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The cause of SAPHO syndrome is unknown&#44; although different theories propose the presence of a certain genetic predisposition&#44; infectious causes and the association of immune disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">3</span></a> The prevalence is unknown&#44; although some authors report that it is 1 per 10&#44;000 population in Caucasians and lower in Asian populations&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">4</span></a> The diagnosis is based mainly on the clinical signs&#44; indicated by the presence of at least one of the inclusion criteria and none of the exclusion criteria&#44; as described by Benhamou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">5</span></a> The study includes ancillary diagnostic tests such as the specific bone scintigraphic image<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">6</span></a> of the &#8220;bull&#39;s head&#8221; sign in the sternoclavicular joint&#46; The laboratory findings are also nonspecific&#44; with the exception of an increase in acute-phase reactants&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">7</span></a> The disease prognosis is usually benign&#44; although&#44; in certain cases&#44; the pain produced by joint inflammation can be quite severe&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">8</span></a> The treatment of this condition includes nonsteroidal anti-inflammatory drugs&#44; intravenous bisphosphonates or biological therapies&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">3</span></a> The response to a treatment is assessed in terms of pain relief&#44; according to the visual analog scale&#44; or using imaging techniques like bone scintigraphy &#40;BS&#41;&#44; computed tomography &#40;CT&#41; or positron emission tomography with CT &#40;PET-CT&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">9&#44;10</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case Report</span><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 64-year-old woman who was diagnosed with stage T1cN0 Mx invasive ductal carcinoma of right breast&#46; After undergoing segmental mastectomy of right breast and selective biopsy of the sentinel lymph node&#44; she was referred to our department by the Breast Disease Committee to receive adjuvant radiation therapy&#46; The patient had a history of hypertension&#44; dyslipidemia and intermittent low back pain&#44; that she had had since her youth and associated with her job as a salesclerk&#46; She had had no previous visits to any specialist and did not require medication on a regular basis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In the physical examination&#44; there was no evidence of infection or inflammation of the mastectomy scar&#46; However&#44; the third proximal to the clavicle was enlarged and the patient perceived mild selective pain on palpation of the sternoclavicular joint&#46; On examination of the abdomen&#44; no masses or enlargement of organs was detected&#46; The patient reported that she had never had clinical signs of skin conditions &#40;palmoplantar pustulosis or acne&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The study of the extension of the disease included BS&#44; which revealed the presence of a diffuse blastic lesion in the sternal manubrium&#44; suggestive of Paget&#39;s disease or a metastatic lesion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The study was completed with radiographs of chest&#44; lumbosacral spine and pelvis &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">Figs&#46; 2 and 3</a>&#41;&#44; in which the only finding was increased density in L4-L5 facet joints&#46; Chest CT&#44; recommended by the professionals in nuclear medicine&#44; revealed sclerosis in the sternal manubrium&#44; suggestive of metastasis &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Laboratory findings included normal values for alkaline phosphatase &#40;95<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#41;&#44; calcium &#40;9&#46;57<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; lactate dehydrogenase &#40;161<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#41; and erythrocyte sedimentation rate &#40;6<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46; Only a slight increase in C-reactive protein &#40;0&#46;60<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; was observed&#46; A test for HLA-B27 was not requested because of the negative results in the laboratory tests and the limited relationship to SAPHO syndrome reported in some case series&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Given the difficulty of the case&#44; a clinical discussion session was held&#44; with the participation of the departments of radiation oncology&#44; rheumatology&#44; radiodiagnostics and nuclear medicine&#44; to review the findings&#46; The outcome was a definitive diagnosis of SAPHO syndrome&#44; as the patient met one of the inclusion criteria described by Benhamou et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">5</span></a> hyperostosis of anterior chest wall&#44; with or without dermal involvement&#44; and none of the exclusion criteria &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; A biopsy of the lesion was ruled out at that time&#44; pending the radiographic evolution&#46; The decision was made to perform BS and osteoarticular CT<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">11</span></a> 6 months later&#44; at which time&#44; no noteworthy changes were observed&#44; and a biopsy of the affected area was definitively ruled out&#44; as the images showed no signs of aggressive disease&#46; During treatment&#44; the patient required no analgesic medication of any type&#46; We excluded the affected area from the field of treatment to avoid provoking modifications secondary to the radiotherapy that could lead to confusion when assessing the changes in the lesion&#46; After 18 months of follow-up&#44; the complete response of the tumor persists and the patient is disease-free&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">SAPHO syndrome is a rare clinical condition of benign nature that usually presents in young individuals&#44; a circumstance that makes it difficult to detect complications in the patients with this disease&#46; The problem arises when it is diagnosed in a cancer patient&#44; as none of the imaging techniques help to definitively rule out metastasis&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">11</span></a> In the literature &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">12&#8211;16</span></a> there are few cases in which SAPHO syndrome was diagnosed on the basis of an image suspected of depicting a metastasis that&#44; after further study&#44; was found to show no evidence of aggressive disease&#46; Of these cases&#44; only one was identified as breast cancer&#59; in addition to the sternoclavicular involvement&#44; there were dermatological signs that could have pointed to the diagnosis&#46; In none of these cases was the biopsy of the region being studied &#40;sternal manubrium&#41; of any help in reaching the definitive diagnosis&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">In our patient&#44; the stage of her tumor &#40;IA&#41; and the phenotypic characteristics indicated that the result of the study of its extension&#44; which was interpreted as a possible sternal metastasis of the breast carcinoma&#44; could be questioned&#46; Therefore&#44; we considered possible diagnostic alternatives that could explain these findings&#46; Although SAPHO syndrome is a clinical condition with a low incidence&#44; knowledge of it can avoid a diagnosis of metastasis in patients found to have the characteristic image of the &#8220;bull&#39;s head&#8221; on BS&#46; If this image had been seen in a patient with factors indicative of a poor prognosis&#44; we probably would not have questioned the possibility of a metastatic lesion&#46; As a result&#44; the patient would have undergone chemotherapy &#40;vinorelbine or taxanes&#41; and more aggressive radiotherapy&#44; and would have been exposed to the complications associated with these strategies&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0045" class="elsevierStylePara elsevierViewall">SAPHO syndrome has different clinical manifestations that&#44; together with the osteitis that is characteristic of this entity&#44; can result in different differential diagnoses&#46; Thus&#44; this syndrome should be taken into account in the context of the neoplastic disease&#44; in order to avoid erroneous diagnoses that require aggressive treatments in a disease that usually has a benign course&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association &#40;Declaration of Helsinki&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflicts of Interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
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            1 => "C&#225;ncer de mama"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">SAPHO syndrome was proposed in the late 80s in order to group different osteoarticular manifestations with specific radiological findings such as the hyperostosis of the front part of the chest wall&#46; Prevalence&#44; etiology and pathogenesis of the disease are unknown&#44; while diagnosis is made both clinically and by the specific gammagraphic image of &#8220;bull horn&#8221; in the sternoclavicular joint&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The following case of a 64-year-old woman diagnosed with infiltrating ductal carcinoma of the right breast pT1N0 Mx is reported&#46; When studying the extent of the disease&#44; a gammagraphic image of diffuse blast injury in the sterna manubrium was evidenced&#44; which allowed the suspicion of Paget&#39;s disease or metastatic injury&#46; Study was completed with a chest CT in which manubrium sclerosis was evidenced&#44; suggesting met&#225;stasis&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Results of the studies pointed out SAPHO syndrome as the most likely diagnostic option&#46; The low tumor stage of the patient prompted the idea of possible alternative diagnoses&#46; A deeper knowledge of this clinical condition may be crucial to avoid mistakes when classifying a subject in more advanced tumor stages&#44; and consequently&#44; to prevent the use of more aggressive chemotherapy and radiotherapy treatments&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome de SAPHO fue propuesto a finales de los a&#241;os 80 para agrupar diversas manifestaciones osteoarticulares con hallazgos radiol&#243;gicos propios como la hiperostosis de la pared anterior del t&#243;rax&#46; La prevalencia&#44; la causa y la patog&#233;nesis de la enfermedad son desconocidas&#46; El diagn&#243;stico se realiza tanto por la cl&#237;nica como por la imagen espec&#237;fica gammagr&#225;fica de &#171;asta de toro&#187; en la articulaci&#243;n esternoclavicular&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Se presenta el caso de una mujer de 64 a&#241;os diagnosticada de carcinoma ductal infiltrante de mama derecha pT1N0 Mx&#46; En el estudio de extensi&#243;n de la enfermedad se evidenci&#243; imagen gammagr&#225;fica de lesi&#243;n bl&#225;stica&#44; difusa&#44; en manubrio esternal&#44; sospechosa de enfermedad de Paget o lesi&#243;n metast&#225;sica&#46; Se complet&#243; el estudio con TC tor&#225;cica en la que se evidenci&#243; esclerosis del manubrio esternal&#44; sugerente de met&#225;stasis&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Por el resultado de los estudios se pens&#243; en el s&#237;ndrome de SAPHO como opci&#243;n diagn&#243;stica m&#225;s probable&#46; El bajo estadio tumoral de la paciente hizo pensar en posibles alternativas diagn&#243;sticas&#46; Conocer esta entidad cl&#237;nica puede evitar errores a la hora de clasificar en estadios tumorales m&#225;s avanzados a un sujeto y&#44; por tanto&#44; evitar tratamientos quimioter&#225;picos y radioter&#225;pico m&#225;s agresivos&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Berenguer Franc&#233;s M&#193;&#44; Lafaurie Acevedo A&#44; Tormo Ferrero V&#44; Cardenal Macia R&#44; Andreu Mart&#237;nez FJ&#46; S&#237;ndrome de SAPHO como diagn&#243;stico diferencial de met&#225;stasis&#46; Reumatol Clin&#46; 2016&#59;12&#58;288&#8211;291&#46;</p>"
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Source</span>&#58; modification of Benhamou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">5</span></a></p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Inclusion criteria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Exclusion criteria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Acne&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Osteomyelitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Palmoplantar pustulosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Arthritis involving chest wall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hyperostosis with or without dermal involvement&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Palmoplantar pustulosis triggered by infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Chronic osteomyelitis in axial or peripheral skeleton with or without dermal involvement</td><td class="td" title="table-entry  " align="left" valign="top">Palmoplantar keratoderma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Diffuse idiopathic hyperostosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Osteoarticular manifestations triggered by retinoids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Inclusion and Exclusion Criteria in SAPHO Syndrome&#46;</p>"
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          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">BS&#44; bone scan&#59; CRP&#44; C-reactive protein&#59; CT&#44; computed tomography&#59; ESR&#44; erythrocyte sedimentation rate&#59; MRI&#44; magnetic resonance imaging&#59; PET&#44; positron emission tomography&#59; SAPHO&#44; synovitis&#44; acne&#44; pustulosis&#44; hyperostosis and osteitis&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Author&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Present case report&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Shibakuki et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Abuhid et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patel et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">14</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Inoue et al&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">15</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Theuman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">16</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Woman&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Woman&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Woman&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Tumor site&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Breast&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lung&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Primary unknown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Primary unknown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Primary unknown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Breast&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Bone involvement&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sternoclavicular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sternoclavicular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sternoclavicular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sternoclavicular&#44; sacroiliac and thoracic vertebral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sternoclavicular and lumbar vertebral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sternoclavicular&#44; sacroiliac and thoracic vertebral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Cutaneous involvement&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Palmoplantar pustulosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Palmoplantar pustulosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Palmoplantar pustulosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Palmoplantar pustulosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Imaging studies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">X-ray&#44; CT&#44; BS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MRI&#44; CT&#44; PET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">X-ray&#44; PET-CT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">CT&#44; BS&#44; PET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">X-ray&#44; MRI&#44; BS&#44; PET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">X-ray&#44; CT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes<br>Nonspecific inflammation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes<br>Nonspecific fibrosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Laboratory tests&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Elevated CRP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Elevated ESR and CRP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Review of Case Reports With a Diagnosis of SAPHO Syndrome Based on Images Suggestive of Metastasis&#46;</p>"
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Case Report
SAPHO Syndrome in the Differential Diagnosis of Metastasis
Síndrome de SAPHO como diagnóstico diferencial de metástasis
Miguel Ángel Berenguer Francés
Corresponding author
migberenguer@hotmail.com

Corresponding author.
, Alejandro Lafaurie Acevedo, Vicente Tormo Ferrero, Rafael Cardenal Macia, Francisco José Andreu Martínez
Servicio de Oncología Radioterápica, Hospital Universitari Sant Joan d’Alacant, Alicante, Spain
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The cause of SAPHO syndrome is unknown&#44; although different theories propose the presence of a certain genetic predisposition&#44; infectious causes and the association of immune disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">3</span></a> The prevalence is unknown&#44; although some authors report that it is 1 per 10&#44;000 population in Caucasians and lower in Asian populations&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">4</span></a> The diagnosis is based mainly on the clinical signs&#44; indicated by the presence of at least one of the inclusion criteria and none of the exclusion criteria&#44; as described by Benhamou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">5</span></a> The study includes ancillary diagnostic tests such as the specific bone scintigraphic image<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">6</span></a> of the &#8220;bull&#39;s head&#8221; sign in the sternoclavicular joint&#46; The laboratory findings are also nonspecific&#44; with the exception of an increase in acute-phase reactants&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">7</span></a> The disease prognosis is usually benign&#44; although&#44; in certain cases&#44; the pain produced by joint inflammation can be quite severe&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">8</span></a> The treatment of this condition includes nonsteroidal anti-inflammatory drugs&#44; intravenous bisphosphonates or biological therapies&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">3</span></a> The response to a treatment is assessed in terms of pain relief&#44; according to the visual analog scale&#44; or using imaging techniques like bone scintigraphy &#40;BS&#41;&#44; computed tomography &#40;CT&#41; or positron emission tomography with CT &#40;PET-CT&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">9&#44;10</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case Report</span><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 64-year-old woman who was diagnosed with stage T1cN0 Mx invasive ductal carcinoma of right breast&#46; After undergoing segmental mastectomy of right breast and selective biopsy of the sentinel lymph node&#44; she was referred to our department by the Breast Disease Committee to receive adjuvant radiation therapy&#46; The patient had a history of hypertension&#44; dyslipidemia and intermittent low back pain&#44; that she had had since her youth and associated with her job as a salesclerk&#46; She had had no previous visits to any specialist and did not require medication on a regular basis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In the physical examination&#44; there was no evidence of infection or inflammation of the mastectomy scar&#46; However&#44; the third proximal to the clavicle was enlarged and the patient perceived mild selective pain on palpation of the sternoclavicular joint&#46; On examination of the abdomen&#44; no masses or enlargement of organs was detected&#46; The patient reported that she had never had clinical signs of skin conditions &#40;palmoplantar pustulosis or acne&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The study of the extension of the disease included BS&#44; which revealed the presence of a diffuse blastic lesion in the sternal manubrium&#44; suggestive of Paget&#39;s disease or a metastatic lesion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The study was completed with radiographs of chest&#44; lumbosacral spine and pelvis &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">Figs&#46; 2 and 3</a>&#41;&#44; in which the only finding was increased density in L4-L5 facet joints&#46; Chest CT&#44; recommended by the professionals in nuclear medicine&#44; revealed sclerosis in the sternal manubrium&#44; suggestive of metastasis &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Laboratory findings included normal values for alkaline phosphatase &#40;95<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#41;&#44; calcium &#40;9&#46;57<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; lactate dehydrogenase &#40;161<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#41; and erythrocyte sedimentation rate &#40;6<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46; Only a slight increase in C-reactive protein &#40;0&#46;60<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; was observed&#46; A test for HLA-B27 was not requested because of the negative results in the laboratory tests and the limited relationship to SAPHO syndrome reported in some case series&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Given the difficulty of the case&#44; a clinical discussion session was held&#44; with the participation of the departments of radiation oncology&#44; rheumatology&#44; radiodiagnostics and nuclear medicine&#44; to review the findings&#46; The outcome was a definitive diagnosis of SAPHO syndrome&#44; as the patient met one of the inclusion criteria described by Benhamou et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">5</span></a> hyperostosis of anterior chest wall&#44; with or without dermal involvement&#44; and none of the exclusion criteria &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; A biopsy of the lesion was ruled out at that time&#44; pending the radiographic evolution&#46; The decision was made to perform BS and osteoarticular CT<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">11</span></a> 6 months later&#44; at which time&#44; no noteworthy changes were observed&#44; and a biopsy of the affected area was definitively ruled out&#44; as the images showed no signs of aggressive disease&#46; During treatment&#44; the patient required no analgesic medication of any type&#46; We excluded the affected area from the field of treatment to avoid provoking modifications secondary to the radiotherapy that could lead to confusion when assessing the changes in the lesion&#46; After 18 months of follow-up&#44; the complete response of the tumor persists and the patient is disease-free&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">SAPHO syndrome is a rare clinical condition of benign nature that usually presents in young individuals&#44; a circumstance that makes it difficult to detect complications in the patients with this disease&#46; The problem arises when it is diagnosed in a cancer patient&#44; as none of the imaging techniques help to definitively rule out metastasis&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">11</span></a> In the literature &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">12&#8211;16</span></a> there are few cases in which SAPHO syndrome was diagnosed on the basis of an image suspected of depicting a metastasis that&#44; after further study&#44; was found to show no evidence of aggressive disease&#46; Of these cases&#44; only one was identified as breast cancer&#59; in addition to the sternoclavicular involvement&#44; there were dermatological signs that could have pointed to the diagnosis&#46; In none of these cases was the biopsy of the region being studied &#40;sternal manubrium&#41; of any help in reaching the definitive diagnosis&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">In our patient&#44; the stage of her tumor &#40;IA&#41; and the phenotypic characteristics indicated that the result of the study of its extension&#44; which was interpreted as a possible sternal metastasis of the breast carcinoma&#44; could be questioned&#46; Therefore&#44; we considered possible diagnostic alternatives that could explain these findings&#46; Although SAPHO syndrome is a clinical condition with a low incidence&#44; knowledge of it can avoid a diagnosis of metastasis in patients found to have the characteristic image of the &#8220;bull&#39;s head&#8221; on BS&#46; If this image had been seen in a patient with factors indicative of a poor prognosis&#44; we probably would not have questioned the possibility of a metastatic lesion&#46; As a result&#44; the patient would have undergone chemotherapy &#40;vinorelbine or taxanes&#41; and more aggressive radiotherapy&#44; and would have been exposed to the complications associated with these strategies&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0045" class="elsevierStylePara elsevierViewall">SAPHO syndrome has different clinical manifestations that&#44; together with the osteitis that is characteristic of this entity&#44; can result in different differential diagnoses&#46; Thus&#44; this syndrome should be taken into account in the context of the neoplastic disease&#44; in order to avoid erroneous diagnoses that require aggressive treatments in a disease that usually has a benign course&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association &#40;Declaration of Helsinki&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflicts of Interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
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            1 => "C&#225;ncer de mama"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">SAPHO syndrome was proposed in the late 80s in order to group different osteoarticular manifestations with specific radiological findings such as the hyperostosis of the front part of the chest wall&#46; Prevalence&#44; etiology and pathogenesis of the disease are unknown&#44; while diagnosis is made both clinically and by the specific gammagraphic image of &#8220;bull horn&#8221; in the sternoclavicular joint&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The following case of a 64-year-old woman diagnosed with infiltrating ductal carcinoma of the right breast pT1N0 Mx is reported&#46; When studying the extent of the disease&#44; a gammagraphic image of diffuse blast injury in the sterna manubrium was evidenced&#44; which allowed the suspicion of Paget&#39;s disease or metastatic injury&#46; Study was completed with a chest CT in which manubrium sclerosis was evidenced&#44; suggesting met&#225;stasis&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Results of the studies pointed out SAPHO syndrome as the most likely diagnostic option&#46; The low tumor stage of the patient prompted the idea of possible alternative diagnoses&#46; A deeper knowledge of this clinical condition may be crucial to avoid mistakes when classifying a subject in more advanced tumor stages&#44; and consequently&#44; to prevent the use of more aggressive chemotherapy and radiotherapy treatments&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome de SAPHO fue propuesto a finales de los a&#241;os 80 para agrupar diversas manifestaciones osteoarticulares con hallazgos radiol&#243;gicos propios como la hiperostosis de la pared anterior del t&#243;rax&#46; La prevalencia&#44; la causa y la patog&#233;nesis de la enfermedad son desconocidas&#46; El diagn&#243;stico se realiza tanto por la cl&#237;nica como por la imagen espec&#237;fica gammagr&#225;fica de &#171;asta de toro&#187; en la articulaci&#243;n esternoclavicular&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Se presenta el caso de una mujer de 64 a&#241;os diagnosticada de carcinoma ductal infiltrante de mama derecha pT1N0 Mx&#46; En el estudio de extensi&#243;n de la enfermedad se evidenci&#243; imagen gammagr&#225;fica de lesi&#243;n bl&#225;stica&#44; difusa&#44; en manubrio esternal&#44; sospechosa de enfermedad de Paget o lesi&#243;n metast&#225;sica&#46; Se complet&#243; el estudio con TC tor&#225;cica en la que se evidenci&#243; esclerosis del manubrio esternal&#44; sugerente de met&#225;stasis&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Por el resultado de los estudios se pens&#243; en el s&#237;ndrome de SAPHO como opci&#243;n diagn&#243;stica m&#225;s probable&#46; El bajo estadio tumoral de la paciente hizo pensar en posibles alternativas diagn&#243;sticas&#46; Conocer esta entidad cl&#237;nica puede evitar errores a la hora de clasificar en estadios tumorales m&#225;s avanzados a un sujeto y&#44; por tanto&#44; evitar tratamientos quimioter&#225;picos y radioter&#225;pico m&#225;s agresivos&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Berenguer Franc&#233;s M&#193;&#44; Lafaurie Acevedo A&#44; Tormo Ferrero V&#44; Cardenal Macia R&#44; Andreu Mart&#237;nez FJ&#46; S&#237;ndrome de SAPHO como diagn&#243;stico diferencial de met&#225;stasis&#46; Reumatol Clin&#46; 2016&#59;12&#58;288&#8211;291&#46;</p>"
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Source</span>&#58; modification of Benhamou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">5</span></a></p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Inclusion criteria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Exclusion criteria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Acne&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Osteomyelitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Palmoplantar pustulosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Arthritis involving chest wall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hyperostosis with or without dermal involvement&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Palmoplantar pustulosis triggered by infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Chronic osteomyelitis in axial or peripheral skeleton with or without dermal involvement</td><td class="td" title="table-entry  " align="left" valign="top">Palmoplantar keratoderma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Diffuse idiopathic hyperostosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Osteoarticular manifestations triggered by retinoids&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Inclusion and Exclusion Criteria in SAPHO Syndrome&#46;</p>"
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          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">BS&#44; bone scan&#59; CRP&#44; C-reactive protein&#59; CT&#44; computed tomography&#59; ESR&#44; erythrocyte sedimentation rate&#59; MRI&#44; magnetic resonance imaging&#59; PET&#44; positron emission tomography&#59; SAPHO&#44; synovitis&#44; acne&#44; pustulosis&#44; hyperostosis and osteitis&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Author&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Present case report&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Shibakuki et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Abuhid et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patel et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">14</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Inoue et al&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">15</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Theuman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">16</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Woman&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Woman&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Man&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Woman&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Tumor site&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Breast&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lung&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Primary unknown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Primary unknown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Primary unknown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Breast&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Bone involvement&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sternoclavicular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sternoclavicular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sternoclavicular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sternoclavicular&#44; sacroiliac and thoracic vertebral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sternoclavicular and lumbar vertebral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sternoclavicular&#44; sacroiliac and thoracic vertebral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Cutaneous involvement&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Palmoplantar pustulosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Palmoplantar pustulosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Palmoplantar pustulosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Palmoplantar pustulosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Imaging studies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">X-ray&#44; CT&#44; BS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MRI&#44; CT&#44; PET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">X-ray&#44; PET-CT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">CT&#44; BS&#44; PET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">X-ray&#44; MRI&#44; BS&#44; PET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">X-ray&#44; CT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes<br>Nonspecific inflammation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes<br>Nonspecific fibrosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Laboratory tests&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Elevated CRP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Elevated ESR and CRP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Review of Case Reports With a Diagnosis of SAPHO Syndrome Based on Images Suggestive of Metastasis&#46;</p>"
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      ]
    ]
    "bibliografia" => array:2 [
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