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A rare genetic disorder simulating juvenile idiopathic arthritis" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1021 "Ancho" => 1300 "Tamanyo" => 145375 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">a y b) Cuerpos vertebrales torácicos y lumbares aplanados, con irregularidades en mesetas vertebrales (platispondilia).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carolina Duarte-Salazar, Concepción Guadalupe Santillán-Chapa, Elisa Martínez-Coria, Norma Marin-Arriaga, Antonio Miranda-Duarte" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Carolina" "apellidos" => "Duarte-Salazar" ] 1 => array:2 [ "nombre" => "Concepción Guadalupe" "apellidos" => "Santillán-Chapa" ] 2 => array:2 [ "nombre" => "Elisa" "apellidos" => "Martínez-Coria" ] 3 => array:2 [ "nombre" => "Norma" "apellidos" => "Marin-Arriaga" ] 4 => array:2 [ "nombre" => "Antonio" "apellidos" => "Miranda-Duarte" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173574313000063" "doi" => "10.1016/j.reumae.2013.01.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574313000063?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X12002483?idApp=UINPBA00004M" "url" => "/1699258X/0000000900000005/v1_201308061043/S1699258X12002483/v1_201308061043/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173574313000713" "issn" => "21735743" "doi" => "10.1016/j.reumae.2012.09.005" "estado" => "S300" "fechaPublicacion" => "2013-09-01" "aid" => "518" "copyright" => "Elsevier España, S.L." 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Desorden genético raro que simula artritis idiopática juvenil" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1019 "Ancho" => 1297 "Tamanyo" => 144472 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">(a and b) Flattened thoracic and lumbar vertebral bodies with irregularities of their surfaces (platyspondylia).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Pseudorheumatoid progressive dysplasia (PRPD) is a hereditary, non-inflammatory skeletal disorder, autosomal, and recessive, associated to the WISP3. It is characterized by joint pain and effusion and progressively involves the hips, knees, wrists, and fingers. A reduction in joint mobility and multiple contractures lead to severe disability.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case Report</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 13-year-old male patient presented pain of the right hip and left knee which had started when he was 13. Five months later he presented swelling of both knees and the interphalangeal joints of the right hand. The patient referred a history of difficulty walking since he was 3 years of age. Upon examination we found a normal teenager with abnormal gait, spinal scoliosis, and kyphosis of the thoracic spine. Mobility of the lumbar spine, coxofemoral joints, knees, ankles, and interphalangeal joints were severely limited. X-rays of the hands and feet (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>a and b), hips and knees (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>a and b) revealed diffuse osteopenia, tubular widening of the epiphysis and loss of joint space, without erosive lesions; X-rays of the hip and knees also showed degenerative changes, with widening of the femoral heads. Thoracic and lumbar vertebrae were flattened and had an irregular surface (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>a and b). C reactive protein and erythrosedimentation rate were normal.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">PRPD clinically simulates early stages of JIA<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a>; however, the evidence used to establish the diagnosis of bone dysplasia is non-inflammatory joint involvement and characteristic radiological findings, such as the presence of enlarged epiphyses, generalized osteoporosis, and platyspondylia.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">This disease is caused by mutations in the WISP 3 gene, essential for normal growth and postnatal skeletal and joint cartilage homeostasis.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Therefore, in contrast to most of the skeletal dysplasias, prenatal skeletal growth and morphogenesis not altered in PRPD and affected individuals are asymptomatic during the first year of life. Subsequently, patients have progressive loss of joint cartilage and severe degenerative changes.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical Responsibilities</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Protection of Persons and Animals</span><p id="par0025" class="elsevierStylePara elsevierViewall">No experiments were performed on humans or animals.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Data Confidentiality</span><p id="par0030" class="elsevierStylePara elsevierViewall">No patient data appear in this article.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Right to Privacy and Informed Consent</span><p id="par0035" class="elsevierStylePara elsevierViewall">No patient data appear in this article.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to make.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:2 [ "identificador" => "xres326512" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec308017" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres326511" "titulo" => "Resumen" ] 3 => array:2 [ "identificador" => "xpalclavsec308016" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case Report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:3 [ "identificador" => "sec0020" "titulo" => "Ethical Responsibilities" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Protection of Persons and Animals" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Data Confidentiality" ] 2 => array:2 [ "identificador" => "sec0035" "titulo" => "Right to Privacy and Informed Consent" ] ] ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflicts of Interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-04-16" "fechaAceptado" => "2012-08-01" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec308017" "palabras" => array:3 [ 0 => "Progressive pseudorheumatoid dysplasia" 1 => "Juvenile idiopathic arthritis" 2 => "Platyspondylia" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec308016" "palabras" => array:3 [ 0 => "Displasia progresiva seudorreumatoide" 1 => "Artritis idiopática juvenil" 2 => "Platispondilia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">We present the case of a teenage patient with progressive pseudorheumatoid dysplasia, an autosomal recessive disorder that may be initially misdiagnosed as juvenile idiopathic arthritis.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Adolescente con displasia progresiva seudorreumatoide, desorden autosómico recesivo que puede ser diagnosticado inicialmente como artritis idiopática juvenil.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please, cite this article as: Duarte-Salazar C, et al. Displasia progresiva seudorreumatoide. Desorden genético raro que simula artritis idiopática juvenil. Reumatol Clin. 2013;9:316–321.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 505 "Ancho" => 1298 "Tamanyo" => 73209 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(a and b) Hand and feet X-rays show osteopenia, tubular epiphyseal widening and loss of joint space, without erosions.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 482 "Ancho" => 1299 "Tamanyo" => 75188 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">(a and b) Coxofemoral and knee X-rays show severe degenerative changes.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1019 "Ancho" => 1297 "Tamanyo" => 144472 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">(a and b) Flattened thoracic and lumbar vertebral bodies with irregularities of their surfaces (platyspondylia).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An eleven year old female Turkish patient with progressive pseudorheumatoid displasia mimicking juvenile idiopathic arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 14 | 11 | 25 |
2024 October | 63 | 37 | 100 |
2024 September | 67 | 17 | 84 |
2024 August | 88 | 29 | 117 |
2024 July | 59 | 26 | 85 |
2024 June | 67 | 33 | 100 |
2024 May | 69 | 28 | 97 |
2024 April | 68 | 33 | 101 |
2024 March | 93 | 37 | 130 |
2024 February | 46 | 33 | 79 |
2024 January | 40 | 27 | 67 |
2023 December | 70 | 38 | 108 |
2023 November | 62 | 57 | 119 |
2023 October | 62 | 33 | 95 |
2023 September | 83 | 41 | 124 |
2023 August | 41 | 16 | 57 |
2023 July | 76 | 24 | 100 |
2023 June | 51 | 23 | 74 |
2023 May | 72 | 21 | 93 |
2023 April | 52 | 9 | 61 |
2023 March | 88 | 27 | 115 |
2023 February | 64 | 33 | 97 |
2023 January | 81 | 42 | 123 |
2022 December | 85 | 31 | 116 |
2022 November | 90 | 32 | 122 |
2022 October | 81 | 47 | 128 |
2022 September | 84 | 31 | 115 |
2022 August | 93 | 50 | 143 |
2022 July | 87 | 53 | 140 |
2022 June | 69 | 36 | 105 |
2022 May | 96 | 47 | 143 |
2022 April | 49 | 56 | 105 |
2022 March | 58 | 58 | 116 |
2022 February | 70 | 31 | 101 |
2022 January | 65 | 33 | 98 |
2021 December | 56 | 45 | 101 |
2021 November | 88 | 46 | 134 |
2021 October | 66 | 53 | 119 |
2021 September | 96 | 46 | 142 |
2021 August | 88 | 39 | 127 |
2021 July | 68 | 44 | 112 |
2021 June | 87 | 36 | 123 |
2021 May | 62 | 32 | 94 |
2021 April | 117 | 72 | 189 |
2021 March | 97 | 18 | 115 |
2021 February | 53 | 23 | 76 |
2021 January | 56 | 18 | 74 |
2020 December | 49 | 21 | 70 |
2020 November | 44 | 22 | 66 |
2020 October | 40 | 10 | 50 |
2020 September | 27 | 34 | 61 |
2020 August | 25 | 20 | 45 |
2020 July | 27 | 24 | 51 |
2020 June | 31 | 22 | 53 |
2020 May | 36 | 8 | 44 |
2020 April | 26 | 13 | 39 |
2020 March | 19 | 9 | 28 |
2020 January | 1 | 0 | 1 |
2019 November | 2 | 0 | 2 |
2019 October | 1 | 0 | 1 |
2019 September | 2 | 0 | 2 |
2019 July | 1 | 0 | 1 |
2019 May | 2 | 0 | 2 |
2019 April | 2 | 0 | 2 |
2019 March | 4 | 0 | 4 |
2019 February | 3 | 0 | 3 |
2019 January | 5 | 0 | 5 |
2018 December | 2 | 0 | 2 |
2018 May | 5 | 0 | 5 |
2018 April | 81 | 5 | 86 |
2018 March | 79 | 7 | 86 |
2018 February | 23 | 4 | 27 |
2018 January | 21 | 4 | 25 |
2017 December | 31 | 10 | 41 |
2017 November | 37 | 7 | 44 |
2017 October | 32 | 5 | 37 |
2017 September | 28 | 8 | 36 |
2017 August | 28 | 10 | 38 |
2017 July | 22 | 11 | 33 |
2017 June | 47 | 8 | 55 |
2017 May | 40 | 10 | 50 |
2017 April | 34 | 7 | 41 |
2017 March | 32 | 5 | 37 |
2017 February | 26 | 6 | 32 |
2017 January | 34 | 9 | 43 |
2016 December | 66 | 10 | 76 |
2016 November | 45 | 9 | 54 |
2016 October | 53 | 15 | 68 |
2016 September | 65 | 7 | 72 |
2016 August | 52 | 5 | 57 |
2016 July | 22 | 5 | 27 |