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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Biologic therapies with tumor necrosis factor &#40;TNF&#41;-&#945; inhibitors are widely used to treat inflammatory diseases&#44; such as rheumatoid arthritis &#40;RA&#41; and spondyloarthropathies &#40;SpA&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> They are administered subcutaneously &#40;SC&#41; or intravenously &#40;IV&#41;&#44; and the route has an influence on their bioavailability&#46; In SC administration&#44; there are 2 aspects to consider&#58; the site and the injection technique&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#8211;5</span></a> both of which are key factors in the proper administration of the injections&#59; thus&#44; training of patients by the nursing staff is essential for SC self-administration of anti-TNF agents&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The thickness of the subcutaneous tissue &#40;ST&#41; can influence the proper distribution of the drugs throughout the organism&#46; This thickness can be affected by age&#44; sex and body mass index &#40;BMI&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;4&#8211;6</span></a> variables that are important for the determination of the administration site and technique for each patient&#46; In the case of insulin-dependent diabetes mellitus&#44; the needles for self-administration devices are available in a wide variety of lengths&#44; depending on the ST thickness&#44; as has been reported previously in a number of publications&#46; However&#44; there are no studies on this subject dealing with rheumatic diseases treated by SC administration of anti-TNF agents&#46; The proper injection technique ensures that the SC anti-TNF agent be injected into ST&#44; rather than intramuscular &#40;IM&#41; or intradermal tissue&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">This prospective cross-sectional observational study involved 117 patients with RA &#40;n&#61;59&#41; or SpA &#40;n&#61;58&#41; being treated with an anti-TNF agent that the patients administered SC to themselves for a minimum of 6 months&#46; The thickness of the ST was measured in all the patients at the sites recommended for SC injection &#40;arms&#44; abdomen&#44; thighs&#41;&#44; regardless of the preferred site for self-administration&#44; using gray-scale ultrasound &#40;ultrasound system equipped with a 6&#8211;18-MHz multifrequency linear transducer&#41;&#46; Ultrasound measurement of the ST was always performed using the same method and with the patient in the sitting position&#46; Gel was applied between the probe and the skin to avoid putting pressure on the ST with the probe &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The probe was placed transversely and longitudinally&#44; on the right and left sides&#44; at the sites recommended for SC injection&#46; We then calculated the average between the two measurements&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The results are expressed as the mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;SD&#41; for continuous variables and as absolute frequencies and percentages for categorical variables&#46; The continuous variables in independent groups were compared using the independent samples <span class="elsevierStyleItalic">t</span>-test when 2 groups were involved&#46; For the comparison of 3 groups&#44; we used 1-way analysis of variance &#40;ANOVA&#41; with the Tukey test&#44; or the Kruskal&#8211;Wallis test with the Mann&#8211;Whitney test and the Bonferroni correction to determine the unpaired samples&#44; depending on the assumption or rejection&#44; respectively&#44; of the null hypothesis&#46; The linear relationship between independent variables was established by means of the Pearson correlation coefficient&#46; Fisher&#39;s exact test of independence for categorical variables was applied in the case of 2 dichotomous variables&#44; and the chi-squared test when any of the variables had more than 2 categories&#46; Logistic models were developed as dichotomous outcomes of clinical remission or no clinical remission&#44; according to the Disease Activity Score for 28 joints &#40;DAS28&#41; and C-reactive protein &#40;CRP&#41; level&#46; We analyzed age&#44; BMI&#44; ST thickness in abdomen&#44; arms and thighs&#44; time since diagnosis&#44; time since initiation of anti-TNF therapy &#40;with etanercept&#44; adalimumab&#44; others &#91;because of the small sample size&#44; patients treated with golimumab and certolizumab pegol were analyzed jointly&#93;&#41;&#44; and concomitant treatment with disease-modifying antirheumatic drugs&#46; The odds ratio was calculated with its 95&#37; confidence interval&#41;&#46; <span class="elsevierStyleItalic">P</span> values &#8804;&#46;05 were considered to indicate significance&#46; The statistical analyses were performed with the SPSS statistical software package &#40;v15&#46;0&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Due to the small sample size&#44; our RA and SpA patients were analyzed jointly&#44; according to the anti-TNF agent utilized&#46; Fifty-nine patients &#40;50&#46;5&#37;&#41; had been diagnosed with RA and 58 &#40;49&#46;5&#37;&#41; with SpA&#46; Fifty-six patients &#40;47&#46;9&#37;&#41; were receiving etanercept&#59; 52 &#40;44&#46;4&#37;&#41;&#44; adalimumab&#59; 7 &#40;6&#37;&#41;&#44; golimumab&#59; and 2 &#40;1&#46;7&#37;&#41;&#44; certolizumab pegol&#46; Eighty-two &#40;70&#37;&#41; self-administered the anti-TNF agent in abdomen&#44; 23 &#40;19&#46;7&#37;&#41; in thigh and 12 &#40;10&#46;3&#37;&#41; in arm&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The majority of the patients were women &#40;n&#61;61&#44; 52&#46;1&#37;&#41;&#46; The mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD &#40;range&#41; for the variables were as follows&#58; age&#44; 52&#46;77<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;28 &#40;24&#8211;82&#41; years&#59; weight&#44; 74&#46;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;19 &#40;46&#8211;125&#41;<span class="elsevierStyleHsp" style=""></span>kg&#59; height&#44; 1&#46;65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;08 &#40;1&#46;43&#8211;1&#46;84&#41;<span class="elsevierStyleHsp" style=""></span>m&#59; and BMI&#44; 27<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;75 &#40;18&#46;44&#8211;41&#46;58&#41;<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; The clinical response to the anti-TNF agent was evaluated using the following remission or activity criteria&#58; DAS28 and CRP for the patients with RA and the Ankylosing Spondylitis Disease Activity Score &#40;ASDAS&#41; for the patients with SpA&#46; In RA&#44; remission was considered to be indicated by a DAS28<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>2&#46;6 and no remission by a DAS28<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2&#46;6&#44; and remission in SpA by an ASDAS<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>1&#46;3 and no remission by an ASDAS<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>1&#46;3&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The mean thickness of the ST was significantly greater in abdomen &#40;mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#44; 24&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;3<span class="elsevierStyleHsp" style=""></span>mm&#41; than in thigh &#40;11&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;9<span class="elsevierStyleHsp" style=""></span>mm&#41; or in arm &#40;9&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;5<span class="elsevierStyleHsp" style=""></span>mm&#41; 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in turn&#44; influences the therapeutic response&#46; High-frequency ultrasound enables direct measurements of ST thickness at any anatomical site and is harmless&#44; easy to perform and rapid&#46; Our results showed a significantly lower percentage of remission in the group that self-administered the anti-TNF agent in arm &#40;n&#61;12&#41;&#44; with a significantly thinner ST layer &#40;ST thickness in arm&#59; mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#44; 7&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;3<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">We propose ultrasound measurement of ST thickness in patients who are to begin anti-TNF therapy or undergo a weight change once being treated&#44; to ensure the correct selection of the injection site&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">Lara Valor has received speaking fees from AbbVie&#44; Roche Farma&#44; Bristol-Myers Squibb and Pfizer&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Inmaculada de la Torre is a European physician who has been working for Eli-Lilly &#38; Co&#46; since February 2013&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Esperanza Naredo has received speaking fees from AbbVie&#44; Roche Farma&#44; Bristol-Myers Squibb&#44; Pfizer&#44; UCB Pharma&#44; General Electric Healthcare and Esaote&#46; She has also received research funding from <span class="elsevierStyleGrantSponsor" id="gs1">UCB Pharma</span> and <span class="elsevierStyleGrantSponsor" id="gs2">Merck Sharp &#38; Dohme</span>&#46;</p></span></span>"
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Letter to the Editor
Impact of the Thickness of the Subcutaneous Tissue at the Site of Injection as Measured by Ultrasound on the Therapeutic Response to Subcutaneous anti-Tumour Necrosis Factor Drugs
Impacto del grosor del tejido celular subcutáneo en el sitio de la inyección medido por ecografía sobre la respuesta terapéutica a fármacos antifactor de necrosis tumoral subcutáneos
Tamara del Río
Corresponding author
t.delrioblasco@hotmail.com

Corresponding author.
, Lara Valor, Inmaculada de la Torre, Esperanza Naredo
Departamento de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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    "titulo" => "Impact of the Thickness of the Subcutaneous Tissue at the Site of Injection as Measured by Ultrasound on the Therapeutic Response to Subcutaneous anti-Tumour Necrosis Factor Drugs"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ultrasound images of subcutaneous tissue&#46; &#40;A&#41; Right arm&#46; &#40;B&#41; Right abdomen&#46; &#40;C&#41; Right thigh&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Biologic therapies with tumor necrosis factor &#40;TNF&#41;-&#945; inhibitors are widely used to treat inflammatory diseases&#44; such as rheumatoid arthritis &#40;RA&#41; and spondyloarthropathies &#40;SpA&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> They are administered subcutaneously &#40;SC&#41; or intravenously &#40;IV&#41;&#44; and the route has an influence on their bioavailability&#46; In SC administration&#44; there are 2 aspects to consider&#58; the site and the injection technique&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#8211;5</span></a> both of which are key factors in the proper administration of the injections&#59; thus&#44; training of patients by the nursing staff is essential for SC self-administration of anti-TNF agents&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The thickness of the subcutaneous tissue &#40;ST&#41; can influence the proper distribution of the drugs throughout the organism&#46; This thickness can be affected by age&#44; sex and body mass index &#40;BMI&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;4&#8211;6</span></a> variables that are important for the determination of the administration site and technique for each patient&#46; In the case of insulin-dependent diabetes mellitus&#44; the needles for self-administration devices are available in a wide variety of lengths&#44; depending on the ST thickness&#44; as has been reported previously in a number of publications&#46; However&#44; there are no studies on this subject dealing with rheumatic diseases treated by SC administration of anti-TNF agents&#46; The proper injection technique ensures that the SC anti-TNF agent be injected into ST&#44; rather than intramuscular &#40;IM&#41; or intradermal tissue&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">This prospective cross-sectional observational study involved 117 patients with RA &#40;n&#61;59&#41; or SpA &#40;n&#61;58&#41; being treated with an anti-TNF agent that the patients administered SC to themselves for a minimum of 6 months&#46; The thickness of the ST was measured in all the patients at the sites recommended for SC injection &#40;arms&#44; abdomen&#44; thighs&#41;&#44; regardless of the preferred site for self-administration&#44; using gray-scale ultrasound &#40;ultrasound system equipped with a 6&#8211;18-MHz multifrequency linear transducer&#41;&#46; Ultrasound measurement of the ST was always performed using the same method and with the patient in the sitting position&#46; Gel was applied between the probe and the skin to avoid putting pressure on the ST with the probe &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The probe was placed transversely and longitudinally&#44; on the right and left sides&#44; at the sites recommended for SC injection&#46; We then calculated the average between the two measurements&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The results are expressed as the mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;SD&#41; for continuous variables and as absolute frequencies and percentages for categorical variables&#46; The continuous variables in independent groups were compared using the independent samples <span class="elsevierStyleItalic">t</span>-test when 2 groups were involved&#46; For the comparison of 3 groups&#44; we used 1-way analysis of variance &#40;ANOVA&#41; with the Tukey test&#44; or the Kruskal&#8211;Wallis test with the Mann&#8211;Whitney test and the Bonferroni correction to determine the unpaired samples&#44; depending on the assumption or rejection&#44; respectively&#44; of the null hypothesis&#46; The linear relationship between independent variables was established by means of the Pearson correlation coefficient&#46; Fisher&#39;s exact test of independence for categorical variables was applied in the case of 2 dichotomous variables&#44; and the chi-squared test when any of the variables had more than 2 categories&#46; Logistic models were developed as dichotomous outcomes of clinical remission or no clinical remission&#44; according to the Disease Activity Score for 28 joints &#40;DAS28&#41; and C-reactive protein &#40;CRP&#41; level&#46; We analyzed age&#44; BMI&#44; ST thickness in abdomen&#44; arms and thighs&#44; time since diagnosis&#44; time since initiation of anti-TNF therapy &#40;with etanercept&#44; adalimumab&#44; others &#91;because of the small sample size&#44; patients treated with golimumab and certolizumab pegol were analyzed jointly&#93;&#41;&#44; and concomitant treatment with disease-modifying antirheumatic drugs&#46; The odds ratio was calculated with its 95&#37; confidence interval&#41;&#46; <span class="elsevierStyleItalic">P</span> values &#8804;&#46;05 were considered to indicate significance&#46; The statistical analyses were performed with the SPSS statistical software package &#40;v15&#46;0&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Due to the small sample size&#44; our RA and SpA patients were analyzed jointly&#44; according to the anti-TNF agent utilized&#46; Fifty-nine patients &#40;50&#46;5&#37;&#41; had been diagnosed with RA and 58 &#40;49&#46;5&#37;&#41; with SpA&#46; Fifty-six patients &#40;47&#46;9&#37;&#41; were receiving etanercept&#59; 52 &#40;44&#46;4&#37;&#41;&#44; adalimumab&#59; 7 &#40;6&#37;&#41;&#44; golimumab&#59; and 2 &#40;1&#46;7&#37;&#41;&#44; certolizumab pegol&#46; Eighty-two &#40;70&#37;&#41; self-administered the anti-TNF agent in abdomen&#44; 23 &#40;19&#46;7&#37;&#41; in thigh and 12 &#40;10&#46;3&#37;&#41; in arm&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The majority of the patients were women &#40;n&#61;61&#44; 52&#46;1&#37;&#41;&#46; The mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD &#40;range&#41; for the variables were as follows&#58; age&#44; 52&#46;77<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;28 &#40;24&#8211;82&#41; years&#59; weight&#44; 74&#46;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;19 &#40;46&#8211;125&#41;<span class="elsevierStyleHsp" style=""></span>kg&#59; height&#44; 1&#46;65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;08 &#40;1&#46;43&#8211;1&#46;84&#41;<span class="elsevierStyleHsp" style=""></span>m&#59; and BMI&#44; 27<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;75 &#40;18&#46;44&#8211;41&#46;58&#41;<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; The clinical response to the anti-TNF agent was evaluated using the following remission or activity criteria&#58; DAS28 and CRP for the patients with RA and the Ankylosing Spondylitis Disease Activity Score &#40;ASDAS&#41; for the patients with SpA&#46; In RA&#44; remission was considered to be indicated by a DAS28<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>2&#46;6 and no remission by a DAS28<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2&#46;6&#44; and remission in SpA by an ASDAS<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>1&#46;3 and no remission by an ASDAS<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>1&#46;3&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The mean thickness of the ST was significantly greater in abdomen &#40;mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#44; 24&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;3<span class="elsevierStyleHsp" style=""></span>mm&#41; than in thigh &#40;11&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;9<span class="elsevierStyleHsp" style=""></span>mm&#41; or in arm &#40;9&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;5<span class="elsevierStyleHsp" style=""></span>mm&#41; &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;0005&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The injection site was significantly associated with clinical disease activity measured by DAS28-CRP&#47;ASDAS&#46; The percentage of patients with active disease was significantly higher among those who self-administered the anti-TNF agents in arm &#40;n&#61;9&#59; 75&#46;0&#37; of the patients&#41; than in those who self-administered the treatment in abdomen &#40;n&#61;33&#59; 40&#46;2&#37; of the patients&#41; or thigh &#40;n&#61;4&#59; 17&#46;4&#37; of the patients&#41; &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;004&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The ST thickness may be an important factor in the selection of the needle length and injection technique&#44;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#8211;9</span></a> to ensure that the drug is administered to ST rather than IM tissue&#44;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#44;10</span></a> which&#44; in turn&#44; influences the therapeutic response&#46; High-frequency ultrasound enables direct measurements of ST thickness at any anatomical site and is harmless&#44; easy to perform and rapid&#46; Our results showed a significantly lower percentage of remission in the group that self-administered the anti-TNF agent in arm &#40;n&#61;12&#41;&#44; with a significantly thinner ST layer &#40;ST thickness in arm&#59; mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#44; 7&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;3<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">We propose ultrasound measurement of ST thickness in patients who are to begin anti-TNF therapy or undergo a weight change once being treated&#44; to ensure the correct selection of the injection site&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">Lara Valor has received speaking fees from AbbVie&#44; Roche Farma&#44; Bristol-Myers Squibb and Pfizer&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Inmaculada de la Torre is a European physician who has been working for Eli-Lilly &#38; Co&#46; since February 2013&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Esperanza Naredo has received speaking fees from AbbVie&#44; Roche Farma&#44; Bristol-Myers Squibb&#44; Pfizer&#44; UCB Pharma&#44; General Electric Healthcare and Esaote&#46; She has also received research funding from <span class="elsevierStyleGrantSponsor" id="gs1">UCB Pharma</span> and <span class="elsevierStyleGrantSponsor" id="gs2">Merck Sharp &#38; Dohme</span>&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; del R&#237;o T&#44; Valor L&#44; de la Torre I&#44; Naredo E&#46; Impacto del grosor del tejido celular subcut&#225;neo en el sitio de la inyecci&#243;n medido por ecograf&#237;a sobre la respuesta terap&#233;utica a f&#225;rmacos antifactor de necrosis tumoral subcut&#225;neos&#46; Reumatol Clin&#46; 2016&#59;12&#58;300&#8211;301&#46;</p>"
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Article information
ISSN: 21735743
Original language: English
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Idiomas
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