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B) TAC pulmonar a los 6 meses del abandono del hábito tabáquico. C) Células de Langerhans (hematoxilina-eosina). D) Técnica IHQ positiva para CD1a (×100).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Pablo Antonio Zurita Prada, Claudia Lía Urrego Laurín, Sow Assyaaton Bobo, Regina Faré García, Graciliano Estrada Trigueros, José Manuel Gallardo Romero, Maria Henar Borrego Pintado" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Pablo Antonio" "apellidos" => "Zurita Prada" ] 1 => array:2 [ "nombre" => "Claudia Lía" "apellidos" => "Urrego Laurín" ] 2 => array:2 [ "nombre" => "Sow" "apellidos" => "Assyaaton Bobo" ] 3 => array:2 [ "nombre" => "Regina" "apellidos" => "Faré García" ] 4 => array:2 [ "nombre" => "Graciliano" "apellidos" => "Estrada Trigueros" ] 5 => array:2 [ "nombre" => "José Manuel" "apellidos" => "Gallardo Romero" ] 6 => array:2 [ "nombre" => "Maria Henar" "apellidos" => "Borrego Pintado" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173574317300333" "doi" => "10.1016/j.reumae.2016.03.012" "estado" => "S300" 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"mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1491 "Ancho" => 2500 "Tamanyo" => 320364 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Evidence of the diagnosis of IgG4-related disease according to diagnostic criteria.</p> <p id="spar0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Source</span>: Adapted from Ryu et al.<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">29</span></a></p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Oscar Ardila-Suarez, Andy Abril, José A. 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(B) Pulmonary CT 6 months after the patient had quit smoking. (C) Langerhans cells (hematoxylin–eosin). (D) Positive immunohistochemical technique for CD1a (100×).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Case Report</span><p id="par0005" class="elsevierStylePara elsevierViewall">The patient was a 50-year-old woman who smoked 20 cigarettes/day. She had been diagnosed with seropositive (rheumatoid factor [RF] and anti-cyclic citrullinated peptide antibodies [anti-CCP]), erosive rheumatoid arthritis (RA) in 1999. She was being treated with methotrexate (MTX) since 2000, in combination with salazopyrin and hydroxychloroquine since February 2009, at which time, she had achieved complete remission. In March 2010, in relation to a self-limiting case of a cold, her primary care physician had asked for a chest radiograph, which showed possible images of nodules, predominantly in the upper lobes. The patient was asymptomatic and the physical examination was normal. She had an immunological study in which she tested positive for RF and anti-CCP and negative for antinuclear antibodies and antineutrophil cytoplasmic antibodies; the Mantoux text was positive, and chest computed tomography revealed multiple bilateral pulmonary nodules measuring about 0.5<span class="elsevierStyleHsp" style=""></span>cm, some showing cavitation, especially in images from the upper and middle lobes, but the lower lobes were also involved (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). The bronchoscopy was normal, with negative results in the smear, bronchoalveolar lavage fluid culture and cytology of the bronchial aspirate for malignant cells. The patient was referred to undergo lung biopsy. Videothoracoscopy revealed that the lung parenchyma had small scattered subpleural lesions, and the pathological study showed the presence of foamy histiocytes with grooved nuclei, with other multinucleated and somewhat elongated histiocytes occupying the alveolar spaces (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C). Immunohistochemical techniques identified cells that were positive for CD1a (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D) and for S100, as well as langerin in the histiocytes described, all of which was consistent with Langerhans cell (LC) histiocytosis (LCH). At that time, it was recommended that she quit smoking and the same immunosuppressive therapy was maintained. During that entire period, she had no joint or respiratory symptoms and underwent radiographic follow-up 6 months later. The images showed residual pulmonary cysts and the nodules had disappeared (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). After 5 years of follow-up with no new incidences, the patient continues to receive triple immunosuppressive therapy.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discussion</span><p id="par0010" class="elsevierStylePara elsevierViewall">Histiocytes are cells of the immune system that include both macrophages and dendritic cells (non-macrophage antigen-presenting cells). Histiocytoses are rare diseases, LCH being the most representative, characterized by the infiltration of LC, a type of dendritic cell found predominantly in the pulmonary alveoli and in the skin, with its distinctive “racket”-shaped cytoplasmic Birbeck granules. The term LCH was coined in the attempt to confer a better classification and identification of the patients, as it combines previous entities (eosinophilic granuloma, histiocytosis X, etc.) in which the lesions were due to a proliferation and infiltration of the same cell type, the identification of LC being the diagnostic criteria called for since then.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">1</span></a> The pathogenesis is unknown, there being either a reactive or clonal proliferative response, with different degrees of phenotypic aggressiveness in the infiltrated organs or systems (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Pulmonary Langerhans cell histiocytosis (PLCH) is the most representative form in adults and is usually recognized as a separate entity.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">This disorder occurs in young adult smokers, and smoking cessation can lead to partial or total remission of the pulmonary lesions. In the early stages, it is characterized by bronchoalveolar inflammatory changes and, in the most advanced phases, by cystic lung destruction. The clinical manifestations vary widely: dyspnea, cough, weakness, fever, weight loss, pleuritic chest pain and, occasionally, spontaneous pneumothorax. The incidence of hemoptysis is minor; thus, should it occur, the cause should be looked for elsewhere (mainly tumor-related). The disease can be detected incidentally in radiological studies performed in asymptomatic patients, occurring in around 15% of the cases, and the same proportion can be applied to those with extrapulmonary manifestations, such as bone cysts, diabetes insipidus or exanthema.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">2,3</span></a> Computed tomography is the technique of choice to characterize pulmonary involvement. The combination of multiple cysts and bilateral nodules distributed throughout the medium and upper lobes, with or without interstitial thickening, in a young smoker, is considered to be a characteristic reason to strongly suspect PLCH.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">4</span></a> This was not the case in our patient, whose disorder had to do mainly with the nodules, there being few cystic lesions and involvement of the lower lobes. Bronchoalveolar lavage is useful for the diagnosis when more than 5% of the LC are detected by electron microscopy or immunostaining, but this technique is not available at every medical center.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">5</span></a> The combination of the typical radiological findings, together with the positive results of bronchoalveolar lavage, can be accepted as a sufficient diagnostic criteria, without pathological confirmation.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">2</span></a> However, should the latter be necessary, the approach should be pulmonary biopsy, since transbronchial biopsy has been found to have a very limited diagnostic yield. The presence of LC is confirmed by immunohistochemical techniques with monoclonal antibodies against the CD1a membrane antigen, the intracellular S100 protein and langerin.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The differential diagnosis should mainly include the formal screening for mycobacteria, hematogenous infections, other types of nodulosis such as sarcoidosis, silicosis, vasculitis, metastases or primary pulmonary tumors, and in our case, obviously, with pulmonary rheumatoid nodules (RN). With respect to the latter, we must recall that pulmonary RN are classically related to tobacco use, RF positivity, coexistence of cutaneous RN and human leukocyte antigen (HLA) DRB1, although there are also cases induced by treatment with synthetic disease-modifying antirheumatic drugs or biological therapy with anti-tumor necrosis factor (TNF) agents. Rheumatoid nodulosis has long been known to be induced by MTX. It is characterized by the rapid development of RN that are histopathologically similar to classic RN, that stops once the drug is no longer being administered and reappears if the attempt is made to reintroduce it.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">7</span></a> It has been associated with the HLA DRB1*0401 allele. Pulmonary rheumatoid nodulosis of similar temporal characteristics as that induced by MTX is much less common. In contrast, in other situations in which the development of cutaneous or pulmonary RN during prolonged chronic treatment with MTX, the causal association would be much more questionable. Moreover, on most occasions, there is a characteristic disparity between the development of nodulosis and a good control of the joint disease. Thus, the strategy to be followed with respect to discontinuing treatment can also be debated, and this all points to differences between the pathophysiological mechanisms that result in the formation of rheumatoid granulomas and those that lead to synovitis and synovial hypertrophy. Similar problems with interpretation in the literature can be found with leflunomide and anti-TNF therapy as inducers of pulmonary rheumatoid nodulosis.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">8</span></a> Finally, the differential diagnosis of purely cystic PLCH would include centrilobular emphysema, cystic fibrosis, tuberous sclerosis and, specifically in women, lymphangioleiomyomatosis (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">The natural course of PLCH is unpredictable; spontaneous remission can be estimated to occur in up to 50% cases, and severe progressive respiratory failure can develop in 10%–20% of the patients. The major consideration for the treatment of PLCH is smoking cessation, which may be achieved in up to one third of the cases. This simultaneously eliminates an important risk factor for lung cancer, chronic obstructive pulmonary disease and cardiovascular disease. However, it is estimated that the disease continues to progress in as many as one third of the patients who stop smoking. Cases of recurrence have been reported in those who quit. The use of corticosteroids as monotherapy or in combination with immunosuppressive agents (methotrexate, cyclophosphamide, vinblastine and, more recently, cladribine) is questioned because of the absence of controlled clinical trials and due to the uncertainty regarding the natural behavior of the disease. It is usually reserved for cases of functional deterioration revealed by spirometry, progressive interstitial disease or extrapulmonary multisystemic involvement. Overall 5-year survival is estimated to be 75%, and the factors most widely associated with poor prognosis are advanced age and deterioration in respiratory function tests and its extension at the time of the diagnosis.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">3</span></a> Lung transplantation is an option for long-standing severe disease, although recurrences have been reported in the transplanted organ.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">9</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Our patient was in clinical remission for her joint disorder, and was receiving triple therapy when the pulmonary manifestations were detected. We maintained the same strategy, especially after seeing the radiological improvement once she had achieved smoking cessation. We found no cases in the literature on the previous coincidence of PLCH and RA. There is a recently described case of PLCH in a patient with Sjögren's syndrome treated with oral steroids and azathioprine, with a favorable radiological and functional response.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a> Multicentric reticulohistiocytosis may be a cause of erosive arthritis and has been associated in patients with RA and Sjögren's syndrome,<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a> although clinically, it is a differential diagnosis that was not considered in our case. With respect to the attitude to take if at some time, she were to need biological therapy, we have only had access to the favorable communication of 2001 on the part of Henter et al., in reference to a patient with very aggressive multifocal infantile LCH with a good response to etanercept.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a> Since then, communications along those lines have not been repeated.</p><p id="par0060" class="elsevierStylePara elsevierViewall">In short, PLCH is the most representative type of LCH in adulthood. It is directly related to tobacco use, and smoking cessation leads to a high percentage of cases in which the outcome proved to be the solution to the disease. We have not found previous references in the literature to the simultaneous coexistence of RA and PLCH. Our patient did not have a characteristic radiological pattern, and triple immunosuppressive therapy does not appear to have influenced the favorable change in the symptoms after more than 5 years of follow-up after smoking cessation.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Ethical Disclosures</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Protection of human and animal subjects</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Confidentiality of data</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Right to privacy and informed consent</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conflicts of Interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres835736" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec831484" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres835735" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec831485" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Case Report" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Discussion" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Ethical Disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0030" "titulo" => "Right to privacy and informed consent" ] ] ] 7 => array:2 [ "identificador" => "sec0035" "titulo" => "Conflicts of Interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-01-02" "fechaAceptado" => "2016-03-14" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec831484" "palabras" => array:3 [ 0 => "Rheumatoid arthritis" 1 => "Langerhans cell histiocytosis" 2 => "Pulmonary nodules" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec831485" "palabras" => array:3 [ 0 => "Artritis reumatoide" 1 => "Histiocitosis de células de Langerhans" 2 => "Nódulos pulmonares" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">We report the case of a 50-year-old female smoker with an 11-year history of seropositive rheumatoid arthritis (rheumatoid factor and anti-cyclic citrullinated peptide antibodies) receiving triple therapy. She developed pulmonary nodules diagnosed as Langerhans cell histiocytosis by lung biopsy. We found no reported cases of the coexistence of these two diseases. Smoking abstinence led to radiologic resolution without modifying the immunosuppressive therapy.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se presenta el caso de una mujer de 50 años, fumadora, con artritis reumatoide seropositiva (FR y CCP) de 11 años de evolución en tratamiento con triple terapia, y aparición de nódulos pulmonares con diagnóstico final de histiocitosis de células de Langerhans por biopsia pulmonar. No hemos encontrado casos descritos de la coexistencia de ambas enfermedades. La abstinencia tabáquica llevó a la resolución radiológica sin necesidad de modificar la terapia inmunosupresora.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Please cite this article as: Zurita Prada PA, Urrego Laurín CL, Assyaaton Bobo S, Faré García R, Estrada Trigueros G, Gallardo Romero JM, et al. Artritis reumatoide y nódulos pulmonares: un diagnóstico final inesperado. 2017;13:167–170.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1297 "Ancho" => 1500 "Tamanyo" => 268987 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A) Pulmonary computed tomography (CT) at the time of diagnosis. (B) Pulmonary CT 6 months after the patient had quit smoking. (C) Langerhans cells (hematoxylin–eosin). (D) Positive immunohistochemical technique for CD1a (100×).</p>" ] ] 1 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:2 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Simplified classification of histiocytosis<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">1. <span class="elsevierStyleItalic">Langerhans cell histiocytosis (LCH)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">2. <span class="elsevierStyleItalic">Hemophagocytic lymphohistiocytosis (HLH)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">3. <span class="elsevierStyleItalic">The rare histiocytic disorders (RHD)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Juvenile xanthogranuloma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Erdheim-Chester disease \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Multicentric reticulohistiocytosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Rosai-Dorfman disease \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>The malignant histiocytosis \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1409684.png" ] ] 1 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Classification of <span class="elsevierStyleItalic">Langerhans cell histiocytosis</span> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">1. <span class="elsevierStyleItalic">Isolated disease in a single organ or system</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pulmonary LCH (85% of the cases of pulmonary LCH in adults) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Bone (single or multiple) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Skin/hypothalamus/hypophysis/lymph nodes/liver, spleen, thyroid glands \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">2. <span class="elsevierStyleItalic">Multisystem disease</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>: <span class="elsevierStyleItalic">affecting two or more organs</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1409682.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Source: <span class="elsevierStyleInterRef" id="intr0005" href="https://www.histiocytesociety.org/">https://www.histiocytesociety.org</span>.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Previous nomenclature: histiocytosis X, eosinophilic granuloma. Hashimoto Pritzker disease: in the newborn, skin lesions and self-healing course.</p>" ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "c" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Previous nomenclature: Letterer–Siwe disease: aggressive infantile disorder with fever, lymphadenopathy, hepatosplenomegaly, bone and lung involvement. Hand–Schuller–Christian: triad of exophthalmos, diabetes insipidus and bone lesions, typical infantile disease, rare in adults.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Classification of Histiocytosis.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Tumor-related</span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lung tumor</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Metastasis</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lymphangitic carcinomatosis</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Infectious</span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hematogenous infection: <span class="elsevierStyleItalic">Staphylococcus aureus</span>, <span class="elsevierStyleItalic">Klebsiella pneumoniae</span>, <span class="elsevierStyleItalic">Pseudomonas</span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Granulomatosis: mycobacterial, <span class="elsevierStyleItalic">Nocardia</span>, fungi</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Parasites: hydatid disease, paragonimiasis, <span class="elsevierStyleItalic">Echinococcus</span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Inflammatory</span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sarcoidosis</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pulmonary Langerhans cell histiocytosis</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pneumoconiosis: asbestosis, silicosis, Caplan syndrome</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Rheumatoid nodules</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Vasculitis: granulomatosis with polyangiitis, eosinophilic granulomatosis</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cryptogenic organizing pneumonia</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Drug-related</span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Rheumatoid nodules induced by disease-modifying antirheumatic drugs (methotrexate and leflunomide) and anti-tumor necrosis factor agents</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Amiodarone, bleomycin, carbamazepine, others</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Miscellaneous</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Differential diagnosis of the cystic pattern on radiology</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Respiratory bronchiolitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pulmonary Langerhans cell histiocytosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Amyloidosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lymphangioleiomyomatosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pulmonary embolism \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cystic fibrosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Congenital pulmonary airway malformation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Tuberous sclerosis \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1409683.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Differential Diagnosis of Pulmonary Nodules in a Patient With Pulmonary Langerhans Cell Histiocytosis and Rheumatoid Arthritis.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib0065" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contemporary classification of histolytic disorders. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 11 | 12 | 23 |
2024 October | 52 | 36 | 88 |
2024 September | 52 | 14 | 66 |
2024 August | 62 | 38 | 100 |
2024 July | 46 | 28 | 74 |
2024 June | 62 | 38 | 100 |
2024 May | 79 | 38 | 117 |
2024 April | 75 | 33 | 108 |
2024 March | 89 | 33 | 122 |
2024 February | 47 | 18 | 65 |
2024 January | 43 | 15 | 58 |
2023 December | 45 | 20 | 65 |
2023 November | 62 | 32 | 94 |
2023 October | 57 | 33 | 90 |
2023 September | 125 | 35 | 160 |
2023 August | 44 | 14 | 58 |
2023 July | 48 | 21 | 69 |
2023 June | 54 | 17 | 71 |
2023 May | 55 | 23 | 78 |
2023 April | 38 | 11 | 49 |
2023 March | 85 | 38 | 123 |
2023 February | 64 | 27 | 91 |
2023 January | 67 | 25 | 92 |
2022 December | 72 | 39 | 111 |
2022 November | 72 | 28 | 100 |
2022 October | 57 | 32 | 89 |
2022 September | 40 | 45 | 85 |
2022 August | 48 | 46 | 94 |
2022 July | 40 | 43 | 83 |
2022 June | 38 | 24 | 62 |
2022 May | 44 | 32 | 76 |
2022 April | 47 | 49 | 96 |
2022 March | 42 | 50 | 92 |
2022 February | 49 | 29 | 78 |
2022 January | 41 | 34 | 75 |
2021 December | 51 | 36 | 87 |
2021 November | 46 | 40 | 86 |
2021 October | 46 | 57 | 103 |
2021 September | 36 | 44 | 80 |
2021 August | 21 | 58 | 79 |
2021 July | 30 | 37 | 67 |
2021 June | 44 | 36 | 80 |
2021 May | 61 | 41 | 102 |
2021 April | 130 | 87 | 217 |
2021 March | 75 | 44 | 119 |
2021 February | 46 | 23 | 69 |
2021 January | 47 | 20 | 67 |
2020 December | 28 | 22 | 50 |
2020 November | 53 | 22 | 75 |
2020 October | 25 | 15 | 40 |
2020 September | 44 | 28 | 72 |
2020 August | 36 | 22 | 58 |
2020 July | 21 | 10 | 31 |
2020 June | 30 | 21 | 51 |
2020 May | 26 | 21 | 47 |
2020 April | 23 | 14 | 37 |
2020 March | 15 | 8 | 23 |
2019 July | 2 | 0 | 2 |
2018 December | 3 | 0 | 3 |
2018 May | 8 | 1 | 9 |
2018 April | 43 | 12 | 55 |
2018 March | 69 | 9 | 78 |
2018 February | 49 | 10 | 59 |
2018 January | 46 | 14 | 60 |
2017 December | 52 | 26 | 78 |
2017 November | 76 | 14 | 90 |
2017 October | 68 | 11 | 79 |
2017 September | 54 | 14 | 68 |
2017 August | 27 | 15 | 42 |
2017 July | 53 | 22 | 75 |
2017 June | 111 | 41 | 152 |
2017 May | 101 | 38 | 139 |
2017 April | 6 | 14 | 20 |
2017 March | 4 | 13 | 17 |