array:24 [
  "pii" => "S2173574314000835"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2013.05.006"
  "estado" => "S300"
  "fechaPublicacion" => "2014-05-01"
  "aid" => "592"
  "copyright" => "Elsevier España, S.L.. All rights reserved"
  "copyrightAnyo" => "2013"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2014;10:198"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1188
    "formatos" => array:3 [
      "EPUB" => 51
      "HTML" => 749
      "PDF" => 388
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S1699258X13001757"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2013.05.009"
      "estado" => "S300"
      "fechaPublicacion" => "2014-05-01"
      "aid" => "592"
      "copyright" => "Elsevier España, S.L."
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Reumatol Clin. 2014;10:198"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 2599
        "formatos" => array:3 [
          "EPUB" => 157
          "HTML" => 1690
          "PDF" => 752
        ]
      ]
      "en" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
        "titulo" => "Eosinophlic pneumonia in a patient with anticentromere antibody"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:1 [
            "paginaInicial" => "198"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Neumon&#237;a eosinof&#237;lica en pacientes con anticuerpos anticentrom&#233;ricos"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Hiroaki Satoh, Katsunori Kagohashi, Gen Ohara, Kunihiko Miyazaki, Koichi Kurishima"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "Hiroaki"
                "apellidos" => "Satoh"
              ]
              1 => array:2 [
                "nombre" => "Katsunori"
                "apellidos" => "Kagohashi"
              ]
              2 => array:2 [
                "nombre" => "Gen"
                "apellidos" => "Ohara"
              ]
              3 => array:2 [
                "nombre" => "Kunihiko"
                "apellidos" => "Miyazaki"
              ]
              4 => array:2 [
                "nombre" => "Koichi"
                "apellidos" => "Kurishima"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574314000835"
          "doi" => "10.1016/j.reumae.2013.05.006"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574314000835?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X13001757?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001000000003/v1_201405040016/S1699258X13001757/v1_201405040016/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574313001548"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2013.12.023"
    "estado" => "S300"
    "fechaPublicacion" => "2014-05-01"
    "aid" => "587"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2014;10:199"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1485
      "formatos" => array:3 [
        "EPUB" => 56
        "HTML" => 1149
        "PDF" => 280
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Eosinophilic Pneumonia&#58; Autoinmune or Immunoallergic Phenomenon&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "199"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Neumon&#237;a eosinof&#237;lica&#44; &#191;fen&#243;meno autoinmune o inmunoal&#233;rgico&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jorge Jaimes-Hern&#225;ndez"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Jorge"
              "apellidos" => "Jaimes-Hern&#225;ndez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X13001551"
        "doi" => "10.1016/j.reuma.2013.05.005"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X13001551?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574313001548?idApp=UINPBA00004M"
    "url" => "/21735743/0000001000000003/v2_201406190029/S2173574313001548/v2_201406190029/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574313001366"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2013.12.005"
    "estado" => "S300"
    "fechaPublicacion" => "2014-05-01"
    "aid" => "595"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2014;10:197-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2064
      "formatos" => array:3 [
        "EPUB" => 50
        "HTML" => 1452
        "PDF" => 562
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Frequency of Gout According to the Perception of Physicians in M&#233;xico"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "197"
          "paginaFinal" => "198"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Frecuencia de la gota seg&#250;n la percepci&#243;n de los m&#233;dicos en M&#233;xico"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 854
              "Ancho" => 1641
              "Tamanyo" => 60019
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Frequency of rheumatic diseases as perceived by physicians&#46; OA &#40;osteoarthritis&#41;&#44; RA &#40;rheumatoid arthritis&#41;&#44; FM &#40;fibromyalgia&#41;&#44; SLE &#40;systemic lupus erythematosus&#41; and AS &#40;ankylosing spondylitis&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Sergio Garc&#237;a-M&#233;ndez, Roberto Arregu&#237;n-Reyes, Omar L&#243;pez-L&#243;pez, Janitzia V&#225;zquez-Mellado"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Sergio"
              "apellidos" => "Garc&#237;a-M&#233;ndez"
            ]
            1 => array:2 [
              "nombre" => "Roberto"
              "apellidos" => "Arregu&#237;n-Reyes"
            ]
            2 => array:2 [
              "nombre" => "Omar"
              "apellidos" => "L&#243;pez-L&#243;pez"
            ]
            3 => array:2 [
              "nombre" => "Janitzia"
              "apellidos" => "V&#225;zquez-Mellado"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X13001782"
        "doi" => "10.1016/j.reuma.2013.06.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X13001782?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574313001366?idApp=UINPBA00004M"
    "url" => "/21735743/0000001000000003/v2_201406190029/S2173574313001366/v2_201406190029/en/main.assets"
  ]
  "en" => array:11 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Eosinophlic pneumonia in a patient with anticentromere antibody"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:1 [
        "paginaInicial" => "198"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Hiroaki Satoh, Katsunori Kagohashi, Gen Ohara, Kunihiko Miyazaki, Koichi Kurishima"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Hiroaki"
            "apellidos" => "Satoh"
            "email" => array:1 [
              0 => "hirosato&#64;md&#46;tsukuba&#46;ac&#46;jp"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Katsunori"
            "apellidos" => "Kagohashi"
          ]
          2 => array:2 [
            "nombre" => "Gen"
            "apellidos" => "Ohara"
          ]
          3 => array:2 [
            "nombre" => "Kunihiko"
            "apellidos" => "Miyazaki"
          ]
          4 => array:2 [
            "nombre" => "Koichi"
            "apellidos" => "Kurishima"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Division of Respiratory Medicine&#44; Mito Medical Center&#44; University of Tsukuba&#44; Japan"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Neumon&#237;a eosinof&#237;lica en pacientes con anticuerpos anticentrom&#233;ricos"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read with interest the article by Jaimes-Hern&#225;ndez et al&#46; &#40;Reumatol Clin 2012 May&#8211;June issue&#41; on eosinophilic pneumonia in patients with autoimmune phenomenon or immunoallergic disease&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> We would like to share our experience with a patient whose condition was similar to that reported by Jaimes-Hern&#225;ndez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A 75-year-old woman was admitted to our hospital because of one-week history of left chest pain&#46; She was never smoker&#46; She had a seven-year history of atrial fibrillation and&#44; thereafter&#44; was prescribed warfarin&#46; On admission&#44; she had no rales in both lungs&#44; and the musculoskeletal examination was also unremarkable&#46; She had no Raynaud&#39;s phenomenon&#44; screloderma&#44; and dysphagia&#46; The chest X-ray and computed tomography revealed bilateral nonsegmental peripheral infiltrates mainly in the left lung&#46; Laboratory data on admission were as follows&#58; white blood cell 4900&#47;&#956;L &#40;eosinophils&#58; 245&#47;&#956;L&#41;&#44; C-reactive protein 3&#46;77<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; anti-nuclear antibody 1&#58;640&#44; anticentromere antibody 1&#58;640&#44; rheumatoid factor 4<span class="elsevierStyleHsp" style=""></span>U&#47;mL&#46; RP3-ANCA&#44; MPO-ANCA&#44; anti-ribonucleoprotein antibody&#44; and anti-topoisomerase l antibody were negative&#46; All tests for acid-fast bacilli including culture&#44; and serologic and microscopic testing for fungi was negative&#46; A bronchoalveolar lavage obtained from left upper lobe showed total cell count 8&#46;4<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">5</span>&#47;mL with 16&#46;7&#37; eosinophilia&#46; Transbronchial biopsy was not performed because the patient had warfarin for atrial fibrillation&#46; The patient was diagnosed as having eosinophilic pneumonia and was started on 30<span class="elsevierStyleHsp" style=""></span>mg prednisolone per day&#46; After two weeks of treatment pulmonary infiltrates had normalized&#46; She was successfully weaned off the prednisolone over a period of two months and followed up without recurrence of eosinophilic pneumonia&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Although very rare&#44; there have been some reports with regard to marked eosinophilic pulmonary infiltration in patients&#44; who had high titers of antiautoimmune antibodies&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Both of them were diagnosed as having Churg-Straus syndrome&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Our patient had no sign and symptoms of Churg-Straus syndrome nor any autoimmune diseases&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Our patient had a high titer of anticentromere antibody in her serum without any symptoms of CREST syndrome&#46; There might be a possibility that eosinophilic pneumonia developed incidentally in a patient with high titer of anticentromere antibody in serum&#46; However&#44; the case reported by Jaimes-Hern&#225;ndez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and ourselves suggested that a certain type of eosinophilic pneumonia might have some relationship with autoimmune phenomenon&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:3 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic eosinophilic pneumonia&#58; autoimmune phenomenon or immunoallergic disease&#63; Case report and literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Jaimes-Hern&#225;ndez"
                            1 => "A&#46; Mendoza-Fuentes"
                            2 => "C&#46;I&#46; Mel&#233;ndez-Mercado"
                            3 => "P&#46; Aranda-Pereira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.reuma.2011.09.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Reumatol Clin"
                        "fecha" => "2012"
                        "volumen" => "8"
                        "paginaInicial" => "145"
                        "paginaFinal" => "148"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22196999"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A rare case of allergic granulomatous angitis &#40;Churg Strauss syndrome&#41; with positive anti-glomerular basement membrane &#40;GBM&#41; antibody in serum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Masuzaki"
                            1 => "M&#46; Iwanishi"
                            2 => "M&#46; Umemiya"
                            3 => "K&#46; Misaki"
                            4 => "S&#46; Sumitomo"
                            5 => "N&#46; Fujimura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nihon Kyobu Shikkan Gakkai Zasshi"
                        "fecha" => "1991"
                        "volumen" => "29"
                        "paginaInicial" => "1644"
                        "paginaFinal" => "1650"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1808391"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of Churg-Strauss syndrome in which MPO-ANCA &#40;antibodies to myeloperoxidase&#41; appeared to reflect the disease activity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Nakagawa"
                            1 => "T&#46; Yamaguchi"
                            2 => "H&#46; Amano"
                            3 => "T&#46; Takao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nihon Kyobu Shikkan Gakkai Zasshi"
                        "fecha" => "1995"
                        "volumen" => "33"
                        "paginaInicial" => "543"
                        "paginaFinal" => "547"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7609341"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001000000003/v2_201406190029/S2173574314000835/v2_201406190029/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8400"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001000000003/v2_201406190029/S2173574314000835/v2_201406190029/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574314000835?idApp=UINPBA00004M"
]
Share
Journal Information
Vol. 10. Issue 3.
Pages 198 (May - June 2014)
Share
Share
Download PDF
More article options
Vol. 10. Issue 3.
Pages 198 (May - June 2014)
Letter to the Editor
Full text access
Eosinophlic pneumonia in a patient with anticentromere antibody
Neumonía eosinofílica en pacientes con anticuerpos anticentroméricos
Visits
3941
Hiroaki Satoh
Corresponding author
hirosato@md.tsukuba.ac.jp

Corresponding author.
, Katsunori Kagohashi, Gen Ohara, Kunihiko Miyazaki, Koichi Kurishima
Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Japan
This item has received
Article information
Full Text
Bibliography
Download PDF
Statistics
Full Text

We read with interest the article by Jaimes-Hernández et al. (Reumatol Clin 2012 May–June issue) on eosinophilic pneumonia in patients with autoimmune phenomenon or immunoallergic disease.1 We would like to share our experience with a patient whose condition was similar to that reported by Jaimes-Hernández et al.1

A 75-year-old woman was admitted to our hospital because of one-week history of left chest pain. She was never smoker. She had a seven-year history of atrial fibrillation and, thereafter, was prescribed warfarin. On admission, she had no rales in both lungs, and the musculoskeletal examination was also unremarkable. She had no Raynaud's phenomenon, screloderma, and dysphagia. The chest X-ray and computed tomography revealed bilateral nonsegmental peripheral infiltrates mainly in the left lung. Laboratory data on admission were as follows: white blood cell 4900/μL (eosinophils: 245/μL), C-reactive protein 3.77mg/dL, anti-nuclear antibody 1:640, anticentromere antibody 1:640, rheumatoid factor 4U/mL. RP3-ANCA, MPO-ANCA, anti-ribonucleoprotein antibody, and anti-topoisomerase l antibody were negative. All tests for acid-fast bacilli including culture, and serologic and microscopic testing for fungi was negative. A bronchoalveolar lavage obtained from left upper lobe showed total cell count 8.4×105/mL with 16.7% eosinophilia. Transbronchial biopsy was not performed because the patient had warfarin for atrial fibrillation. The patient was diagnosed as having eosinophilic pneumonia and was started on 30mg prednisolone per day. After two weeks of treatment pulmonary infiltrates had normalized. She was successfully weaned off the prednisolone over a period of two months and followed up without recurrence of eosinophilic pneumonia.

Although very rare, there have been some reports with regard to marked eosinophilic pulmonary infiltration in patients, who had high titers of antiautoimmune antibodies.2,3 Both of them were diagnosed as having Churg-Straus syndrome.2,3 Our patient had no sign and symptoms of Churg-Straus syndrome nor any autoimmune diseases.

Our patient had a high titer of anticentromere antibody in her serum without any symptoms of CREST syndrome. There might be a possibility that eosinophilic pneumonia developed incidentally in a patient with high titer of anticentromere antibody in serum. However, the case reported by Jaimes-Hernández et al.1 and ourselves suggested that a certain type of eosinophilic pneumonia might have some relationship with autoimmune phenomenon.

References
[1]
J. Jaimes-Hernández, A. Mendoza-Fuentes, C.I. Meléndez-Mercado, P. Aranda-Pereira.
Chronic eosinophilic pneumonia: autoimmune phenomenon or immunoallergic disease? Case report and literature review.
Reumatol Clin, 8 (2012), pp. 145-148
[2]
H. Masuzaki, M. Iwanishi, M. Umemiya, K. Misaki, S. Sumitomo, N. Fujimura, et al.
A rare case of allergic granulomatous angitis (Churg Strauss syndrome) with positive anti-glomerular basement membrane (GBM) antibody in serum.
Nihon Kyobu Shikkan Gakkai Zasshi, 29 (1991), pp. 1644-1650
[3]
A. Nakagawa, T. Yamaguchi, H. Amano, T. Takao.
A case of Churg-Strauss syndrome in which MPO-ANCA (antibodies to myeloperoxidase) appeared to reflect the disease activity.
Nihon Kyobu Shikkan Gakkai Zasshi, 33 (1995), pp. 543-547
Copyright © 2013. Elsevier España, S.L.. All rights reserved
Download PDF
Idiomas
Reumatología Clínica (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?