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at room temperature&#46; His vital signs were the following&#58; RR 29<span class="elsevierStyleHsp" style=""></span>min&#44; HR 112<span class="elsevierStyleHsp" style=""></span>min&#44; BP 145&#47;85<span class="elsevierStyleHsp" style=""></span>mmHg and a temperature of 37<span class="elsevierStyleHsp" style=""></span>&#176;<span class="elsevierStyleSmallCaps">C</span>&#46; Physical examination showed a right-sided pleural effusion syndrome and very scarce fine crackles in the left hemithorax&#46; The chest X-ray and computed tomography showed bilateral alveolar opacities and verified the presence of a right-sided pleural effusion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Laboratory results only showed leukocytosis of 21&#44;400<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;L&#44; out of which 9400<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;L corresponded to lymphocytes&#46; The patient showed no increased nitrogen compounds&#44; and the general urinalysis showed no signs of sediment or proteinuria&#46; In thoracentesis&#44; a thick yellow fluid was obtained with a pH 7&#46;0&#59; protein 6<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#59; glucose 22<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; LDH 1&#46;066<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; scarce polymorphonuclear cells without the presence of Gram staining bacteria&#46; The patient was initially treated for pneumonia associated with a complicated pleural effusion and was intubated through the right hemithorax and started receiving <span class="elsevierStyleSmallCaps">IV</span> moxifloxacin 400<span class="elsevierStyleHsp" style=""></span>mg every 24<span class="elsevierStyleHsp" style=""></span>h and <span class="elsevierStyleSmallCaps">IV</span> meropenem 1<span class="elsevierStyleHsp" style=""></span>g every 8<span class="elsevierStyleHsp" style=""></span>h&#59; subsequently&#44; said schedule was replaced by <span class="elsevierStyleSmallCaps">IV</span> vancomycin 500<span class="elsevierStyleHsp" style=""></span>mg every 6<span class="elsevierStyleHsp" style=""></span>h and <span class="elsevierStyleSmallCaps">IV</span> piperacillin 4<span class="elsevierStyleHsp" style=""></span>g&#47;tazobactam 0&#46;5<span class="elsevierStyleHsp" style=""></span>g every 6<span class="elsevierStyleHsp" style=""></span>h&#46; However&#44; during the following days no clinical or radiological improvement was observed&#44; and pleural fluid drainage persisted despite said antimicrobial schedules&#46; The results of the acid-fast bacilli smear&#44; pleural fluid cultures&#44; and blood cultures were negative&#46; After a lengthy hospital stay&#44; the patient showed systemic dermatosis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>a&#41;&#44; and in a skin biopsy&#44; a lymphocytic vasculitis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>c&#41; was documented&#46; This scenario was initially attributed to an antimicrobial adverse effect&#46; Viral hepatitis B and C&#44; HIV&#44; VDRL&#44; pANCA and cANCA profiles were all negative&#46; It was only after a detailed physical exam that some ulcers were found in the penis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>b&#41;&#59; however&#44; the result of the pathergy test was not conclusive&#46; The case was diagnosed as an incomplete form of Beh&#231;et&#39;s disease versus ANCA-negative Wegener&#39;s granulomatosis&#59; for this reason&#44; the patient was treated with <span class="elsevierStyleSmallCaps">IV</span> methylprednisolone 125<span class="elsevierStyleHsp" style=""></span>mg every 6<span class="elsevierStyleHsp" style=""></span>h&#44; showing a rapid improvement in his general and breathing conditions&#44; which enabled the successful removal of thoracic intubation and hospital discharge soon after having started treatment&#46; Unluckily&#44; the patient died a few weeks later due to a clinical picture of diffuse alveolar haemorrhage&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">We presented the case of a patient with a complex&#44; active&#44; systemic vasculitic syndrome&#44; with no kidney compromise&#44; with inconclusive lab results&#44; and associated with a pleural effusion not attributed to sequelae&#44; comorbidities&#44; or complications of any medical treatment&#44; which eventually resulted in a fatal outbreak or relapse a few weeks following discharge&#46; From the clinical point of view&#44; it poses a diagnostic challenge given its low prevalence and the unspecified nature of the symptoms&#44; which may overlap with those produced by other diseases&#44; including the different types of SV&#46; In spite of the fact that the presence of pleural effusion may not represent a major criterion of the SV clinical spectrum&#44; it may indeed delay diagnosis and treatment on many occasions&#44; causing disastrous results&#44; mainly in sites where significant similarities with diseases featuring a higher prevalence&#44; such as tuberculosis&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> exist&#46; Pleural effusion has hardly ever been reported<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> as a form of presentation of SV&#59; however&#44; the incidence of this complication on Wegener&#39;s disease has been described to be in the range of 5&#37;&#8211;55&#37; and on Beh&#231;et&#39;s disease up to 20&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#44;3</span></a> Nevertheless&#44; as pleural effusion could be attributed to vasculitis itself&#44; other clinical conditions that are often associated with SV&#44; such as thrombosis&#44; infections&#44; and heart or kidney failure&#44; should be excluded first&#46; Up to date&#44; there exists no distinctive cytochemical profile of pleural effusion produced by SV&#46; The presence of exudate acidosis with a low concentration of glucose has suggested the diagnosis of another type of SV and&#44; likewise&#44; the closed pleural biopsy has occasionally contributed to showing pleural vasculitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a> Similarly&#44; and as mentioned hereinbefore&#44; it is imperative to consider other clinical entities showing pleural fluid acidosis and low glucose &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; since vasculitic pleural effusion treatment and prognosis correspond to those of the underlying disease&#46; Therefore&#44; we suggest that the physician pay attention to the presence of those clinical findings suggestive of SV in each and every patient showing pleural fluid acidosis of unknown origin&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span>"
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Letter to the Editor
Vasculitic Pleural Effusion
Derrame pleural vasculítico
René Agustín Flores-Francoa,
Corresponding author
rflores99@prontomail.com

Corresponding author.
, Ernesto Ramos-Martínezb
a Departamento de Medicina Interna, Hospital General Regional “Dr. Salvador Zubirán Anchondo”, Chihuahua, Mexico
b Patología e Inmunohistoquímica de Chihuahua SC, Chihuahua, Mexico
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at room temperature&#46; His vital signs were the following&#58; RR 29<span class="elsevierStyleHsp" style=""></span>min&#44; HR 112<span class="elsevierStyleHsp" style=""></span>min&#44; BP 145&#47;85<span class="elsevierStyleHsp" style=""></span>mmHg and a temperature of 37<span class="elsevierStyleHsp" style=""></span>&#176;<span class="elsevierStyleSmallCaps">C</span>&#46; Physical examination showed a right-sided pleural effusion syndrome and very scarce fine crackles in the left hemithorax&#46; The chest X-ray and computed tomography showed bilateral alveolar opacities and verified the presence of a right-sided pleural effusion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Laboratory results only showed leukocytosis of 21&#44;400<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;L&#44; out of which 9400<span class="elsevierStyleHsp" style=""></span>cells&#47;&#956;L corresponded to lymphocytes&#46; The patient showed no increased nitrogen compounds&#44; and the general urinalysis showed no signs of sediment or proteinuria&#46; In thoracentesis&#44; a thick yellow fluid was obtained with a pH 7&#46;0&#59; protein 6<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#59; glucose 22<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; LDH 1&#46;066<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; scarce polymorphonuclear cells without the presence of Gram staining bacteria&#46; The patient was initially treated for pneumonia associated with a complicated pleural effusion and was intubated through the right hemithorax and started receiving <span class="elsevierStyleSmallCaps">IV</span> moxifloxacin 400<span class="elsevierStyleHsp" style=""></span>mg every 24<span class="elsevierStyleHsp" style=""></span>h and <span class="elsevierStyleSmallCaps">IV</span> meropenem 1<span class="elsevierStyleHsp" style=""></span>g every 8<span class="elsevierStyleHsp" style=""></span>h&#59; subsequently&#44; said schedule was replaced by <span class="elsevierStyleSmallCaps">IV</span> vancomycin 500<span class="elsevierStyleHsp" style=""></span>mg every 6<span class="elsevierStyleHsp" style=""></span>h and <span class="elsevierStyleSmallCaps">IV</span> piperacillin 4<span class="elsevierStyleHsp" style=""></span>g&#47;tazobactam 0&#46;5<span class="elsevierStyleHsp" style=""></span>g every 6<span class="elsevierStyleHsp" style=""></span>h&#46; However&#44; during the following days no clinical or radiological improvement was observed&#44; and pleural fluid drainage persisted despite said antimicrobial schedules&#46; The results of the acid-fast bacilli smear&#44; pleural fluid cultures&#44; and blood cultures were negative&#46; After a lengthy hospital stay&#44; the patient showed systemic dermatosis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>a&#41;&#44; and in a skin biopsy&#44; a lymphocytic vasculitis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>c&#41; was documented&#46; This scenario was initially attributed to an antimicrobial adverse effect&#46; Viral hepatitis B and C&#44; HIV&#44; VDRL&#44; pANCA and cANCA profiles were all negative&#46; It was only after a detailed physical exam that some ulcers were found in the penis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>b&#41;&#59; however&#44; the result of the pathergy test was not conclusive&#46; The case was diagnosed as an incomplete form of Beh&#231;et&#39;s disease versus ANCA-negative Wegener&#39;s granulomatosis&#59; for this reason&#44; the patient was treated with <span class="elsevierStyleSmallCaps">IV</span> methylprednisolone 125<span class="elsevierStyleHsp" style=""></span>mg every 6<span class="elsevierStyleHsp" style=""></span>h&#44; showing a rapid improvement in his general and breathing conditions&#44; which enabled the successful removal of thoracic intubation and hospital discharge soon after having started treatment&#46; Unluckily&#44; the patient died a few weeks later due to a clinical picture of diffuse alveolar haemorrhage&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">We presented the case of a patient with a complex&#44; active&#44; systemic vasculitic syndrome&#44; with no kidney compromise&#44; with inconclusive lab results&#44; and associated with a pleural effusion not attributed to sequelae&#44; comorbidities&#44; or complications of any medical treatment&#44; which eventually resulted in a fatal outbreak or relapse a few weeks following discharge&#46; From the clinical point of view&#44; it poses a diagnostic challenge given its low prevalence and the unspecified nature of the symptoms&#44; which may overlap with those produced by other diseases&#44; including the different types of SV&#46; In spite of the fact that the presence of pleural effusion may not represent a major criterion of the SV clinical spectrum&#44; it may indeed delay diagnosis and treatment on many occasions&#44; causing disastrous results&#44; mainly in sites where significant similarities with diseases featuring a higher prevalence&#44; such as tuberculosis&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> exist&#46; Pleural effusion has hardly ever been reported<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> as a form of presentation of SV&#59; however&#44; the incidence of this complication on Wegener&#39;s disease has been described to be in the range of 5&#37;&#8211;55&#37; and on Beh&#231;et&#39;s disease up to 20&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#44;3</span></a> Nevertheless&#44; as pleural effusion could be attributed to vasculitis itself&#44; other clinical conditions that are often associated with SV&#44; such as thrombosis&#44; infections&#44; and heart or kidney failure&#44; should be excluded first&#46; Up to date&#44; there exists no distinctive cytochemical profile of pleural effusion produced by SV&#46; The presence of exudate acidosis with a low concentration of glucose has suggested the diagnosis of another type of SV and&#44; likewise&#44; the closed pleural biopsy has occasionally contributed to showing pleural vasculitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a> Similarly&#44; and as mentioned hereinbefore&#44; it is imperative to consider other clinical entities showing pleural fluid acidosis and low glucose &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; since vasculitic pleural effusion treatment and prognosis correspond to those of the underlying disease&#46; Therefore&#44; we suggest that the physician pay attention to the presence of those clinical findings suggestive of SV in each and every patient showing pleural fluid acidosis of unknown origin&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Flores-Franco RA&#44; Ramos-Mart&#237;nez E&#46; Derrame pleural vascul&#237;tico&#46; Reumatol Clin&#46; 2015&#59;11&#58;186&#8211;187&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Chest X-ray showing a right-sided pleural effusion&#46; &#40;b&#41; The computed tomography showed left lung pulmonary opacities besides the pleural effusion&#46;</p>"
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Reumatología Clínica (English Edition)
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