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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Individuals with primary Sj&#246;gren&#39;s syndrome &#40;pSS&#41; have over 40-fold increased risk of the development B-cell lymphoma&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The relationship of SS with T-cell lymphoma is&#44; nevertheless&#44; enigmatic&#46; We herein describe a case of a patient with features compatible with SS who evolved to a hepatosplenic gammadelta T-cell lymphoma &#40;GDTL&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient&#44; a 25-year-old white female&#44; had complained of fatigue&#44; &#8220;dry eyes&#8221; &#40;confirmed by an Ophthalmologist&#41;&#44; parotid enlargement and xerostomia for the last four years&#46; Physical examination in December 2008 revealed increased parotid glands and hepatosplenomegaly&#44; but no peripheral lymphadenopathy&#46; Pancytopenia was present &#40;hemoglobin 7&#46;9<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#44; white blood cell 1000<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span>&#44; platelet count 107&#44;000<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span>&#41;&#46; The erythrocyte sedimentation rate was of 37<span class="elsevierStyleHsp" style=""></span>mm in the first hour&#46; Polyclonal hypergammaglobulinemia was present&#46; The antinuclear antibody test was strongly positive &#40;1&#47;5120&#44; speckled pattern&#41;&#44; and anti-SSA antibodies were detected in high levels &#40;124 units in an ELISA&#41;&#46; The rheumatoid factor test was weakly positive &#40;45 units&#41;&#46; Abdominal ecography confirmed hepatosplenomegaly&#46; A bone marrow biopsy &#40;BMB&#41; showed hypercellularity&#44; without evidence of malignancy&#46; Considering the clinical and laboratory findings suggestive of pSS&#44; the patient was treated with prednisone and azathioprine&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">After eight months&#44; a notable improvement of clinical and hematological features was seen&#46; Hepatosplenomegaly remained&#44; however&#44; and a new BMB plus splenectomy were carried out&#46; At that time&#44; hemoglobin was 10<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#44; the leukocyte count was 21&#44;900<span class="elsevierStyleHsp" style=""></span>cells&#47;cm<span class="elsevierStyleSup">3</span> &#40;with 65 erythroblasts per 100 leukocytes&#41;&#44; and the platelet count was 106&#44;000&#47;cm<span class="elsevierStyleSup">3</span>&#46; The spleen histology was inconclusive&#44; and the BMB showed interstitial infiltration by atypical lymphoid cells&#46; Immunohistochemistry of spleen and bone marrow revealed the following lymphocyte profile&#58; CD3&#43;&#44; CD4&#8722;&#44; CD5&#8722;&#44; CD8&#8722;&#44; Ki 67&#43; with a rate of 50&#37; CD56&#43; focal&#46; The karyotype showed&#44; of importance&#44; eight trisomy and absence of chromosome seven&#46; Altogether&#44; morphologic&#44; phenotypic and genetic findings were compatible with a hepatosplenic GDTL&#46; After eighteen months of standard chemotherapy&#44; the patient died in September 2011&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Hepatosplenic GDTL is an aggressive and uncommon malignancy &#40;&#60;1&#37; of lymphoid neoplasms&#41;&#46; Intense gammadelta T-cell proliferation is characteristically seen in liver&#44; spleen and bone marrow sinusoids&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The disorder usually affects young adults&#44; and the outcome is poor&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Hepatosplenomegaly and severe cytopenias&#44; both seen in our patient&#44; are usual aspects&#59; lymphadenopathy is rare&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Of interest&#44; hepatosplenic GDTL can mimic the hemophagocytic syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In 2009&#44; a cutaneous GDTL was diagnosed in a patient with rheumatoid arthritis using etanercept&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Current ACR classification criteria for SS include autoantibodies&#44; ocular staining and salivary gland histology&#44; suggesting that case definition requires two of the three&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> pSS was initially a suitable diagnosis for our patient due to the presence of ophthalmic sicca&#44; parotiditis&#44; typical autoantibodies&#44; polyclonal hypergammaglobulinemia&#44; and peripheral pancytopenia&#46; The first BMB showed no malignancy&#44; and clinical features responded well to traditional immunosuppression&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The unexpected persistence of hepatosplenomegaly led to an immunohistochemistry diagnosis of hepatosplenic GDTL eight months ahead&#46; Thus&#44; it is conceivable that the patient firstly had pSS and later developed a GDTL&#46; Although one cannot rule out the possibility that she presented GDTL with SS features since the beginning&#44; the reported median survival time of six months for GDTL<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> turns it less plausible&#46; Also&#44; an atypical form of SS &#8220;secondary&#8221; to GDTL could be brought about&#46; Necessary to say&#44; the occurrence of SS and GDTL could have been only coincidental in our patient&#46; For any of these circumstances&#44; no similar clinical scenario combining SS features and GDTL has been described so far&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In summary&#44; we describe a case of a young patient with features of SS who evolved&#44; unusually&#44; to a hepatosplenic GDTL&#46; The interplay of SS with non-B lymphomas has yet to be clarified&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;</p></span></span>"
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Letter to the Editor
Hepatosplenic gammadelta T-cell lymphoma and Sjögren's syndrome
Linfoma T hepatoesplénico gamma-delta y síndrome de Sjögren
Ronaldo Godinhoa, Paula Vanessa de Oliveirab, Deonilson Ghizoni Schmoellera, Henrique L. Stauba,
Corresponding author
reumatoacademico@gmail.com

Corresponding author.
a Rheumatology Department, Faculty of Medicine, Saint Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil
b Hematology Department, Faculty of Medicine, Saint Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil
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        "titulo" => "Linfoma T hepatoespl&#233;nico gamma-delta y s&#237;ndrome de Sj&#246;gren"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Individuals with primary Sj&#246;gren&#39;s syndrome &#40;pSS&#41; have over 40-fold increased risk of the development B-cell lymphoma&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The relationship of SS with T-cell lymphoma is&#44; nevertheless&#44; enigmatic&#46; We herein describe a case of a patient with features compatible with SS who evolved to a hepatosplenic gammadelta T-cell lymphoma &#40;GDTL&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient&#44; a 25-year-old white female&#44; had complained of fatigue&#44; &#8220;dry eyes&#8221; &#40;confirmed by an Ophthalmologist&#41;&#44; parotid enlargement and xerostomia for the last four years&#46; Physical examination in December 2008 revealed increased parotid glands and hepatosplenomegaly&#44; but no peripheral lymphadenopathy&#46; Pancytopenia was present &#40;hemoglobin 7&#46;9<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#44; white blood cell 1000<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span>&#44; platelet count 107&#44;000<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span>&#41;&#46; The erythrocyte sedimentation rate was of 37<span class="elsevierStyleHsp" style=""></span>mm in the first hour&#46; Polyclonal hypergammaglobulinemia was present&#46; The antinuclear antibody test was strongly positive &#40;1&#47;5120&#44; speckled pattern&#41;&#44; and anti-SSA antibodies were detected in high levels &#40;124 units in an ELISA&#41;&#46; The rheumatoid factor test was weakly positive &#40;45 units&#41;&#46; Abdominal ecography confirmed hepatosplenomegaly&#46; A bone marrow biopsy &#40;BMB&#41; showed hypercellularity&#44; without evidence of malignancy&#46; Considering the clinical and laboratory findings suggestive of pSS&#44; the patient was treated with prednisone and azathioprine&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">After eight months&#44; a notable improvement of clinical and hematological features was seen&#46; Hepatosplenomegaly remained&#44; however&#44; and a new BMB plus splenectomy were carried out&#46; At that time&#44; hemoglobin was 10<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#44; the leukocyte count was 21&#44;900<span class="elsevierStyleHsp" style=""></span>cells&#47;cm<span class="elsevierStyleSup">3</span> &#40;with 65 erythroblasts per 100 leukocytes&#41;&#44; and the platelet count was 106&#44;000&#47;cm<span class="elsevierStyleSup">3</span>&#46; The spleen histology was inconclusive&#44; and the BMB showed interstitial infiltration by atypical lymphoid cells&#46; Immunohistochemistry of spleen and bone marrow revealed the following lymphocyte profile&#58; CD3&#43;&#44; CD4&#8722;&#44; CD5&#8722;&#44; CD8&#8722;&#44; Ki 67&#43; with a rate of 50&#37; CD56&#43; focal&#46; The karyotype showed&#44; of importance&#44; eight trisomy and absence of chromosome seven&#46; Altogether&#44; morphologic&#44; phenotypic and genetic findings were compatible with a hepatosplenic GDTL&#46; After eighteen months of standard chemotherapy&#44; the patient died in September 2011&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Hepatosplenic GDTL is an aggressive and uncommon malignancy &#40;&#60;1&#37; of lymphoid neoplasms&#41;&#46; Intense gammadelta T-cell proliferation is characteristically seen in liver&#44; spleen and bone marrow sinusoids&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The disorder usually affects young adults&#44; and the outcome is poor&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Hepatosplenomegaly and severe cytopenias&#44; both seen in our patient&#44; are usual aspects&#59; lymphadenopathy is rare&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Of interest&#44; hepatosplenic GDTL can mimic the hemophagocytic syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In 2009&#44; a cutaneous GDTL was diagnosed in a patient with rheumatoid arthritis using etanercept&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Current ACR classification criteria for SS include autoantibodies&#44; ocular staining and salivary gland histology&#44; suggesting that case definition requires two of the three&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> pSS was initially a suitable diagnosis for our patient due to the presence of ophthalmic sicca&#44; parotiditis&#44; typical autoantibodies&#44; polyclonal hypergammaglobulinemia&#44; and peripheral pancytopenia&#46; The first BMB showed no malignancy&#44; and clinical features responded well to traditional immunosuppression&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The unexpected persistence of hepatosplenomegaly led to an immunohistochemistry diagnosis of hepatosplenic GDTL eight months ahead&#46; Thus&#44; it is conceivable that the patient firstly had pSS and later developed a GDTL&#46; Although one cannot rule out the possibility that she presented GDTL with SS features since the beginning&#44; the reported median survival time of six months for GDTL<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> turns it less plausible&#46; Also&#44; an atypical form of SS &#8220;secondary&#8221; to GDTL could be brought about&#46; Necessary to say&#44; the occurrence of SS and GDTL could have been only coincidental in our patient&#46; For any of these circumstances&#44; no similar clinical scenario combining SS features and GDTL has been described so far&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In summary&#44; we describe a case of a young patient with features of SS who evolved&#44; unusually&#44; to a hepatosplenic GDTL&#46; The interplay of SS with non-B lymphomas has yet to be clarified&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;</p></span></span>"
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