Letter to the Editor
Strontium Ranelate Improves Osteointegration of a Hip Prosthesis
El ranelato de estroncio mejora la osteointegración de una prótesis de cadera
Piedad León Rubio
, Manuel Baturone Castillo
Corresponding author
Centro de Enfermedades del Aparato Locomotor, Sevilla, Spain
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"documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Reumatol Clin. 2013;9:324-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 924 "formatos" => array:3 [ "EPUB" => 64 "HTML" => 735 "PDF" => 125 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>" "titulo" => "Gouty Inflammation Confused With Septic Arthritis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "324" "paginaFinal" => "325" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Ataque agudo de gota sospechoso de artritis infecciosa" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1882 "Ancho" => 1660 "Tamanyo" => 237991 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">X-rays centered on the fifth metacarpophalangeal joint of both hands that allows for the assessment of the bone erosion comparatively and shows the sclerotic margin (arrows) with soft tissue augmentation and high density in the medial aspect of the right metacarpal head. 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She attended the clinic due to mechanical right hip pain with claudication, progressing in months. On examination we found limitation and pain on right hip rotation. We performed a hip X-ray (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) and, suspecting aseptic displacement of the prosthesis, bone scintigraphy was performed in 3 phases showing uptake in the distal third (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>a), confirming the diagnosis. We started treatment with strontium ranelate plus calcium and vitamin D. After 2 months, the patient improved significantly and her claudication disappeared. At 6 months, the bone scan was repeated, which showed a reduction to close to normal of the increased uptake seen at baseline (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>b).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Due to the aging of the population, there is an increase of patients undergoing joint replacement surgery. Stable and lasting fixation of the prosthesis depends, among other factors, on the surgical technique used, the characteristics of the implant surface which contacts the bone and bone quantity and quality in the patient. One of the most common complications is the displacement of the prosthesis, especially in patients with osteoporosis. It is therefore expected that therapies directed at improving bone microarchitecture and increase bone mass facilitate osteointegration of the prosthesis.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Strontium ranelate, used to prevent osteoporotic fractures,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> has been shown effective in improving prosthesis osteointegration in animals.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> However, to date there are no studies assessing its effects in humans for this same purpose. Thus, the case presented here provides data suggesting that strontium ranelate can be beneficial for osteointegration of a hip prosthesis. The substantial improvement in symptoms just 2 months after treatment onset with normalization of bone scan at 6 months are promising and suggest its potential application in orthopedic surgery.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: León Rubio P, Baturone Castillo M. El ranelato de estroncio mejora la osteointegración de una prótesis de cadera. Reumatol Clin. 2013;9:326–327.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2064 "Ancho" => 894 "Tamanyo" => 90418 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">X-ray of hip prosthesis.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 602 "Ancho" => 1298 "Tamanyo" => 63839 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(a) Bone scan showing displacement of the prosthesis at the femoral shaft level (arrow). (b) Same patient after 6 months of treatment with strontium ranelate.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Osteoinduction, osteoconduction and osseointegration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Albrektsson" 1 => "C. Johansson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s005860100282" "Revista" => array:7 [ "tituloSerie" => "Eur Spine J" "fecha" => "2001" "volumen" => "10" "numero" => "Suppl. 2" "paginaInicial" => "S96" "paginaFinal" => "S101" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11716023" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Strontium Ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis Treatment Of Peripheral Osteoporosis (TROPOS) stydy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.Y. Reginster" 1 => "E. Seeman" 2 => "M.C. De Vernejoul" 3 => "S. Adami" 4 => "J. Compston" 5 => "C. Phenekos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jc.2004-1774" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2005" "volumen" => "90" "paginaInicial" => "2816" "paginaFinal" => "2822" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15728210" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Strontium ranelate improves implant osteointegration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Maïmoun" 1 => "T.C. Brennan" 2 => "I. Badoud" 3 => "V. Dubois-Ferriere" 4 => "R. Rizzoli" 5 => "P. Ammann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.bone.2010.01.379" "Revista" => array:6 [ "tituloSerie" => "Bone" "fecha" => "2010" "volumen" => "46" "paginaInicial" => "1436" "paginaFinal" => "1441" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20116464" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Strontium ranelate treatment enhances hydroxyapatitecoated titanium screws fixation in osteoporotic rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y. Li" 1 => "G. Feng" 2 => "Y. Gao" 3 => "E. Luo" 4 => "X. Liu" 5 => "J. Hu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jor.21050" "Revista" => array:6 [ "tituloSerie" => "J Orthop Res" "fecha" => "2010" "volumen" => "28" "paginaInicial" => "578" "paginaFinal" => "582" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20014319" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000900000005/v2_201403300049/S2173574313000348/v2_201403300049/en/main.assets" "Apartado" => array:4 [ "identificador" => "8400" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000900000005/v2_201403300049/S2173574313000348/v2_201403300049/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574313000348?idApp=UINPBA00004M" ]
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