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Letter to the Editor
Eosinophlic pneumonia in a patient with anticentromere antibody
Neumonía eosinofílica en pacientes con anticuerpos anticentroméricos
Hiroaki Satoh
Corresponding author
hirosato@md.tsukuba.ac.jp

Corresponding author.
, Katsunori Kagohashi, Gen Ohara, Kunihiko Miyazaki, Koichi Kurishima
Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Japan
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read with interest the article by Jaimes-Hern&#225;ndez et al&#46; &#40;Reumatol Clin 2012 May&#8211;June issue&#41; on eosinophilic pneumonia in patients with autoimmune phenomenon or immunoallergic disease&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> We would like to share our experience with a patient whose condition was similar to that reported by Jaimes-Hern&#225;ndez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A 75-year-old woman was admitted to our hospital because of one-week history of left chest pain&#46; She was never smoker&#46; She had a seven-year history of atrial fibrillation and&#44; thereafter&#44; was prescribed warfarin&#46; On admission&#44; she had no rales in both lungs&#44; and the musculoskeletal examination was also unremarkable&#46; She had no Raynaud&#39;s phenomenon&#44; screloderma&#44; and dysphagia&#46; The chest X-ray and computed tomography revealed bilateral nonsegmental peripheral infiltrates mainly in the left lung&#46; Laboratory data on admission were as follows&#58; white blood cell 4900&#47;&#956;L &#40;eosinophils&#58; 245&#47;&#956;L&#41;&#44; C-reactive protein 3&#46;77<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; anti-nuclear antibody 1&#58;640&#44; anticentromere antibody 1&#58;640&#44; rheumatoid factor 4<span class="elsevierStyleHsp" style=""></span>U&#47;mL&#46; RP3-ANCA&#44; MPO-ANCA&#44; anti-ribonucleoprotein antibody&#44; and anti-topoisomerase l antibody were negative&#46; All tests for acid-fast bacilli including culture&#44; and serologic and microscopic testing for fungi was negative&#46; A bronchoalveolar lavage obtained from left upper lobe showed total cell count 8&#46;4<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">5</span>&#47;mL with 16&#46;7&#37; eosinophilia&#46; Transbronchial biopsy was not performed because the patient had warfarin for atrial fibrillation&#46; The patient was diagnosed as having eosinophilic pneumonia and was started on 30<span class="elsevierStyleHsp" style=""></span>mg prednisolone per day&#46; After two weeks of treatment pulmonary infiltrates had normalized&#46; She was successfully weaned off the prednisolone over a period of two months and followed up without recurrence of eosinophilic pneumonia&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Although very rare&#44; there have been some reports with regard to marked eosinophilic pulmonary infiltration in patients&#44; who had high titers of antiautoimmune antibodies&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Both of them were diagnosed as having Churg-Straus syndrome&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Our patient had no sign and symptoms of Churg-Straus syndrome nor any autoimmune diseases&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Our patient had a high titer of anticentromere antibody in her serum without any symptoms of CREST syndrome&#46; There might be a possibility that eosinophilic pneumonia developed incidentally in a patient with high titer of anticentromere antibody in serum&#46; However&#44; the case reported by Jaimes-Hern&#225;ndez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and ourselves suggested that a certain type of eosinophilic pneumonia might have some relationship with autoimmune phenomenon&#46;</p></span>"
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Article information
ISSN: 21735743
Original language: English
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2018 April 23 11 34
2018 March 31 4 35
2018 February 7 5 12
2018 January 13 4 17
2017 December 14 3 17
2017 November 12 5 17
2017 October 16 8 24
2017 September 10 6 16
2017 August 11 15 26
2017 July 11 8 19
2017 June 26 23 49
2017 May 33 27 60
2017 April 23 10 33
2017 March 24 23 47
2017 February 18 11 29
2017 January 16 5 21
2016 December 37 9 46
2016 November 19 9 28
2016 October 33 12 45
2016 September 41 12 53
2016 August 26 7 33
2016 July 16 7 23
2016 April 1 0 1
2015 November 1 0 1
2015 September 2 0 2
2015 August 1 0 1
2015 July 9 7 16
2015 June 13 3 16
2015 May 29 10 39
2015 April 9 7 16
2015 March 14 3 17
2015 February 22 4 26
2015 January 14 12 26
2014 December 20 20 40
2014 November 18 10 28
2014 October 18 8 26
2014 September 14 7 21
2014 August 14 18 32
2014 July 28 13 41
2014 June 38 22 60
2014 May 20 20 40
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