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Report of a Case" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "297" "paginaFinal" => "298" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "María Jose Moreno Martínez, Deseada Palma Sánchez, Elena Peñas Martínez, Ana Haro Martínez, Marta Mayor González" "autores" => array:5 [ 0 => array:4 [ "nombre" => "María Jose" "apellidos" => "Moreno Martínez" "email" => array:1 [ 0 => "mjmorenomartinez@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Deseada" "apellidos" => "Palma Sánchez" ] 2 => array:2 [ "nombre" => "Elena" "apellidos" => "Peñas Martínez" ] 3 => array:2 [ "nombre" => "Ana" "apellidos" => "Haro Martínez" ] 4 => array:2 [ "nombre" => "Marta" "apellidos" => "Mayor González" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Hospital Rafael Méndez, Lorca, Murcia, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Vasculitis leucocitoclástica e infección. A propósito de un caso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 673 "Ancho" => 1500 "Tamanyo" => 100367 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Vesiculobullous form of cutaneous leukocytoclastic vasculitis. (A) Prior to antibiotic therapy. (B) After antibiotic therapy.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Cutaneous vasculitides are inflammatory disorders affecting the wall of the vessels of the skin. There can be a number of causes (drug exposure, infection, neoplastic disease or systemic inflammatory disease),<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> and skin involvement may be its only manifestation.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Leukocytoclastic vasculitis is the most frequent cause of cutaneous vasculitis found in clinical practice.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> On occasion, it can be associated with constitutional symptoms, and thus be confused with systemic diseases and certain conditions like mycoplasma.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Ureaplasma</span>, which belongs to the same family as <span class="elsevierStyleItalic">Mycoplasma</span>, is associated, in adults, with genital infections like nongonococcal urethritis.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical Observation</span><p id="par0020" class="elsevierStylePara elsevierViewall">We present the case of a 28-year-old man who had no significant previous medical history. He presented at the emergency service with lesions in the skin on lower limbs and trunk that did not disappear when pressed by a finger. The patient had no other systemic symptoms. He did not have fever or signs of infection anywhere else, except certain genital symptoms that were not well defined. He denied the use of drugs, sexual risk behavior and the consumption of any type of medication. He had arthralgia but not arthritis and, on the level of the skin, he had flat, erythematous, nonpruritic lesions, together with other bullous lesions (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). He underwent a skin biopsy which revealed leukocytoclastic vasculitis (perivascular inflammatory infiltrate with predominance of neutrophils, and nuclear dust, fibrinoid degeneration and extravasated red blood cells; subepidermal blisters with hemorrhagic and pustular content and focal epidermal necrosis). The analytical study, which involved acute-phase reactants, complete blood count and biochemical and immunological data, was normal. A urine culture was negative, as were serological tests for the hepatotropic viruses. Colonies of <span class="elsevierStyleItalic">Ureaplasma urealyticum</span> were identified in the urethral exudate. At admission, treatment was begun with prednisone (30<span class="elsevierStyleHsp" style=""></span>mg/day) and a nonsteroidal anti-inflammatory drug (ibuprofen at 600<span class="elsevierStyleHsp" style=""></span>mg every 8<span class="elsevierStyleHsp" style=""></span>h). This was followed by clinical improvement; however, it did not persist until antibiotic therapy was initiated with doxycycline, in accordance with antibiogram indications for <span class="elsevierStyleItalic">Ureaplasma</span>. Steroids were discontinued after 1 month and, 6 months later, the patient was asymptomatic without treatment.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">Leukocytoclastic vasculitis is the most common cutaneous vasculitis. Although in 50% of the cases, the cause is usually idiopathic, the histopathological diagnosis enabled by biopsy should be established as soon as possible to rule out other possibilities such as systemic, neoplastic or infectious diseases.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1,3–5</span></a> Nevertheless, the term “leukocytoclastic vasculitis” does not specify the exact diagnosis.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4,5</span></a> In sexually active patients, we cannot forget that sexually transmitted diseases, which include <span class="elsevierStyleItalic">Ureaplasma</span> infection, can be asymptomatic and are related to a wide variety of pathological settings, one of which is leukocytoclastic vasculitis.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">With regard to the treatment of leukocytoclastic vasculitis, the first situation that should be treated is the triggering factor,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleItalic">Ureaplasma</span> infection in our patient, leaving immunosuppressive therapy for cases that are refractory or in which the involvement is severe.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0035" class="elsevierStylePara elsevierViewall">There are many factors that can be associated with leukocytoclastic vasculitis as triggers of the disease.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Infections are a frequent cause of cutaneous vasculitis and joint involvement.</p><p id="par0045" class="elsevierStylePara elsevierViewall">There are infections in which the symptoms are less evident that should be taken into account in the examination of our patients, because there may be a causal relationship.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflicts of Interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres884942" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec871142" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres884943" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec871141" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Clinical Observation" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conclusions" ] 8 => array:3 [ "identificador" => "sec0025" "titulo" => "Ethical Disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0030" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0035" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0040" "titulo" => "Right to privacy and informed consent" ] ] ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Conflicts of Interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-01-25" "fechaAceptado" => "2016-04-08" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec871142" "palabras" => array:4 [ 0 => "Cutaneous vasculitis" 1 => "Infection" 2 => "<span class="elsevierStyleItalic">Ureaplasma urealyticum</span>" 3 => "Leukocytoclastic vasculitis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec871141" "palabras" => array:4 [ 0 => "Vasculitis cutánea" 1 => "Infección" 2 => "<span class="elsevierStyleItalic">Ureaplasma urealyticum</span>" 3 => "Vasculitis leucocitoclástica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Leukocytoclastic vasculitis is the most common cause of cutaneous vasculitis in clinical practice. Its causes are various, among which are certain infections. We report the case of a man (28 years old) who debuted with vasculitic lesions in inferior members compatibles leukocytoclastic vasculitis on pathology. The study of causation is the presence of a positive urethral discharge to <span class="elsevierStyleItalic">Ureaplasma urealyticum</span>, dramatically improving lesions after treatment thereof.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La vasculitis leucocitoclástica es la causa más frecuente de vasculitis cutánea en la práctica clínica. Sus causas son diversas, entre las que se encuentran ciertas infecciones.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Presentamos el caso de un varón de 28 años que debuta con lesiones vasculíticas en miembros inferiores, compatibles con una vasculitis leucocitoclástica en la anatomía patológica. En el estudio de causalidad se encuentra la presencia de un exudado uretral positivo a <span class="elsevierStyleItalic">Ureaplasma urealyticum</span>, mejorando drásticamente las lesiones tras el tratamiento del mismo.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Moreno Martínez MJ, Palma Sánchez D, Peñas Martínez E, Haro Martínez A, Mayor González M. Vasculitis leucocitoclástica e infección. A propósito de un caso. Reumatol Clin. 2017;13:297–298.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 673 "Ancho" => 1500 "Tamanyo" => 100367 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Vesiculobullous form of cutaneous leukocytoclastic vasculitis. (A) Prior to antibiotic therapy. (B) After antibiotic therapy.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vasculitis cutáneas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. 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Year/Month | Html | Total | |
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2024 November | 12 | 17 | 29 |
2024 October | 87 | 57 | 144 |
2024 September | 131 | 49 | 180 |
2024 August | 132 | 63 | 195 |
2024 July | 114 | 45 | 159 |
2024 June | 126 | 43 | 169 |
2024 May | 149 | 55 | 204 |
2024 April | 123 | 35 | 158 |
2024 March | 111 | 41 | 152 |
2024 February | 108 | 30 | 138 |
2024 January | 124 | 28 | 152 |
2023 December | 85 | 26 | 111 |
2023 November | 120 | 14 | 134 |
2023 October | 117 | 30 | 147 |
2023 September | 149 | 38 | 187 |
2023 August | 124 | 20 | 144 |
2023 July | 144 | 33 | 177 |
2023 June | 141 | 25 | 166 |
2023 May | 119 | 22 | 141 |
2023 April | 90 | 19 | 109 |
2023 March | 120 | 52 | 172 |
2023 February | 129 | 31 | 160 |
2023 January | 170 | 17 | 187 |
2022 December | 113 | 40 | 153 |
2022 November | 157 | 26 | 183 |
2022 October | 128 | 37 | 165 |
2022 September | 112 | 40 | 152 |
2022 August | 149 | 38 | 187 |
2022 July | 93 | 49 | 142 |
2022 June | 85 | 34 | 119 |
2022 May | 130 | 51 | 181 |
2022 April | 152 | 60 | 212 |
2022 March | 141 | 51 | 192 |
2022 February | 167 | 28 | 195 |
2022 January | 142 | 48 | 190 |
2021 December | 133 | 56 | 189 |
2021 November | 90 | 40 | 130 |
2021 October | 64 | 55 | 119 |
2021 September | 77 | 40 | 117 |
2021 August | 64 | 36 | 100 |
2021 July | 62 | 35 | 97 |
2021 June | 89 | 35 | 124 |
2021 May | 105 | 42 | 147 |
2021 April | 317 | 81 | 398 |
2021 March | 150 | 38 | 188 |
2021 February | 78 | 17 | 95 |
2021 January | 95 | 31 | 126 |
2020 December | 79 | 18 | 97 |
2020 November | 70 | 29 | 99 |
2020 October | 50 | 23 | 73 |
2020 September | 82 | 28 | 110 |
2020 August | 54 | 20 | 74 |
2020 July | 39 | 12 | 51 |
2020 June | 66 | 29 | 95 |
2020 May | 52 | 17 | 69 |
2020 April | 40 | 25 | 65 |
2020 March | 12 | 5 | 17 |
2020 February | 1 | 0 | 1 |
2019 February | 1 | 0 | 1 |
2018 May | 5 | 0 | 5 |
2018 April | 70 | 7 | 77 |
2018 March | 103 | 10 | 113 |
2018 February | 44 | 5 | 49 |
2018 January | 47 | 7 | 54 |
2017 December | 43 | 12 | 55 |
2017 November | 50 | 18 | 68 |
2017 October | 73 | 33 | 106 |
2017 September | 95 | 31 | 126 |
2017 August | 37 | 21 | 58 |
2017 July | 13 | 10 | 23 |
2017 June | 21 | 13 | 34 |
2017 May | 12 | 11 | 23 |
2017 April | 9 | 13 | 22 |
2017 March | 1 | 1 | 2 |