array:24 [
  "pii" => "S2173574317300448"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2016.06.003"
  "estado" => "S300"
  "fechaPublicacion" => "2017-05-01"
  "aid" => "946"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2017;13:181-2"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 598
    "formatos" => array:3 [
      "EPUB" => 52
      "HTML" => 390
      "PDF" => 156
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X16300651"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2016.06.005"
      "estado" => "S300"
      "fechaPublicacion" => "2017-05-01"
      "aid" => "946"
      "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Reumatol Clin. 2017;13:181-2"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 8227
        "formatos" => array:3 [
          "EPUB" => 176
          "HTML" => 6918
          "PDF" => 1133
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "Leishmaniasis cut&#225;nea&#46; Una infecci&#243;n oportunista"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "181"
            "paginaFinal" => "182"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Cutaneous leishmaniasis&#58; An opportunistic infection"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1044
                "Ancho" => 950
                "Tamanyo" => 155136
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Lesi&#243;n de leishmaniasis cut&#225;nea en carpo &#40;bot&#243;n de Oriente&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Mar&#237;a Jos&#233; Moreno Mart&#237;nez, Manuel Jos&#233; Moreno Ramos, Paloma S&#225;nchez Pedre&#241;o"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "Mar&#237;a Jos&#233;"
                "apellidos" => "Moreno Mart&#237;nez"
              ]
              1 => array:2 [
                "nombre" => "Manuel Jos&#233;"
                "apellidos" => "Moreno Ramos"
              ]
              2 => array:2 [
                "nombre" => "Paloma"
                "apellidos" => "S&#225;nchez Pedre&#241;o"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574317300448"
          "doi" => "10.1016/j.reumae.2016.06.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300448?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16300651?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001300000003/v1_201704290027/S1699258X16300651/v1_201704290027/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574317300588"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2016.08.001"
    "estado" => "S300"
    "fechaPublicacion" => "2017-05-01"
    "aid" => "961"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2017;13:182-3"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 441
      "formatos" => array:3 [
        "EPUB" => 49
        "HTML" => 273
        "PDF" => 119
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Autoimmune pitfalls in treatment with TNF&#945; inhibitors"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "182"
          "paginaFinal" => "183"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Los escollos autoinmunes en el tratamiento de pacientes con anti-TNF&#945;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rita Fonseca, Eva Mariz, Miguel Bernardes, L&#250;cia Costa"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Rita"
              "apellidos" => "Fonseca"
            ]
            1 => array:2 [
              "nombre" => "Eva"
              "apellidos" => "Mariz"
            ]
            2 => array:2 [
              "nombre" => "Miguel"
              "apellidos" => "Bernardes"
            ]
            3 => array:2 [
              "nombre" => "L&#250;cia"
              "apellidos" => "Costa"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1699258X16300985"
        "doi" => "10.1016/j.reuma.2016.08.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16300985?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300588?idApp=UINPBA00004M"
    "url" => "/21735743/0000001300000003/v1_201705040052/S2173574317300588/v1_201705040052/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574317300436"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2016.07.006"
    "estado" => "S300"
    "fechaPublicacion" => "2017-05-01"
    "aid" => "948"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2017;13:180-1"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 625
      "formatos" => array:3 [
        "EPUB" => 55
        "HTML" => 409
        "PDF" => 161
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Lipoma arborescens in Pediatric Knee&#46; Nuclear Magnetic Resonance"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "180"
          "paginaFinal" => "181"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Lipomatosis <span class="elsevierStyleItalic">arborescens</span> en rodilla pedi&#225;trica&#46; Resonancia magn&#233;tica nuclear"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Fig&#46; 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 753
              "Ancho" => 1001
              "Tamanyo" => 141576
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Villous proliferation in the synovium&#46; <span class="elsevierStyleItalic">Inset&#58;</span> adipose infiltration&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Maria Dolores Ruiz Montesino, Virginia Moreira Navarrete, Carmen Vargas Lebr&#243;n, Juan J&#46; Rios-Mart&#237;n"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Maria Dolores"
              "apellidos" => "Ruiz Montesino"
            ]
            1 => array:2 [
              "nombre" => "Virginia"
              "apellidos" => "Moreira Navarrete"
            ]
            2 => array:2 [
              "nombre" => "Carmen"
              "apellidos" => "Vargas Lebr&#243;n"
            ]
            3 => array:2 [
              "nombre" => "Juan J&#46;"
              "apellidos" => "Rios-Mart&#237;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X16300675"
        "doi" => "10.1016/j.reuma.2016.07.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16300675?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300436?idApp=UINPBA00004M"
    "url" => "/21735743/0000001300000003/v1_201705040052/S2173574317300436/v1_201705040052/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Cutaneous Leishmaniasis&#58; An Opportunistic Infection"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "181"
        "paginaFinal" => "182"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Mar&#237;a Jos&#233; Moreno Mart&#237;nez, Manuel Jos&#233; Moreno Ramos, Paloma S&#225;nchez Pedre&#241;o"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "Mar&#237;a Jos&#233;"
            "apellidos" => "Moreno Mart&#237;nez"
            "email" => array:1 [
              0 => "mjmorenomartinez&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Manuel Jos&#233;"
            "apellidos" => "Moreno Ramos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Paloma"
            "apellidos" => "S&#225;nchez Pedre&#241;o"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Departamento de Reumatolog&#237;a&#44; H&#46;C&#46;U&#46; Virgen de la Arrixaca&#44; Murcia&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Dermatolog&#237;a&#44; H&#46;C&#46;U&#46; Virgen de la Arrixaca&#44; Murcia&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Leishmaniasis cut&#225;nea&#46; Una infecci&#243;n oportunista"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1044
            "Ancho" => 950
            "Tamanyo" => 155136
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cutaneous leishmaniasis lesion in carpus &#40;Oriental sore&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Leishmaniasis is a parasitic disease caused by the intracellular protozoa <span class="elsevierStyleItalic">Leishmania</span>&#46; It is transmitted by through the bite of a mosquito&#58; the female phlebotomus&#46; There are 21 species of <span class="elsevierStyleItalic">Leishmania</span>&#46; The species most widespread in Spain is <span class="elsevierStyleItalic">Leishmania infantum</span> and its major reservoir is the dog&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A number of cases of leishmaniasis have been reported in patients with different rheumatic diseases who were being treated with biological drugs&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We describe a case of cutaneous leishmaniasis in a woman with rheumatoid arthritis who was receiving an anti-tumor necrosis factor &#40;TNF&#41;-&#945; and methotrexate&#46; The patient was 54 years old and had been born in Murcia&#44; a city in southeastern Spain&#46; She had been diagnosed with rheumatoid arthritis 5 years earlier&#44; and was positive for rheumatoid factor and anti-cyclic citrullinated peptide antibodies&#46; She was being treated with subcutaneous methotrexate &#40;25<span class="elsevierStyleHsp" style=""></span>mg each week&#41; together with adalimumab at a dose of 40<span class="elsevierStyleHsp" style=""></span>mg every 15 days&#46; She had no significant medical history or harmful habits&#46; The patient was in clinical remission and it was decided to increase the interval between adalimumab doses to 21 days&#46; Weeks later&#44; she developed a nodular and ulcerated lesion on the palmar side of her left carpus &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Biopsy led to a diagnosis of cutaneous leishmaniasis&#46; Immunosuppressive therapy was discontinued and she underwent an analytical and imaging study&#44; which ruled out visceral leishmaniasis&#46; The patient was treated with amphotericin B at a dose of 3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg body weight&#47;day for 5 days&#44; and the lesion disappeared&#46; Intralesional treatment was not performed and there were no secondary effects of the therapy&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">In Spain&#44; according to a report of the Ministry of Health dated 2012&#44; the autonomous communities that had reported cases of leishmaniasis during the preceding decade were&#58; Andalusia&#44; Aragon&#44; Balearic Islands&#44; Cantabria&#44; Castile-Le&#243;n&#44; Catalonia&#44; Valencian Community&#44; Extremadura&#44; Community of Madrid&#44; Region of Murcia&#44; Chartered Community of Navarre and La Rioja&#46; According to the registry of the Center for the Coordination of Health Warnings and Emergencies&#44; between 2002 and 2010&#44; 82 cases were reported in Murcia&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The disease can present in 3 clinical forms<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a>&#58; cutaneous&#44; mucocutaneous and visceral leishmaniasis&#46; In the cutaneous and mucocutaneous forms&#44; the diagnosis is reached by biopsy and visualization of <span class="elsevierStyleItalic">Leishmania</span> in the cells&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The mucocutaneous form presents with erythema&#44; erosion and ulcers around the lips and nose&#59; the differential diagnosis should include Wegener granulomatosis&#44; among others&#46; In the cutaneous form&#44; we find lesions in areas of exposed skin&#44; like face&#44; arms and legs&#46; Each lesion represents a bite&#46; Visceral leishmaniasis can present with a febrile syndrome with constitutional symptoms and manifestations depending on the affected organs &#40;spleen&#44; liver&#44; bone marrow&#44; among others&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Tumor necrosis factor-&#945; is a cytokine implicated in the immune response against intracellular parasites&#46; It has been involved in granuloma formation and in containing the protozoa&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Since the introduction of anti-TNF-&#945; agents&#44; there have been several cases of leishmaniasis&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> According to the reports&#44; it seems that the risk is greatest during the first year of treatment&#44; and to a greater extent with infliximab than with the subcutaneous drugs&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">5&#44;6</span></a> There have also been cases with other types of immunosuppressive agents&#44; like azathioprine&#44; methotrexate&#44; cyclosporine&#44; steroid and cyclophosphamide&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In immunocompromised patients&#44; the risk of reactivation&#44; and thus&#44; of active visceral leishmaniasis is increasing&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">4&#44;7</span></a> In regions in which it is endemic&#44; in an immunocompromised patient with fever&#44; asthenia&#44; splenomegaly and pancytopenia&#44; this diagnostic possibility should be considered&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> In our case&#44; the patient was receiving treatment with an immunosuppressive agent&#44; and came from an area in which leishmaniasis is endemic&#46; Thus&#44; upon the first diagnostic suspicion&#44; after the development of the skin lesion&#44; the latter was biopsied and immunosuppressive therapy was discontinued&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Moreno Mart&#237;nez MJ&#44; Moreno Ramos MJ&#44; S&#225;nchez Pedre&#241;o P&#46; Leishmaniasis cut&#225;nea&#46; Una infecci&#243;n oportunista&#46; Reumatol Clin&#46; 2017&#59;13&#58;181&#8211;182&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1044
            "Ancho" => 950
            "Tamanyo" => 155136
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cutaneous leishmaniasis lesion in carpus &#40;Oriental sore&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Lucientes J&#44; Castillo JA&#44; Gracia MJ&#44; Perib&#225;&#241;ez MA&#46; Flebotomos&#44; de la biolog&#237;a al control&#46; Revista Electr&#243;nica de Veterinaria REDVET&#46; Available in&#58; <a href="http://www.veterinaria.org/revistas/redvet/n080805.html">http&#58;&#47;&#47;www&#46;veterinaria&#46;org&#47;revistas&#47;redvet&#47;n080805&#46;html</a> &#91;accessed 14&#46;10&#46;13&#93;&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous and mucocutaneous leishmaniasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;V&#46; David"
                            1 => "N&#46; Craft"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1529-8019.2009.01272.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Ther"
                        "fecha" => "2009"
                        "volumen" => "22"
                        "paginaInicial" => "491"
                        "paginaFinal" => "502"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19889134"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Distinct roles for lymphotoxin and tumornecrosis factor in the control of leishmania donovani infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46;R&#46; Engwerda"
                            1 => "M&#46; Ato"
                            2 => "S&#46; Stager"
                            3 => "C&#46;E&#46; Alexander"
                            4 => "A&#46;C&#46; Stanley"
                            5 => "P&#46;M&#46; Kaye"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Pathol"
                        "fecha" => "2004"
                        "volumen" => "165"
                        "paginaInicial" => "2123"
                        "paginaFinal" => "2133"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15579454"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leishmaniasis and biologic therapies for rheumatologic diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Cascio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.semarthrit.2009.07.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "2010"
                        "volumen" => "40"
                        "paginaInicial" => "e3"
                        "paginaFinal" => "e5"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19782386"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infectious complications of biologic agents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Martin-Mola"
                            1 => "A&#46; Balsa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheum Dis Clin N Am"
                        "fecha" => "2009"
                        "volumen" => "35"
                        "paginaInicial" => "183"
                        "paginaFinal" => "199"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leishmaniasis during anti-tumor necrosis factor therapy&#58; report of 4 cases and review of the literature &#40;additional 28 cases&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46;S&#46; Guedes-Barbosa"
                            1 => "I&#46;P&#46; Costa"
                            2 => "V&#46; Fernandes"
                            3 => "L&#46;M&#46; Mota"
                            4 => "I&#46; Menezes"
                            5 => "M&#46;A&#46; Scheinberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.semarthrit.2013.01.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "2013"
                        "volumen" => "43"
                        "paginaInicial" => "152"
                        "paginaFinal" => "215"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23777708"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leishmaniasis in immunosuppressed individuals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Van Griensven"
                            1 => "E&#46; Carrillo"
                            2 => "R&#46; Lopez-Velez"
                            3 => "L&#46; Lynen"
                            4 => "L&#46; Moreno"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/1469-0691.12556"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Microbiol Infect"
                        "fecha" => "2014"
                        "volumen" => "20"
                        "paginaInicial" => "286"
                        "paginaFinal" => "299"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24450618"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001300000003/v1_201705040052/S2173574317300448/v1_201705040052/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8400"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001300000003/v1_201705040052/S2173574317300448/v1_201705040052/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300448?idApp=UINPBA00004M"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Letter to the Editor
Cutaneous Leishmaniasis: An Opportunistic Infection
Leishmaniasis cutánea. Una infección oportunista
María José Moreno Martíneza,
Corresponding author
mjmorenomartinez@gmail.com

Corresponding author.
, Manuel José Moreno Ramosa, Paloma Sánchez Pedreñob
a Departamento de Reumatología, H.C.U. Virgen de la Arrixaca, Murcia, Spain
b Departamento de Dermatología, H.C.U. Virgen de la Arrixaca, Murcia, Spain
Read
5594
Times
was read the article
1867
Total PDF
3727
Total HTML
Share statistics
 array:24 [
  "pii" => "S2173574317300448"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2016.06.003"
  "estado" => "S300"
  "fechaPublicacion" => "2017-05-01"
  "aid" => "946"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2017;13:181-2"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 598
    "formatos" => array:3 [
      "EPUB" => 52
      "HTML" => 390
      "PDF" => 156
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X16300651"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2016.06.005"
      "estado" => "S300"
      "fechaPublicacion" => "2017-05-01"
      "aid" => "946"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Reumatol Clin. 2017;13:181-2"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 8227
        "formatos" => array:3 [
          "EPUB" => 176
          "HTML" => 6918
          "PDF" => 1133
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "Leishmaniasis cut&#225;nea&#46; Una infecci&#243;n oportunista"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "181"
            "paginaFinal" => "182"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Cutaneous leishmaniasis&#58; An opportunistic infection"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1044
                "Ancho" => 950
                "Tamanyo" => 155136
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Lesi&#243;n de leishmaniasis cut&#225;nea en carpo &#40;bot&#243;n de Oriente&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Mar&#237;a Jos&#233; Moreno Mart&#237;nez, Manuel Jos&#233; Moreno Ramos, Paloma S&#225;nchez Pedre&#241;o"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "Mar&#237;a Jos&#233;"
                "apellidos" => "Moreno Mart&#237;nez"
              ]
              1 => array:2 [
                "nombre" => "Manuel Jos&#233;"
                "apellidos" => "Moreno Ramos"
              ]
              2 => array:2 [
                "nombre" => "Paloma"
                "apellidos" => "S&#225;nchez Pedre&#241;o"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574317300448"
          "doi" => "10.1016/j.reumae.2016.06.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300448?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16300651?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001300000003/v1_201704290027/S1699258X16300651/v1_201704290027/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574317300588"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2016.08.001"
    "estado" => "S300"
    "fechaPublicacion" => "2017-05-01"
    "aid" => "961"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2017;13:182-3"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 441
      "formatos" => array:3 [
        "EPUB" => 49
        "HTML" => 273
        "PDF" => 119
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Autoimmune pitfalls in treatment with TNF&#945; inhibitors"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "182"
          "paginaFinal" => "183"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Los escollos autoinmunes en el tratamiento de pacientes con anti-TNF&#945;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rita Fonseca, Eva Mariz, Miguel Bernardes, L&#250;cia Costa"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Rita"
              "apellidos" => "Fonseca"
            ]
            1 => array:2 [
              "nombre" => "Eva"
              "apellidos" => "Mariz"
            ]
            2 => array:2 [
              "nombre" => "Miguel"
              "apellidos" => "Bernardes"
            ]
            3 => array:2 [
              "nombre" => "L&#250;cia"
              "apellidos" => "Costa"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1699258X16300985"
        "doi" => "10.1016/j.reuma.2016.08.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16300985?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300588?idApp=UINPBA00004M"
    "url" => "/21735743/0000001300000003/v1_201705040052/S2173574317300588/v1_201705040052/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574317300436"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2016.07.006"
    "estado" => "S300"
    "fechaPublicacion" => "2017-05-01"
    "aid" => "948"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2017;13:180-1"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 625
      "formatos" => array:3 [
        "EPUB" => 55
        "HTML" => 409
        "PDF" => 161
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Lipoma arborescens in Pediatric Knee&#46; Nuclear Magnetic Resonance"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "180"
          "paginaFinal" => "181"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Lipomatosis <span class="elsevierStyleItalic">arborescens</span> en rodilla pedi&#225;trica&#46; Resonancia magn&#233;tica nuclear"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Fig&#46; 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 753
              "Ancho" => 1001
              "Tamanyo" => 141576
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Villous proliferation in the synovium&#46; <span class="elsevierStyleItalic">Inset&#58;</span> adipose infiltration&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Maria Dolores Ruiz Montesino, Virginia Moreira Navarrete, Carmen Vargas Lebr&#243;n, Juan J&#46; Rios-Mart&#237;n"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Maria Dolores"
              "apellidos" => "Ruiz Montesino"
            ]
            1 => array:2 [
              "nombre" => "Virginia"
              "apellidos" => "Moreira Navarrete"
            ]
            2 => array:2 [
              "nombre" => "Carmen"
              "apellidos" => "Vargas Lebr&#243;n"
            ]
            3 => array:2 [
              "nombre" => "Juan J&#46;"
              "apellidos" => "Rios-Mart&#237;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X16300675"
        "doi" => "10.1016/j.reuma.2016.07.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16300675?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300436?idApp=UINPBA00004M"
    "url" => "/21735743/0000001300000003/v1_201705040052/S2173574317300436/v1_201705040052/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Cutaneous Leishmaniasis&#58; An Opportunistic Infection"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "181"
        "paginaFinal" => "182"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Mar&#237;a Jos&#233; Moreno Mart&#237;nez, Manuel Jos&#233; Moreno Ramos, Paloma S&#225;nchez Pedre&#241;o"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "Mar&#237;a Jos&#233;"
            "apellidos" => "Moreno Mart&#237;nez"
            "email" => array:1 [
              0 => "mjmorenomartinez&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Manuel Jos&#233;"
            "apellidos" => "Moreno Ramos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Paloma"
            "apellidos" => "S&#225;nchez Pedre&#241;o"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Departamento de Reumatolog&#237;a&#44; H&#46;C&#46;U&#46; Virgen de la Arrixaca&#44; Murcia&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Dermatolog&#237;a&#44; H&#46;C&#46;U&#46; Virgen de la Arrixaca&#44; Murcia&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Leishmaniasis cut&#225;nea&#46; Una infecci&#243;n oportunista"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1044
            "Ancho" => 950
            "Tamanyo" => 155136
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cutaneous leishmaniasis lesion in carpus &#40;Oriental sore&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Leishmaniasis is a parasitic disease caused by the intracellular protozoa <span class="elsevierStyleItalic">Leishmania</span>&#46; It is transmitted by through the bite of a mosquito&#58; the female phlebotomus&#46; There are 21 species of <span class="elsevierStyleItalic">Leishmania</span>&#46; The species most widespread in Spain is <span class="elsevierStyleItalic">Leishmania infantum</span> and its major reservoir is the dog&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A number of cases of leishmaniasis have been reported in patients with different rheumatic diseases who were being treated with biological drugs&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We describe a case of cutaneous leishmaniasis in a woman with rheumatoid arthritis who was receiving an anti-tumor necrosis factor &#40;TNF&#41;-&#945; and methotrexate&#46; The patient was 54 years old and had been born in Murcia&#44; a city in southeastern Spain&#46; She had been diagnosed with rheumatoid arthritis 5 years earlier&#44; and was positive for rheumatoid factor and anti-cyclic citrullinated peptide antibodies&#46; She was being treated with subcutaneous methotrexate &#40;25<span class="elsevierStyleHsp" style=""></span>mg each week&#41; together with adalimumab at a dose of 40<span class="elsevierStyleHsp" style=""></span>mg every 15 days&#46; She had no significant medical history or harmful habits&#46; The patient was in clinical remission and it was decided to increase the interval between adalimumab doses to 21 days&#46; Weeks later&#44; she developed a nodular and ulcerated lesion on the palmar side of her left carpus &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Biopsy led to a diagnosis of cutaneous leishmaniasis&#46; Immunosuppressive therapy was discontinued and she underwent an analytical and imaging study&#44; which ruled out visceral leishmaniasis&#46; The patient was treated with amphotericin B at a dose of 3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg body weight&#47;day for 5 days&#44; and the lesion disappeared&#46; Intralesional treatment was not performed and there were no secondary effects of the therapy&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">In Spain&#44; according to a report of the Ministry of Health dated 2012&#44; the autonomous communities that had reported cases of leishmaniasis during the preceding decade were&#58; Andalusia&#44; Aragon&#44; Balearic Islands&#44; Cantabria&#44; Castile-Le&#243;n&#44; Catalonia&#44; Valencian Community&#44; Extremadura&#44; Community of Madrid&#44; Region of Murcia&#44; Chartered Community of Navarre and La Rioja&#46; According to the registry of the Center for the Coordination of Health Warnings and Emergencies&#44; between 2002 and 2010&#44; 82 cases were reported in Murcia&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The disease can present in 3 clinical forms<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a>&#58; cutaneous&#44; mucocutaneous and visceral leishmaniasis&#46; In the cutaneous and mucocutaneous forms&#44; the diagnosis is reached by biopsy and visualization of <span class="elsevierStyleItalic">Leishmania</span> in the cells&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The mucocutaneous form presents with erythema&#44; erosion and ulcers around the lips and nose&#59; the differential diagnosis should include Wegener granulomatosis&#44; among others&#46; In the cutaneous form&#44; we find lesions in areas of exposed skin&#44; like face&#44; arms and legs&#46; Each lesion represents a bite&#46; Visceral leishmaniasis can present with a febrile syndrome with constitutional symptoms and manifestations depending on the affected organs &#40;spleen&#44; liver&#44; bone marrow&#44; among others&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Tumor necrosis factor-&#945; is a cytokine implicated in the immune response against intracellular parasites&#46; It has been involved in granuloma formation and in containing the protozoa&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Since the introduction of anti-TNF-&#945; agents&#44; there have been several cases of leishmaniasis&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> According to the reports&#44; it seems that the risk is greatest during the first year of treatment&#44; and to a greater extent with infliximab than with the subcutaneous drugs&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">5&#44;6</span></a> There have also been cases with other types of immunosuppressive agents&#44; like azathioprine&#44; methotrexate&#44; cyclosporine&#44; steroid and cyclophosphamide&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In immunocompromised patients&#44; the risk of reactivation&#44; and thus&#44; of active visceral leishmaniasis is increasing&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">4&#44;7</span></a> In regions in which it is endemic&#44; in an immunocompromised patient with fever&#44; asthenia&#44; splenomegaly and pancytopenia&#44; this diagnostic possibility should be considered&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> In our case&#44; the patient was receiving treatment with an immunosuppressive agent&#44; and came from an area in which leishmaniasis is endemic&#46; Thus&#44; upon the first diagnostic suspicion&#44; after the development of the skin lesion&#44; the latter was biopsied and immunosuppressive therapy was discontinued&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Moreno Mart&#237;nez MJ&#44; Moreno Ramos MJ&#44; S&#225;nchez Pedre&#241;o P&#46; Leishmaniasis cut&#225;nea&#46; Una infecci&#243;n oportunista&#46; Reumatol Clin&#46; 2017&#59;13&#58;181&#8211;182&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1044
            "Ancho" => 950
            "Tamanyo" => 155136
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cutaneous leishmaniasis lesion in carpus &#40;Oriental sore&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Lucientes J&#44; Castillo JA&#44; Gracia MJ&#44; Perib&#225;&#241;ez MA&#46; Flebotomos&#44; de la biolog&#237;a al control&#46; Revista Electr&#243;nica de Veterinaria REDVET&#46; Available in&#58; <a href="http://www.veterinaria.org/revistas/redvet/n080805.html">http&#58;&#47;&#47;www&#46;veterinaria&#46;org&#47;revistas&#47;redvet&#47;n080805&#46;html</a> &#91;accessed 14&#46;10&#46;13&#93;&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous and mucocutaneous leishmaniasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;V&#46; David"
                            1 => "N&#46; Craft"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1529-8019.2009.01272.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Ther"
                        "fecha" => "2009"
                        "volumen" => "22"
                        "paginaInicial" => "491"
                        "paginaFinal" => "502"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19889134"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Distinct roles for lymphotoxin and tumornecrosis factor in the control of leishmania donovani infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46;R&#46; Engwerda"
                            1 => "M&#46; Ato"
                            2 => "S&#46; Stager"
                            3 => "C&#46;E&#46; Alexander"
                            4 => "A&#46;C&#46; Stanley"
                            5 => "P&#46;M&#46; Kaye"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Pathol"
                        "fecha" => "2004"
                        "volumen" => "165"
                        "paginaInicial" => "2123"
                        "paginaFinal" => "2133"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15579454"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leishmaniasis and biologic therapies for rheumatologic diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Cascio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.semarthrit.2009.07.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "2010"
                        "volumen" => "40"
                        "paginaInicial" => "e3"
                        "paginaFinal" => "e5"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19782386"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infectious complications of biologic agents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Martin-Mola"
                            1 => "A&#46; Balsa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheum Dis Clin N Am"
                        "fecha" => "2009"
                        "volumen" => "35"
                        "paginaInicial" => "183"
                        "paginaFinal" => "199"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leishmaniasis during anti-tumor necrosis factor therapy&#58; report of 4 cases and review of the literature &#40;additional 28 cases&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46;S&#46; Guedes-Barbosa"
                            1 => "I&#46;P&#46; Costa"
                            2 => "V&#46; Fernandes"
                            3 => "L&#46;M&#46; Mota"
                            4 => "I&#46; Menezes"
                            5 => "M&#46;A&#46; Scheinberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.semarthrit.2013.01.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "2013"
                        "volumen" => "43"
                        "paginaInicial" => "152"
                        "paginaFinal" => "215"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23777708"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leishmaniasis in immunosuppressed individuals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Van Griensven"
                            1 => "E&#46; Carrillo"
                            2 => "R&#46; Lopez-Velez"
                            3 => "L&#46; Lynen"
                            4 => "L&#46; Moreno"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/1469-0691.12556"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Microbiol Infect"
                        "fecha" => "2014"
                        "volumen" => "20"
                        "paginaInicial" => "286"
                        "paginaFinal" => "299"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24450618"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001300000003/v1_201705040052/S2173574317300448/v1_201705040052/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8400"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001300000003/v1_201705040052/S2173574317300448/v1_201705040052/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300448?idApp=UINPBA00004M"
]
Article information
ISSN: 21735743
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 12 9 21
2024 October 65 38 103
2024 September 92 15 107
2024 August 66 36 102
2024 July 53 24 77
2024 June 74 41 115
2024 May 85 45 130
2024 April 83 22 105
2024 March 59 35 94
2024 February 44 19 63
2024 January 47 23 70
2023 December 36 27 63
2023 November 48 22 70
2023 October 53 26 79
2023 September 87 39 126
2023 August 45 22 67
2023 July 34 23 57
2023 June 45 18 63
2023 May 43 23 66
2023 April 30 14 44
2023 March 68 24 92
2023 February 66 25 91
2023 January 56 24 80
2022 December 55 27 82
2022 November 61 27 88
2022 October 59 44 103
2022 September 74 31 105
2022 August 66 41 107
2022 July 53 35 88
2022 June 60 30 90
2022 May 55 34 89
2022 April 60 50 110
2022 March 114 54 168
2022 February 80 36 116
2022 January 113 37 150
2021 December 36 35 71
2021 November 43 42 85
2021 October 65 57 122
2021 September 55 45 100
2021 August 58 35 93
2021 July 56 20 76
2021 June 35 25 60
2021 May 66 40 106
2021 April 125 128 253
2021 March 95 33 128
2021 February 56 18 74
2021 January 42 18 60
2020 December 54 22 76
2020 November 60 27 87
2020 October 61 9 70
2020 September 62 21 83
2020 August 39 20 59
2020 July 39 23 62
2020 June 34 16 50
2020 May 57 14 71
2020 April 45 16 61
2020 March 13 7 20
2018 December 1 0 1
2018 September 0 1 1
2018 May 6 4 10
2018 April 29 8 37
2018 March 77 5 82
2018 February 25 9 34
2018 January 13 5 18
2017 December 28 12 40
2017 November 19 9 28
2017 October 20 9 29
2017 September 16 8 24
2017 August 13 9 22
2017 July 25 10 35
2017 June 57 37 94
2017 May 59 28 87
2017 April 2 2 4
Show all

Follow this link to access the full text of the article

Idiomas
Reumatología Clínica (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?