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usually&#44; monoarticular&#44; although there are cases in which it is bilateral or occurs at another location like the elbow&#44; ankle&#44; wrist or hip&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In most cases&#44; it occurs <span class="elsevierStyleItalic">de novo</span>&#44; but it is not that rare that it be associated with osteoarthritis&#44; rheumatoid arthritis or an injury&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#8211;4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The clinical signs include intermittent episodes of pain and joint inflammation with inconclusive laboratory findings and synovial fluid that shows no evidence of inflammation&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;2&#44;5</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Although plain radiography&#44; 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she noted progressive inflammation in her right knee&#44; with occasional functional disability&#46; She came to the emergency department&#44; where she underwent arthrocentesis&#44; which yielded a yellowish fluid with negative cultures&#44; including Ziehl-Neelsen staining and culture on L&#246;wenstein-Jensen medium&#46; She was referred to rheumatology to be studied&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">She had no other symptoms or evidence of disease in a physical examination&#44; except swelling of the knee&#44; which was painless at that time&#44; and there was only slight synovial effusion&#46; Chest radiograph was normal&#44; purified protein derivative &#40;PPD&#41; test was negative&#44; complete blood count was normal&#44; erythrocyte sedimentation rate 6<span class="elsevierStyleHsp" style=""></span>mm&#47;h&#44; urine analysis normal&#44; C reactive protein 0&#46;21<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#44; antinuclear antibody test negative&#44; rheumatoid factor 7<span class="elsevierStyleHsp" style=""></span>IU&#47;mL&#44; immunoglobulins normal&#44; human leukocyte antigen &#40;HLA&#41;-B27 negative&#44; and her celiac profile and &#945;-1-acid glycoprotein were normal&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">We also took a plain radiograph of the knee&#44; which was normal&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Ultrasound of the affected knee&#58;</span> marked thickening of the synovium&#44; especially in the suprapatellar recess&#44; where it was accompanied by slight joint effusion&#46; The synovial membrane showed&#44; at some points&#44; polypoid thickening that seemed to be floating in the middle of the effusion&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Right knee NMR</span>&#58; there was a small Baker&#39;s cyst on the medial side of the popliteal fossa and a moderate joint effusion in the suprapatellar recess&#46; In the middle of the effusion there was a marked thickening of the synovial membrane that gave it finger-like or polypoid images&#44; and occupied the suprapatellar recess&#44; Hoffa&#39;s fat pad and the part adjacent to the cruciate ligaments and menisci&#46; These formations had a signal like that corresponding to fat&#46; After the intravenous administration of the contrast medium&#44; there was an enhancement marked by the synovium that surrounded the polypoid lesions&#46; This image was the confirmation of lipoma <span class="elsevierStyleItalic">arborescens</span> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">Ultimately&#44; we decided to perform an NMR study of the patient&#39;s shoulder in view of the septic arthritis&#44; and the result was normal&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">She was referred to an orthopedic surgeon for synovectomy&#44; and the symptoms disappeared&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Five months after the synovectomy&#44; she noted inflammation in the left knee and functional disability&#46; Nuclear magnetic resonance and ultrasound led to a diagnosis of lipoma <span class="elsevierStyleItalic">arborescens</span>&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">She underwent surgery&#44; and the pathological study of the synovial membrane confirmed the diagnosis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0175" class="elsevierStylePara elsevierViewall">Nuclear magnetic resonance can be highly useful in the evaluation of noninflammatory processes in patients with atypical monoarthritis&#46;</p></span>"
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Letter to the Editor
Lipoma arborescens in Pediatric Knee. Nuclear Magnetic Resonance
Lipomatosis arborescens en rodilla pediátrica. Resonancia magnética nuclear
Maria Dolores Ruiz Montesinoa,
Corresponding author
lruizmontesino@yahoo.es

Corresponding author.
, Virginia Moreira Navarreteb, Carmen Vargas Lebrónb, Juan J. Rios-Martínc
a Unidad de Gestión Clínica de Reumatología, Unidad de investigación (Imagen), Hospital Universitario Virgen Macarena, Sevilla, Spain
b Unidad de Gestión Clínica de Reumatología, Hospital Universitario Virgen Macarena, Sevilla, Spain
c Unidad de Gestión Clínica de Anatomía Patológica, Hospital Universitario Virgen Macarena, Sevilla, Spain
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usually&#44; monoarticular&#44; although there are cases in which it is bilateral or occurs at another location like the elbow&#44; ankle&#44; wrist or hip&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In most cases&#44; it occurs <span class="elsevierStyleItalic">de novo</span>&#44; but it is not that rare that it be associated with osteoarthritis&#44; rheumatoid arthritis or an injury&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#8211;4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The clinical signs include intermittent episodes of pain and joint inflammation with inconclusive laboratory findings and synovial fluid that shows no evidence of inflammation&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;2&#44;5</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Although plain radiography&#44; ultrasound&#44; arthrography and computed tomography can be of help&#44; NMR is the best imaging technique for the diagnosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">6&#8211;9</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The recommended treatment is total synovectomy<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;2&#44;5</span></a> by arthrotomy or arthroscopy&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Our patient was a 12-year-old girl with no significant previous medical history&#44; except for a diagnosis of septic arthritis of the shoulder when she was 9&#46; She had been treated with empirical antibiotic therapy and arthrotomy for drainage&#46; There had been no signs of microorganisms in either the synovial fluid or blood cultures&#46; All of the studies performed during her hospital stay were negative and all of the symptoms had completely disappeared&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Three months before a follow-up visit&#44; she noted progressive inflammation in her right knee&#44; with occasional functional disability&#46; She came to the emergency department&#44; where she underwent arthrocentesis&#44; which yielded a yellowish fluid with negative cultures&#44; including Ziehl-Neelsen staining and culture on L&#246;wenstein-Jensen medium&#46; She was referred to rheumatology to be studied&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">She had no other symptoms or evidence of disease in a physical examination&#44; except swelling of the knee&#44; which was painless at that time&#44; and there was only slight synovial effusion&#46; Chest radiograph was normal&#44; purified protein derivative &#40;PPD&#41; test was negative&#44; complete blood count was normal&#44; erythrocyte sedimentation rate 6<span class="elsevierStyleHsp" style=""></span>mm&#47;h&#44; urine analysis normal&#44; C reactive protein 0&#46;21<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#44; antinuclear antibody test negative&#44; rheumatoid factor 7<span class="elsevierStyleHsp" style=""></span>IU&#47;mL&#44; immunoglobulins normal&#44; human leukocyte antigen &#40;HLA&#41;-B27 negative&#44; and her celiac profile and &#945;-1-acid glycoprotein were normal&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">We also took a plain radiograph of the knee&#44; which was normal&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Ultrasound of the affected knee&#58;</span> marked thickening of the synovium&#44; especially in the suprapatellar recess&#44; where it was accompanied by slight joint effusion&#46; The synovial membrane showed&#44; at some points&#44; polypoid thickening that seemed to be floating in the middle of the effusion&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Right knee NMR</span>&#58; there was a small Baker&#39;s cyst on the medial side of the popliteal fossa and a moderate joint effusion in the suprapatellar recess&#46; In the middle of the effusion there was a marked thickening of the synovial membrane that gave it finger-like or polypoid images&#44; and occupied the suprapatellar recess&#44; Hoffa&#39;s fat pad and the part adjacent to the cruciate ligaments and menisci&#46; These formations had a signal like that corresponding to fat&#46; After the intravenous administration of the contrast medium&#44; there was an enhancement marked by the synovium that surrounded the polypoid lesions&#46; This image was the confirmation of lipoma <span class="elsevierStyleItalic">arborescens</span> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">Ultimately&#44; we decided to perform an NMR study of the patient&#39;s shoulder in view of the septic arthritis&#44; and the result was normal&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">She was referred to an orthopedic surgeon for synovectomy&#44; and the symptoms disappeared&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Five months after the synovectomy&#44; she noted inflammation in the left knee and functional disability&#46; Nuclear magnetic resonance and ultrasound led to a diagnosis of lipoma <span class="elsevierStyleItalic">arborescens</span>&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">She underwent surgery&#44; and the pathological study of the synovial membrane confirmed the diagnosis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0175" class="elsevierStylePara elsevierViewall">Nuclear magnetic resonance can be highly useful in the evaluation of noninflammatory processes in patients with atypical monoarthritis&#46;</p></span>"
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