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diagnosed with neuroBeh&#231;et and showing a favorable clinical response to treatment with triple immunomodulatory therapy&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient is a Spanish man of 34 years with BD&#44; in whom the diagnosis was established by the presence of oral and genital ulcers and repeated episodes of anterior uveitis three years prior&#44; treated with prednisone at a dose of 5<span class="elsevierStyleHsp" style=""></span>mg&#47;day and cyclosporin A&#46; He came to the emergency department 24<span class="elsevierStyleHsp" style=""></span>h before due to a self-limited episode of loss of consciousness and subsequent headache and vomiting&#46; The general physical examination and vital signs were normal except for the presence of nuchal rigidity upon neurological examination&#46; There were no signs of disease activity at the time of the initial evaluation&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">He was put in reverse isolation for suspected intracranial meningeal syndrome secondary to infection due to immunosuppression&#46; During observation in the emergency department a blood count was performed which showed 4130 WBC E9&#47;l and no left shift&#44; hemoglobin 11&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; hematocrit 36&#37;&#44; ESR 12<span class="elsevierStyleHsp" style=""></span>mm&#47;h&#44; lactate dehydrogenase 97<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; total protein 6&#46;2<span class="elsevierStyleHsp" style=""></span>g&#47;l albumin 3<span class="elsevierStyleHsp" style=""></span>g&#47;l&#44; and a computed tomography that revealed no significant structural alterations&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In accordance with the headache and meningeal signs a lumbar puncture was performed&#44; resulting inconclusive due to a traumatic technique&#44; and no second sample was obtained&#46; However&#44; the patient was admitted to the neurology department with empirical intravenous antibiotic therapy based on ceftriaxone and vancomycin as well as acyclovir for antiherpetic coverage&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">During admission&#44; he underwent a second lumbar puncture with glucose 56<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; protein 68<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and WBC 600&#47;&#956;l &#40;90&#37; polymorphonuclear cells&#44; 10&#37; lymphocytes&#41;&#46; Due to the polymorphonuclear pleiocitosis we performed a magnetic resonance imaging &#40;MRI&#41; scan &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; which showed an extrusion affection with extension to the left cerebral peduncle which appeared isointense on T1&#44; hyperintense on T2 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; and flair&#44; and hypointense on T1 IR&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Microbiological studies with Gram and Ziehl&#8211;Neelsen stains of the cerebrospinal fluid cultures &#40;including Lowenstein&#41;&#44; polymerase chain reaction for herpes virus&#44; Brucella and Borrelia serologies were negative&#46; We also excluded other possible differential diagnoses considering the history of immunosuppression&#58; varicella zoster virus&#44; herpes virus&#44; pox&#44; cytomegalovirus&#44; Candida and meningeal lymphomatosis&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">He was assessed by neurology who considered neuroBeh&#231;et given the persistence of symptoms despite antibiotic treatment and the medical history of the patient and who initiated infliximab therapy associated with tuberculosis prophylaxis with isoniazid&#44; prior suspension of antibiotic treatment and cyclosporin A&#44; the latter due to the relationship described in the literature with worsening neurologic manifestations&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Regarding the imaging differential diagnosis it should be noted that&#44; because of its topography and signal intensity&#44; similar images can be seen in early forms of multiple sclerosis and postinfectious encephalopathy&#46; Viral rhomboencephalitis would be a differential diagnosis also&#44; but it is a rare condition in which the injury is unique&#44; extensive and of pontine dominance&#46; Given the history&#44; the clinical and laboratory tests&#44; we oriented the diagnosis toward neuroBeh&#231;et&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The patient showed significant clinical improvement and resolution of the headache and nuchal rigidity&#46; A third lumbar puncture was performed 72<span class="elsevierStyleHsp" style=""></span>h after treatment initiation&#44; with glucose 52<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; protein 48<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and 100&#47;&#956;l with predominantly mononuclear leukocytes&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Considering the rapid radiographic and clinical improvement after receiving anti-TNF therapy&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> we conclude that the patient had BD related aseptic meningitis&#59; the patient was discharged with prednisone 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#44; isoniazide-pyridoxine&#44; infliximab and azathioprine&#46; Control brain MRI showed no lesions described in the previous study and presently the patient had no recurrence of neurological affectation&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The central and&#47;or peripheral nervous system affection occurs in about 5&#37;&#8211;25&#37; of patients with BD&#46; It is more common in males and usually presents between 3 and 6 years following the onset of illness&#46; Presentation as the first manifestation of the disease is rare&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Involvement of the central nervous system &#40;CNS&#41; is the most prevalent and there are two clinical forms&#58; parenchymal and non-parenchymal affection&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> This clinical&#44; pathological&#44; radiological differentiation is important and influences prognosis since parenchymal injury is more prevalent &#40;80&#37; of cases&#41; and has a worse prognosis&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> The clinical presentation is nonspecific and varied&#44; including loss of consciousness&#44; seizures&#44; confusion&#44; lethargy&#44; psychiatric disorders&#44; personality changes and dementia&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;11</span></a> Unlike immunosuppressed patients without BD&#44; meningitis can be present as oligosymptomatic&#44; subacute&#44; or associated to cranial nerve disorders&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In the context of an BD our patient presented neurological manifestations and we established the diagnosis of neuroBeh&#231;et supported in patient study and prior exclusion of other causes&#46; The presence of signs of meningeal inflammation is common in the CNS parenchymal form&#59; however&#44; the presentation as isolated meningitis is quite rare&#46; This case highlights&#44; therefore&#44; the importance of ruling out an infectious etiology&#44; particularly in patients undergoing immunomodulator treatment&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">MRI findings in relation to the progression of the disease and the initial phase T2 hyperintensity areas in the brainstem&#44; basal ganglia and brain hemispheres&#44; followed by an intermediate stage of edema with a mass effect and microhemorrhages and a third stage with brainstem atrophy have been described&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a> In our case&#44; there was no clinical but rather imaging evidence of thromboencephalic involvement&#44; with findings corresponding in our patient with his initial changes&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In accordance with the above&#44; it is advisable to perform MRI controls for tracking injuries once the treatment is started although these lesions can take months or years to disappear<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&#59; in our case&#44; we verified resolution after 5 weeks of triple therapy with immunomodulatory therapy&#46;</p></span>"
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                      "titulo" => "Neuro beh&#231;et&#58; a prop&#243;sito de un caso"
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Letter to the Editor
Acute Meningitis in Behcet's Disease
Meningitis aguda en la enfermedad de Behçet
Fernando Mario Andrade-Rodadoa, Robert Hurtado-Garcíaa,
Corresponding author
, Antonio Álvarez Cienfuegosb, Santiago Mola Caballeroc, Juan Carlos Barreras Mateosd, Juan Custardoy Olavarrietaa
a Servicio de Medicina Interna, Hospital Vega Baja, Orihuela, Alicante, Spain
b Servicio de Reumatología, Hospital Vega Baja, Orihuela, Alicante, Spain
c Servicio de Neurología, Hospital Vega Baja, Orihuela, Alicante, Spain
d Servicio de Radiología, Hospital Vega Baja, Orihuela, Alicante, Spain
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diagnosed with neuroBeh&#231;et and showing a favorable clinical response to treatment with triple immunomodulatory therapy&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient is a Spanish man of 34 years with BD&#44; in whom the diagnosis was established by the presence of oral and genital ulcers and repeated episodes of anterior uveitis three years prior&#44; treated with prednisone at a dose of 5<span class="elsevierStyleHsp" style=""></span>mg&#47;day and cyclosporin A&#46; He came to the emergency department 24<span class="elsevierStyleHsp" style=""></span>h before due to a self-limited episode of loss of consciousness and subsequent headache and vomiting&#46; The general physical examination and vital signs were normal except for the presence of nuchal rigidity upon neurological examination&#46; There were no signs of disease activity at the time of the initial evaluation&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">He was put in reverse isolation for suspected intracranial meningeal syndrome secondary to infection due to immunosuppression&#46; During observation in the emergency department a blood count was performed which showed 4130 WBC E9&#47;l and no left shift&#44; hemoglobin 11&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; hematocrit 36&#37;&#44; ESR 12<span class="elsevierStyleHsp" style=""></span>mm&#47;h&#44; lactate dehydrogenase 97<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; total protein 6&#46;2<span class="elsevierStyleHsp" style=""></span>g&#47;l albumin 3<span class="elsevierStyleHsp" style=""></span>g&#47;l&#44; and a computed tomography that revealed no significant structural alterations&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In accordance with the headache and meningeal signs a lumbar puncture was performed&#44; resulting inconclusive due to a traumatic technique&#44; and no second sample was obtained&#46; However&#44; the patient was admitted to the neurology department with empirical intravenous antibiotic therapy based on ceftriaxone and vancomycin as well as acyclovir for antiherpetic coverage&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">During admission&#44; he underwent a second lumbar puncture with glucose 56<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; protein 68<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and WBC 600&#47;&#956;l &#40;90&#37; polymorphonuclear cells&#44; 10&#37; lymphocytes&#41;&#46; Due to the polymorphonuclear pleiocitosis we performed a magnetic resonance imaging &#40;MRI&#41; scan &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; which showed an extrusion affection with extension to the left cerebral peduncle which appeared isointense on T1&#44; hyperintense on T2 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; and flair&#44; and hypointense on T1 IR&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Microbiological studies with Gram and Ziehl&#8211;Neelsen stains of the cerebrospinal fluid cultures &#40;including Lowenstein&#41;&#44; polymerase chain reaction for herpes virus&#44; Brucella and Borrelia serologies were negative&#46; We also excluded other possible differential diagnoses considering the history of immunosuppression&#58; varicella zoster virus&#44; herpes virus&#44; pox&#44; cytomegalovirus&#44; Candida and meningeal lymphomatosis&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">He was assessed by neurology who considered neuroBeh&#231;et given the persistence of symptoms despite antibiotic treatment and the medical history of the patient and who initiated infliximab therapy associated with tuberculosis prophylaxis with isoniazid&#44; prior suspension of antibiotic treatment and cyclosporin A&#44; the latter due to the relationship described in the literature with worsening neurologic manifestations&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Regarding the imaging differential diagnosis it should be noted that&#44; because of its topography and signal intensity&#44; similar images can be seen in early forms of multiple sclerosis and postinfectious encephalopathy&#46; Viral rhomboencephalitis would be a differential diagnosis also&#44; but it is a rare condition in which the injury is unique&#44; extensive and of pontine dominance&#46; Given the history&#44; the clinical and laboratory tests&#44; we oriented the diagnosis toward neuroBeh&#231;et&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The patient showed significant clinical improvement and resolution of the headache and nuchal rigidity&#46; A third lumbar puncture was performed 72<span class="elsevierStyleHsp" style=""></span>h after treatment initiation&#44; with glucose 52<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; protein 48<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and 100&#47;&#956;l with predominantly mononuclear leukocytes&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Considering the rapid radiographic and clinical improvement after receiving anti-TNF therapy&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> we conclude that the patient had BD related aseptic meningitis&#59; the patient was discharged with prednisone 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#44; isoniazide-pyridoxine&#44; infliximab and azathioprine&#46; Control brain MRI showed no lesions described in the previous study and presently the patient had no recurrence of neurological affectation&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The central and&#47;or peripheral nervous system affection occurs in about 5&#37;&#8211;25&#37; of patients with BD&#46; It is more common in males and usually presents between 3 and 6 years following the onset of illness&#46; Presentation as the first manifestation of the disease is rare&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Involvement of the central nervous system &#40;CNS&#41; is the most prevalent and there are two clinical forms&#58; parenchymal and non-parenchymal affection&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> This clinical&#44; pathological&#44; radiological differentiation is important and influences prognosis since parenchymal injury is more prevalent &#40;80&#37; of cases&#41; and has a worse prognosis&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> The clinical presentation is nonspecific and varied&#44; including loss of consciousness&#44; seizures&#44; confusion&#44; lethargy&#44; psychiatric disorders&#44; personality changes and dementia&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;11</span></a> Unlike immunosuppressed patients without BD&#44; meningitis can be present as oligosymptomatic&#44; subacute&#44; or associated to cranial nerve disorders&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In the context of an BD our patient presented neurological manifestations and we established the diagnosis of neuroBeh&#231;et supported in patient study and prior exclusion of other causes&#46; The presence of signs of meningeal inflammation is common in the CNS parenchymal form&#59; however&#44; the presentation as isolated meningitis is quite rare&#46; This case highlights&#44; therefore&#44; the importance of ruling out an infectious etiology&#44; particularly in patients undergoing immunomodulator treatment&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">MRI findings in relation to the progression of the disease and the initial phase T2 hyperintensity areas in the brainstem&#44; basal ganglia and brain hemispheres&#44; followed by an intermediate stage of edema with a mass effect and microhemorrhages and a third stage with brainstem atrophy have been described&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a> In our case&#44; there was no clinical but rather imaging evidence of thromboencephalic involvement&#44; with findings corresponding in our patient with his initial changes&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In accordance with the above&#44; it is advisable to perform MRI controls for tracking injuries once the treatment is started although these lesions can take months or years to disappear<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&#59; in our case&#44; we verified resolution after 5 weeks of triple therapy with immunomodulatory therapy&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please&#44; cite this article as&#58; Andrade-Rodado FM&#44; et al&#46; Meningitis aguda en la enfermedad de Beh&#231;et&#46; Reumatol Clin&#46; 2014&#59;10&#58;59&#8211;61&#46;</p>"
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                      "titulo" => "Neuro beh&#231;et&#58; a prop&#243;sito de un caso"
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                          "etal" => false
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                  "contribucion" => array:1 [
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Benamour"
                            1 => "T&#46; Naji"
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                        ]
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                  ]
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                  ]
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Article information
ISSN: 21735743
Original language: English
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Idiomas
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