarthritis of the knees&#44; followed for 6 months&#46; It establishes three treatment arms with 50 patients each&#58; activated PRP &#40;infiltration every 21 days&#41;&#44; HMWHA &#40;single dose&#41; and low molecular weight hyaluronic acid &#40;LMWHA&#41; &#40;single dose&#41;&#46; It analyzed the effect on the visual analogue scale of quality of life related to health status &#40;EQ VAS&#41; and knee function using the International Knee Documentation Committee index &#40;IKDC&#41;&#46; At follow-up&#44; the authors reported better response rates in PRP-treated patients than in those treated with AHAPM or AHBPM &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;005&#41;&#46; In all groups&#44; the response was better in younger patients and in those who had a more recent onset osteoarthritis&#46; As in previous studies&#44; a comparative analysis was not entirely fair and in this case&#44; the AHBPM comparison was not clear&#46; The use of infra treatment therapeutic dose control&#44; as in this case&#44; for AHBPM&#44;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a> favors the intervention to be analyzed &#40;PRP&#41;&#46; Besides this bias&#44; lack of randomization and blinding lack credibility and&#44; on the other hand&#44; employs rare outcome measures and doubtful discriminative ability for osteoarthritis of the knee&#44; such as IKDC&#44; for example&#44; as it is an index originally designed for the analysis of knee<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> ligamentous instability&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Some series of patients with osteoarthritis of the knees&#44; successfully treated with PRP have also been reported in recent years&#46; The largest number belongs to a Spanish group that included 261 patients treated with three injections of activated PRP every 15 days &#40;infiltrated volume not detailed&#41;&#44; which was followed for 6 months&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a> VAS&#44; WOMAC &#40;pain&#44; stiffness and functional class&#41;&#44; and SF-36 Lequesme &#40;baseline and 6 months&#41; were assessed&#46; In their results&#44; the authors reported improvement in all outcome measures&#44; with percentages &#40;relative to baseline&#41; ranging from 8&#46;4 in SF-36 and 30&#46;7 in the WOMAC pain subscale&#46; Another series with a longer follow-up&#44; included 100 patients with osteoarthritis of the knee treated and followed for a year&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> In this work&#44; which also employed 3 doses of activated PRP administered every three weeks&#44; the authors found a significant improvement in VAS and EQ IKDC that&#44; although more marked in the first 6 months&#44; remained for a year&#46; As in other studies of the same group&#44; patients with the most benefit were young and had a less evolved osteoarthritis&#46; Finally&#44; one last article is worth mentioning that evaluates the effect of PRP in 14 patients with refractory prosthetic gonarthrosis<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">62</span></a> proposed for replacement&#46; It included patients with osteoarthritis of the knee refractory to conservative treatment &#40;NSAIDs&#44; rehabilitation&#44; acupuncture&#44; corrective splints&#44; injections of corticosteroids or hyaluronic acid&#41; that were treated with 3 doses of activated PRP &#40;one per month&#41;&#46; An effect was observed one year after infiltration on the VAS and the Knee Injury &#38; Osteoartrhitis Outcome measure&#46; The authors observed a linear improvement of VAS and Knee Injury &#38; Osteoartrhitis Outcome in 60&#37; of patients at follow-up&#46; Although 40&#37; of patients did not improve&#44; none had to undergo surgery during the study&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Significant adverse effects were not reported in the five above mentioned studies&#44; except for local postpuncture pain&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusions</span><p id="par0090" class="elsevierStylePara elsevierViewall">PRP is a novel therapeutic tool that has arguments for and against its use in the rheumatologist&#39;s therapeutic spectrum&#46; Proponents point out to&#44; among its highest virtues&#44; its autologous nature in guaranteeing an excellent safety profile&#46; However&#44; in the reviewed literature&#44; there are no safety studies and clinical trials that can permit such conclusions to be drawn&#46; Series of patients and published works provide information about adverse local reactions&#46; While tolerance to PRP infiltration is excellent as is its short-term safety&#44; this profile in the long-term is still incomplete or at least uncertain&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The supposed effectiveness of PRP in various diseases has not been studied in clinical trials of proven quality&#46; The studies supporting its effectiveness have a level of evidence under multiple biases penalized for both design and implementation&#46; However&#44; the results reported so far are unanimous in stating that PRP&#44; if not effective&#44; is useful in the treatment of epicondylitis and knee osteoarthritis&#46; Among a number of specialists there may be sufficient evidence to justify the use of PRP&#46; They may argue that medicine &#40;until recent years&#41; has progressed and grown outside the orthodoxy of clinical trials&#44; sustained by a less demanding scientific rigor than that reviewed here&#46; They are right&#46; For another great part of clinicians&#44; this evidence will be inadequate and will not neutralize the logical suspicion that a treatment prescribed for multiple conditions that have nothing in common produces&#44; protected by an aura of safety that transcends the strictly scientific&#46; It may be more appropriate not to be seduced by fashion prejudices nor dwell on academics&#44; substantiating the value of this therapy through quality clinical trials that to date do not exist&#44; and seem indispensable to properly develop the therapeutic potential of PRP&#46; This work will require the measurement of many important aspects of the therapeutic usefulness that are still confusing such as collection&#44; processing or activation&#46; Additionally&#44; this will help formalize the doses&#44; volumes and more appropriate management schemes&#44; establish guidelines&#44; and especially more rigorously evaluate its potential safety issues&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Rheumatologists&#44; as leaders in medical pathology of the musculoskeletal system&#44; should enforce judgment and properly size up this novel treatment&#44; as other specialists in the field have already done&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><p id="par0110" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Protection of human and animal subjects&#46;</span> The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Confidentiality of Data&#46;</span> The authors declare that no patient data appears in this article&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Right to privacy and informed consent&#46;</span> The authors declare that no patient data appears in this article&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of Interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">The author declares no conflict of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:13 [
        0 => array:2 [
          "identificador" => "xres243414"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec229972"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres243413"
          "titulo" => "Resumen"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec229971"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Background"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Preparation and Dosing Schedules"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Safety"
        ]
        7 => array:3 [
          "identificador" => "sec0020"
          "titulo" => "Preclinical Evidence"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Tendon and Muscle"
            ]
            1 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Bone and Joints"
            ]
          ]
        ]
        8 => array:3 [
          "identificador" => "sec0035"
          "titulo" => "Clinical Evidence"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Platelet Rich Plasma and Subacromial Tendonitis"
            ]
            1 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Platelet Rich Plasma and Epicondylitis"
            ]
            2 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Platelet Rich Plasma and Plantar Fasciitis"
            ]
            3 => array:2 [
              "identificador" => "sec0055"
              "titulo" => "Platelet Rich Plasma and Knee Osteoarthritis"
            ]
          ]
        ]
        9 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Conclusions"
        ]
        10 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Ethical disclosures"
        ]
        11 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conflict of Interest"
        ]
        12 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2012-02-08"
    "fechaAceptado" => "2012-05-23"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec229972"
          "palabras" => array:5 [
            0 => "Platelet rich plasma"
            1 => "Impingement syndrome"
            2 => "Tennis elbow"
            3 => "Plantar fasciitis"
            4 => "Knee osteoarthritis"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec229971"
          "palabras" => array:5 [
            0 => "Plasma rico en plaquetas"
            1 => "S&#237;ndrome subacromial"
            2 => "Epicondilitis"
            3 => "Fascitis plantar"
            4 => "Osteoartritis de rodilla"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Platelet rich plasma &#40;PRP&#41; is a novel therapeutic tool that has revolutionized the world of sports medicine and trauma due to therapeutic success shown in the media&#46; Subject to ongoing debate&#44; the PRP is outlined along a spectrum of musculoskeletal therapies with many qualities that make it ideal for use in the rheumatology&#58; effectiveness&#44; safety&#44; easy handling and low cost&#46; Is PRP a product of marketing&#63; Or&#44; conversely&#44; is an interesting tool to consider in the armamentarium of the rheumatologist&#46; In the following review we will analyze in detail its principles&#44; preparation&#44; and management regimes&#46; We will reflect on potential adverse effects and&#44; finally&#44; there will be a critical analysis of the scientific evidence that supports its potential use in the rheumatology clinic&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El plasma rico en plaquetas &#40;PRP&#41; es una novedosa herramienta terap&#233;utica que ha revolucionado el mundo de la medicina deportiva y la traumatolog&#237;a debido a &#233;xitos terap&#233;uticos medi&#225;ticos en deportistas de &#233;lite&#46; Sujeto a continuo debate&#44; el PRP se perfila en el espectro de las terapias musculoesquel&#233;ticas con m&#250;ltiples cualidades que potencialmente lo hacen id&#243;neo para su uso en la consulta de reumatolog&#237;a&#58; efectividad&#44; seguridad&#44; f&#225;cil manejo y bajo coste&#46; &#191;Es el PRP un nuevo producto de la mercadotecnia&#63; o&#44; por el contrario&#44; es una herramienta con fundamento que debe incluirse en el arsenal terap&#233;utico del reumat&#243;logo&#46; En la siguiente revisi&#243;n se repasar&#225;n en detalle su fundamento&#44; preparaci&#243;n y reg&#237;menes de administraci&#243;n&#46; Se reflexionar&#225; sobre potenciales efectos adversos y&#44; por &#250;ltimo&#44; se realizar&#225; un an&#225;lisis cr&#237;tico de la evidencia cient&#237;fica que avala su posible uso en la consulta de reumatolog&#237;a&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; De La Mata J&#46; Plasma rico en plaquetas&#58; &#191;un nuevo tratamiento para el reumat&#243;logo&#63; Reumatol Clin&#46; 2012&#46; <span class="elsevierStyleInterRef" href="doi:10.1016/j.reuma.2012.05.011">http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;reuma&#46;2012&#46;05&#46;011</span>&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Growth Factor &#40;GF&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Origin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Function&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Transforming GF &#946; &#40;TGF &#946;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelets&#44; bone and cartilage matrix&#44; monocytes&#44; neutrophils&#44; &#171;natural killer&#187; cells and activated TH1 cells&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Proliferation of undifferentiated mesenchimal cells&#59; inhibition of lymphocyte and macrophage proliferation&#59; regulate&#58;- Endothelial&#44; fibroblastic and osteoblastic mitogenesis- Collagen synthesis and secretion of collagenases- Mitogenous effect on other GF&#46;- Endothelial chemotaxis and angiogenesis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Basic fibroblast GF &#40;FGFb&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelets&#44; macrophages&#44; mesenchimal cells&#44; chondrocytes and osteoblasts&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stimulates mitogenesis&#44; growth and differentiation of chondrocytes and osteoblasts and mesenchimal cell mitogenesis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelet derived GF &#40;PDGF&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelets&#44; osteoblasts&#44; endothelial cells&#44; macrophages&#44; monocytes&#44; smooth muscle cells&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stimulates mitogenesis of mesenchimal cells and osteoblasts&#59; mitogenesis and chemotaxis of fibroblastic&#44; glial&#44; smooth muscle linage cells&#59; regulates collagenase secretion and stimulates epithelial mesenchimal mitogenesis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vascular endothelial GF &#40;VEGF&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelets&#44; endothelial cells&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Increases angiogenesis&#44; vascular permeability and endothelial cell mitogenesis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Connective tissue GF &#40;CTGF&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelets&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Promotes angiogenesis&#44; chondral regeneration&#44; fibrosis and platelet adhesion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Epidermal GF &#40;EGF&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelets&#44; macrophages and monocytes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stimulates endothelial chemotaxis and angiogenesis&#59; regulates secretion of collagenases&#59; stimulates mitogenesis of mesenchimal and epithelial cells&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab351510.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Growth Factors Contained in Platelet Rich Plasma&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:62 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Schwartz A&#46; A promising treatment for athletes in blood&#46; The New York Times Website &#91;accessed 17 Feb 2009&#93;&#46; Available from&#58; <a class="elsevierStyleInterRef" href="http://www.nytimes.com/2009/02/17/sports/17blood.htlm%3Fscp=1%26sq=A">http&#58;&#47;&#47;www&#46;nytimes&#46;com&#47;2009&#47;02&#47;17&#47;sports&#47;17blood&#46;htlm&#63;scp&#61;1&#38;sq&#61;A</a>"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Musculoskeletal applications of platelet-rich plasma&#58; fad or future&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46;S&#46; Lee"
                            1 => "J&#46;J&#46; Wilson"
                            2 => "D&#46;P&#46; Rabago"
                            3 => "G&#46;S&#46; Baer"
                            4 => "J&#46;A&#46; Jacobson"
                            5 => "C&#46;G&#46; Borrero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "American Journal of Roentgenology"
                        "fecha" => "2011"
                        "volumen" => "196"
                        "paginaInicial" => "628"
                        "paginaFinal" => "636"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of platelet-rich plasma in bone reconstruction therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46; Intini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.biomaterials.2009.05.055"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biomaterials"
                        "fecha" => "2009"
                        "volumen" => "30"
                        "paginaInicial" => "4956"
                        "paginaFinal" => "4966"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19573909"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growth factors improve muscle healing in vivo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Menetrey"
                            1 => "C&#46; Kasemkijwattana"
                            2 => "C&#46;S&#46; Day"
                            3 => "P&#46; Bosch"
                            4 => "M&#46; Vogt"
                            5 => "F&#46;H&#46; Fu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Journal of Bone and Joint Surgery&#46; British Volume"
                        "fecha" => "2000"
                        "volumen" => "82"
                        "paginaInicial" => "131"
                        "paginaFinal" => "137"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Mishra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3928/01477447-20100526-13"
                      "Revista" => array:6 [
                        "tituloSerie" => "Orthopedics"
                        "fecha" => "2010"
                        "volumen" => "33"
                        "paginaInicial" => "486"
                        "paginaFinal" => "487"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20608601"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of platelets in bone remodeling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;S&#46; Sharif"
                            1 => "M&#46; Abdollahi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3305/nh.2015.31.4.8457"
                      "Revista" => array:6 [
                        "tituloSerie" => "Inflammation &#38; Allergy Drug Targets"
                        "fecha" => "2010"
                        "volumen" => "9"
                        "paginaInicial" => "393"
                        "paginaFinal" => "399"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25795948"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interaction between macrophages&#44; TGF-beta1&#44; and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "W&#46; Shen"
                            1 => "Y&#46; Li"
                            2 => "J&#46; Zhu"
                            3 => "R&#46; Schwendener"
                            4 => "J&#46; Huard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jcp.21212"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Cellular Physiology"
                        "fecha" => "2008"
                        "volumen" => "214"
                        "paginaInicial" => "405"
                        "paginaFinal" => "412"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17657727"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma&#58; growth factor enhancement for bone grafts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46;E&#46; Marx"
                            1 => "E&#46;R&#46; Carlson"
                            2 => "R&#46;M&#46; Eichstaedt"
                            3 => "S&#46;R&#46; Schimmele"
                            4 => "J&#46;E&#46; Strauss"
                            5 => "K&#46;R&#46; Georgeff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Oral Surgery&#44; Oral Medicine&#44; Oral Pathology&#44; Oral Radiology and Endodontics"
                        "fecha" => "1998"
                        "volumen" => "85"
                        "paginaInicial" => "638"
                        "paginaFinal" => "646"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of chronic elbow tendinosis with buffered platelet-rich plasma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Mishra"
                            1 => "T&#46; Pavelko"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0363546506288850"
                      "Revista" => array:6 [
                        "tituloSerie" => "American Journal of Sports Medicine"
                        "fecha" => "2006"
                        "volumen" => "34"
                        "paginaInicial" => "1774"
                        "paginaFinal" => "1778"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16735582"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Sanchez"
                            1 => "E&#46; Anitua"
                            2 => "J&#46; Azofra"
                            3 => "I&#46; Andia"
                            4 => "S&#46; Padilla"
                            5 => "I&#46; Mujika"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0363546506294078"
                      "Revista" => array:7 [
                        "tituloSerie" => "American Journal of Sports Medicine"
                        "fecha" => "2007"
                        "volumen" => "35"
                        "paginaInicial" => "245"
                        "paginaFinal" => "251"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17099241"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1542356509007745"
                          "estado" => "S300"
                          "issn" => "15423565"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma injection for chronic Achilles tendinopathy&#58; a randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; de Vos"
                            1 => "A&#46; Weir"
                            2 => "H&#46;T&#46; van Schie"
                            3 => "S&#46;M&#46; Bierma-Zeinstra"
                            4 => "J&#46;A&#46; Verhaar"
                            5 => "H&#46; Weinans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2009.1986"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2010"
                        "volumen" => "303"
                        "paginaInicial" => "144"
                        "paginaFinal" => "149"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20068208"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growth factors for chronic plantar fasciitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Barret"
                            1 => "S&#46; Erredge"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Podiatry Today"
                        "fecha" => "2004"
                        "volumen" => "17"
                        "paginaInicial" => "37"
                        "paginaFinal" => "42"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of platelet-rich plasma for the treatment of refractory jumper&#39;s knee"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Filardo"
                            1 => "E&#46; Kon"
                            2 => "S&#46; Della Villa"
                            3 => "F&#46; Vincentelli"
                            4 => "P&#46;M&#46; Fornasari"
                            5 => "M&#46; Marcacci"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "International Orthopaedics"
                        "fecha" => "2009"
                        "volumen" => "34"
                        "paginaInicial" => "909"
                        "paginaFinal" => "915"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA&#58; a retrospective cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Sanchez"
                            1 => "E&#46; Anitua"
                            2 => "J&#46; Azofra"
                            3 => "J&#46;J&#46; Aguirre"
                            4 => "I&#46; Andia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical and Experimental Rheumatology"
                        "fecha" => "2008"
                        "volumen" => "26"
                        "paginaInicial" => "910"
                        "paginaFinal" => "913"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19032827"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma&#58; intra-articular knee injections produced favorable results on degenerative cartilage lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Kon"
                            1 => "R&#46; Buda"
                            2 => "G&#46; Filardo"
                            3 => "A&#46; Di Martino"
                            4 => "A&#46; Timoncini"
                            5 => "A&#46; Cenacchi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00167-009-0940-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Knee Surgery&#44; Sports Traumatology&#44; Arthroscopy"
                        "fecha" => "2010"
                        "volumen" => "18"
                        "paginaInicial" => "472"
                        "paginaFinal" => "479"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19838676"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances&#58; an in vitro study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46;M&#46; Bielecki"
                            1 => "T&#46;S&#46; Gazdzik"
                            2 => "J&#46; Arendt"
                            3 => "T&#46; Szczepanski"
                            4 => "W&#46; Krol"
                            5 => "T&#46; Wielkoszynski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Journal of Bone and Joint Surgery&#46; British Volume"
                        "fecha" => "2007"
                        "volumen" => "89"
                        "paginaInicial" => "417"
                        "paginaFinal" => "420"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; DiGiovanni"
                            1 => "D&#46;K&#46; Bol"
                            2 => "E&#46; Wilker"
                            3 => "L&#46; Beltran"
                            4 => "S&#46; Carbajal"
                            5 => "S&#46; Moats"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Cancer Research"
                        "fecha" => "2000"
                        "volumen" => "60"
                        "paginaInicial" => "1561"
                        "paginaFinal" => "1570"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10749124"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S021056911200112X"
                          "estado" => "S300"
                          "issn" => "02105691"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of the vascular endothelial growth factor &#40;VEGF&#41; receptor gene&#44; KDR&#44; in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46; Katoh"
                            1 => "H&#46; Tauchi"
                            2 => "K&#46; Kawaishi"
                            3 => "A&#46; Kimura"
                            4 => "Y&#46; Satow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Research"
                        "fecha" => "1995"
                        "volumen" => "55"
                        "paginaInicial" => "5687"
                        "paginaFinal" => "5692"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7585655"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#191;Existen riesgos al utilizar los concentrados de Plasma Rico en Plaquetas &#40;PRP&#41; de uso ambulatorio&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;M&#46; Martinez"
                            1 => "J&#46;C&#46; Gonzalo"
                            2 => "J&#46; Campo"
                            3 => "G&#46;C&#46; Esparza"
                            4 => "J&#46;M&#46; Seoane"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Medicina Oral"
                        "fecha" => "2002"
                        "volumen" => "7"
                        "paginaInicial" => "375"
                        "paginaFinal" => "390"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12415222"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growth factor delivery methods in the management of sports injuries&#58; the state of play"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Creaney"
                            1 => "B&#46; Hamilton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bjsm.2007.040071"
                      "Revista" => array:6 [
                        "tituloSerie" => "British Journal of Sports Medicine"
                        "fecha" => "2008"
                        "volumen" => "42"
                        "paginaInicial" => "314"
                        "paginaFinal" => "320"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17984193"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Circulating osteoblast-lineage cells in humans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46;Z&#46; Eghbali-Fatourechi"
                            1 => "J&#46; Lamsam"
                            2 => "D&#46; Fraser"
                            3 => "D&#46; Nagel"
                            4 => "B&#46;L&#46; Riggs"
                            5 => "S&#46; Khosla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa044264"
                      "Revista" => array:6 [
                        "tituloSerie" => "New England Journal of Medicine"
                        "fecha" => "2005"
                        "volumen" => "352"
                        "paginaInicial" => "1959"
                        "paginaFinal" => "1966"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15888696"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Circulating osteogenic cells&#58; implications for injury&#44; repair&#44; and regeneration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;J&#46; Pignolo"
                            1 => "M&#46; Kassem"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jbmr.370"
                      "Revista" => array:7 [
                        "tituloSerie" => "Journal of Bone and Mineral Research"
                        "fecha" => "2011"
                        "volumen" => "26"
                        "paginaInicial" => "1685"
                        "paginaFinal" => "1693"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21538513"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016508510008644"
                          "estado" => "S300"
                          "issn" => "00165085"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Kajikawa"
                            1 => "T&#46; Morihara"
                            2 => "H&#46; Sakamoto"
                            3 => "K&#46; Matsuda"
                            4 => "Y&#46; Oshima"
                            5 => "A&#46; Yoshida"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jcp.21368"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Cellular Physiology"
                        "fecha" => "2008"
                        "volumen" => "215"
                        "paginaInicial" => "837"
                        "paginaFinal" => "845"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18181148"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stromal stem cells and platelet-rich plasma improve bone allograft integration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Lucarelli"
                            1 => "M&#46; Fini"
                            2 => "A&#46; Beccheroni"
                            3 => "G&#46; Giavaresi"
                            4 => "C&#46; Di Bella"
                            5 => "N&#46; Aldini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical Orthopaedics and Related Research"
                        "fecha" => "2005"
                        "volumen" => "435"
                        "paginaInicial" => "62"
                        "paginaFinal" => "68"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15930922"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Flexor tendon healing in vitro&#58; effects of TGF-beta on tendon cell collagen production"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;B&#46; Klein"
                            1 => "N&#46; Yalamanchi"
                            2 => "H&#46; Pham"
                            3 => "M&#46;T&#46; Longaker"
                            4 => "J&#46; Chang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "The Journal of Hand Surgery"
                        "fecha" => "2002"
                        "volumen" => "27"
                        "paginaInicial" => "615"
                        "paginaFinal" => "620"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12132085"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improved bone healing by angiogenic factor-enriched platelet-rich plasma and its synergistic enhancement by bone morphogenetic protein-2"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;J&#46; Park"
                            1 => "E&#46;S&#46; Kim"
                            2 => "H&#46;P&#46; Weber"
                            3 => "R&#46;F&#46; Wright"
                            4 => "D&#46;J&#46; Mooney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "International Journal of Oral and Maxillofacial Implants"
                        "fecha" => "2008"
                        "volumen" => "23"
                        "paginaInicial" => "818"
                        "paginaFinal" => "826"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19014150"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet rich plasma &#40;PRP&#41; enhances anabolic gene expression patterns in flexor digitorum superficialis tendons"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;V&#46; Schnabel"
                            1 => "H&#46;O&#46; Mohammed"
                            2 => "B&#46;J&#46; Miller"
                            3 => "W&#46;G&#46; McDermott"
                            4 => "M&#46;S&#46; Jacobson"
                            5 => "K&#46;S&#46; Santangelo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jor.20278"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Orthopaedic Research"
                        "fecha" => "2007"
                        "volumen" => "25"
                        "paginaInicial" => "230"
                        "paginaFinal" => "240"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17106885"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet concentrate injection improves Achilles tendon repair in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Aspenberg"
                            1 => "O&#46; Virchenko"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/00016470410001708190"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Orthopaedica Scandinavica"
                        "fecha" => "2004"
                        "volumen" => "75"
                        "paginaInicial" => "93"
                        "paginaFinal" => "99"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15022816"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks&#63; Interplay between early regeneration and mechanical stimulation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46; Virchenko"
                            1 => "P&#46; Aspenberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Orthopaedica"
                        "fecha" => "2006"
                        "volumen" => "77"
                        "paginaInicial" => "806"
                        "paginaFinal" => "812"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of autologous platelet-rich plasma to treat muscle strain injuries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;W&#46; Hammond"
                            1 => "R&#46;Y&#46; Hinton"
                            2 => "L&#46;A&#46; Curl"
                            3 => "J&#46;M&#46; Muriel"
                            4 => "R&#46;M&#46; Lovering"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0363546508330974"
                      "Revista" => array:7 [
                        "tituloSerie" => "American Journal of Sports Medicine"
                        "fecha" => "2009"
                        "volumen" => "37"
                        "paginaInicial" => "1135"
                        "paginaFinal" => "1142"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19282509"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1542356511009086"
                          "estado" => "S300"
                          "issn" => "15423565"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An experimental model of tennis elbow in rats&#58; a study of the contribution of the nervous system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Haker"
                            1 => "E&#46; Theodorsson"
                            2 => "T&#46; Lundeberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Inflammation"
                        "fecha" => "1998"
                        "volumen" => "22"
                        "paginaInicial" => "435"
                        "paginaFinal" => "444"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9675613"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma&#58; evidence to support its use"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;E&#46; Marx"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Oral and Maxillofacial Surgery"
                        "fecha" => "2004"
                        "volumen" => "62"
                        "paginaInicial" => "489"
                        "paginaFinal" => "496"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15085519"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich therapies in the treatment of orthopaedic sport injuries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Sanchez"
                            1 => "E&#46; Anitua"
                            2 => "G&#46; Orive"
                            3 => "I&#46; Mujika"
                            4 => "I&#46; Andia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sports Medicine"
                        "fecha" => "2009"
                        "volumen" => "39"
                        "paginaInicial" => "345"
                        "paginaFinal" => "354"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19402740"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Graham"
                            1 => "A&#46; Leonidou"
                            2 => "M&#46; Lester"
                            3 => "M&#46; Heliotis"
                            4 => "A&#46; Mantalaris"
                            5 => "E&#46; Tsiridis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1517/13543780903241607"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Opinion on Investigational Drugs"
                        "fecha" => "2009"
                        "volumen" => "18"
                        "paginaInicial" => "1633"
                        "paginaFinal" => "1654"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19747084"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermal growth factor &#40;EGF&#41; treatment on multipotential stromal cells &#40;MSCs&#41;&#46; Possible enhancement of therapeutic potential of MSC"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46; Tamama"
                            1 => "H&#46; Kawasaki"
                            2 => "A&#46; Wells"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2010/795385"
                      "Revista" => array:5 [
                        "tituloSerie" => "Journal of Biomedicine and Biotechnology"
                        "fecha" => "2010"
                        "volumen" => "2010"
                        "paginaInicial" => "795385"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20182548"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "X&#46; Zhang"
                            1 => "J&#46; Tamasi"
                            2 => "X&#46; Lu"
                            3 => "J&#46; Zhu"
                            4 => "H&#46; Chen"
                            5 => "X&#46; Tian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jbmr.295"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Bone and Mineral Research"
                        "fecha" => "2011"
                        "volumen" => "26"
                        "paginaInicial" => "1022"
                        "paginaFinal" => "1034"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21542005"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46; Fei"
                            1 => "L&#46; Xiao"
                            2 => "T&#46; Doetschman"
                            3 => "D&#46;J&#46; Coffin"
                            4 => "M&#46;M&#46; Hurley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.M111.274910"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Biological Chemistry"
                        "fecha" => "2011"
                        "volumen" => "286"
                        "paginaInicial" => "40575"
                        "paginaFinal" => "40583"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21987573"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of experimental osteonecrosis of the hip in adult rabbits with a single local injection of recombinant human FGF-2 microspheres"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46; Kuroda"
                            1 => "H&#46; Akiyama"
                            2 => "K&#46; Kawanabe"
                            3 => "Y&#46; Tabata"
                            4 => "T&#46; Nakamura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00774-010-0172-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Bone and Mineral Metabolism"
                        "fecha" => "2010"
                        "volumen" => "28"
                        "paginaInicial" => "608"
                        "paginaFinal" => "616"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20354742"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Local application of recombinant human fibroblast growth factor-2 on bone repair&#58; a dose-escalation prospective trial on patients with osteotomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Kawaguchi"
                            1 => "S&#46; Jingushi"
                            2 => "T&#46; Izumi"
                            3 => "M&#46; Fukunaga"
                            4 => "T&#46; Matsushita"
                            5 => "T&#46; Nakamura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jor.20315"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Orthopaedic Research"
                        "fecha" => "2007"
                        "volumen" => "25"
                        "paginaInicial" => "480"
                        "paginaFinal" => "487"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17205557"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transforming growth factor-beta isoforms and the induction of bone formation&#58; implications for reconstructive craniofacial surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "U&#46; Ripamonti"
                            1 => "C&#46; Ferretti"
                            2 => "J&#46; Teare"
                            3 => "L&#46; Blann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/SCS.0b013e3181b09ca6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Craniofacial Surgery"
                        "fecha" => "2009"
                        "volumen" => "20"
                        "paginaInicial" => "1544"
                        "paginaFinal" => "1555"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19816294"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TGF-beta-related mechanisms of bone destruction in multiple myeloma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Matsumoto"
                            1 => "M&#46; Abe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bone.2010.05.036"
                      "Revista" => array:6 [
                        "tituloSerie" => "Bone"
                        "fecha" => "2010"
                        "volumen" => "48"
                        "paginaInicial" => "129"
                        "paginaFinal" => "134"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20570621"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transforming growth factor-beta in osteolytic breast cancer bone metastases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46;A&#46; Guise"
                            1 => "J&#46;M&#46; Chirgwin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.blo.0000093055.96273.69"
                      "Revista" => array:7 [
                        "tituloSerie" => "Clinical Orthopaedics and Related Research"
                        "fecha" => "2003"
                        "volumen" => "415"
                        "numero" => "Suppl&#46; 10"
                        "paginaInicial" => "S32"
                        "paginaFinal" => "S38"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14600590"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma concentrate to augment bone fusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Bibbo"
                            1 => "P&#46;S&#46; Hatfield"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.fcl.2010.09.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Foot and Ankle Clinics"
                        "fecha" => "2010"
                        "volumen" => "15"
                        "paginaInicial" => "641"
                        "paginaFinal" => "649"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21056862"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mandibular reconstruction&#58; a histological and histomorphometric study on the use of autogenous scaffolds&#44; particulate cortico-cancellous bone grafts and platelet rich plasma in goats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;P&#46; Fennis"
                            1 => "P&#46;J&#46; Stoelinga"
                            2 => "J&#46;A&#46; Jansen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1054/ijom.2003.0452"
                      "Revista" => array:6 [
                        "tituloSerie" => "International Journal of Oral and Maxillofacial Surgery"
                        "fecha" => "2004"
                        "volumen" => "33"
                        "paginaInicial" => "48"
                        "paginaFinal" => "55"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14690659"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet concentration and its effect on bone formation in calvarial defects&#58; an experimental study in rabbits"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46;S&#46; Kim"
                            1 => "E&#46;J&#46; Park"
                            2 => "P&#46;H&#46; Choung"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mpr.2001.115874"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Prosthetic Dentistry"
                        "fecha" => "2001"
                        "volumen" => "86"
                        "paginaInicial" => "428"
                        "paginaFinal" => "433"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11677539"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Application of PRP gel alone or in combination with guided bone regeneration does not enhance bone healing process&#58; an experimental study in rabbits"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Kazakos"
                            1 => "D&#46;N&#46; Lyras"
                            2 => "V&#46; Thomaidis"
                            3 => "G&#46; Agrogiannis"
                            4 => "S&#46; Botaitis"
                            5 => "G&#46; Drosos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jcms.2010.03.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Cranio-Maxillo-Facial Surgery"
                        "fecha" => "2010"
                        "volumen" => "39"
                        "paginaInicial" => "49"
                        "paginaFinal" => "53"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20456969"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of platelet-rich plasma on a rabbit model of nicotine-compromised bone healing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Ma"
                            1 => "L&#46;W&#46; Zheng"
                            2 => "M&#46;H&#46; Sham"
                            3 => "C&#46;K&#46; Lam"
                            4 => "R&#46;A&#46; Zwahlen"
                            5 => "L&#46;K&#46; Cheung"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.joms.2010.05.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Oral and Maxillofacial Surgery"
                        "fecha" => "2010"
                        "volumen" => "69"
                        "paginaInicial" => "28"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20971543"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma inhibits demineralized bone matrix-induced bone formation in nude mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;M&#46; Ranly"
                            1 => "C&#46;H&#46; Lohmann"
                            2 => "D&#46; Andreacchio"
                            3 => "B&#46;D&#46; Boyan"
                            4 => "Z&#46; Schwartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2106/JBJS.F.00388"
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Bone and Joint Surgery"
                        "fecha" => "2007"
                        "volumen" => "89"
                        "paginaInicial" => "139"
                        "paginaFinal" => "147"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17200321"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraarticular administration of platelet-rich plasma with biodegradable gelatin hydrogel microspheres prevents osteoarthritis progression in the rabbit knee"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Saito"
                            1 => "K&#46;A&#46; Takahashi"
                            2 => "Y&#46; Arai"
                            3 => "A&#46; Inoue"
                            4 => "K&#46; Sakao"
                            5 => "H&#46; Tonomura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical and Experimental Rheumatology"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "201"
                        "paginaFinal" => "207"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19473558"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraarticular injection of platelet-rich plasma reduces inflammation in a pig model of rheumatoid arthritis of the knee joint"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Lippross"
                            1 => "B&#46; Moeller"
                            2 => "H&#46; Haas"
                            3 => "M&#46; Tohidnezhad"
                            4 => "N&#46; Steubesand"
                            5 => "C&#46;J&#46; Wruck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.30547"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis and Rheumatism"
                        "fecha" => "2011"
                        "volumen" => "63"
                        "paginaInicial" => "3344"
                        "paginaFinal" => "3353"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21769848"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelets amplify inflammation in arthritis via collagen-dependent microparticle production"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Boilard"
                            1 => "P&#46;A&#46; Nigrovic"
                            2 => "K&#46; Larabee"
                            3 => "G&#46;F&#46; Watts"
                            4 => "J&#46;S&#46; Coblyn"
                            5 => "M&#46;E&#46; Weinblatt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1126/science.1181928"
                      "Revista" => array:7 [
                        "tituloSerie" => "Science"
                        "fecha" => "2010"
                        "volumen" => "327"
                        "paginaInicial" => "580"
                        "paginaFinal" => "583"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20110505"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1542356511003077"
                          "estado" => "S300"
                          "issn" => "15423565"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exogenous application of platelet-leukocyte gel during open subacromial decompression contributes to improved patient outcome&#58; a prospective randomized double-blind study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;A&#46; Everts"
                            1 => "R&#46;J&#46;J&#46; Devilee"
                            2 => "C&#46; Brown Mahoney"
                            3 => "A&#46; Van Erp"
                            4 => "C&#46;J&#46;M&#46; Oosterbos"
                            5 => "M&#46; Stellenboom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000110862"
                      "Revista" => array:6 [
                        "tituloSerie" => "European Surgical Research"
                        "fecha" => "2008"
                        "volumen" => "40"
                        "paginaInicial" => "203"
                        "paginaFinal" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17998780"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of platelet-rich plasma in rotator cuff repair"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46; Mei-Dan"
                            1 => "M&#46;R&#46; Carmont"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Sports Medicine and Arthroscopy"
                        "fecha" => "2011"
                        "volumen" => "19"
                        "paginaInicial" => "244"
                        "paginaFinal" => "250"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Platelet-rich plasma injection reduces pain in patients with recalcitrant epicondylitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;S&#46; Hechtman"
                            1 => "J&#46;W&#46; Uribe"
                            2 => "A&#46; Botto-vanDemden"
                            3 => "G&#46;M&#46; Kiebzak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3928/01477447-20101221-05"
                      "Revista" => array:6 [
                        "tituloSerie" => "Orthopedics"
                        "fecha" => "2011"
                        "volumen" => "34"
                        "paginaInicial" => "92"
                        "paginaFinal" => "100"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21323296"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial&#58; platelet-rich plasma versus corticosteroid injection with a 1-year follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;C&#46; Peerbooms"
                            1 => "J&#46; Sluimer"
                            2 => "D&#46;J&#46; Bruijn"
                            3 => "T&#46; Gosens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0363546509355445"
                      "Revista" => array:6 [
                        "tituloSerie" => "American Journal of Sports Medicine"
                        "fecha" => "2010"
                        "volumen" => "38"
                        "paginaInicial" => "255"
                        "paginaFinal" => "262"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20448192"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hylan g-f 20&#58; review of its safety and efficacy in the management of joint pain in osteoarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Migliore"
                            1 => "F&#46; Giovannangeli"
                            2 => "M&#46; Granata"
                            3 => "B&#46; Lagana"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Journals of Clinical Medicine Insights&#58; Arthritis and Musculoskeletal Disorders"
                        "fecha" => "2010"
                        "volumen" => "3"
                        "paginaInicial" => "55"
                        "paginaFinal" => "68"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Viscosupplementation for the treatment of osteoarthritis of the knee"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46; Bellamy"
                            1 => "J&#46; Campbell"
                            2 => "V&#46; Robinson"
                            3 => "T&#46; Gee"
                            4 => "R&#46; Bourne"
                            5 => "G&#46; Wells"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Cochrane Database of Systematic Reviews"
                        "fecha" => "2005"
                        "paginaInicial" => "CD005321"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil infiltration in exercise-injured skeletal muscle&#58; how do we resolve the controversy&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46;S&#46; Schneider"
                            1 => "P&#46;M&#46; Tiidus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sports Medicine"
                        "fecha" => "2007"
                        "volumen" => "37"
                        "paginaInicial" => "837"
                        "paginaFinal" => "856"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17887810"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A prospective&#44; randomized&#44; double-blind&#44; placebo controlled study to evaluate the efficacy of intraarticular hyaluronic acid for osteoarthritis of the knee"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;J&#46; Petrella"
                            1 => "M&#46; Petrella"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of Rheumatology"
                        "fecha" => "2006"
                        "volumen" => "33"
                        "paginaInicial" => "951"
                        "paginaFinal" => "956"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16652426"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Determining utility values in patients with anterior cruciate ligament tears using clinical scoring systems"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Farshad"
                            1 => "C&#46; Gerber"
                            2 => "T&#46; Szucs"
                            3 => "D&#46;C&#46; Meyer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1472-6963-11-182"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Health Services Research"
                        "fecha" => "2011"
                        "volumen" => "11"
                        "paginaInicial" => "182"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21813026"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Wang-Saegusa"
                            1 => "R&#46; Cugat"
                            2 => "O&#46; Ares"
                            3 => "R&#46; Seijas"
                            4 => "X&#46; Cusco"
                            5 => "M&#46; Garcia-Balletbo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00402-010-1167-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Archives of Orthopaedic and Trauma Surgery"
                        "fecha" => "2010"
                        "volumen" => "131"
                        "paginaInicial" => "311"
                        "paginaFinal" => "317"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20714903"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis&#58; a pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Sampson"
                            1 => "M&#46; Reed"
                            2 => "H&#46; Silvers"
                            3 => "M&#46; Meng"
                            4 => "B&#46; Mandelbaum"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/PHM.0b013e3181fc7edf"
                      "Revista" => array:6 [
                        "tituloSerie" => "American Journal of Physical Medicine and Rehabilitation"
                        "fecha" => "2010"
                        "volumen" => "89"
                        "paginaInicial" => "961"
                        "paginaFinal" => "969"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21403592"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000000900000003/v1_201307311407/S2173574312001554/v1_201307311407/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8383"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Review Article"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000900000003/v1_201307311407/S2173574312001554/v1_201307311407/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574312001554?idApp=UINPBA00004M"
]
Article information
ISSN: 21735743
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 24 12 36
2024 October 125 44 169
2024 September 136 34 170
2024 August 146 52 198
2024 July 152 30 182
2024 June 120 27 147
2024 May 125 36 161
2024 April 113 36 149
2024 March 140 49 189
2024 February 84 24 108
2024 January 96 25 121
2023 December 60 36 96
2023 November 105 25 130
2023 October 105 28 133
2023 September 247 42 289
2023 August 256 33 289
2023 July 98 41 139
2023 June 119 24 143
2023 May 92 28 120
2023 April 78 21 99
2023 March 120 44 164
2023 February 106 25 131
2023 January 108 18 126
2022 December 126 40 166
2022 November 100 36 136
2022 October 123 49 172
2022 September 103 50 153
2022 August 129 67 196
2022 July 133 50 183
2022 June 130 50 180
2022 May 136 49 185
2022 April 203 62 265
2022 March 189 70 259
2022 February 133 53 186
2022 January 155 63 218
2021 December 181 56 237
2021 November 210 49 259
2021 October 170 55 225
2021 September 107 49 156
2021 August 85 41 126
2021 July 125 35 160
2021 June 112 37 149
2021 May 134 53 187
2021 April 258 81 339
2021 March 234 48 282
2021 February 158 31 189
2021 January 116 31 147
2020 December 109 34 143
2020 November 84 17 101
2020 October 140 17 157
2020 September 101 38 139
2020 August 105 23 128
2020 July 113 21 134
2020 June 73 17 90
2020 May 71 21 92
2020 April 37 21 58
2020 March 34 7 41
2020 January 4 0 4
2019 September 3 0 3
2019 June 1 0 1
2019 March 1 0 1
2019 January 1 0 1
2018 May 18 0 18
2018 April 114 8 122
2018 March 194 20 214
2018 February 149 8 157
2018 January 118 8 126
2017 December 110 16 126
2017 November 130 10 140
2017 October 170 7 177
2017 September 151 6 157
2017 August 136 13 149
2017 July 140 11 151
2017 June 170 28 198
2017 May 175 16 191
2017 April 187 16 203
2017 March 223 10 233
2017 February 197 12 209
2017 January 199 14 213
2016 December 245 27 272
2016 November 275 15 290
2016 October 284 18 302
2016 September 398 25 423
2016 August 358 23 381
2016 July 179 21 200
2016 April 1 22 23
2016 March 1 0 1
2016 January 1 0 1
2015 December 2 0 2
2015 November 3 33 36
2015 October 2 0 2
2015 September 2 0 2
2015 August 3 35 38
2015 July 112 12 124
2015 June 124 16 140
2015 May 191 53 244
2015 April 203 26 229
2015 March 222 36 258
2015 February 167 25 192
2015 January 194 23 217
2014 December 181 22 203
2014 November 177 36 213
2014 October 178 37 215
2014 September 142 27 169
2014 August 132 36 168
2014 July 140 30 170
2014 June 156 27 183
2014 May 151 37 188
2014 April 136 31 167
2014 March 120 46 166
2014 February 106 34 140
2014 January 85 33 118
2013 December 84 19 103
2013 November 88 25 113
2013 October 70 20 90
2013 September 61 25 86
2013 August 67 20 87
2013 July 47 21 68
2013 June 73 39 112
2013 May 19 9 28
Show all

Follow this link to access the full text of the article

Idiomas
Reumatología Clínica (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?