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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Mycobacterium chelonae</span> is a rapidly growing mycobacterium that causes skin and soft tissue infections after trauma in immunocompetent individuals and in immunocompromised hosts with disseminated disease&#44; especially in patients with rheumatic diseases receiving immunosuppressive therapy&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#8211;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 29-year-old woman whose medical record included systemic lupus erythematosus&#44; sarcoidosis and a 4-year history of sickle cell anemia plus &#946;-thalassemia&#46; At the time of writing&#44; she was being treated with rituximab &#40;she had received 2 cycles of 1<span class="elsevierStyleHsp" style=""></span>g each&#41;&#44; azathioprine 100<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; methylprednisolone 16<span class="elsevierStyleHsp" style=""></span>mg&#47;day and hydroxyurea 1<span class="elsevierStyleHsp" style=""></span>g&#47;day&#46; She was admitted to a quaternary care center with a 3-month history of pain in her right hip&#46; Drug treatment with a variety of analgesics and multiple local injections in right hip and gluteus resulted in a partial improvement of her symptoms&#46; One month later&#44; the clinical symptoms returned and she presented with an abscess in right gluteus&#44; with local inflammatory changes&#46; Physical examination revealed the presence of a painful nodule&#46; She underwent surgical drainage of the abscess&#44; and cultures for the usual bacteria&#44; fungi and mycobacteria &#40;auramine&#8211;rhodamine stain and culture in L&#246;wenstein&#8211;Jensen solid medium&#41; were negative&#46; Antibiotic therapy was initiated with ceftriaxone<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>vancomycin and ampicillin&#47;sulbactam&#44; with no improvement whatsoever&#46; A biopsy was performed with the drained material&#44; and the latter was analyzed by polymerase chain reaction &#40;PCR&#41; for the detection of mycobacteria&#44; in which <span class="elsevierStyleItalic">M&#46; chelonae</span> DNA was isolated&#46; The patient began treatment with clarithromycin 1<span class="elsevierStyleHsp" style=""></span>g&#47;day and moxifloxacin 400<span class="elsevierStyleHsp" style=""></span>mg&#47;day in May 2014&#44; with which she continued at the time of writing&#44; with resolution of the clinical condition&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Nontuberculous mycobacteria constitute a group of species that includes <span class="elsevierStyleItalic">Mycobacterium abscessus</span> &#40;with 3 subspecies&#41;&#44; <span class="elsevierStyleItalic">M&#46; chelonae</span> and <span class="elsevierStyleItalic">Mycobacterium fortuitum</span>&#44; which are widely distributed in nature&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">As a pathogen in humans&#44; <span class="elsevierStyleItalic">M&#46; chelonae</span> has a number of clinical forms&#44; the severity of which ranges from frequent mild skin and soft tissue infections to potentially fatal systemic infections&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Skin infection is the most common clinical condition in immunocompetent individuals&#44; and is usually preceded by an injury&#44; open fracture&#44; wound from a sharp&#44; cutting weapon&#44; or a surgical procedure &#40;especially plastic surgery&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In immunocompromised individuals&#44; this pathogen causes disseminated skin infections&#44; and the entry route or route of transmission is generally unidentified&#46; The clinical manifestations consist of infections in organs and skin abscesses that generally affect the lower extremities&#46; Localized injuries can also cause infections &#40;cellulitis&#44; abscesses and osteomyelitis&#41;&#44; as can surgical wounds and catheters&#44; although to a lesser degree&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">It is important that general practitioners&#44; when treating patients with autoimmune diseases and using biologic therapies&#44; have a high index of suspicion of infection by <span class="elsevierStyleItalic">M&#46; chelonae</span>&#44; founded on 3 criteria&#58; &#40;a&#41; a previous skin lesion&#44; mainly from cosmetic or surgical procedures&#59; &#40;b&#41; the presence of painful subcutaneous nodules and abscesses at the site of the lesion&#59; and &#40;c&#41; a poor or inadequate response to the antibiotic therapy received&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The diagnosis starts with the direct observation of mycobacteria in the aspirate of secretions or in the tissue obtained&#44; using Ziehl&#8211;Neelsen or auramine&#8211;rhodamine stain&#44; plus the performance of special cultures for the diagnosis&#46; The classical Ziehl&#8211;Neelsen technique and the fluorescence technique with auramine&#8211;rhodamine are equally effective for the diagnosis&#44; but around 30&#37; of the rapidly growing mycobacteria can exhibit negative fluorescence with the auramine-rhodamine technique&#46; Thus&#44; when infection by rapidly growing mycobacteria is suspected&#44; the procedure of choice is the Ziehl&#8211;Neelsen stain&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Bacteriological culture enables us to enhance the sensitivity of the diagnosis&#59; even if the result of direct observation is negative&#44; the disease is not ruled out&#46; Therefore&#44; sampling should be carried out for DNA amplification using the PCR technique&#44; to obtain the patterns of sensitivity to first-line and second-line drugs that serve as a guide to the most adequate and effective treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they had no source of funding&#46;</p></span></span>"
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Letter to the Editor
Adverse Effects of Immunosuppressive Therapy in Rheumatic Patients: Non-tuberculous Mycobacterial Infection
Efectos adversos de terapia inmunosupresora en paciente reumatológico: infección por micobacterias no tuberculosas
Jean Sebastian Hurtado Hurtado
Internist, Salucoop, Cali, Colombia
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methylprednisolone 16<span class="elsevierStyleHsp" style=""></span>mg&#47;day and hydroxyurea 1<span class="elsevierStyleHsp" style=""></span>g&#47;day&#46; She was admitted to a quaternary care center with a 3-month history of pain in her right hip&#46; Drug treatment with a variety of analgesics and multiple local injections in right hip and gluteus resulted in a partial improvement of her symptoms&#46; One month later&#44; the clinical symptoms returned and she presented with an abscess in right gluteus&#44; with local inflammatory changes&#46; Physical examination revealed the presence of a painful nodule&#46; She underwent surgical drainage of the abscess&#44; and cultures for the usual bacteria&#44; fungi and mycobacteria &#40;auramine&#8211;rhodamine stain and culture in L&#246;wenstein&#8211;Jensen solid medium&#41; were negative&#46; Antibiotic therapy was initiated with ceftriaxone<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>vancomycin and ampicillin&#47;sulbactam&#44; with no improvement whatsoever&#46; A biopsy was performed with the drained material&#44; and the latter was analyzed by polymerase chain reaction &#40;PCR&#41; for the detection of mycobacteria&#44; in which <span class="elsevierStyleItalic">M&#46; chelonae</span> DNA was isolated&#46; The patient began treatment with clarithromycin 1<span class="elsevierStyleHsp" style=""></span>g&#47;day and moxifloxacin 400<span class="elsevierStyleHsp" style=""></span>mg&#47;day in May 2014&#44; with which she continued at the time of writing&#44; with resolution of the clinical condition&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Nontuberculous mycobacteria constitute a group of species that includes <span class="elsevierStyleItalic">Mycobacterium abscessus</span> &#40;with 3 subspecies&#41;&#44; <span class="elsevierStyleItalic">M&#46; chelonae</span> and <span class="elsevierStyleItalic">Mycobacterium fortuitum</span>&#44; which are widely distributed in nature&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">As a pathogen in humans&#44; <span class="elsevierStyleItalic">M&#46; chelonae</span> has a number of clinical forms&#44; the severity of which ranges from frequent mild skin and soft tissue infections to potentially fatal systemic infections&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Skin infection is the most common clinical condition in immunocompetent individuals&#44; and is usually preceded by an injury&#44; open fracture&#44; wound from a sharp&#44; cutting weapon&#44; or a surgical procedure &#40;especially plastic surgery&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In immunocompromised individuals&#44; this pathogen causes disseminated skin infections&#44; and the entry route or route of transmission is generally unidentified&#46; The clinical manifestations consist of infections in organs and skin abscesses that generally affect the lower extremities&#46; Localized injuries can also cause infections &#40;cellulitis&#44; abscesses and osteomyelitis&#41;&#44; as can surgical wounds and catheters&#44; although to a lesser degree&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">It is important that general practitioners&#44; when treating patients with autoimmune diseases and using biologic therapies&#44; have a high index of suspicion of infection by <span class="elsevierStyleItalic">M&#46; chelonae</span>&#44; founded on 3 criteria&#58; &#40;a&#41; a previous skin lesion&#44; mainly from cosmetic or surgical procedures&#59; &#40;b&#41; the presence of painful subcutaneous nodules and abscesses at the site of the lesion&#59; and &#40;c&#41; a poor or inadequate response to the antibiotic therapy received&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The diagnosis starts with the direct observation of mycobacteria in the aspirate of secretions or in the tissue obtained&#44; using Ziehl&#8211;Neelsen or auramine&#8211;rhodamine stain&#44; plus the performance of special cultures for the diagnosis&#46; The classical Ziehl&#8211;Neelsen technique and the fluorescence technique with auramine&#8211;rhodamine are equally effective for the diagnosis&#44; but around 30&#37; of the rapidly growing mycobacteria can exhibit negative fluorescence with the auramine-rhodamine technique&#46; Thus&#44; when infection by rapidly growing mycobacteria is suspected&#44; the procedure of choice is the Ziehl&#8211;Neelsen stain&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Bacteriological culture enables us to enhance the sensitivity of the diagnosis&#59; even if the result of direct observation is negative&#44; the disease is not ruled out&#46; Therefore&#44; sampling should be carried out for DNA amplification using the PCR technique&#44; to obtain the patterns of sensitivity to first-line and second-line drugs that serve as a guide to the most adequate and effective treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they had no source of funding&#46;</p></span></span>"
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