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1</a>A and B&#41;&#46; Tocilizumab was suspended permanently&#44; with normalization of AST&#44; TB&#44; fibrinogen and INR&#44; but the levels of ALT&#44; GGT&#44; AP and thrombocytopenia remained unchanged&#46; In successive imaging controls&#44; an increased diameter of the portal vein &#40;17<span class="elsevierStyleHsp" style=""></span>mm&#41; was observed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#44; with no evidence of thrombosis&#46; Currently&#44; the patient receives only steroids at a variable dose&#44; with mild to moderate activity of JIA and without developing other complications of PH&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">HNRH pathogenesis is unknown&#44; but it is considered a nonspecific tissue adaptive response to an altered distribution of hepatic vascular flow with a multifactorial cause&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Among the identified factors which can cause this condition are thrombosis &#40;thrombophilia&#44; malignancies&#44; myeloproliferative disorders&#44; APS&#41; and endothelial cell injury in the portal venules and hepatic sinusoids &#40;drugs&#44; autoimmune diseases&#44; and viruses&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In this case&#44; the underlying disease and drug therapy could have been involved&#46; The chronic inflammatory state secondary to the long duration of systemic onset JIA is associated with high circulating levels of proinflammatory cytokines such as interleukin 6 &#40;IL-6&#41;&#44; which has been implicated in the development of HNRH&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> This cytokine is important in the proliferation of hepatocytes and liver regeneration&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> However&#44; transgenic mice expressing high levels of IL-6 and its soluble receptor &#40;sIL-6R&#41; exhibit hepatocellular hyperplastic nodules around the portal tracts&#44; as do patients with HNRH&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> There is also clinical evidence that the increase in IL-6 is associated HNRH in Castleman&#39;s disease&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Other HNRH related disorders&#44; such as SLE and hematological malignancies&#44; have high levels of the IL-6&#47;sIL-6R complex&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Although patients with systemic onset JIA have a higher concentration of these complexes&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> HNRH has rarely been described in this disease&#44; with only the case of a 17-year-old patient with hepatomegaly and PH<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> having been published&#44; but this is probably due to an underdiagnosis of this condition&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Drugs are also associated with the development of HNRH&#44; mainly thiopurines &#40;azathioprine&#44; 6-mercaptopurine&#44; 6-thioguanine&#41;&#44; cyclophosphamide&#44; busulfan&#44; oxaliplatin and antiretroviral drugs&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Our patient did not receive any of these agents but was treated for 15 years with methotrexate&#44; a drug that has been associated with hepatotoxicity and liver fibrosis but not HNRH&#44; with only one case found in the literature of a patient with adult-onset Still&#39;s disease treated simultaneously with azathioprine and glucocorticoids&#44; attributing its development to the combination of the latter 2 drugs&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> and another in a patient with Felty&#39;s syndrome who was diagnosed with HNRH after receiving methotrexate for a short period of time&#44; leading the authors to conclude that there was no association&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> This case also received varying doses of corticosteroids for 28 years&#46; The association of these drugs with HNRH<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> through an unknown mechanism has been suggested&#46; However&#44; chronic corticosteroid therapy is associated with the development of vascular lesions in autoimmune diseases&#44; which could contribute to the development of liver vascular flow alterations that lead to the development of HNRH&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The possibility of HNRH should be considered in patients with symptomatic PH &#40;splenomegaly&#44; ascites&#44; esophageal varices&#41;&#44; who have normal transaminases and no manifestations of cirrhosis&#46; HNRH is estimated to represent 27&#37; of all cases of non-cirrhotic PH in Europe&#44; but its diagnosis suffers a significant delay because only 50&#37; have a PH and 11&#37;&#8211;25&#37; have only mildly elevated liver enzymes&#44; generally AP&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Our case probably developed HNRH insidiously during the prolonged course of systemic onset JIA and the emergence of hepatotoxicity during administration of tocilizumab finally led to the diagnosis&#44; when the patient developed PH&#46; Imaging tests have poor sensitivity and specificity for detecting HNRH&#44; so a definitive diagnosis requires histologic confirmation&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Treating HNRH focuses on correcting the underlying cause &#40;autoimmune disease&#44; hematologic disorder&#44; drugs&#41; and&#44; in patients in whom PH has developed&#44; preventing and treating the complications&#44; with esophageal varices bleeding constituting the leading cause of mortality in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In conclusion&#44; HNRH is a complication that can occur during the development of autoimmune diseases&#44; including systemic onset JIA&#44; so it should be considered in cases with a persistent abnormal liver profile&#44; even without other data from PH&#46;</p></span>"
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Letter to the Editor
Nodular Regenerative Hyperplasia of the Liver as a Complication of Long-standing Systemic-onset Juvenile Idiopathic Arthritis
Hiperplasia nodular regenerativa hepática como complicación tardía de la artritis idiopática juvenil de inicio sistémico
Walter Alberto Sifuentes Giraldoa,
Corresponding author
albertosifuentesg@gmail.com

Corresponding author.
, Ana Burdaspal Moratillab, Alberto Moreno Caparrósb, María Luz Gámir Gámira
a Unidad de Reumatología Pediátrica, Servicio de Reumatología, Hospital Universitario Ramón y Cajal, Madrid, Spain
b Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Madrid, Spain
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&#40;79<span class="elsevierStyleHsp" style=""></span>U&#47;l&#41; and total bilirubin &#40;TB&#41; &#40;3&#46;51<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; levels&#44; presenting hypofibrinogenemia &#40;122<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#44; abnormal INR &#40;1&#46;5&#41; and an increase in the severity of thrombocytopenia &#40;57&#215;10<span class="elsevierStyleSup">3</span>&#47;&#956;l&#41;&#46; He was admitted to the hospital with suspected Macrophage Activation Syndrome&#46; The patient had not concomitantly received NSAIDs or other potentially hepatotoxic drugs&#46; Serologic testing for hepatitis viruses B and C&#44; Epstein Barr virus and human immunodeficiency virus were negative&#44; and a bone marrow biopsy showed reactive changes and no hemophagocytosis&#46; Endoscopy revealed the presence of grade <span class="elsevierStyleSmallCaps">i</span>&#8211;<span class="elsevierStyleSmallCaps">ii</span> esophageal varices and a biopsy confirmed the diagnosis of HNRH &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A and B&#41;&#46; Tocilizumab was suspended permanently&#44; with normalization of AST&#44; TB&#44; fibrinogen and INR&#44; but the levels of ALT&#44; GGT&#44; AP and thrombocytopenia remained unchanged&#46; In successive imaging controls&#44; an increased diameter of the portal vein &#40;17<span class="elsevierStyleHsp" style=""></span>mm&#41; was observed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#44; with no evidence of thrombosis&#46; Currently&#44; the patient receives only steroids at a variable dose&#44; with mild to moderate activity of JIA and without developing other complications of PH&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">HNRH pathogenesis is unknown&#44; but it is considered a nonspecific tissue adaptive response to an altered distribution of hepatic vascular flow with a multifactorial cause&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Among the identified factors which can cause this condition are thrombosis &#40;thrombophilia&#44; malignancies&#44; myeloproliferative disorders&#44; APS&#41; and endothelial cell injury in the portal venules and hepatic sinusoids &#40;drugs&#44; autoimmune diseases&#44; and viruses&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In this case&#44; the underlying disease and drug therapy could have been involved&#46; The chronic inflammatory state secondary to the long duration of systemic onset JIA is associated with high circulating levels of proinflammatory cytokines such as interleukin 6 &#40;IL-6&#41;&#44; which has been implicated in the development of HNRH&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> This cytokine is important in the proliferation of hepatocytes and liver regeneration&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> However&#44; transgenic mice expressing high levels of IL-6 and its soluble receptor &#40;sIL-6R&#41; exhibit hepatocellular hyperplastic nodules around the portal tracts&#44; as do patients with HNRH&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> There is also clinical evidence that the increase in IL-6 is associated HNRH in Castleman&#39;s disease&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Other HNRH related disorders&#44; such as SLE and hematological malignancies&#44; have high levels of the IL-6&#47;sIL-6R complex&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Although patients with systemic onset JIA have a higher concentration of these complexes&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> HNRH has rarely been described in this disease&#44; with only the case of a 17-year-old patient with hepatomegaly and PH<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> having been published&#44; but this is probably due to an underdiagnosis of this condition&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Drugs are also associated with the development of HNRH&#44; mainly thiopurines &#40;azathioprine&#44; 6-mercaptopurine&#44; 6-thioguanine&#41;&#44; cyclophosphamide&#44; busulfan&#44; oxaliplatin and antiretroviral drugs&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Our patient did not receive any of these agents but was treated for 15 years with methotrexate&#44; a drug that has been associated with hepatotoxicity and liver fibrosis but not HNRH&#44; with only one case found in the literature of a patient with adult-onset Still&#39;s disease treated simultaneously with azathioprine and glucocorticoids&#44; attributing its development to the combination of the latter 2 drugs&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> and another in a patient with Felty&#39;s syndrome who was diagnosed with HNRH after receiving methotrexate for a short period of time&#44; leading the authors to conclude that there was no association&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> This case also received varying doses of corticosteroids for 28 years&#46; The association of these drugs with HNRH<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> through an unknown mechanism has been suggested&#46; However&#44; chronic corticosteroid therapy is associated with the development of vascular lesions in autoimmune diseases&#44; which could contribute to the development of liver vascular flow alterations that lead to the development of HNRH&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The possibility of HNRH should be considered in patients with symptomatic PH &#40;splenomegaly&#44; ascites&#44; esophageal varices&#41;&#44; who have normal transaminases and no manifestations of cirrhosis&#46; HNRH is estimated to represent 27&#37; of all cases of non-cirrhotic PH in Europe&#44; but its diagnosis suffers a significant delay because only 50&#37; have a PH and 11&#37;&#8211;25&#37; have only mildly elevated liver enzymes&#44; generally AP&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Our case probably developed HNRH insidiously during the prolonged course of systemic onset JIA and the emergence of hepatotoxicity during administration of tocilizumab finally led to the diagnosis&#44; when the patient developed PH&#46; Imaging tests have poor sensitivity and specificity for detecting HNRH&#44; so a definitive diagnosis requires histologic confirmation&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Treating HNRH focuses on correcting the underlying cause &#40;autoimmune disease&#44; hematologic disorder&#44; drugs&#41; and&#44; in patients in whom PH has developed&#44; preventing and treating the complications&#44; with esophageal varices bleeding constituting the leading cause of mortality in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In conclusion&#44; HNRH is a complication that can occur during the development of autoimmune diseases&#44; including systemic onset JIA&#44; so it should be considered in cases with a persistent abnormal liver profile&#44; even without other data from PH&#46;</p></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Liver biopsy in which a hyperplastic nodular zone &#40;arrowheads&#41; partially surrounded by dilated sinusoids &#40;arrow&#41; and absence of fibrosis &#40;hematoxylin&#8211;eosin 2&#215;&#41; &#40;A&#41; is observed&#46; At higher magnification&#44; the sinusoids are compressed by the thickened hepatocyte plaques &#40;hematoxylin&#8211;eosin 40&#215;&#41; &#40;B&#41;&#46; An abdominal CT scan shows dilation of the portal vein and its branches &#40;arrow&#41; &#40;C&#41;&#46;</p>"
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