array:24 [
  "pii" => "S2173574317300667"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2016.09.001"
  "estado" => "S300"
  "fechaPublicacion" => "2017-07-01"
  "aid" => "965"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2017;13:242-3"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 694
    "formatos" => array:3 [
      "EPUB" => 48
      "HTML" => 502
      "PDF" => 144
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X16301024"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2016.09.001"
      "estado" => "S300"
      "fechaPublicacion" => "2017-07-01"
      "aid" => "965"
      "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Reumatol Clin. 2017;13:242-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 4534
        "formatos" => array:3 [
          "EPUB" => 170
          "HTML" => 3328
          "PDF" => 1036
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "Enfermedad de Gaucher&#58; a prop&#243;sito de un caso"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "242"
            "paginaFinal" => "243"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "A case report of Gaucher disease"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1309
                "Ancho" => 1738
                "Tamanyo" => 341174
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">C&#233;lulas de Gaucher&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Mar&#237;a Mar Herr&#225;ez-Albendea, Eva Gloria Fern&#225;ndez-Cofrades, Mar&#237;a Castillo Jarilla-Fern&#225;ndez, Francisco Jim&#233;nez-Burgos"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Mar&#237;a Mar"
                "apellidos" => "Herr&#225;ez-Albendea"
              ]
              1 => array:2 [
                "nombre" => "Eva Gloria"
                "apellidos" => "Fern&#225;ndez-Cofrades"
              ]
              2 => array:2 [
                "nombre" => "Mar&#237;a Castillo"
                "apellidos" => "Jarilla-Fern&#225;ndez"
              ]
              3 => array:2 [
                "nombre" => "Francisco"
                "apellidos" => "Jim&#233;nez-Burgos"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574317300667"
          "doi" => "10.1016/j.reumae.2016.09.001"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300667?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16301024?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001300000004/v1_201706290122/S1699258X16301024/v1_201706290122/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574317300655"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2016.08.002"
    "estado" => "S300"
    "fechaPublicacion" => "2017-07-01"
    "aid" => "960"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2017;13:243-4"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 543
      "formatos" => array:3 [
        "EPUB" => 41
        "HTML" => 378
        "PDF" => 124
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "The Great Unknown&#44; Whipple&#39;s Disease"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "243"
          "paginaFinal" => "244"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Enfermedad de Whipple&#44; la gran desconocida"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Fig&#46; 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1002
              "Ancho" => 950
              "Tamanyo" => 255186
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Small bowel &#40;duodenal&#41; biopsy&#46; &#40;A&#41; Intestinal villi with expansion of the lamina propria by numerous pink-colored foamy macrophages &#40;hematoxylin &#38; eosin 20&#215;&#41;&#46; Occasional &#8220;empty spaces&#8221; correspond to extracellular lipid deposits&#46; &#40;B&#41; Macrophages loaded with periodic acid Schiff &#40;PAS&#41;-diastase-positive intracytoplasmic granules &#40;20&#8211;40&#215;&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Marina Soledad Moreno Garc&#237;a, Marta Casorr&#225;n Berges, Pilar S&#46; del R&#237;o-Mart&#237;nez, Mar&#237;a Teresa Bosque Peralta"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Marina Soledad"
              "apellidos" => "Moreno Garc&#237;a"
            ]
            1 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Casorr&#225;n Berges"
            ]
            2 => array:2 [
              "nombre" => "Pilar S&#46;"
              "apellidos" => "del R&#237;o-Mart&#237;nez"
            ]
            3 => array:2 [
              "nombre" => "Mar&#237;a Teresa"
              "apellidos" => "Bosque Peralta"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X16300973"
        "doi" => "10.1016/j.reuma.2016.08.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16300973?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300655?idApp=UINPBA00004M"
    "url" => "/21735743/0000001300000004/v1_201707050008/S2173574317300655/v1_201707050008/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574317300679"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2016.09.002"
    "estado" => "S300"
    "fechaPublicacion" => "2017-07-01"
    "aid" => "972"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2017;13:240-2"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 559
      "formatos" => array:3 [
        "EPUB" => 44
        "HTML" => 371
        "PDF" => 144
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Osteoid Osteoma of the Knee Mimicking Juvenile Psoriatic Arthritis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "240"
          "paginaFinal" => "242"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Osteoma osteoide de rodilla simulando artritis psori&#225;sica juvenil"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 596
              "Ancho" => 1594
              "Tamanyo" => 73700
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Anteroposterior radiographs of both knees &#40;A&#41; and lateral view of right knee &#40;B&#41; showing sclerosis in upper third of right tibia &#40;asterisks&#41; with no apparent &#8220;nidus&#8221;&#44; and a reduction in the volume of the distal third of the quadriceps due to muscle atrophy &#40;arrows&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Alina Lucica Boteanu, Walter Alberto Sifuentes-Giraldo, Fred Ant&#243;n-Pag&#233;s, Mar&#237;a Luz G&#225;mir-G&#225;mir"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Alina Lucica"
              "apellidos" => "Boteanu"
            ]
            1 => array:2 [
              "nombre" => "Walter Alberto"
              "apellidos" => "Sifuentes-Giraldo"
            ]
            2 => array:2 [
              "nombre" => "Fred"
              "apellidos" => "Ant&#243;n-Pag&#233;s"
            ]
            3 => array:2 [
              "nombre" => "Mar&#237;a Luz"
              "apellidos" => "G&#225;mir-G&#225;mir"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X16301267"
        "doi" => "10.1016/j.reuma.2016.09.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16301267?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300679?idApp=UINPBA00004M"
    "url" => "/21735743/0000001300000004/v1_201707050008/S2173574317300679/v1_201707050008/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "A Case Report of Gaucher Disease"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "242"
        "paginaFinal" => "243"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Mar&#237;a Mar Herr&#225;ez-Albendea, Eva Gloria Fern&#225;ndez-Cofrades, Mar&#237;a Castillo Jarilla-Fern&#225;ndez, Francisco Jim&#233;nez-Burgos"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Mar&#237;a Mar"
            "apellidos" => "Herr&#225;ez-Albendea"
            "email" => array:1 [
              0 => "marherraez&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Eva Gloria"
            "apellidos" => "Fern&#225;ndez-Cofrades"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Mar&#237;a Castillo"
            "apellidos" => "Jarilla-Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Francisco"
            "apellidos" => "Jim&#233;nez-Burgos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Hematolog&#237;a&#44; Hospital de Santa B&#225;rbara&#44; Puertollano&#44; Ciudad Real&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital de Santa B&#225;rbara&#44; Puertollano&#44; Ciudad Real&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital de Santa B&#225;rbara&#44; Puertollano&#44; Ciudad Real&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Enfermedad de Gaucher&#58; a prop&#243;sito de un caso"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1309
            "Ancho" => 1738
            "Tamanyo" => 341174
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Gaucher cells&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Gaucher disease &#40;GD&#41;&#44; described in 1882 by Philippe Charles Ernest Gaucher&#44; is a progressive&#44; rare hereditary disease&#44; with an autosomal recessive inheritance pattern&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Included in the group of lysosomal storage diseases&#44; it is characterized as being the most prevalent&#44; with an estimated frequency of 1 per 50&#44;000 to 1 per 100&#44;000 population&#44; with the exception of the Ashkenazi Jewish ethnicity in which the incidence is estimated to be 1 per 850 births&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> It produces a deficiency in the activity of the enzyme acid &#946;-glucosidase &#40;GBA&#41;&#44; provoking an accumulation of glucocerebroside in the lysosomes of different cells&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> causing cytopenias&#44; hepatosplenomegaly&#44; changes in the central nervous system &#40;CNS&#41; and skeletal manifestations&#44; the latter being one of the most disabling aspects&#46; Depending on the clinical expression&#44; different types can be distinguished&#58; type 1 &#40;adult non-neuronopathic&#41;&#44; the most common form&#44; occurring frequently in Ashkenazi Jews&#44; with variable manifestations&#44; and not involving the CNS&#59; type 2 &#40;acute neuronopathic&#41;&#44; infrequent&#44; with no ethnic-related dominance&#44; fatal after birth and involvement of the CNS&#59; and type 3 &#40;subacute or chronic neuronopathic&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> beginning during childhood&#44; adolescence or adulthood&#44; with involvement of the CNS&#46; Given the variety of conditions associated with bone pain&#44; we consider it appropriate to report the case of our patient&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 53-year-old man with no significant family or personal history&#46; He was being studied because of neutropenia and thrombocytopenia with a duration of 10 years&#44; as well as bone pain that had started 3 years earlier&#46; He reported no hemorrhagic diathesis&#44; infections or abdominal pain&#46; Physical examination revealed splenomegaly&#44; but the rest was normal&#46; The results of laboratory tests included a leukocyte count of 3400<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#44; neutrophils at 1200&#47;mm<span class="elsevierStyleSup">3</span> and platelets at 93&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#59; findings regarding hemoglobin&#44; reticulocytes&#44; coagulation&#44; serum electrolytes&#44; liver function&#44; vitamin B<span class="elsevierStyleInf">12</span>&#44; folic acid&#44; tumor markers &#40;carcinoembryonic antigen&#44; alpha-fetoprotein&#44; CA 19-9&#44; CA 15-3&#44; prostate-specific antigen&#41;&#44; &#946;<span class="elsevierStyleInf">2</span>-microglobulin&#44; rheumatoid factor&#44; erythrocyte sedimentation rate&#44; antinuclear antibodies&#44; immunoglobulins&#44; protein profile and lymphocyte populations were normal&#46; Serologic tests for hepatitis B and C viruses and human immunodeficiency virus were negative&#46; Plain radiography of distal femur and thoracolumbar spine were normal&#46; However&#44; lumbar magnetic resonance showed a homogeneous hypointense signal in the vertebral bodies on T1 and T2-weighted sequences&#46; Splenomegaly was confirmed by abdominal ultrasound and osteoporosis by bone densitometry &#40;T-score femur&#58; &#8722;2&#46;9 standard deviations &#40;SD&#41;&#59; T-score spine&#58; &#8722;2&#46;8 SD&#41;&#46; Bone marrow aspirate&#47;biopsy &#40;BMA&#47;BMB&#41; detected cells with eccentric nucleus&#44; basophilic cytoplasm with the appearance of tissue paper&#44; suggestive of Gaucher cells &#40;GC&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The GBA enzyme activity was determined in leukocytes by spectrofluorometry&#44; which confirmed that it was lacking&#46; The molecular genetic study showed double heterozygosity for the L444P and p&#46;Tyr244Cys mutations&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">This observation constitutes a representative example of the clinical&#44; biochemical and genetic characteristics of type 1 GD&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> The fact that our patient had a history of years of bone pain can make diagnosis more difficult&#44; when these manifestations are associated with other signs of the disease like cytopenias or organomegaly&#46; Extra-articular manifestations are useful for reaching a correct diagnosis&#44; avoiding incorrect diagnoses of inflammatory and&#47;or autoimmune diseases&#46; The BMA confirmed GD&#44; which is accountable for an accumulation that generates substances responsible for bone resorption&#44; producing pain&#44; deformity and functional disability&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Radiographic examination reveals manifestations such as abnormal bone remodeling &#40;disclosing the Erlenmeyer flask deformity&#44; which was not found in our patient&#41;&#44; spontaneous fractures&#44; osteopenia&#44; osteonecrosis and osteolysis&#46; However&#44; the development of osteoporosis of unknown cause&#44; whether or not it is associated with thrombocytopenia and splenomegaly&#44; should lead us to suspect GD&#46; These findings were significant and enabled the quantification of GBA activity&#44; and led us to request a genetic study to confirm the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> A high index of suspicion and initial biochemical studies are needed to verify the diagnosis and begin enzyme replacement therapy to revert&#44; establish and improve the clinical prospects of the patient&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Herr&#225;ez-Albendea MM&#44; Fern&#225;ndez-Cofrades EG&#44; Jarilla-Fern&#225;ndez MC&#44; Jim&#233;nez-Burgos F&#46; Enfermedad de Gaucher&#58; a prop&#243;sito de un caso&#46; Reumatol Clin&#46; 2017&#59;13&#58;242&#8211;243&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1309
            "Ancho" => 1738
            "Tamanyo" => 341174
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Gaucher cells&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gaucher disease&#58; clinical&#44; biological and therapeutic aspects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Dandana"
                            1 => "S&#46; Ben Khelifa"
                            2 => "H&#46; Chahed"
                            3 => "A&#46; Miled"
                            4 => "S&#46; Ferchichi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000440865"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pathobiology"
                        "fecha" => "2016"
                        "volumen" => "83"
                        "paginaInicial" => "13"
                        "paginaFinal" => "23"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26588331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical manifestations and management of Gaucher disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Linari"
                            1 => "G&#46; Castaman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.11138/ccmbm/2015.12.2.157"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cases Miner Bone Metab"
                        "fecha" => "2015"
                        "volumen" => "12"
                        "paginaInicial" => "157"
                        "paginaFinal" => "164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26604942"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Objetivos terap&#233;uticos en la enfermedad de Gaucher"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Giraldo"
                            1 => "M&#46; Roca"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2011"
                        "volumen" => "137"
                        "numero" => "Supl 1"
                        "paginaInicial" => "S46"
                        "paginaFinal" => "S49"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gaucher&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Elstein"
                            1 => "A&#46; Abrahamov"
                            2 => "I&#46; Hadas-Halpem"
                            3 => "A&#46; Zimran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(01)05490-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2001"
                        "volumen" => "358"
                        "paginaInicial" => "324"
                        "paginaFinal" => "327"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11498237"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patients with type 1 Gaucher disease in Spain&#58; a cross-sectional evaluation of health status"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Giraldo"
                            1 => "J&#46; P&#233;rez-L&#243;pez"
                            2 => "R&#46; N&#250;&#241;ez"
                            3 => "R&#46;F&#46; De la Puebla"
                            4 => "E&#46; Lu&#241;o"
                            5 => "S&#46; Saura-Grau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bcmd.2015.10.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood Cells Mol Dis"
                        "fecha" => "2016"
                        "volumen" => "56"
                        "paginaInicial" => "23"
                        "paginaFinal" => "30"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26603719"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gaucher disease&#58; haematological presentations and complications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;S&#46; Thomas"
                            1 => "A&#46; Mehta"
                            2 => "D&#46;A&#46; Hughes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjh.12804"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Haematol"
                        "fecha" => "2014"
                        "volumen" => "165"
                        "paginaInicial" => "427"
                        "paginaFinal" => "440"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24588457"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001300000004/v1_201707050008/S2173574317300667/v1_201707050008/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8400"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001300000004/v1_201707050008/S2173574317300667/v1_201707050008/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300667?idApp=UINPBA00004M"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Letter to the Editor
A Case Report of Gaucher Disease
Enfermedad de Gaucher: a propósito de un caso
María Mar Herráez-Albendeaa,
Corresponding author
marherraez@gmail.com

Corresponding author.
, Eva Gloria Fernández-Cofradesb, María Castillo Jarilla-Fernándeza, Francisco Jiménez-Burgosc
a Servicio de Hematología, Hospital de Santa Bárbara, Puertollano, Ciudad Real, Spain
b Servicio de Medicina Interna, Hospital de Santa Bárbara, Puertollano, Ciudad Real, Spain
c Servicio de Anatomía Patológica, Hospital de Santa Bárbara, Puertollano, Ciudad Real, Spain
Read
8481
Times
was read the article
2312
Total PDF
6169
Total HTML
Share statistics
 array:24 [
  "pii" => "S2173574317300667"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2016.09.001"
  "estado" => "S300"
  "fechaPublicacion" => "2017-07-01"
  "aid" => "965"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2017;13:242-3"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 694
    "formatos" => array:3 [
      "EPUB" => 48
      "HTML" => 502
      "PDF" => 144
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X16301024"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2016.09.001"
      "estado" => "S300"
      "fechaPublicacion" => "2017-07-01"
      "aid" => "965"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Reumatol Clin. 2017;13:242-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 4534
        "formatos" => array:3 [
          "EPUB" => 170
          "HTML" => 3328
          "PDF" => 1036
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "Enfermedad de Gaucher&#58; a prop&#243;sito de un caso"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "242"
            "paginaFinal" => "243"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "A case report of Gaucher disease"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1309
                "Ancho" => 1738
                "Tamanyo" => 341174
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">C&#233;lulas de Gaucher&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Mar&#237;a Mar Herr&#225;ez-Albendea, Eva Gloria Fern&#225;ndez-Cofrades, Mar&#237;a Castillo Jarilla-Fern&#225;ndez, Francisco Jim&#233;nez-Burgos"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Mar&#237;a Mar"
                "apellidos" => "Herr&#225;ez-Albendea"
              ]
              1 => array:2 [
                "nombre" => "Eva Gloria"
                "apellidos" => "Fern&#225;ndez-Cofrades"
              ]
              2 => array:2 [
                "nombre" => "Mar&#237;a Castillo"
                "apellidos" => "Jarilla-Fern&#225;ndez"
              ]
              3 => array:2 [
                "nombre" => "Francisco"
                "apellidos" => "Jim&#233;nez-Burgos"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574317300667"
          "doi" => "10.1016/j.reumae.2016.09.001"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300667?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16301024?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001300000004/v1_201706290122/S1699258X16301024/v1_201706290122/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574317300655"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2016.08.002"
    "estado" => "S300"
    "fechaPublicacion" => "2017-07-01"
    "aid" => "960"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2017;13:243-4"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 543
      "formatos" => array:3 [
        "EPUB" => 41
        "HTML" => 378
        "PDF" => 124
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "The Great Unknown&#44; Whipple&#39;s Disease"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "243"
          "paginaFinal" => "244"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Enfermedad de Whipple&#44; la gran desconocida"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Fig&#46; 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1002
              "Ancho" => 950
              "Tamanyo" => 255186
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Small bowel &#40;duodenal&#41; biopsy&#46; &#40;A&#41; Intestinal villi with expansion of the lamina propria by numerous pink-colored foamy macrophages &#40;hematoxylin &#38; eosin 20&#215;&#41;&#46; Occasional &#8220;empty spaces&#8221; correspond to extracellular lipid deposits&#46; &#40;B&#41; Macrophages loaded with periodic acid Schiff &#40;PAS&#41;-diastase-positive intracytoplasmic granules &#40;20&#8211;40&#215;&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Marina Soledad Moreno Garc&#237;a, Marta Casorr&#225;n Berges, Pilar S&#46; del R&#237;o-Mart&#237;nez, Mar&#237;a Teresa Bosque Peralta"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Marina Soledad"
              "apellidos" => "Moreno Garc&#237;a"
            ]
            1 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Casorr&#225;n Berges"
            ]
            2 => array:2 [
              "nombre" => "Pilar S&#46;"
              "apellidos" => "del R&#237;o-Mart&#237;nez"
            ]
            3 => array:2 [
              "nombre" => "Mar&#237;a Teresa"
              "apellidos" => "Bosque Peralta"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X16300973"
        "doi" => "10.1016/j.reuma.2016.08.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16300973?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300655?idApp=UINPBA00004M"
    "url" => "/21735743/0000001300000004/v1_201707050008/S2173574317300655/v1_201707050008/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574317300679"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2016.09.002"
    "estado" => "S300"
    "fechaPublicacion" => "2017-07-01"
    "aid" => "972"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2017;13:240-2"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 559
      "formatos" => array:3 [
        "EPUB" => 44
        "HTML" => 371
        "PDF" => 144
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Osteoid Osteoma of the Knee Mimicking Juvenile Psoriatic Arthritis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "240"
          "paginaFinal" => "242"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Osteoma osteoide de rodilla simulando artritis psori&#225;sica juvenil"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 596
              "Ancho" => 1594
              "Tamanyo" => 73700
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Anteroposterior radiographs of both knees &#40;A&#41; and lateral view of right knee &#40;B&#41; showing sclerosis in upper third of right tibia &#40;asterisks&#41; with no apparent &#8220;nidus&#8221;&#44; and a reduction in the volume of the distal third of the quadriceps due to muscle atrophy &#40;arrows&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Alina Lucica Boteanu, Walter Alberto Sifuentes-Giraldo, Fred Ant&#243;n-Pag&#233;s, Mar&#237;a Luz G&#225;mir-G&#225;mir"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Alina Lucica"
              "apellidos" => "Boteanu"
            ]
            1 => array:2 [
              "nombre" => "Walter Alberto"
              "apellidos" => "Sifuentes-Giraldo"
            ]
            2 => array:2 [
              "nombre" => "Fred"
              "apellidos" => "Ant&#243;n-Pag&#233;s"
            ]
            3 => array:2 [
              "nombre" => "Mar&#237;a Luz"
              "apellidos" => "G&#225;mir-G&#225;mir"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X16301267"
        "doi" => "10.1016/j.reuma.2016.09.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16301267?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300679?idApp=UINPBA00004M"
    "url" => "/21735743/0000001300000004/v1_201707050008/S2173574317300679/v1_201707050008/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "A Case Report of Gaucher Disease"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "242"
        "paginaFinal" => "243"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Mar&#237;a Mar Herr&#225;ez-Albendea, Eva Gloria Fern&#225;ndez-Cofrades, Mar&#237;a Castillo Jarilla-Fern&#225;ndez, Francisco Jim&#233;nez-Burgos"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Mar&#237;a Mar"
            "apellidos" => "Herr&#225;ez-Albendea"
            "email" => array:1 [
              0 => "marherraez&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Eva Gloria"
            "apellidos" => "Fern&#225;ndez-Cofrades"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Mar&#237;a Castillo"
            "apellidos" => "Jarilla-Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Francisco"
            "apellidos" => "Jim&#233;nez-Burgos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Hematolog&#237;a&#44; Hospital de Santa B&#225;rbara&#44; Puertollano&#44; Ciudad Real&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital de Santa B&#225;rbara&#44; Puertollano&#44; Ciudad Real&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital de Santa B&#225;rbara&#44; Puertollano&#44; Ciudad Real&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Enfermedad de Gaucher&#58; a prop&#243;sito de un caso"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1309
            "Ancho" => 1738
            "Tamanyo" => 341174
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Gaucher cells&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Gaucher disease &#40;GD&#41;&#44; described in 1882 by Philippe Charles Ernest Gaucher&#44; is a progressive&#44; rare hereditary disease&#44; with an autosomal recessive inheritance pattern&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Included in the group of lysosomal storage diseases&#44; it is characterized as being the most prevalent&#44; with an estimated frequency of 1 per 50&#44;000 to 1 per 100&#44;000 population&#44; with the exception of the Ashkenazi Jewish ethnicity in which the incidence is estimated to be 1 per 850 births&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> It produces a deficiency in the activity of the enzyme acid &#946;-glucosidase &#40;GBA&#41;&#44; provoking an accumulation of glucocerebroside in the lysosomes of different cells&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> causing cytopenias&#44; hepatosplenomegaly&#44; changes in the central nervous system &#40;CNS&#41; and skeletal manifestations&#44; the latter being one of the most disabling aspects&#46; Depending on the clinical expression&#44; different types can be distinguished&#58; type 1 &#40;adult non-neuronopathic&#41;&#44; the most common form&#44; occurring frequently in Ashkenazi Jews&#44; with variable manifestations&#44; and not involving the CNS&#59; type 2 &#40;acute neuronopathic&#41;&#44; infrequent&#44; with no ethnic-related dominance&#44; fatal after birth and involvement of the CNS&#59; and type 3 &#40;subacute or chronic neuronopathic&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> beginning during childhood&#44; adolescence or adulthood&#44; with involvement of the CNS&#46; Given the variety of conditions associated with bone pain&#44; we consider it appropriate to report the case of our patient&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 53-year-old man with no significant family or personal history&#46; He was being studied because of neutropenia and thrombocytopenia with a duration of 10 years&#44; as well as bone pain that had started 3 years earlier&#46; He reported no hemorrhagic diathesis&#44; infections or abdominal pain&#46; Physical examination revealed splenomegaly&#44; but the rest was normal&#46; The results of laboratory tests included a leukocyte count of 3400<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#44; neutrophils at 1200&#47;mm<span class="elsevierStyleSup">3</span> and platelets at 93&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#59; findings regarding hemoglobin&#44; reticulocytes&#44; coagulation&#44; serum electrolytes&#44; liver function&#44; vitamin B<span class="elsevierStyleInf">12</span>&#44; folic acid&#44; tumor markers &#40;carcinoembryonic antigen&#44; alpha-fetoprotein&#44; CA 19-9&#44; CA 15-3&#44; prostate-specific antigen&#41;&#44; &#946;<span class="elsevierStyleInf">2</span>-microglobulin&#44; rheumatoid factor&#44; erythrocyte sedimentation rate&#44; antinuclear antibodies&#44; immunoglobulins&#44; protein profile and lymphocyte populations were normal&#46; Serologic tests for hepatitis B and C viruses and human immunodeficiency virus were negative&#46; Plain radiography of distal femur and thoracolumbar spine were normal&#46; However&#44; lumbar magnetic resonance showed a homogeneous hypointense signal in the vertebral bodies on T1 and T2-weighted sequences&#46; Splenomegaly was confirmed by abdominal ultrasound and osteoporosis by bone densitometry &#40;T-score femur&#58; &#8722;2&#46;9 standard deviations &#40;SD&#41;&#59; T-score spine&#58; &#8722;2&#46;8 SD&#41;&#46; Bone marrow aspirate&#47;biopsy &#40;BMA&#47;BMB&#41; detected cells with eccentric nucleus&#44; basophilic cytoplasm with the appearance of tissue paper&#44; suggestive of Gaucher cells &#40;GC&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The GBA enzyme activity was determined in leukocytes by spectrofluorometry&#44; which confirmed that it was lacking&#46; The molecular genetic study showed double heterozygosity for the L444P and p&#46;Tyr244Cys mutations&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">This observation constitutes a representative example of the clinical&#44; biochemical and genetic characteristics of type 1 GD&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> The fact that our patient had a history of years of bone pain can make diagnosis more difficult&#44; when these manifestations are associated with other signs of the disease like cytopenias or organomegaly&#46; Extra-articular manifestations are useful for reaching a correct diagnosis&#44; avoiding incorrect diagnoses of inflammatory and&#47;or autoimmune diseases&#46; The BMA confirmed GD&#44; which is accountable for an accumulation that generates substances responsible for bone resorption&#44; producing pain&#44; deformity and functional disability&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Radiographic examination reveals manifestations such as abnormal bone remodeling &#40;disclosing the Erlenmeyer flask deformity&#44; which was not found in our patient&#41;&#44; spontaneous fractures&#44; osteopenia&#44; osteonecrosis and osteolysis&#46; However&#44; the development of osteoporosis of unknown cause&#44; whether or not it is associated with thrombocytopenia and splenomegaly&#44; should lead us to suspect GD&#46; These findings were significant and enabled the quantification of GBA activity&#44; and led us to request a genetic study to confirm the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> A high index of suspicion and initial biochemical studies are needed to verify the diagnosis and begin enzyme replacement therapy to revert&#44; establish and improve the clinical prospects of the patient&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Herr&#225;ez-Albendea MM&#44; Fern&#225;ndez-Cofrades EG&#44; Jarilla-Fern&#225;ndez MC&#44; Jim&#233;nez-Burgos F&#46; Enfermedad de Gaucher&#58; a prop&#243;sito de un caso&#46; Reumatol Clin&#46; 2017&#59;13&#58;242&#8211;243&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1309
            "Ancho" => 1738
            "Tamanyo" => 341174
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Gaucher cells&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gaucher disease&#58; clinical&#44; biological and therapeutic aspects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Dandana"
                            1 => "S&#46; Ben Khelifa"
                            2 => "H&#46; Chahed"
                            3 => "A&#46; Miled"
                            4 => "S&#46; Ferchichi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000440865"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pathobiology"
                        "fecha" => "2016"
                        "volumen" => "83"
                        "paginaInicial" => "13"
                        "paginaFinal" => "23"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26588331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical manifestations and management of Gaucher disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Linari"
                            1 => "G&#46; Castaman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.11138/ccmbm/2015.12.2.157"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cases Miner Bone Metab"
                        "fecha" => "2015"
                        "volumen" => "12"
                        "paginaInicial" => "157"
                        "paginaFinal" => "164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26604942"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Objetivos terap&#233;uticos en la enfermedad de Gaucher"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Giraldo"
                            1 => "M&#46; Roca"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2011"
                        "volumen" => "137"
                        "numero" => "Supl 1"
                        "paginaInicial" => "S46"
                        "paginaFinal" => "S49"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gaucher&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Elstein"
                            1 => "A&#46; Abrahamov"
                            2 => "I&#46; Hadas-Halpem"
                            3 => "A&#46; Zimran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(01)05490-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2001"
                        "volumen" => "358"
                        "paginaInicial" => "324"
                        "paginaFinal" => "327"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11498237"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patients with type 1 Gaucher disease in Spain&#58; a cross-sectional evaluation of health status"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Giraldo"
                            1 => "J&#46; P&#233;rez-L&#243;pez"
                            2 => "R&#46; N&#250;&#241;ez"
                            3 => "R&#46;F&#46; De la Puebla"
                            4 => "E&#46; Lu&#241;o"
                            5 => "S&#46; Saura-Grau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bcmd.2015.10.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood Cells Mol Dis"
                        "fecha" => "2016"
                        "volumen" => "56"
                        "paginaInicial" => "23"
                        "paginaFinal" => "30"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26603719"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gaucher disease&#58; haematological presentations and complications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;S&#46; Thomas"
                            1 => "A&#46; Mehta"
                            2 => "D&#46;A&#46; Hughes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjh.12804"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Haematol"
                        "fecha" => "2014"
                        "volumen" => "165"
                        "paginaInicial" => "427"
                        "paginaFinal" => "440"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24588457"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001300000004/v1_201707050008/S2173574317300667/v1_201707050008/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8400"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001300000004/v1_201707050008/S2173574317300667/v1_201707050008/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300667?idApp=UINPBA00004M"
]
Article information
ISSN: 21735743
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 20 17 37
2024 October 119 45 164
2024 September 127 47 174
2024 August 121 39 160
2024 July 107 30 137
2024 June 103 43 146
2024 May 148 50 198
2024 April 126 33 159
2024 March 95 39 134
2024 February 113 33 146
2024 January 82 39 121
2023 December 96 28 124
2023 November 102 53 155
2023 October 107 31 138
2023 September 88 37 125
2023 August 92 12 104
2023 July 89 39 128
2023 June 84 31 115
2023 May 85 26 111
2023 April 69 15 84
2023 March 110 36 146
2023 February 72 39 111
2023 January 86 21 107
2022 December 91 35 126
2022 November 112 31 143
2022 October 96 26 122
2022 September 68 37 105
2022 August 98 40 138
2022 July 90 38 128
2022 June 166 40 206
2022 May 98 39 137
2022 April 111 53 164
2022 March 95 63 158
2022 February 97 35 132
2022 January 110 54 164
2021 December 93 42 135
2021 November 99 59 158
2021 October 277 80 357
2021 September 222 47 269
2021 August 72 59 131
2021 July 83 50 133
2021 June 118 25 143
2021 May 95 55 150
2021 April 177 120 297
2021 March 132 43 175
2021 February 111 33 144
2021 January 115 15 130
2020 December 102 33 135
2020 November 108 53 161
2020 October 57 22 79
2020 September 101 41 142
2020 August 55 19 74
2020 July 32 18 50
2020 June 52 29 81
2020 May 36 25 61
2020 April 44 23 67
2020 March 12 3 15
2020 February 2 0 2
2019 May 1 0 1
2018 May 4 3 7
2018 April 64 7 71
2018 March 102 7 109
2018 February 45 6 51
2018 January 56 6 62
2017 December 36 12 48
2017 November 28 15 43
2017 October 35 11 46
2017 September 36 10 46
2017 August 46 21 67
2017 July 43 38 81
2017 June 5 8 13
Show all

Follow this link to access the full text of the article

Idiomas
Reumatología Clínica (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?