Clinical Characteristics, Treatment and Ocular Complications of HLA-B27-Related Anterior Uveitis and HLA-B27-Non Related Anterior Uveitis

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=> array:4 [ "autoresLista" => "Elia Valls Pascual, Pablo Fontanilla Ortega, Elvira Vicens Bernabeu, Lucía Martínez-Costa, Ricardo Blanco Alonso" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Elia" "apellidos" => "Valls Pascual" "email" => array:1 [ 0 => "elialtea@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Pablo" "apellidos" => "Fontanilla Ortega" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Elvira" "apellidos" => "Vicens Bernabeu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Lucía" "apellidos" => "Martínez-Costa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Ricardo" "apellidos" => "Blanco Alonso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Sección de Reumatología, Hospital Universitari Doctor Peset, Valencia, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Oftalmología, Hospital Universitari Doctor Peset, Valencia, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Características clínicas, tratamiento y complicaciones oculares de uveítis anterior asociada y no asociada a HLA-B27" ] ] "textoCompleto" => "IntroductionUveitis is inflammation of the middle layer of the eye (uvea), located between the sclera and the retina, which is comprised of the iris, ciliary body, pars plana and/or choroid. In some cases, by extension, it can also affect the retina.The incidence of uveitis is 45–52 cases per 100,000population/year, it peaks between the ages of 20 and 44 years, and the prevalence of the disease is 70 cases per 100000 population.<a class="elsevierStyleCrossRefs" href="#bib0085">1,2</a> It is the third leading cause of blindness in the working age population in developed countries, and 10% of the cases of total loss of vision are due to uveitis.Anterior uveitis is the most common form of intraocular inflammation, representing between 50% and 92% of all cases of uveitis reported in a Western population.<a class="elsevierStyleCrossRef" href="#bib0095">3</a> Anterior uveitis associated with HLA-B27 accounts for between 18% and 32% of the cases of anterior uveitis found in that population.<a class="elsevierStyleCrossRef" href="#bib0100">4</a>It has been reported more frequently in men, in whom onset is earlier (20–40 years), it tends to be unilateral and there are higher rates of recurrences and complications. Anterior uveitis is more severe when associated with the HLA-B27 antigen, with a higher degree of inflammation and a more frequent use of systemic corticosteroids.<a class="elsevierStyleCrossRef" href="#bib0105">5</a>ObjectivesThe purpose of this article is to describe the clinical features, the need for systemic therapy and the frequency and types of ocular complications in a cohort of patients with anterior uveitis associated with HLA-B27 and in a cohort of patients with endogenous noninfectious anterior uveitis not associated with HLA-B27.We also proposed to establish whether there were differences between the 2 cohorts in terms of clinical features, frequency and types of ocular complications, and the frequency of the use of systemic corticosteroids and other systemic immunosuppressive agents.Material and MethodsStudy Design and PatientsWe conducted a retrospective descriptive cohort study with analytical components, including patients diagnosed with anterior uveitis associated with HLA-B27 with follow-up in a multidisciplinary uveitis clinic at Hospital Universitari Doctor Peset in Valencia, Spain (HLA-B27+) and patients diagnosed with endogenous noninfectious anterior uveitis not associated with HLA-B27 with follow-up in the same multidisciplinary uveitis clinic at Hospital Universitari Doctor Peset (HLA-B27−).Inclusion Criteria<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005">–HLA B27+ cohort: patients diagnosed with anterior uveitis (acute, recurrent or chronic) associated with HLA-B27, with a follow-up of at least 1 month in the multidisciplinary uveitis clinic at Hospital Universitari Doctor Peset.</li><li class="elsevierStyleListItem" id="lsti0010">–HLA B27− cohort: patients diagnosed with endogenous noninfectious anterior uveitis (acute, recurrent or chronic) not associated with HLA-B27, with a follow-up of at least 1 month in the multidisciplinary uveitis clinic at Hospital Universitari Doctor Peset.</li></ul>Exclusion Criteria<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015">–Anterior uveitis associated with other locations (intermediate, posterior, panuveitis).</li><li class="elsevierStyleListItem" id="lsti0020">–Traumatic uveitis.</li><li class="elsevierStyleListItem" id="lsti0025">–Infectious uveitis.</li></ul>Data Collection and VariablesThe data were obtained from an electronic registry (.sav format) that includes patients who underwent follow-up between 1 January 2008 and 17 March 2015.The variables considered in the study were: length of follow-up, age, sex, diagnosis, clinical course according to the criteria of the Standardization of Uveitis Nomenclature (SUN) Working Group,<a class="elsevierStyleCrossRef" href="#bib0110">6</a> laterality, use of systemic immunosuppression, use of systemic corticosteroids, and presence and type of complications.Data ManagementDescriptive StatisticsWe calculated proportions for the categorical variables and mean±standard deviation (or median and interquartile range if the data for the sample did not follow a normal distribution) for continuous variables.Inferential StatisticsThe chi-square statistic was used to compare proportions, applying the continuity correction if necessary.Student's t statistic was utilized to compare means. If the data of the sample did not follow a normal distribution, the Kruskal–Wallis statistic was utilized.A P value <.05 was considered to indicate statistical significance.The statistical analysis was performed using the SPSS software package (version 13).ResultsWe included a total of 162 patients, 58 with anterior uveitis associated with HLA-B27 (HLA-B27+) and 104 with endogenous noninfectious anterior uveitis not associated with HLA-B27 (HLA-B27−).Of the HLA-B27+ patients, 30 had a diagnosis of spondyloarthritis and 1 had a diagnosis of juvenile idiopathic arthritis (JIA). The different types of spondyloarthritis are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. We wish to point out the fact that 64.5% of these patients were diagnosed with spondyloarthritis after having been referred from the ophthalmology department to the rheumatology department after a first episode of uveitis. Most of these patients described symptoms characteristic of long-standing spondyloarthritis.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Most of the HLA-B27− patients had been diagnosed with idiopathic uveitis. The various diagnoses included and their frequency in this cohort can be seen in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>The demographic and clinical characteristics of both cohorts are shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>.<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>The mean age of the patients in the two cohorts was between 40 and 50 years, and there were no statistically significant differences between them.We did not observe a significant predominance of one sex over the other in either of the 2 cohorts, although there was a somewhat higher number of men in the HLA-B27+ cohort and of women in the HLA-B27− cohort.The median length of follow-up was greater in the HLA-B27+ cohort, but the difference did not reach statistical significance when compared with the HLA-B27− cohort.Likewise, no significant differences were found with regard to laterality; unilateral involvement was more frequent in both cohorts.However, differences were observed in terms of the clinical course. In the HLA-B27+ cohort, somewhat more than 2 thirds of the patients experienced recurrences and there were no cases of chronic uveitis. In the HLA-B27− cohort, half of the patients had had only 1 episode of uveitis, somewhat more than a fourth of the patients had a recurrent course, and the remainder, chronic.The proportion of patients who developed some type of complication was similar in both cohorts, there being no statistically significant differences (P=.686). However, when the types of complications that were documented for the patients in the 2 cohorts were analyzed, we observed differences, but the statistical significance could not be determined because the sample size was not large enough (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>), except in the case of synechiae, which were more common in the HLA-B27+ cohort, although the difference was not statistically significant (P=.07). One patient in this cohort developed central serous choroiditis related to the use of systemic corticosteroids. In the HLA-B27− cohort, band keratopathy was observed in 6 patients, all of whom had been diagnosed with JIA. We also found a higher frequency of cataracts and ocular hypertension (OHT) in the HLA-B27− cohort. This fact was not associated with a more widespread use of systemic corticosteroids given that, as was seen in the case of cataracts, the higher frequency in the HLA-B27− cohort can be explained by a greater trend toward chronicity. In the case of OHT, the differences can be explained by the greater trend toward hypertension in some of the types of uveitis, such as Fuchs’ heterochromic iridocyclitis, included in the HLA-B27− cohort. The presence of OHT coincided with ocular inflammatory activity in all the patients.<elsevierMultimedia ident="tbl0020"></elsevierMultimedia>Regarding the use of corticosteroids or other systemic immunosuppressive agents, again, there were no statistically significant differences, as these treatments were seldom required in either cohort (<a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>).<elsevierMultimedia ident="tbl0025"></elsevierMultimedia>Most of the patients treated with systemic corticosteroids began the therapy with a dose of 30mg a day of prednisone or the equivalent. In every case, immunosuppressive therapy was introduced due to ocular inflammatory activity that could not be controlled with other treatments, in general, to prevent recurrences or chronicity.The immunosuppressive agents utilized were sulfasalazine, methotrexate, adalimumab and tocilizumab (<a class="elsevierStyleCrossRef" href="#tbl0030">Table 6</a>).<elsevierMultimedia ident="tbl0030"></elsevierMultimedia>DiscussionThere are a considerable number of publications dealing with the clinical features and prognosis of HLA-B27-associated anterior uveitis.<a class="elsevierStyleCrossRefs" href="#bib0115">7–16</a>The description of the clinical features coincides in the majority of the publications, but the prognosis does not. We found articles in which the authors reported a better prognosis for uveitis associated with HLA-B27,<a class="elsevierStyleCrossRef" href="#bib0115">7</a> whereas others affirmed the opposite,<a class="elsevierStyleCrossRef" href="#bib0120">8</a> and still others who observed a prognosis similar to that of anterior uveitis not associated with HLA-B27.<a class="elsevierStyleCrossRefs" href="#bib0125">9–13</a>In contrast to earlier publications,<a class="elsevierStyleCrossRefs" href="#bib0100">4,5</a> in the present study, we did not observe male predominance in the cohort of patients with anterior uveitis associated with HLA-B27, an earlier onset or a greater trend toward unilaterality in that cohort. However, we did find a greater trend toward recurrence in the patients with anterior uveitis associated with HLA-B27, similar to that reported in previous publications.<a class="elsevierStyleCrossRefs" href="#bib0100">4,12</a> The rest of the clinical features were similar in both cohorts.One noteworthy finding is the high percentage of patients who were diagnosed with spondyloarthritis after being referred from the ophthalmology department to the rheumatology department due to an episode of uveitis. This circumstance demonstrates the importance of the collaboration between the two specialties.In this study, we did not take into account the degree of inflammatory activity at the time of the onset of the episode of uveitis because of the difficulty in standardizing the information, since the episodes were evaluated by different ophthalmologists and there was wide variability in terms of the establishment of the degree of inflammation.Likewise, we did not take into account the visual prognosis of the patients, as we considered that the study design was not the most appropriate for that assessment or for establishing prognostic factors. We would like to continue the study, carrying out a prospective evaluation of the patients for the purpose of clarifying this point.The fact that we found no statistically significant differences between the two cohorts in terms of the use of corticosteroids—in contrast to results published elsewhere<a class="elsevierStyleCrossRef" href="#bib0105">5</a>—and other systemic immunosuppressive agents, and the presence or absence of complications could indicate that the severity and the visual prognosis is comparable in the two groups, but we cannot reach any further conclusions because of the limitations of the study, which include the unavailability of data on the changes in the visual acuity of the patients. Moreover, in the HLA-B27− cohort, we observed an incidence of chronic uveitis of 21% and not a single case in the HLA-B27+ cohort. This difference would mean that, although the uveitides in the HLA-B27+ cohort were more severe, no significant differences were observed in terms of the use of systemic therapy on comparing the two cohorts, because in the patients with chronic uveitis, even if the activity was lower, systemic therapy would be initiated more often.With respect to the differences observed in the various types of ocular complications, which, as we mentioned above, cannot be measured accurately because of the small sample size, we should consider the influence of the heterogeneity in the HLA-B27− cohort, which includes 8 different diagnoses. This would explain, for example, the elevated presence of band keratopathy, observed only in those patients of the sample with a diagnosis of JIA.If we exclude synechiae, whose influence on the visual prognosis of the patient is low, the rate of complications is low in both cohorts.In conclusion, in the present article, there are no significant differences between the clinical features of uveitides associated with HLA-B27 and those of uveitides not associated with HLA-B27, with the exception of a greater trend toward recurrence.The study design does not enable us to establish differences with respect to the visual prognosis.We would like to increase the sample size of the study and carry out a prospective follow-up to obtain information on the differences in the development of different types of ocular complications, and on differences and possible factors that intervene in the prognosis.Ethical DisclosuresProtection of human and animal subjectsThe authors declare that no experiments were performed on humans or animals for this study.Confidentiality of dataThe authors declare that they have followed the protocols of their work center on the publication of patient data.Right to privacy and informed consentThe authors declare that no patient data appear in this article.Conflict of InterestThe authors declare they have no conflicts of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres823624" "titulo" => "Abstract" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Material and methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Discussion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec820290" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres823625" "titulo" => "Resumen" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivos" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Material y métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec820291" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Objectives" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Material and Methods" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Study Design and Patients" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Inclusion Criteria" ] 2 => array:2 [ "identificador" => "sec0030" "titulo" => "Exclusion Criteria" ] 3 => array:2 [ "identificador" => "sec0035" "titulo" => "Data Collection and Variables" ] 4 => array:3 [ "identificador" => "sec0040" "titulo" => "Data Management" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0045" "titulo" => "Descriptive Statistics" ] 1 => array:2 [ "identificador" => "sec0050" "titulo" => "Inferential Statistics" ] ] ] ] ] 7 => array:2 [ "identificador" => "sec0055" "titulo" => "Results" ] 8 => array:2 [ "identificador" => "sec0060" "titulo" => "Discussion" ] 9 => array:3 [ "identificador" => "sec0065" "titulo" => "Ethical Disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0070" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0075" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0080" "titulo" => "Right to privacy and informed consent" ] ] ] 10 => array:2 [ "identificador" => "sec0085" "titulo" => "Conflict of Interest" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-04-12" "fechaAceptado" => "2015-11-16" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec820290" "palabras" => array:3 [ 0 => "Anterior uveitis" 1 => "HLA-B27" 2 => "Ocular complications" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec820291" "palabras" => array:3 [ 0 => "Uveítis anterior" 1 => "HLA-B27" 2 => "Complicaciones oculares" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "IntroductionAnterior uveitis is the most common type of intraocular inflammation. Those associated to HLA-B27 represent 18 to 32% of all anterior uveitis cases. ObjectivesTo describe clinical characteristics, systemic treatment need, and frequency and type of ocular complications in a cohort of patients diagnosed with HLAB27-related anterior uveitis and in a cohort of patients diagnosed with HLA-B27 non-related anterior uveitis.To establish if statistically significant differences between both cohorts exist. Material and methodsWe performed a retrospective cohort study including patients with non infectious anterior uveitis related and not related to the antigen HLA-B27. Results162 patients were included, 58 diagnosed with HLA-B27-related anterior uveitis (cohort HLA-B27+1) and 104 diagnosed with HLA-B27-non related anterior uveitis (cohort HLA-B27−).No statistically significant differences were found regarding clinical characteristics between both cohorts with the exception of a higher frequency of recurrences in cohort HLA-B27+ and a higher frequency of chronic uveitis in cohort HLA-B27−. No differences were found regarding systemic treatment use nor development of ocular complications. DiscussionIn contrast to previous studies, we neither found higher male gender predominance in the cohort of patients with HLA-B27-related anterior uveitis, nor did we find differences regarding average age, laterality, development of complications nor use of systemic corticosteroids." "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Material and methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Discussion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "IntroducciónLa uveítis anterior es la forma más frecuente de inflamación intraocular. Las formas asociadas al antígeno HLA-B27 suponen entre un 18 y un 32% de los casos de uveítis anterior. ObjetivosDescribir las características clínicas, la necesidad de tratamiento sistémico y la frecuencia y el tipo de complicaciones oculares de una cohorte de pacientes con uveítis anterior asociada a HLA-B27 y de una cohorte de pacientes con uveítis anterior no asociada a HLA-B27.Establecer si existen diferencias entre ambas cohortes. Material y métodosSe realiza un estudio de cohortes retrospectivo descriptivo con componentes analíticos incluyendo a pacientes con uveítis anterior endógena no infecciosa asociada y no asociada a HLA-B27. ResultadosSe incluye un total de 162 pacientes, 58 con uveítis anterior asociada a HLAB27 (cohorte HLA-B27+) y 104 con uveítis anterior no asociada a HLA-B27 (cohorte HLA-B27–).No se aprecian diferencias estadísticamente significativas en las características clínicas de ambas cohortes a excepción de una mayor tendencia a la recurrencia en la cohorte HLA-B27+ y una mayor tendencia a la cronicidad en la cohorte HLA-B27–. Tampoco se aprecian diferencias en cuanto al uso de tratamiento sistémico ni al desarrollo de complicaciones oculares de forma global. ConclusionesA diferencia de lo descrito con anterioridad, en este trabajo no encontramos un mayor predominio masculino en la cohorte de uveítis asociada a HLA-B27. Tampoco se aprecian diferencias en edad media, lateralidad, presencia de complicaciones ni frecuencia de uso de corticoides sistémicos." "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivos" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Material y métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Valls Pascual E, Fontanilla Ortega P, Vicens Bernabeu E, Martínez-Costa L, Blanco Alonso R. Características clínicas, tratamiento y complicaciones oculares de uveítis anterior asociada y no asociada a HLA-B27. Reumatol Clin. 2016;12:244–247." ] ] "multimedia" => array:6 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Type of spondyloarthritis \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">n (%) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ankylosing spondylitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 (63.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Nonradiographic axial spondyloarthritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (20) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Peripheral spondyloarthritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (3.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Psoriatic spondyloarthritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (3.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Spondyloarthritis associated with inflammatory bowel disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (3.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Undifferentiated spondyloarthritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (6.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 (100) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1384871.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Association With Spondyloarthritis in the HLA-B27+ Cohort." ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "TINU, tubulointerstitial nephritis and uveitis." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnosis \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">n (%) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Idiopathic uveitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">81 (77.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Uveitis associated with juvenile idiopathic arthritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (6.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Uveitis associated with spondyloarthritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (5.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TINU syndrome \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (2.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sjögren's syndrome \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (1.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Behçet's disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (1.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fuchs’ heterochromic iridocyclitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (1.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Relapsing polychondritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">104 (100) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1384869.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Diagnoses in the HLA-B27− Cohort." ] ] 2 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "A, acute; B, bilateral (simultaneous or alternating); C, chronic; M, men; M: women; R, recurrent; SD, standard deviation; U, unilateral." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Characteristics and features \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HLA-B27+ (n=58) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HLA-B27− (n=104) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P value \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age (years), mean±SD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">41±13.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">47.24±20.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.071 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Sex, n (%)</td><td class="td" title="table-entry " align="left" valign="top">M 31 (53.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M 42 (40.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.109 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">W 27 (46.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">W 62 (59.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Length of follow-up in months, median (interquartile range) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">34.5 (4.75–54) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13.5 (3–47) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.074 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Laterality, n (%)</td><td class="td" title="table-entry " align="left" valign="top">U 36 (62.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">U 55 (52.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.259 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">B 22 (37.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">B 49 (47.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="3" align="left" valign="top">Clinical course, n (%)</td><td class="td" title="table-entry " align="left" valign="top">A 19 (32.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A 53 (51) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">R 39 (67.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">R 29 (27.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C 0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">C 22 (21.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1384867.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Patient Characteristics and Clinical Features." ] ] 3 => array:8 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at4" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "CSC, central serous choroiditis; ERM: epiretinal membrane; OHT, ocular hypertension." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Ocular complications \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HLA-B27+ (n=58) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HLA-B27− (n=104) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Synechiae \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 (32.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23 (22.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Macular edema \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (6.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (8.8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cataracts \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (1.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (8.8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ERM \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (1.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (5.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">OHT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (5.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Band keratopathy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (4.8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CSC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (1.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1384870.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Ocular Complications." ] ] 4 => array:8 [ "identificador" => "tbl0025" "etiqueta" => "Table 5" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at5" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Systemic therapy \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HLA-B27+ (n=58) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HLA-B27− (n=104) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P value \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Corticosteroids \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (13.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 (16.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.666 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Other immunosuppressive agents \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 (19%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 (18.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.913 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1384866.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Systemic Therapy." ] ] 5 => array:8 [ "identificador" => "tbl0030" "etiqueta" => "Table 6" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at6" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Systemic therapy \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HLA-B27+ (n=11) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HLA-B27− (n=19) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sulfasalazine \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Methotrexate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Adalimumab \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tocilizumab \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1384868.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Types of Immunosuppressive Agents." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib0085" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Causes and frequency of blindness in patients with intraocular inflammatory disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. 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Original Article

Clinical Characteristics, Treatment and Ocular Complications of HLA-B27-Related Anterior Uveitis and HLA-B27-Non Related Anterior Uveitis

Características clínicas, tratamiento y complicaciones oculares de uveítis anterior asociada y no asociada a HLA-B27

Elia Valls Pascuala,

Corresponding author

elialtea@gmail.com

Corresponding author.

, Pablo Fontanilla Ortegab, Elvira Vicens Bernabeua, Lucía Martínez-Costab, Ricardo Blanco Alonsoc

a Sección de Reumatología, Hospital Universitari Doctor Peset, Valencia, Spain

b Servicio de Oftalmología, Hospital Universitari Doctor Peset, Valencia, Spain

c Servicio de Reumatología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain

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            "entidad" => "Secci&#243;n de Reumatolog&#237;a&#44; Hospital Universitari Doctor Peset&#44; Valencia&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
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            "entidad" => "Servicio de Oftalmolog&#237;a&#44; Hospital Universitari Doctor Peset&#44; Valencia&#44; Spain"
            "etiqueta" => "b"
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            "entidad" => "Servicio de Reumatolog&#237;a&#44; Hospital Universitario Marqu&#233;s de Valdecilla&#44; Santander&#44; Cantabria&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
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        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
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    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Caracter&#237;sticas cl&#237;nicas&#44; tratamiento y complicaciones oculares de uve&#237;tis anterior asociada y no asociada a HLA-B27"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Uveitis is inflammation of the middle layer of the eye &#40;uvea&#41;&#44; located between the sclera and the retina&#44; which is comprised of the iris&#44; ciliary body&#44; pars plana and&#47;or choroid&#46; In some cases&#44; by extension&#44; it can also affect the retina&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The incidence of uveitis is 45&#8211;52 cases per 100&#44;000<span class="elsevierStyleHsp" style=""></span>population&#47;year&#44; it peaks between the ages of 20 and 44 years&#44; and the prevalence of the disease is 70 cases per 100<span class="elsevierStyleHsp" style=""></span>000 population&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">1&#44;2</span></a> It is the third leading cause of blindness in the working age population in developed countries&#44; and 10&#37; of the cases of total loss of vision are due to uveitis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Anterior uveitis is the most common form of intraocular inflammation&#44; representing between 50&#37; and 92&#37; of all cases of uveitis reported in a Western population&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">3</span></a> Anterior uveitis associated with HLA-B27 accounts for between 18&#37; and 32&#37; of the cases of anterior uveitis found in that population&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">It has been reported more frequently in men&#44; in whom onset is earlier &#40;20&#8211;40 years&#41;&#44; it tends to be unilateral and there are higher rates of recurrences and complications&#46; Anterior uveitis is more severe when associated with the HLA-B27 antigen&#44; with a higher degree of inflammation and a more frequent use of systemic corticosteroids&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">5</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Objectives</span><p id="par0025" class="elsevierStylePara elsevierViewall">The purpose of this article is to describe the clinical features&#44; the need for systemic therapy and the frequency and types of ocular complications in a cohort of patients with anterior uveitis associated with HLA-B27 and in a cohort of patients with endogenous noninfectious anterior uveitis not associated with HLA-B27&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">We also proposed to establish whether there were differences between the 2 cohorts in terms of clinical features&#44; frequency and types of ocular complications&#44; and the frequency of the use of systemic corticosteroids and other systemic immunosuppressive agents&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Material and Methods</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Study Design and Patients</span><p id="par0035" class="elsevierStylePara elsevierViewall">We conducted a retrospective descriptive cohort study with analytical components&#44; including patients diagnosed with anterior uveitis associated with HLA-B27 with follow-up in a multidisciplinary uveitis clinic at Hospital Universitari Doctor Peset in Valencia&#44; Spain &#40;HLA-B27&#43;&#41; and patients diagnosed with endogenous noninfectious anterior uveitis not associated with HLA-B27 with follow-up in the same multidisciplinary uveitis clinic at Hospital Universitari Doctor Peset &#40;HLA-B27&#8722;&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Inclusion Criteria</span><p id="par0040" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8211;</span><p id="par0045" class="elsevierStylePara elsevierViewall">HLA B27&#43; cohort&#58; patients diagnosed with anterior uveitis &#40;acute&#44; recurrent or chronic&#41; associated with HLA-B27&#44; with a follow-up of at least 1 month in the multidisciplinary uveitis clinic at Hospital Universitari Doctor Peset&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8211;</span><p id="par0050" class="elsevierStylePara elsevierViewall">HLA B27&#8722; cohort&#58; patients diagnosed with endogenous noninfectious anterior uveitis &#40;acute&#44; recurrent or chronic&#41; not associated with HLA-B27&#44; with a follow-up of at least 1 month in the multidisciplinary uveitis clinic at Hospital Universitari Doctor Peset&#46;</p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Exclusion Criteria</span><p id="par0055" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8211;</span><p id="par0060" class="elsevierStylePara elsevierViewall">Anterior uveitis associated with other locations &#40;intermediate&#44; posterior&#44; panuveitis&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8211;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Traumatic uveitis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8211;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Infectious uveitis&#46;</p></li></ul></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Data Collection and Variables</span><p id="par0075" class="elsevierStylePara elsevierViewall">The data were obtained from an electronic registry &#40;&#46;sav format&#41; that includes patients who underwent follow-up between 1 January 2008 and 17 March 2015&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The variables considered in the study were&#58; length of follow-up&#44; age&#44; sex&#44; diagnosis&#44; clinical course according to the criteria of the Standardization of Uveitis Nomenclature &#40;SUN&#41; Working Group&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">6</span></a> laterality&#44; use of systemic immunosuppression&#44; use of systemic corticosteroids&#44; and presence and type of complications&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Data Management</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Descriptive Statistics</span><p id="par0085" class="elsevierStylePara elsevierViewall">We calculated proportions for the categorical variables and mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;or median and interquartile range if the data for the sample did not follow a normal distribution&#41; for continuous variables&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Inferential Statistics</span><p id="par0090" class="elsevierStylePara elsevierViewall">The chi-square statistic was used to compare proportions&#44; applying the continuity correction if necessary&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Student&#39;s <span class="elsevierStyleItalic">t</span> statistic was utilized to compare means&#46; If the data of the sample did not follow a normal distribution&#44; the Kruskal&#8211;Wallis statistic was utilized&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">A <span class="elsevierStyleItalic">P</span> value &#60;&#46;05 was considered to indicate statistical significance&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The statistical analysis was performed using the SPSS software package &#40;version 13&#41;&#46;</p></span></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Results</span><p id="par0110" class="elsevierStylePara elsevierViewall">We included a total of 162 patients&#44; 58 with anterior uveitis associated with HLA-B27 &#40;HLA-B27&#43;&#41; and 104 with endogenous noninfectious anterior uveitis not associated with HLA-B27 &#40;HLA-B27&#8722;&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Of the HLA-B27&#43; patients&#44; 30 had a diagnosis of spondyloarthritis and 1 had a diagnosis of juvenile idiopathic arthritis &#40;JIA&#41;&#46; The different types of spondyloarthritis are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; We wish to point out the fact that 64&#46;5&#37; of these patients were diagnosed with spondyloarthritis after having been referred from the ophthalmology department to the rheumatology department after a first episode of uveitis&#46; Most of these patients described symptoms characteristic of long-standing spondyloarthritis&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">Most of the HLA-B27&#8722; patients had been diagnosed with idiopathic uveitis&#46; The various diagnoses included and their frequency in this cohort can be seen in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">The demographic and clinical characteristics of both cohorts are shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">The mean age of the patients in the two cohorts was between 40 and 50 years&#44; and there were no statistically significant differences between them&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">We did not observe a significant predominance of one sex over the other in either of the 2 cohorts&#44; although there was a somewhat higher number of men in the HLA-B27&#43; cohort and of women in the HLA-B27&#8722; cohort&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">The median length of follow-up was greater in the HLA-B27&#43; cohort&#44; but the difference did not reach statistical significance when compared with the HLA-B27&#8722; cohort&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Likewise&#44; no significant differences were found with regard to laterality&#59; unilateral involvement was more frequent in both cohorts&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">However&#44; differences were observed in terms of the clinical course&#46; In the HLA-B27&#43; cohort&#44; somewhat more than 2 thirds of the patients experienced recurrences and there were no cases of chronic uveitis&#46; In the HLA-B27&#8722; cohort&#44; half of the patients had had only 1 episode of uveitis&#44; somewhat more than a fourth of the patients had a recurrent course&#44; and the remainder&#44; chronic&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">The proportion of patients who developed some type of complication was similar in both cohorts&#44; there being no statistically significant differences &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;686&#41;&#46; However&#44; when the types of complications that were documented for the patients in the 2 cohorts were analyzed&#44; we observed differences&#44; but the statistical significance could not be determined because the sample size was not large enough &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#44; except in the case of synechiae&#44; which were more common in the HLA-B27&#43; cohort&#44; although the difference was not statistically significant &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;07&#41;&#46; One patient in this cohort developed central serous choroiditis related to the use of systemic corticosteroids&#46; In the HLA-B27&#8722; cohort&#44; band keratopathy was observed in 6 patients&#44; all of whom had been diagnosed with JIA&#46; We also found a higher frequency of cataracts and ocular hypertension &#40;OHT&#41; in the HLA-B27&#8722; cohort&#46; This fact was not associated with a more widespread use of systemic corticosteroids given that&#44; as was seen in the case of cataracts&#44; the higher frequency in the HLA-B27&#8722; cohort can be explained by a greater trend toward chronicity&#46; In the case of OHT&#44; the differences can be explained by the greater trend toward hypertension in some of the types of uveitis&#44; such as Fuchs&#8217; heterochromic iridocyclitis&#44; included in the HLA-B27&#8722; cohort&#46; The presence of OHT coincided with ocular inflammatory activity in all the patients&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0160" class="elsevierStylePara elsevierViewall">Regarding the use of corticosteroids or other systemic immunosuppressive agents&#44; again&#44; there were no statistically significant differences&#44; as these treatments were seldom required in either cohort &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0165" class="elsevierStylePara elsevierViewall">Most of the patients treated with systemic corticosteroids began the therapy with a dose of 30<span class="elsevierStyleHsp" style=""></span>mg a day of prednisone or the equivalent&#46; In every case&#44; immunosuppressive therapy was introduced due to ocular inflammatory activity that could not be controlled with other treatments&#44; in general&#44; to prevent recurrences or chronicity&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">The immunosuppressive agents utilized were sulfasalazine&#44; methotrexate&#44; adalimumab and tocilizumab &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">Table 6</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0030"></elsevierMultimedia></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Discussion</span><p id="par0175" class="elsevierStylePara elsevierViewall">There are a considerable number of publications dealing with the clinical features and prognosis of HLA-B27-associated anterior uveitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">7&#8211;16</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">The description of the clinical features coincides in the majority of the publications&#44; but the prognosis does not&#46; We found articles in which the authors reported a better prognosis for uveitis associated with HLA-B27&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">7</span></a> whereas others affirmed the opposite&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">8</span></a> and still others who observed a prognosis similar to that of anterior uveitis not associated with HLA-B27&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">9&#8211;13</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">In contrast to earlier publications&#44;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">4&#44;5</span></a> in the present study&#44; we did not observe male predominance in the cohort of patients with anterior uveitis associated with HLA-B27&#44; an earlier onset or a greater trend toward unilaterality in that cohort&#46; However&#44; we did find a greater trend toward recurrence in the patients with anterior uveitis associated with HLA-B27&#44; similar to that reported in previous publications&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">4&#44;12</span></a> The rest of the clinical features were similar in both cohorts&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">One noteworthy finding is the high percentage of patients who were diagnosed with spondyloarthritis after being referred from the ophthalmology department to the rheumatology department due to an episode of uveitis&#46; This circumstance demonstrates the importance of the collaboration between the two specialties&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">In this study&#44; we did not take into account the degree of inflammatory activity at the time of the onset of the episode of uveitis because of the difficulty in standardizing the information&#44; since the episodes were evaluated by different ophthalmologists and there was wide variability in terms of the establishment of the degree of inflammation&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">Likewise&#44; we did not take into account the visual prognosis of the patients&#44; as we considered that the study design was not the most appropriate for that assessment or for establishing prognostic factors&#46; We would like to continue the study&#44; carrying out a prospective evaluation of the patients for the purpose of clarifying this point&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">The fact that we found no statistically significant differences between the two cohorts in terms of the use of corticosteroids&#8212;in contrast to results published elsewhere<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">5</span></a>&#8212;and other systemic immunosuppressive agents&#44; and the presence or absence of complications could indicate that the severity and the visual prognosis is comparable in the two groups&#44; but we cannot reach any further conclusions because of the limitations of the study&#44; which include the unavailability of data on the changes in the visual acuity of the patients&#46; Moreover&#44; in the HLA-B27&#8722; cohort&#44; we observed an incidence of chronic uveitis of 21&#37; and not a single case in the HLA-B27&#43; cohort&#46; This difference would mean that&#44; although the uveitides in the HLA-B27&#43; cohort were more severe&#44; no significant differences were observed in terms of the use of systemic therapy on comparing the two cohorts&#44; because in the patients with chronic uveitis&#44; even if the activity was lower&#44; systemic therapy would be initiated more often&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">With respect to the differences observed in the various types of ocular complications&#44; which&#44; as we mentioned above&#44; cannot be measured accurately because of the small sample size&#44; we should consider the influence of the heterogeneity in the HLA-B27&#8722; cohort&#44; which includes 8 different diagnoses&#46; This would explain&#44; for example&#44; the elevated presence of band keratopathy&#44; observed only in those patients of the sample with a diagnosis of JIA&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">If we exclude synechiae&#44; whose influence on the visual prognosis of the patient is low&#44; the rate of complications is low in both cohorts&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">In conclusion&#44; in the present article&#44; there are no significant differences between the clinical features of uveitides associated with HLA-B27 and those of uveitides not associated with HLA-B27&#44; with the exception of a greater trend toward recurrence&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">The study design does not enable us to establish differences with respect to the visual prognosis&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">We would like to increase the sample size of the study and carry out a prospective follow-up to obtain information on the differences in the development of different types of ocular complications&#44; and on differences and possible factors that intervene in the prognosis&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Ethical Disclosures</span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Protection of human and animal subjects</span><p id="par0235" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Confidentiality of data</span><p id="par0240" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Right to privacy and informed consent</span><p id="par0245" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Conflict of Interest</span><p id="par0250" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Anterior uveitis is the most common type of intraocular inflammation&#46; Those associated to HLA-B27 represent 18 to 32&#37; of all anterior uveitis cases&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To describe clinical characteristics&#44; systemic treatment need&#44; and frequency and type of ocular complications in a cohort of patients diagnosed with HLAB27-related anterior uveitis and in a cohort of patients diagnosed with HLA-B27 non-related anterior uveitis&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">To establish if statistically significant differences between both cohorts exist&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material and methods</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We performed a retrospective cohort study including patients with non infectious anterior uveitis related and not related to the antigen HLA-B27&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">162 patients were included&#44; 58 diagnosed with HLA-B27-related anterior uveitis &#40;cohort HLA-B27&#43;1&#41; and 104 diagnosed with HLA-B27-non related anterior uveitis &#40;cohort HLA-B27&#8722;&#41;&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">No statistically significant differences were found regarding clinical characteristics between both cohorts with the exception of a higher frequency of recurrences in cohort HLA-B27&#43; and a higher frequency of chronic uveitis in cohort HLA-B27&#8722;&#46; No differences were found regarding systemic treatment use nor development of ocular complications&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discussion</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">In contrast to previous studies&#44; we neither found higher male gender predominance in the cohort of patients with HLA-B27-related anterior uveitis&#44; nor did we find differences regarding average age&#44; laterality&#44; development of complications nor use of systemic corticosteroids&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objectives"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Material and methods"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Results"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Discussion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La uve&#237;tis anterior es la forma m&#225;s frecuente de inflamaci&#243;n intraocular&#46; Las formas asociadas al ant&#237;geno HLA-B27 suponen entre un 18 y un 32&#37; de los casos de uve&#237;tis anterior&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Describir las caracter&#237;sticas cl&#237;nicas&#44; la necesidad de tratamiento sist&#233;mico y la frecuencia y el tipo de complicaciones oculares de una cohorte de pacientes con uve&#237;tis anterior asociada a HLA-B27 y de una cohorte de pacientes con uve&#237;tis anterior no asociada a HLA-B27&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Establecer si existen diferencias entre ambas cohortes&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material y m&#233;todos</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Se realiza un estudio de cohortes retrospectivo descriptivo con componentes anal&#237;ticos incluyendo a pacientes con uve&#237;tis anterior end&#243;gena no infecciosa asociada y no asociada a HLA-B27&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Se incluye un total de 162 pacientes&#44; 58 con uve&#237;tis anterior asociada a HLAB27 &#40;cohorte HLA-B27&#43;&#41; y 104 con uve&#237;tis anterior no asociada a HLA-B27 &#40;cohorte HLA-B27&#8211;&#41;&#46;</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">No se aprecian diferencias estad&#237;sticamente significativas en las caracter&#237;sticas cl&#237;nicas de ambas cohortes a excepci&#243;n de una mayor tendencia a la recurrencia en la cohorte HLA-B27&#43; y una mayor tendencia a la cronicidad en la cohorte HLA-B27&#8211;&#46; Tampoco se aprecian diferencias en cuanto al uso de tratamiento sist&#233;mico ni al desarrollo de complicaciones oculares de forma global&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">A diferencia de lo descrito con anterioridad&#44; en este trabajo no encontramos un mayor predominio masculino en la cohorte de uve&#237;tis asociada a HLA-B27&#46; Tampoco se aprecian diferencias en edad media&#44; lateralidad&#44; presencia de complicaciones ni frecuencia de uso de corticoides sist&#233;micos&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Objetivos"
          ]
          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Material y m&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Valls Pascual E&#44; Fontanilla Ortega P&#44; Vicens Bernabeu E&#44; Mart&#237;nez-Costa L&#44; Blanco Alonso R&#46; Caracter&#237;sticas cl&#237;nicas&#44; tratamiento y complicaciones oculares de uve&#237;tis anterior asociada y no asociada a HLA-B27&#46; Reumatol Clin&#46; 2016&#59;12&#58;244&#8211;247&#46;</p>"
      ]
    ]
    "multimedia" => array:6 [
      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
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        ]
        "tabla" => array:1 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Type of spondyloarthritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ankylosing spondylitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;63&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Nonradiographic axial spondyloarthritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Peripheral spondyloarthritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;3&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Psoriatic spondyloarthritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;3&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Spondyloarthritis associated with inflammatory bowel disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;3&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Undifferentiated spondyloarthritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;6&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                0 => "xTab1384871.png"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Association With Spondyloarthritis in the HLA-B27&#43; Cohort&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">TINU&#44; tubulointerstitial nephritis and uveitis&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Idiopathic uveitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81 &#40;77&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Uveitis associated with juvenile idiopathic arthritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;6&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Uveitis associated with spondyloarthritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;5&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TINU syndrome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;2&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sj&#246;gren&#39;s syndrome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;1&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Beh&#231;et&#39;s disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;1&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fuchs&#8217; heterochromic iridocyclitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;1&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Relapsing polychondritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">104 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1384869.png"
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          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Diagnoses in the HLA-B27&#8722; Cohort&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Table "
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        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">A&#44; acute&#59; B&#44; bilateral &#40;simultaneous or alternating&#41;&#59; C&#44; chronic&#59; M&#44; men&#59; M&#58; women&#59; R&#44; recurrent&#59; SD&#44; standard deviation&#59; U&#44; unilateral&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Characteristics and features&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HLA-B27&#43; &#40;n&#61;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HLA-B27&#8722; &#40;n&#61;104&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age &#40;years&#41;&#44; mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">41<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&#46;24<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;071&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Sex&#44; n &#40;&#37;&#41;</td><td class="td" title="table-entry  " align="left" valign="top">M 31 &#40;53&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M 42 &#40;40&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;109&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">W 27 &#40;46&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">W 62 &#40;59&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Length of follow-up in months&#44; median &#40;interquartile range&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#46;5 &#40;4&#46;75&#8211;54&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;5 &#40;3&#8211;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;074&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Laterality&#44; n &#40;&#37;&#41;</td><td class="td" title="table-entry  " align="left" valign="top">U 36 &#40;62&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">U 55 &#40;52&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;259&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">B 22 &#40;37&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B 49 &#40;47&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Clinical course&#44; n &#40;&#37;&#41;</td><td class="td" title="table-entry  " align="left" valign="top">A 19 &#40;32&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A 53 &#40;51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">R 39 &#40;67&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">R 29 &#40;27&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Rothova"
                            1 => "M&#46;S&#46; Suttorp-van Schulten"
                            2 => "W&#46; Frits Tretters"
                            3 => "A&#46; Kijlstra"
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                      "Revista" => array:6 [
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                0 => array:2 [
                  "contribucion" => array:1 [
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                          "etal" => false
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                            0 => "S&#46;C&#46; Foster"
                            1 => "A&#46;T&#46; Vitale"
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                      "Libro" => array:4 [
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                        "fecha" => "2002"
                        "editorial" => "W&#46;B&#46; Saunders Company"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
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                          "etal" => false
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                            0 => "J&#46;H&#46; Chang"
                            1 => "D&#46; Wakefield"
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ocul Immunol Inflamm"
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                          0 => array:2 [
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                0 => array:2 [
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                      "titulo" => "Acute anterior uveitis and HLA-B27"
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                        0 => array:2 [
                          "etal" => false
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                            0 => "J&#46;H&#46; Chang"
                            1 => "P&#46;J&#46; McCluskey"
                            2 => "D&#46; Wakefield"
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                    0 => array:2 [
                      "doi" => "10.1016/j.survophthal.2005.04.003"
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                    0 => array:2 [
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                0 => array:2 [
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                    0 => array:2 [
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                            0 => "D&#46;A&#46; Jabs"
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                    0 => array:2 [
                      "titulo" => "Clinical features of HLA-B27 anterior uveitis"
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                        0 => array:2 [
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                            0 => "D&#46; Wakefield"
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                  "host" => array:1 [
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                      "Revista" => array:5 [
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                    0 => array:2 [
                      "titulo" => "Outcomes in anterior uve&#237;tis associated with the HLA-B27 haplotype"
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                        0 => array:2 [
                          "etal" => false
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                            0 => "W&#46;J&#46; Power"
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                    0 => array:2 [
                      "doi" => "10.1016/S0161-6420(98)99033-9"
                      "Revista" => array:7 [
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Article information

ISSN: 21735743
Original language: English

DOI:10.1016/j.reumae.2015.11.014

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Year/Month	Html	Pdf	Total

2024 November	11	12	23
2024 October	57	26	83
2024 September	76	19	95
2024 August	76	34	110
2024 July	63	59	122
2024 June	66	36	102
2024 May	74	27	101
2024 April	57	17	74
2024 March	45	27	72
2024 February	29	27	56
2024 January	40	23	63
2023 December	46	38	84
2023 November	46	23	69
2023 October	49	27	76
2023 September	78	31	109
2023 August	37	17	54
2023 July	51	28	79
2023 June	33	25	58
2023 May	57	28	85
2023 April	26	19	45
2023 March	65	22	87
2023 February	61	28	89
2023 January	40	18	58
2022 December	57	25	82
2022 November	51	27	78
2022 October	47	40	87
2022 September	38	40	78
2022 August	45	43	88
2022 July	38	39	77
2022 June	31	38	69
2022 May	39	37	76
2022 April	49	38	87
2022 March	68	56	124
2022 February	57	33	90
2022 January	54	60	114
2021 December	52	51	103
2021 November	44	48	92
2021 October	68	68	136
2021 September	43	34	77
2021 August	41	37	78
2021 July	54	46	100
2021 June	62	43	105
2021 May	82	53	135
2021 April	214	116	330
2021 March	97	49	146
2021 February	66	22	88
2021 January	74	30	104
2020 December	59	29	88
2020 November	51	15	66
2020 October	41	13	54
2020 September	60	28	88
2020 August	46	24	70
2020 July	67	21	88
2020 June	55	21	76
2020 May	57	15	72
2020 April	38	22	60
2020 March	21	11	32
2019 June	1	0	1
2018 May	3	1	4
2018 April	38	11	49
2018 March	67	15	82
2018 February	45	8	53
2018 January	24	14	38
2017 December	24	10	34
2017 November	40	6	46
2017 October	14	14	28
2017 September	29	14	43
2017 August	29	19	48
2017 July	30	13	43
2017 June	38	26	64
2017 May	43	28	71
2017 April	49	30	79
2017 March	32	24	56
2017 February	17	22	39
2017 January	20	17	37
2016 December	41	36	77
2016 November	39	36	75
2016 October	82	42	124
2016 September	72	27	99
2016 August	34	11	45
2016 July	1	0	1

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