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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Rheumatoid arthritis &#40;RA&#41; is a systemic inflammatory disease&#44; with a chronic and variable evolution&#44; characterized by persistent and symmetrical synovitis of the peripheral joints&#46; In recent years its natural history has changed thanks to advances in treatment&#44; so comorbidities have become more important&#59; in fact&#44; increased mortality compared to the general population is primarily a result of diseases of cardiovascular origin&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> with rates up to 50&#37; or higher&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In RA underlying atherosclerotic disease is increased<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> secondary to chronic inflammation&#44; which involves activation of T lymphocytes and macrophages&#44; production of proinflammatory cytokines<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> &#40;gamma interferon&#44; tumor necrosis factor&#44; IL-1 and IL-6&#41;&#46; It is potentiated due to classic cardiovascular risk factors &#40;CVRF&#41;&#44; including the metabolic syndrome&#44; which is more prevalent probably due to less physical activity because of joint pain and moreover&#44; dyslipidemia follows a more atherogenic<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> pattern&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">With all these data&#44; we conclude that the RA is a situation with a high CVR&#44; where cardiovascular morbidity is related to the disease activity&#44; so its control could reduce the risk&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Therefore&#44; this study proposes to detect subclinical CVD by measuring the ankle-brachial index &#40;ABI&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We performed a descriptive cross-sectional study on 60 RA patients with no history of CVD&#44; at the University Hospital of La Princesa&#44; Madrid&#44; selected consecutively in the rheumatology clinic during the 6 months when the study was carried out&#46; Sociodemographic variables&#44; analytical data&#44; classic CVRF&#44; duration of RA and immunomodulatory treatment were collected&#46; ABI was defined as abnormal if less than 0&#46;9&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Of the 60 patients enrolled&#44; 3 were men &#40;5&#37;&#41; and 57 women &#40;95&#37;&#41; with a mean age<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation of 53&#46;75 years &#40;53&#46;75<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;38&#44; range 29&#8211;87&#41;&#46; 38 had mild RA &#40;63&#46;3&#37;&#41;&#44; while 22 &#40;36&#46;7&#37;&#41; had important deformities&#46; The time of disease progression was 9&#46;14 years &#40;9&#46;14<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;505&#44; range 0&#46;6&#8211;40&#41;&#44; 58 patients &#40;96&#46;7&#37;&#41; were under immunomodulatory therapy&#44; mostly with methotrexate &#40;75&#37;&#41;&#46; The result of the ABI was similar in both lower limbs&#58; 1&#46;074 &#40;1&#46;074<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;082&#44; range 0&#46;88&#8211;1&#46;28&#41; on the right and 1&#46;077 &#40;1&#46;077<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;088&#44; range 0&#46;92&#8211;1&#46;27&#41; on the left&#44; with no significant differences between them&#46; Only one patient &#40;1&#46;7&#37;&#41; had an abnormal ABI&#58; a woman of 87 years&#44; with hypertension&#44; and RA for 12 years and using corticosteroids during virtually all this time&#59; the ABI on the other extremity was 0&#46;92&#46; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows the ABI results&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In our sample&#44; there is an overrepresentation of women &#40;19&#58;1&#41; with respect to other RA populations &#40;3&#58;1&#41;&#46; However&#44; the profile of CVR did not differ regarding the Spanish general population&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Only one pathological case was detected&#44; much lower than other studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> with rates of 20&#37;&#8211;25&#37;&#44; although the frequency cutoff point considered as pathological was 1&#44; rather than the value of 0&#46;9 currently accepted&#46; However&#44; in another publication with the same cutoff&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> the prevalence was 10&#37;&#44; although in their sample the mean age&#44; duration of RA and&#44; above all&#44; the prevalence of cardiovascular risk factors &#40;especially diabetes and dyslipidemia&#41; were superior&#46; Other possible factors involved could be the adequate control of the disease&#44; since only 3&#46;3&#37; of patients had no specific treatment and the value of the acute phase reactants was normal&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">A major limitation to the study was accessibility&#44; as the ABI was performed after the patient visit&#44; so many of the patients excluded were those who refused to participate&#44; claiming physical difficulty to go and get tested&#44; which may have been a selection bias&#44; having lost the sickest patients&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion&#44; based on our results we do not consider routine ABI testing justified in asymptomatic patients with RA from a cardiovascular point of view&#46;</p></span>"
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Letter to the Editor
Usefulness of the Ankle-brachial Index as a Survey Method for Subclinical Vascular Disease in Patients With Rheumatoid Arthritis
Utilidad del índice tobillo-brazo como método de cribado de enfermedad vascular subclínica en pacientes con artritis reumatoide
Cristina Marcos de Frutos, Daniel Abad Pérez
Corresponding author
danielabadperez@hotmail.com

Corresponding author.
, Carmen Suárez Fernández
Servicio de Medicina Interna, Hospital Universitario de La Princesa, Madrid, Spain
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    "titulo" => "Usefulness of the Ankle-brachial Index as a Survey Method for Subclinical Vascular Disease in Patients With Rheumatoid Arthritis"
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        "titulo" => "Utilidad del &#237;ndice tobillo-brazo como m&#233;todo de cribado de enfermedad vascular subcl&#237;nica en pacientes con artritis reumatoide"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Rheumatoid arthritis &#40;RA&#41; is a systemic inflammatory disease&#44; with a chronic and variable evolution&#44; characterized by persistent and symmetrical synovitis of the peripheral joints&#46; In recent years its natural history has changed thanks to advances in treatment&#44; so comorbidities have become more important&#59; in fact&#44; increased mortality compared to the general population is primarily a result of diseases of cardiovascular origin&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> with rates up to 50&#37; or higher&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In RA underlying atherosclerotic disease is increased<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> secondary to chronic inflammation&#44; which involves activation of T lymphocytes and macrophages&#44; production of proinflammatory cytokines<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> &#40;gamma interferon&#44; tumor necrosis factor&#44; IL-1 and IL-6&#41;&#46; It is potentiated due to classic cardiovascular risk factors &#40;CVRF&#41;&#44; including the metabolic syndrome&#44; which is more prevalent probably due to less physical activity because of joint pain and moreover&#44; dyslipidemia follows a more atherogenic<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> pattern&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">With all these data&#44; we conclude that the RA is a situation with a high CVR&#44; where cardiovascular morbidity is related to the disease activity&#44; so its control could reduce the risk&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Therefore&#44; this study proposes to detect subclinical CVD by measuring the ankle-brachial index &#40;ABI&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We performed a descriptive cross-sectional study on 60 RA patients with no history of CVD&#44; at the University Hospital of La Princesa&#44; Madrid&#44; selected consecutively in the rheumatology clinic during the 6 months when the study was carried out&#46; Sociodemographic variables&#44; analytical data&#44; classic CVRF&#44; duration of RA and immunomodulatory treatment were collected&#46; ABI was defined as abnormal if less than 0&#46;9&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Of the 60 patients enrolled&#44; 3 were men &#40;5&#37;&#41; and 57 women &#40;95&#37;&#41; with a mean age<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation of 53&#46;75 years &#40;53&#46;75<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;38&#44; range 29&#8211;87&#41;&#46; 38 had mild RA &#40;63&#46;3&#37;&#41;&#44; while 22 &#40;36&#46;7&#37;&#41; had important deformities&#46; The time of disease progression was 9&#46;14 years &#40;9&#46;14<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;505&#44; range 0&#46;6&#8211;40&#41;&#44; 58 patients &#40;96&#46;7&#37;&#41; were under immunomodulatory therapy&#44; mostly with methotrexate &#40;75&#37;&#41;&#46; The result of the ABI was similar in both lower limbs&#58; 1&#46;074 &#40;1&#46;074<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;082&#44; range 0&#46;88&#8211;1&#46;28&#41; on the right and 1&#46;077 &#40;1&#46;077<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;088&#44; range 0&#46;92&#8211;1&#46;27&#41; on the left&#44; with no significant differences between them&#46; Only one patient &#40;1&#46;7&#37;&#41; had an abnormal ABI&#58; a woman of 87 years&#44; with hypertension&#44; and RA for 12 years and using corticosteroids during virtually all this time&#59; the ABI on the other extremity was 0&#46;92&#46; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows the ABI results&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In our sample&#44; there is an overrepresentation of women &#40;19&#58;1&#41; with respect to other RA populations &#40;3&#58;1&#41;&#46; However&#44; the profile of CVR did not differ regarding the Spanish general population&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Only one pathological case was detected&#44; much lower than other studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> with rates of 20&#37;&#8211;25&#37;&#44; although the frequency cutoff point considered as pathological was 1&#44; rather than the value of 0&#46;9 currently accepted&#46; However&#44; in another publication with the same cutoff&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> the prevalence was 10&#37;&#44; although in their sample the mean age&#44; duration of RA and&#44; above all&#44; the prevalence of cardiovascular risk factors &#40;especially diabetes and dyslipidemia&#41; were superior&#46; Other possible factors involved could be the adequate control of the disease&#44; since only 3&#46;3&#37; of patients had no specific treatment and the value of the acute phase reactants was normal&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">A major limitation to the study was accessibility&#44; as the ABI was performed after the patient visit&#44; so many of the patients excluded were those who refused to participate&#44; claiming physical difficulty to go and get tested&#44; which may have been a selection bias&#44; having lost the sickest patients&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion&#44; based on our results we do not consider routine ABI testing justified in asymptomatic patients with RA from a cardiovascular point of view&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Marcos de Frutos C&#44; Abad P&#233;rez D&#44; Su&#225;rez Fern&#225;ndez C&#46; Utilidad del &#237;ndice tobillo-brazo como m&#233;todo de cribado de enfermedad vascular subcl&#237;nica en pacientes con artritis reumatoide&#46; Reumatol Clin&#46; 2014&#59;10&#58;268&#8211;269&#46;</p>"
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Article information
ISSN: 21735743
Original language: English
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Idiomas
Reumatología Clínica (English Edition)
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