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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Macrophage activation syndrome &#40;MAS&#41; occurs in a minority of patients with adult Still&#39;s disease &#40;ASD&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> It can be the diseases&#8217; first manifestation or be triggered by an infection or change in treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Two cases are presented&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The first case is a 30-year-old woman with ASD&#44; who came to the ER with a fever lasting for one week that did not improve with antibiotics&#44; so she was admitted to the Rheumatology department&#46; During admission&#44; treatment with ceftriaxone and glucocorticoids &#40;GC&#41; mg&#47;kg was started&#44; and multiple complementary tests performed&#58; blood culture positive for <span class="elsevierStyleItalic">pneumococcus</span> and positive serology for <span class="elsevierStyleItalic">cytomegalovirus</span>&#59; analytically&#58; hepatitis&#44; elevated acute phase reactants &#40;APR&#41;&#44; hyperferritinemia&#44; hypertriglyceridemia&#44; thrombocytopenia&#44; and anemia&#44; in addition to splenomegaly in the computed tomography &#40;CT&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Despite treatment&#44; evolution was unfavorable&#44; with persistent thrombocytopenia and declining ESR&#46; With these data&#44; we decided to perform a bone marrow biopsy &#40;BMB&#41;&#44; observing hemophagocytic cells &#40;HC&#41;&#44; diagnosing MAS and initiating treatment with cyclosporine &#40;CSP&#41; 5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day and 60<span class="elsevierStyleHsp" style=""></span>GC mg&#47;day&#44; with progressive improvement&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The second case is a 35-year-old woman who presented with fever&#44; a sore throat&#44; musculoskeletal pain&#44; vomiting and rash for a week&#44; diagnosed as the flu&#46; Three days later she came to the ER because of persistent fever and rash&#44; and the onset of lymphadenopathy&#44; and was hospitalized&#46; During admission&#44; treatment was started with ceftriaxone and gentamicin&#59; associated infection and autoimmunity was ruled out&#46; Analytically she presented&#58; anemia&#44; elevated APR&#44; hepatitis&#44; hyperferritinemia&#44; hypertriglyceridemia&#44; impaired renal function and ascites&#46; A CT was performed&#44; which reported a systemic infection with lymphadenopathy and hepatosplenomegaly&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The initial suspicion was ASD&#44; starting GC therapy at a dose of 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day and presenting an initial improvement&#46; Subsequently&#44; the fever persisted and skin lesions progressed&#44; added to respiratory and renal failure&#44; which led to her transfer to the Intensive Care Unit &#40;ICU&#41; of our hospital&#46; On admission to the ICU&#44; we performed a BMB&#44; ascites analysis&#44; observing HC in both &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; She was diagnosed as MAS&#46; Evolution was poor despite GC&#44; so we added CSP 5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#44; with partial improvement and anakinra 100<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#46; The evolution was favorable&#44; so she was transferred to the rheumatology department&#44; where after a few days she was discharged&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Both conditions share several features&#44; such as fever&#44; hepatosplenomegaly&#44; lymphadenopathy&#44; hepatitis&#44; coagulopathy and hyperferritinemia&#44; and often are indistinguishable&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Pleuritis&#44; acute respiratory distress syndrome and pancytopenia are more common in the MAS<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> and cutaneous and articular affection in ASD&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Leukopenia&#44; thrombocytopenia and hypertriglyceridemia are not common in ASD&#44; so these could serve as warning signs<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#59; Additionally&#44; hyperferritinemia is generally higher in MAS&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Most of the cases described in the literature have been treated with GC&#44; immunoglobulins&#44; CSP and biological drugs&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Both conditions share certain pathophysiologic characteristics such as the production factor tumor necrosis &#945; and interleukins &#40;IL&#41;&#44; IL-1&#44; IL-6&#44; IL-8 and IL-18&#44; with these being potential therapeutic targets&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The first patient probably presented MAS after a triggering infection&#46; We hypothesize that the MAS in ASD can occur after a change in treatment or an infection&#59; the most studied is the Epstein&#8211;Barr virus infection&#44; but it has also been described<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;6</span></a> in cases of cytomegalovirus&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Patient 2 presented HC in ascites&#59; the first case was described in 2007 in a patient with liver cirrhosis and <span class="elsevierStyleItalic">Escherichia coli</span> infection&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In addition&#44; cases described with HC in<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> pleural fluid and in cerebrospinal fluid&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors have no disclosures to make&#46;</p></span></span>"
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Letter to the Editor
Macrophage Activation Syndrome as a Severe Manifestation of Adult's Still's Disease. Hemophagocytic Cells in Ascites
Síndrome de activación macrofágica como complicación severa de la enfermedad de Still del adulto. Células hemofagocíticas en líquido ascítico
César Egües Dubuc
Corresponding author
tonoeguesdubuc@hotmail.com

Corresponding author.
, Miren Uriarte Ecenarro, Nerea Errazquin Aguirre, Joaquín Belzunegui Otano
Servicio de Reumatología, Hospital Universitario Donostia, San Sebastián, Guipúzcoa, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Macrophage activation syndrome &#40;MAS&#41; occurs in a minority of patients with adult Still&#39;s disease &#40;ASD&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> It can be the diseases&#8217; first manifestation or be triggered by an infection or change in treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Two cases are presented&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The first case is a 30-year-old woman with ASD&#44; who came to the ER with a fever lasting for one week that did not improve with antibiotics&#44; so she was admitted to the Rheumatology department&#46; During admission&#44; treatment with ceftriaxone and glucocorticoids &#40;GC&#41; mg&#47;kg was started&#44; and multiple complementary tests performed&#58; blood culture positive for <span class="elsevierStyleItalic">pneumococcus</span> and positive serology for <span class="elsevierStyleItalic">cytomegalovirus</span>&#59; analytically&#58; hepatitis&#44; elevated acute phase reactants &#40;APR&#41;&#44; hyperferritinemia&#44; hypertriglyceridemia&#44; thrombocytopenia&#44; and anemia&#44; in addition to splenomegaly in the computed tomography &#40;CT&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Despite treatment&#44; evolution was unfavorable&#44; with persistent thrombocytopenia and declining ESR&#46; With these data&#44; we decided to perform a bone marrow biopsy &#40;BMB&#41;&#44; observing hemophagocytic cells &#40;HC&#41;&#44; diagnosing MAS and initiating treatment with cyclosporine &#40;CSP&#41; 5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day and 60<span class="elsevierStyleHsp" style=""></span>GC mg&#47;day&#44; with progressive improvement&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The second case is a 35-year-old woman who presented with fever&#44; a sore throat&#44; musculoskeletal pain&#44; vomiting and rash for a week&#44; diagnosed as the flu&#46; Three days later she came to the ER because of persistent fever and rash&#44; and the onset of lymphadenopathy&#44; and was hospitalized&#46; During admission&#44; treatment was started with ceftriaxone and gentamicin&#59; associated infection and autoimmunity was ruled out&#46; Analytically she presented&#58; anemia&#44; elevated APR&#44; hepatitis&#44; hyperferritinemia&#44; hypertriglyceridemia&#44; impaired renal function and ascites&#46; A CT was performed&#44; which reported a systemic infection with lymphadenopathy and hepatosplenomegaly&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The initial suspicion was ASD&#44; starting GC therapy at a dose of 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day and presenting an initial improvement&#46; Subsequently&#44; the fever persisted and skin lesions progressed&#44; added to respiratory and renal failure&#44; which led to her transfer to the Intensive Care Unit &#40;ICU&#41; of our hospital&#46; On admission to the ICU&#44; we performed a BMB&#44; ascites analysis&#44; observing HC in both &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; She was diagnosed as MAS&#46; Evolution was poor despite GC&#44; so we added CSP 5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#44; with partial improvement and anakinra 100<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#46; The evolution was favorable&#44; so she was transferred to the rheumatology department&#44; where after a few days she was discharged&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Both conditions share several features&#44; such as fever&#44; hepatosplenomegaly&#44; lymphadenopathy&#44; hepatitis&#44; coagulopathy and hyperferritinemia&#44; and often are indistinguishable&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Pleuritis&#44; acute respiratory distress syndrome and pancytopenia are more common in the MAS<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> and cutaneous and articular affection in ASD&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Leukopenia&#44; thrombocytopenia and hypertriglyceridemia are not common in ASD&#44; so these could serve as warning signs<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#59; Additionally&#44; hyperferritinemia is generally higher in MAS&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Most of the cases described in the literature have been treated with GC&#44; immunoglobulins&#44; CSP and biological drugs&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Both conditions share certain pathophysiologic characteristics such as the production factor tumor necrosis &#945; and interleukins &#40;IL&#41;&#44; IL-1&#44; IL-6&#44; IL-8 and IL-18&#44; with these being potential therapeutic targets&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The first patient probably presented MAS after a triggering infection&#46; We hypothesize that the MAS in ASD can occur after a change in treatment or an infection&#59; the most studied is the Epstein&#8211;Barr virus infection&#44; but it has also been described<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;6</span></a> in cases of cytomegalovirus&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Patient 2 presented HC in ascites&#59; the first case was described in 2007 in a patient with liver cirrhosis and <span class="elsevierStyleItalic">Escherichia coli</span> infection&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In addition&#44; cases described with HC in<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> pleural fluid and in cerebrospinal fluid&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors have no disclosures to make&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Eg&#252;es Dubuc C&#44; Uriarte Ecenarro M&#44; Errazquin Aguirre N&#44; Belzunegui Otano J&#46; S&#237;ndrome de activaci&#243;n macrof&#225;gica como complicaci&#243;n severa de la enfermedad de Still del adulto&#46; C&#233;lulas hemofagoc&#237;ticas en l&#237;quido asc&#237;tico&#46; Reumatol Clin&#46; 2014&#59;10&#58;420&#8211;421&#46;</p>"
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Article information
ISSN: 21735743
Original language: English
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2016 October 121 6 127
2016 September 165 15 180
2016 August 111 9 120
2016 July 48 7 55
2015 December 2 0 2
2015 September 1 0 1
2015 August 2 0 2
2015 July 30 8 38
2015 June 55 12 67
2015 May 107 17 124
2015 April 59 7 66
2015 March 45 12 57
2015 February 50 6 56
2015 January 86 23 109
2014 December 68 13 81
2014 November 84 17 101
2014 October 33 14 47
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