array:23 [
  "pii" => "S2173574317300965"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2016.10.004"
  "estado" => "S300"
  "fechaPublicacion" => "2017-09-01"
  "aid" => "984"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2017;13:307-9"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 688
    "formatos" => array:3 [
      "EPUB" => 50
      "HTML" => 506
      "PDF" => 132
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X1630153X"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2016.10.009"
      "estado" => "S300"
      "fechaPublicacion" => "2017-09-01"
      "aid" => "984"
      "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Reumatol Clin. 2017;13:307-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 3137
        "formatos" => array:3 [
          "EPUB" => 200
          "HTML" => 2044
          "PDF" => 893
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "Osteosarcoma en gota tof&#225;cea&#58; descripci&#243;n de un caso cl&#237;nico y revisi&#243;n de la literatura"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "307"
            "paginaFinal" => "309"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Osteosarcoma in tophaceous gout&#58; A case report and literature review"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2805
                "Ancho" => 2500
                "Tamanyo" => 867759
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Osteosarcoma en dorso de pie derecho&#44; en paciente con gota tof&#225;cea&#46; A&#41; Descripci&#243;n macrosc&#243;pica&#58; placa de aspecto tumoral eritemato-viol&#225;cea infiltrada de 6<span class="elsevierStyleHsp" style=""></span>cm de di&#225;metro m&#225;ximo&#44; compuesta de n&#243;dulos tumorales duros&#44; de consistencia &#243;sea&#44; petrificados&#44; y en superficie lesiones tumorales excrecentes y de base ligeramente pediculada de unos 3<span class="elsevierStyleHsp" style=""></span>cm de di&#225;metro&#46; B&#41; Descripci&#243;n microsc&#243;pica &#40;hematoxilina eosina &#91;HE&#93;&#59; de izquierda a derecha y de arriba a abajo&#58; B1&#58; H&#38;E &#215;2&#59; B2&#58; H&#38;E &#215;4&#59; B3&#58; H&#38;E &#215;10&#59; B4&#58; H&#38;E &#215;20&#41;&#46; Osteosarcoma de alto grado&#44; de tipo telangiect&#225;sico&#44; con abundante formaci&#243;n de osteoide y espacios llenos de sangre sin revestimiento epitelial&#46; A gran aumento se observan c&#233;lulas de talla grande&#44; con n&#250;cleos irregulares y pleom&#243;rficos&#44; reconoci&#233;ndose numerosas mitosis&#44; muchas de ellas at&#237;picas&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Enrique Calvo Aranda, Irene Rodr&#237;guez P&#233;rez, Jes&#250;s Rodr&#237;guez-Pascual, Paloma Garc&#237;a de la Pe&#241;a Lefebvre"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Enrique"
                "apellidos" => "Calvo Aranda"
              ]
              1 => array:2 [
                "nombre" => "Irene"
                "apellidos" => "Rodr&#237;guez P&#233;rez"
              ]
              2 => array:2 [
                "nombre" => "Jes&#250;s"
                "apellidos" => "Rodr&#237;guez-Pascual"
              ]
              3 => array:2 [
                "nombre" => "Paloma"
                "apellidos" => "Garc&#237;a de la Pe&#241;a Lefebvre"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574317300965"
          "doi" => "10.1016/j.reumae.2016.10.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300965?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X1630153X?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001300000005/v1_201708130010/S1699258X1630153X/v1_201708130010/es/main.assets"
    ]
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574317300941"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2016.11.002"
    "estado" => "S300"
    "fechaPublicacion" => "2017-09-01"
    "aid" => "985"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2017;13:306-7"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 769
      "formatos" => array:3 [
        "EPUB" => 42
        "HTML" => 600
        "PDF" => 127
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Vocal cord palsy as a clinical manifestation of Beh&#231;et&#39;s disease"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "306"
          "paginaFinal" => "307"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Par&#225;lisis de cuerda vocal como manifestaci&#243;n cl&#237;nica de enfermedad de Beh&#231;et"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 800
              "Ancho" => 1600
              "Tamanyo" => 113645
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">On the left side&#44; a cross-sectional slice of a cervical CT showing the paramedial position of the left vocal cord &#40;arrow&#41;&#46; On the right side&#44; an axial slice showing the same position of the vocal cord &#40;arrow&#41;&#44; findings compatible with paralysis&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Elvis Amao-Ruiz, Ana Mar&#237;a Correa-Fern&#225;ndez, Jes&#250;s Gallego-Gil"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Elvis"
              "apellidos" => "Amao-Ruiz"
            ]
            1 => array:2 [
              "nombre" => "Ana Mar&#237;a"
              "apellidos" => "Correa-Fern&#225;ndez"
            ]
            2 => array:2 [
              "nombre" => "Jes&#250;s"
              "apellidos" => "Gallego-Gil"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X16301541"
        "doi" => "10.1016/j.reuma.2016.11.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16301541?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300941?idApp=UINPBA00004M"
    "url" => "/21735743/0000001300000005/v1_201708230012/S2173574317300941/v1_201708230012/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Osteosarcoma in Tophaceous Gout&#58; A Case Report and Literature Review"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "307"
        "paginaFinal" => "309"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Enrique Calvo Aranda, Irene Rodr&#237;guez P&#233;rez, Jes&#250;s Rodr&#237;guez-Pascual, Paloma Garc&#237;a de la Pe&#241;a Lefebvre"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Enrique"
            "apellidos" => "Calvo Aranda"
            "email" => array:1 [
              0 => "ecalvoa&#64;hotmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Irene"
            "apellidos" => "Rodr&#237;guez P&#233;rez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Jes&#250;s"
            "apellidos" => "Rodr&#237;guez-Pascual"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Paloma"
            "apellidos" => "Garc&#237;a de la Pe&#241;a Lefebvre"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Reumatolog&#237;a&#44; HM Hospitales&#44; Hospital Universitario HM Sanchinarro&#44; Madrid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; HM Hospitales&#44; Hospital Universitario HM Sanchinarro&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Oncolog&#237;a M&#233;dica&#44; HM Hospitales&#44; Hospital Universitario HM Sanchinarro&#44; Madrid&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Osteosarcoma en gota tof&#225;cea&#58; descripci&#243;n de un caso cl&#237;nico y revisi&#243;n de la literatura"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2808
            "Ancho" => 2502
            "Tamanyo" => 836089
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">High-grade osteosarcoma on the dorsum of right foot in a patient with tophaceous gout&#46; &#40;A&#41; Macroscopic description&#58; tumor-like infiltrated erythematous violaceous plaque measuring 6<span class="elsevierStyleHsp" style=""></span>cm in maximum diameter&#44; composed of hard tumor nodules&#44; with the consistency of bone and petrified&#46; The surface consisted of excrescent tumor lesions that were slightly pedicled measuring about 3<span class="elsevierStyleHsp" style=""></span>cm in diameter&#46; &#40;B&#41; Microscopic description &#40;hematoxylin and eosin &#91;H&#38;E&#93;&#59; from upper left to right and lower left to right&#58; B1&#58; H&#38;E 2&#215;&#59; B2&#58; H&#38;E 4&#215;&#59; B3&#58; H&#38;E 10&#215;&#59; B4&#58; H&#38;E 20&#215;&#41;&#46; Telangiectatic osteosarcoma&#44; with abundant osteoid formation and blood-filled spaces and no epithelial lining&#46; At high magnification&#44; it is possible to observe large cells with irregular and pleomorphic nuclei&#44; and numerous mitoses&#44; many atypical&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Gout is a disease that involves the deposit of monosodium urate &#40;MSU&#41; crystals&#44; which mostly affects men&#44; and constitutes the most common cause of arthritis in that gender&#46; On occasion&#44; it can lead to accumulations of crystals of variable size and location referred to as tophi&#46; Considered to be a &#8220;mimicking&#8221; disease&#44; gout can simulate&#44; among others&#44; infectious or neoplastic processes&#46; We report the case of a patient with gout who developed an osteosarcoma arising at the site of a preexisting tophus&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 65-year-old man with tophaceous gout who had been followed at another center and was referred to us by way of the medical oncology department for the management an acute attack of polyarthralgia and olecranon bursitis after a transfusion while undergoing chemotherapy&#46; He had been diagnosed a year earlier with osteosarcoma on the dorsum of his foot arising at the location of a tophus that had been removed 7 months before&#44; after pathological confirmation &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; and negative findings in the study of the extension&#46; It required infracondylar amputation and preoperative and postoperative chemotherapy with cisplatin and adriamycin&#46; He had been taking allopurinol for 3 years &#40;up to 300<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41;&#44; and employed colchicine and&#47;or nonsteroidal anti-inflammatory drugs during attacks&#46; He had levels of uric acid in blood of up to 8<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; and began to have symptoms at the age of 40 years with podagra&#44; and later developed tophi in the olecranon bursa and the dorsum of his foot&#46; The inflammatory attack was resolved with low-dose prednisone and aspiration of the olecranon bursa&#46; Gram staining and culture of the fluid obtained were negative&#44; and a study with polarized light microscopy revealed the presence of MSU crystals&#46; He was discharged and began colchicine at 1<span class="elsevierStyleHsp" style=""></span>mg&#47;day after gradual interruption of prednisone therapy&#46; During follow-up&#44; he changed from allopurinol to febuxostat &#40;at a dose of 80<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41;&#44; which achieved optimization of his uric acid level in blood and progressive dissolution of the olecranon tophi&#46; Several months later&#44; colchicine was discontinued and he continued to take febuxostat at the same dose&#46; He has not had any further attacks and maintains his level of uric acid at 5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46; In May of 2016&#44; he developed an &#8220;in-transit&#8221; recurrence of the neoplastic disease&#44; with a superficial mass in ipsilateral thigh that required local resection and chemotherapy &#40;ifosfamide&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Gout is the most common cause of arthritis in men&#44; and is originated by deposits of MSU crystals in tissues&#46; Some patients develop tophi &#40;subcutaneous&#44; periarticular or intraarticular crystal accumulations&#41; which can have a marked inflammatory activity and present calcifications or ossifications as they increase in size&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;3</span></a> Moreover&#44; tophi can mimic infectious or neoplastic processes and become superinfected or undergo malignant transformation&#44; having an adverse effect on the prognosis of the patient&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A number of publications have reported tumors that arise at the sites of tophi&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#8211;9</span></a> All occurred in extremities of middle-aged or elderly men and involved recurrences or metastasis&#46; There are descriptions of benign neoplasms such as giant cell tumors or malignant diseases such as different sarcomas &#40;undifferentiated pleomorphic sarcoma&#44; cutaneous angiosarcoma or fibrosarcoma&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The authors of these articles provide interesting hypotheses such as the role of prolonged hyperuricemia and the severity of the MSU deposit as factors leading to secondary cell transformation toward inflammation&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> or the theory of sarcoma associated with a foreign body&#44; similar to those originated by other materials&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Sarcomas are mesenchymal tumors originating from connective tissue &#40;fibrosarcoma&#41;&#44; cartilage &#40;chondrosarcoma&#41;&#44; bone &#40;osteosarcoma&#41;&#44; endothelium &#40;angiosarcoma&#41;&#44; etc&#46; Although there may be a certain underestimation of the incidence of these neoplasms in gout&#44; sarcomas seem to be uncommon&#44; but occasionally are aggressive&#46; Thus&#44; they should be included in the differential diagnosis in the case of a subcutaneous or periarticular mass in a patient with gout or with the atypical complication of a preexisting tophus&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Calvo Aranda E&#44; Rodr&#237;guez P&#233;rez I&#44; Rodr&#237;guez-Pascual J&#44; Garc&#237;a de la Pe&#241;a Lefebvre P&#46; Osteosarcoma en gota tof&#225;cea&#58; descripci&#243;n de un caso cl&#237;nico y revisi&#243;n de la literatura&#46; Reumatol Clin&#46; 2017&#59;13&#58;307&#8211;309&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2808
            "Ancho" => 2502
            "Tamanyo" => 836089
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">High-grade osteosarcoma on the dorsum of right foot in a patient with tophaceous gout&#46; &#40;A&#41; Macroscopic description&#58; tumor-like infiltrated erythematous violaceous plaque measuring 6<span class="elsevierStyleHsp" style=""></span>cm in maximum diameter&#44; composed of hard tumor nodules&#44; with the consistency of bone and petrified&#46; The surface consisted of excrescent tumor lesions that were slightly pedicled measuring about 3<span class="elsevierStyleHsp" style=""></span>cm in diameter&#46; &#40;B&#41; Microscopic description &#40;hematoxylin and eosin &#91;H&#38;E&#93;&#59; from upper left to right and lower left to right&#58; B1&#58; H&#38;E 2&#215;&#59; B2&#58; H&#38;E 4&#215;&#59; B3&#58; H&#38;E 10&#215;&#59; B4&#58; H&#38;E 20&#215;&#41;&#46; Telangiectatic osteosarcoma&#44; with abundant osteoid formation and blood-filled spaces and no epithelial lining&#46; At high magnification&#44; it is possible to observe large cells with irregular and pleomorphic nuclei&#44; and numerous mitoses&#44; many atypical&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of the measurement of tophi with magnetic resonance imaging as an outcome measure for chronic gout"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46; P&#233;rez-Ruiz"
                            1 => "A&#46; Urresola"
                            2 => "D&#46; Gorostiza"
                            3 => "B&#46; Canteli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2011"
                        "volumen" => "63"
                        "numero" => "Suppl&#46; 10"
                        "paginaInicial" => "S208"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "MR imaging of tophaceous gout"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;S&#46; Yu"
                            1 => "C&#46; Chung"
                            2 => "M&#46; Recht"
                            3 => "T&#46; Dailiana"
                            4 => "R&#46; Jurdi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2214/ajr.168.2.9016240"
                      "Revista" => array:6 [
                        "tituloSerie" => "AJR Am J Roentgenol"
                        "fecha" => "1997"
                        "volumen" => "168"
                        "paginaInicial" => "523"
                        "paginaFinal" => "527"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9016240"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Magnetic resonance imaging of tophaceous gout in the hands and wrists"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;D&#46; Popp"
                            1 => "W&#46;D&#46; Bidgood Jr&#46;"
                            2 => "N&#46;L&#46; Edwards"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "1996"
                        "volumen" => "25"
                        "paginaInicial" => "282"
                        "paginaFinal" => "289"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8834016"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibrohistiocitoma maligno &#40;sarcoma pleom&#243;rfico indiferenciado de alto grado&#41; sobre tofo gotoso"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; P&#233;rez-Mies"
                            1 => "A&#46; Ruiz de la Parte"
                            2 => "C&#46; Echevarr&#237;a Iturbe"
                            3 => "I&#46; Garc&#237;a Higuera"
                            4 => "A&#46; Velasco Os&#233;s"
                            5 => "P&#46; Ter&#225;n Saavedra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Esp Patol"
                        "fecha" => "2006"
                        "volumen" => "39"
                        "paginaInicial" => "113"
                        "paginaFinal" => "116"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant fibrous histiocytoma arising in a gouty tophus at the second metacarpophalangeal joint"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Carnero"
                            1 => "P&#46; Ter&#225;n"
                            2 => "E&#46; Trillo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bjps.2005.12.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Plast Reconstr Aesthet Surg"
                        "fecha" => "2006"
                        "volumen" => "59"
                        "paginaInicial" => "775"
                        "paginaFinal" => "778"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16782578"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Undifferentiated high grade pleomorphic sarcoma&#47;malignant fibrous histiocytoma associated a gouty tophus&#46; A case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Szlabi"
                            1 => "J&#46;O&#46; Flores"
                            2 => "A&#46;L&#46; Diller"
                            3 => "M&#46; Cabrera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Fac Cien Med Univ Nac Cordoba"
                        "fecha" => "2012"
                        "volumen" => "69"
                        "paginaInicial" => "224"
                        "paginaFinal" => "227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23751790"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1134282X09000694"
                          "estado" => "S300"
                          "issn" => "1134282X"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous angiosarcoma arising in a gouty tophus&#58; report of a unique case and a review of foreign material-associated angiosarcomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;L&#46; Folpe"
                            1 => "C&#46;A&#46; Johnston"
                            2 => "S&#46;W&#46; Weiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "2000"
                        "volumen" => "22"
                        "paginaInicial" => "418"
                        "paginaFinal" => "421"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11048977"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Associated giant cell tumor and tophaceous deposits in a finger pulp&#58; a case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46;A&#46; Schuind"
                            1 => "B&#46; Stallenberg"
                            2 => "M&#46; Remmelink"
                            3 => "J&#46;L&#46; Pasteels"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hand Surg Am"
                        "fecha" => "2003"
                        "volumen" => "28"
                        "paginaInicial" => "871"
                        "paginaFinal" => "874"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14507521"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibrosarcoma arising from gouty tophi&#58; report of a unique case and review of literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;J&#46; Wang"
                            1 => "H&#46;Y&#46; Wang"
                            2 => "K&#46; Cheng"
                            3 => "X&#46; Wang"
                            4 => "B&#46; Yu"
                            5 => "S&#46;S&#46; Shi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Clin Exp Pathol"
                        "fecha" => "2015"
                        "volumen" => "8"
                        "paginaInicial" => "4227"
                        "paginaFinal" => "4232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26097616"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new complication of retained surgical gauze&#58; development of malignant fibrous histiocytoma-report of a case with a literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Kaplan"
                            1 => "H&#46;&#304;&#46; &#304;yik&#246;&#351;ker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1477-7819-10-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "World J Surg Oncol"
                        "fecha" => "2012"
                        "volumen" => "10"
                        "paginaInicial" => "1"
                        "paginaFinal" => "5"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22214417"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack295643"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0035" class="elsevierStylePara elsevierViewall">To the Pathology and Medical Oncology Departments of Grupo HM Hospitales&#44; Madrid&#44; Spain&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001300000005/v1_201708230012/S2173574317300965/v1_201708230012/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8400"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001300000005/v1_201708230012/S2173574317300965/v1_201708230012/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300965?idApp=UINPBA00004M"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Letter to the Editor
Osteosarcoma in Tophaceous Gout: A Case Report and Literature Review
Osteosarcoma en gota tofácea: descripción de un caso clínico y revisión de la literatura
Enrique Calvo Arandaa,
Corresponding author
ecalvoa@hotmail.com

Corresponding author.
, Irene Rodríguez Pérezb, Jesús Rodríguez-Pascualc, Paloma García de la Peña Lefebvrea
a Servicio de Reumatología, HM Hospitales, Hospital Universitario HM Sanchinarro, Madrid, Spain
b Servicio de Anatomía Patológica, HM Hospitales, Hospital Universitario HM Sanchinarro, Madrid, Spain
c Servicio de Oncología Médica, HM Hospitales, Hospital Universitario HM Sanchinarro, Madrid, Spain
Read
6322
Times
was read the article
1884
Total PDF
4438
Total HTML
Share statistics
 array:23 [
  "pii" => "S2173574317300965"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2016.10.004"
  "estado" => "S300"
  "fechaPublicacion" => "2017-09-01"
  "aid" => "984"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2017;13:307-9"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 688
    "formatos" => array:3 [
      "EPUB" => 50
      "HTML" => 506
      "PDF" => 132
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X1630153X"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2016.10.009"
      "estado" => "S300"
      "fechaPublicacion" => "2017-09-01"
      "aid" => "984"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Reumatol Clin. 2017;13:307-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 3137
        "formatos" => array:3 [
          "EPUB" => 200
          "HTML" => 2044
          "PDF" => 893
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "Osteosarcoma en gota tof&#225;cea&#58; descripci&#243;n de un caso cl&#237;nico y revisi&#243;n de la literatura"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "307"
            "paginaFinal" => "309"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Osteosarcoma in tophaceous gout&#58; A case report and literature review"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2805
                "Ancho" => 2500
                "Tamanyo" => 867759
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Osteosarcoma en dorso de pie derecho&#44; en paciente con gota tof&#225;cea&#46; A&#41; Descripci&#243;n macrosc&#243;pica&#58; placa de aspecto tumoral eritemato-viol&#225;cea infiltrada de 6<span class="elsevierStyleHsp" style=""></span>cm de di&#225;metro m&#225;ximo&#44; compuesta de n&#243;dulos tumorales duros&#44; de consistencia &#243;sea&#44; petrificados&#44; y en superficie lesiones tumorales excrecentes y de base ligeramente pediculada de unos 3<span class="elsevierStyleHsp" style=""></span>cm de di&#225;metro&#46; B&#41; Descripci&#243;n microsc&#243;pica &#40;hematoxilina eosina &#91;HE&#93;&#59; de izquierda a derecha y de arriba a abajo&#58; B1&#58; H&#38;E &#215;2&#59; B2&#58; H&#38;E &#215;4&#59; B3&#58; H&#38;E &#215;10&#59; B4&#58; H&#38;E &#215;20&#41;&#46; Osteosarcoma de alto grado&#44; de tipo telangiect&#225;sico&#44; con abundante formaci&#243;n de osteoide y espacios llenos de sangre sin revestimiento epitelial&#46; A gran aumento se observan c&#233;lulas de talla grande&#44; con n&#250;cleos irregulares y pleom&#243;rficos&#44; reconoci&#233;ndose numerosas mitosis&#44; muchas de ellas at&#237;picas&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Enrique Calvo Aranda, Irene Rodr&#237;guez P&#233;rez, Jes&#250;s Rodr&#237;guez-Pascual, Paloma Garc&#237;a de la Pe&#241;a Lefebvre"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Enrique"
                "apellidos" => "Calvo Aranda"
              ]
              1 => array:2 [
                "nombre" => "Irene"
                "apellidos" => "Rodr&#237;guez P&#233;rez"
              ]
              2 => array:2 [
                "nombre" => "Jes&#250;s"
                "apellidos" => "Rodr&#237;guez-Pascual"
              ]
              3 => array:2 [
                "nombre" => "Paloma"
                "apellidos" => "Garc&#237;a de la Pe&#241;a Lefebvre"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574317300965"
          "doi" => "10.1016/j.reumae.2016.10.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300965?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X1630153X?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001300000005/v1_201708130010/S1699258X1630153X/v1_201708130010/es/main.assets"
    ]
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574317300941"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2016.11.002"
    "estado" => "S300"
    "fechaPublicacion" => "2017-09-01"
    "aid" => "985"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2017;13:306-7"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 769
      "formatos" => array:3 [
        "EPUB" => 42
        "HTML" => 600
        "PDF" => 127
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Vocal cord palsy as a clinical manifestation of Beh&#231;et&#39;s disease"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "306"
          "paginaFinal" => "307"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Par&#225;lisis de cuerda vocal como manifestaci&#243;n cl&#237;nica de enfermedad de Beh&#231;et"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 800
              "Ancho" => 1600
              "Tamanyo" => 113645
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">On the left side&#44; a cross-sectional slice of a cervical CT showing the paramedial position of the left vocal cord &#40;arrow&#41;&#46; On the right side&#44; an axial slice showing the same position of the vocal cord &#40;arrow&#41;&#44; findings compatible with paralysis&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Elvis Amao-Ruiz, Ana Mar&#237;a Correa-Fern&#225;ndez, Jes&#250;s Gallego-Gil"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Elvis"
              "apellidos" => "Amao-Ruiz"
            ]
            1 => array:2 [
              "nombre" => "Ana Mar&#237;a"
              "apellidos" => "Correa-Fern&#225;ndez"
            ]
            2 => array:2 [
              "nombre" => "Jes&#250;s"
              "apellidos" => "Gallego-Gil"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X16301541"
        "doi" => "10.1016/j.reuma.2016.11.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16301541?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300941?idApp=UINPBA00004M"
    "url" => "/21735743/0000001300000005/v1_201708230012/S2173574317300941/v1_201708230012/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Osteosarcoma in Tophaceous Gout&#58; A Case Report and Literature Review"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "307"
        "paginaFinal" => "309"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Enrique Calvo Aranda, Irene Rodr&#237;guez P&#233;rez, Jes&#250;s Rodr&#237;guez-Pascual, Paloma Garc&#237;a de la Pe&#241;a Lefebvre"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Enrique"
            "apellidos" => "Calvo Aranda"
            "email" => array:1 [
              0 => "ecalvoa&#64;hotmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Irene"
            "apellidos" => "Rodr&#237;guez P&#233;rez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Jes&#250;s"
            "apellidos" => "Rodr&#237;guez-Pascual"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Paloma"
            "apellidos" => "Garc&#237;a de la Pe&#241;a Lefebvre"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Reumatolog&#237;a&#44; HM Hospitales&#44; Hospital Universitario HM Sanchinarro&#44; Madrid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; HM Hospitales&#44; Hospital Universitario HM Sanchinarro&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Oncolog&#237;a M&#233;dica&#44; HM Hospitales&#44; Hospital Universitario HM Sanchinarro&#44; Madrid&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Osteosarcoma en gota tof&#225;cea&#58; descripci&#243;n de un caso cl&#237;nico y revisi&#243;n de la literatura"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2808
            "Ancho" => 2502
            "Tamanyo" => 836089
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">High-grade osteosarcoma on the dorsum of right foot in a patient with tophaceous gout&#46; &#40;A&#41; Macroscopic description&#58; tumor-like infiltrated erythematous violaceous plaque measuring 6<span class="elsevierStyleHsp" style=""></span>cm in maximum diameter&#44; composed of hard tumor nodules&#44; with the consistency of bone and petrified&#46; The surface consisted of excrescent tumor lesions that were slightly pedicled measuring about 3<span class="elsevierStyleHsp" style=""></span>cm in diameter&#46; &#40;B&#41; Microscopic description &#40;hematoxylin and eosin &#91;H&#38;E&#93;&#59; from upper left to right and lower left to right&#58; B1&#58; H&#38;E 2&#215;&#59; B2&#58; H&#38;E 4&#215;&#59; B3&#58; H&#38;E 10&#215;&#59; B4&#58; H&#38;E 20&#215;&#41;&#46; Telangiectatic osteosarcoma&#44; with abundant osteoid formation and blood-filled spaces and no epithelial lining&#46; At high magnification&#44; it is possible to observe large cells with irregular and pleomorphic nuclei&#44; and numerous mitoses&#44; many atypical&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Gout is a disease that involves the deposit of monosodium urate &#40;MSU&#41; crystals&#44; which mostly affects men&#44; and constitutes the most common cause of arthritis in that gender&#46; On occasion&#44; it can lead to accumulations of crystals of variable size and location referred to as tophi&#46; Considered to be a &#8220;mimicking&#8221; disease&#44; gout can simulate&#44; among others&#44; infectious or neoplastic processes&#46; We report the case of a patient with gout who developed an osteosarcoma arising at the site of a preexisting tophus&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 65-year-old man with tophaceous gout who had been followed at another center and was referred to us by way of the medical oncology department for the management an acute attack of polyarthralgia and olecranon bursitis after a transfusion while undergoing chemotherapy&#46; He had been diagnosed a year earlier with osteosarcoma on the dorsum of his foot arising at the location of a tophus that had been removed 7 months before&#44; after pathological confirmation &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; and negative findings in the study of the extension&#46; It required infracondylar amputation and preoperative and postoperative chemotherapy with cisplatin and adriamycin&#46; He had been taking allopurinol for 3 years &#40;up to 300<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41;&#44; and employed colchicine and&#47;or nonsteroidal anti-inflammatory drugs during attacks&#46; He had levels of uric acid in blood of up to 8<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; and began to have symptoms at the age of 40 years with podagra&#44; and later developed tophi in the olecranon bursa and the dorsum of his foot&#46; The inflammatory attack was resolved with low-dose prednisone and aspiration of the olecranon bursa&#46; Gram staining and culture of the fluid obtained were negative&#44; and a study with polarized light microscopy revealed the presence of MSU crystals&#46; He was discharged and began colchicine at 1<span class="elsevierStyleHsp" style=""></span>mg&#47;day after gradual interruption of prednisone therapy&#46; During follow-up&#44; he changed from allopurinol to febuxostat &#40;at a dose of 80<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41;&#44; which achieved optimization of his uric acid level in blood and progressive dissolution of the olecranon tophi&#46; Several months later&#44; colchicine was discontinued and he continued to take febuxostat at the same dose&#46; He has not had any further attacks and maintains his level of uric acid at 5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46; In May of 2016&#44; he developed an &#8220;in-transit&#8221; recurrence of the neoplastic disease&#44; with a superficial mass in ipsilateral thigh that required local resection and chemotherapy &#40;ifosfamide&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Gout is the most common cause of arthritis in men&#44; and is originated by deposits of MSU crystals in tissues&#46; Some patients develop tophi &#40;subcutaneous&#44; periarticular or intraarticular crystal accumulations&#41; which can have a marked inflammatory activity and present calcifications or ossifications as they increase in size&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;3</span></a> Moreover&#44; tophi can mimic infectious or neoplastic processes and become superinfected or undergo malignant transformation&#44; having an adverse effect on the prognosis of the patient&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A number of publications have reported tumors that arise at the sites of tophi&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#8211;9</span></a> All occurred in extremities of middle-aged or elderly men and involved recurrences or metastasis&#46; There are descriptions of benign neoplasms such as giant cell tumors or malignant diseases such as different sarcomas &#40;undifferentiated pleomorphic sarcoma&#44; cutaneous angiosarcoma or fibrosarcoma&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The authors of these articles provide interesting hypotheses such as the role of prolonged hyperuricemia and the severity of the MSU deposit as factors leading to secondary cell transformation toward inflammation&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> or the theory of sarcoma associated with a foreign body&#44; similar to those originated by other materials&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Sarcomas are mesenchymal tumors originating from connective tissue &#40;fibrosarcoma&#41;&#44; cartilage &#40;chondrosarcoma&#41;&#44; bone &#40;osteosarcoma&#41;&#44; endothelium &#40;angiosarcoma&#41;&#44; etc&#46; Although there may be a certain underestimation of the incidence of these neoplasms in gout&#44; sarcomas seem to be uncommon&#44; but occasionally are aggressive&#46; Thus&#44; they should be included in the differential diagnosis in the case of a subcutaneous or periarticular mass in a patient with gout or with the atypical complication of a preexisting tophus&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Calvo Aranda E&#44; Rodr&#237;guez P&#233;rez I&#44; Rodr&#237;guez-Pascual J&#44; Garc&#237;a de la Pe&#241;a Lefebvre P&#46; Osteosarcoma en gota tof&#225;cea&#58; descripci&#243;n de un caso cl&#237;nico y revisi&#243;n de la literatura&#46; Reumatol Clin&#46; 2017&#59;13&#58;307&#8211;309&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2808
            "Ancho" => 2502
            "Tamanyo" => 836089
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">High-grade osteosarcoma on the dorsum of right foot in a patient with tophaceous gout&#46; &#40;A&#41; Macroscopic description&#58; tumor-like infiltrated erythematous violaceous plaque measuring 6<span class="elsevierStyleHsp" style=""></span>cm in maximum diameter&#44; composed of hard tumor nodules&#44; with the consistency of bone and petrified&#46; The surface consisted of excrescent tumor lesions that were slightly pedicled measuring about 3<span class="elsevierStyleHsp" style=""></span>cm in diameter&#46; &#40;B&#41; Microscopic description &#40;hematoxylin and eosin &#91;H&#38;E&#93;&#59; from upper left to right and lower left to right&#58; B1&#58; H&#38;E 2&#215;&#59; B2&#58; H&#38;E 4&#215;&#59; B3&#58; H&#38;E 10&#215;&#59; B4&#58; H&#38;E 20&#215;&#41;&#46; Telangiectatic osteosarcoma&#44; with abundant osteoid formation and blood-filled spaces and no epithelial lining&#46; At high magnification&#44; it is possible to observe large cells with irregular and pleomorphic nuclei&#44; and numerous mitoses&#44; many atypical&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of the measurement of tophi with magnetic resonance imaging as an outcome measure for chronic gout"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46; P&#233;rez-Ruiz"
                            1 => "A&#46; Urresola"
                            2 => "D&#46; Gorostiza"
                            3 => "B&#46; Canteli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2011"
                        "volumen" => "63"
                        "numero" => "Suppl&#46; 10"
                        "paginaInicial" => "S208"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "MR imaging of tophaceous gout"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;S&#46; Yu"
                            1 => "C&#46; Chung"
                            2 => "M&#46; Recht"
                            3 => "T&#46; Dailiana"
                            4 => "R&#46; Jurdi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2214/ajr.168.2.9016240"
                      "Revista" => array:6 [
                        "tituloSerie" => "AJR Am J Roentgenol"
                        "fecha" => "1997"
                        "volumen" => "168"
                        "paginaInicial" => "523"
                        "paginaFinal" => "527"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9016240"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Magnetic resonance imaging of tophaceous gout in the hands and wrists"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;D&#46; Popp"
                            1 => "W&#46;D&#46; Bidgood Jr&#46;"
                            2 => "N&#46;L&#46; Edwards"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "1996"
                        "volumen" => "25"
                        "paginaInicial" => "282"
                        "paginaFinal" => "289"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8834016"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibrohistiocitoma maligno &#40;sarcoma pleom&#243;rfico indiferenciado de alto grado&#41; sobre tofo gotoso"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; P&#233;rez-Mies"
                            1 => "A&#46; Ruiz de la Parte"
                            2 => "C&#46; Echevarr&#237;a Iturbe"
                            3 => "I&#46; Garc&#237;a Higuera"
                            4 => "A&#46; Velasco Os&#233;s"
                            5 => "P&#46; Ter&#225;n Saavedra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Esp Patol"
                        "fecha" => "2006"
                        "volumen" => "39"
                        "paginaInicial" => "113"
                        "paginaFinal" => "116"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant fibrous histiocytoma arising in a gouty tophus at the second metacarpophalangeal joint"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Carnero"
                            1 => "P&#46; Ter&#225;n"
                            2 => "E&#46; Trillo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bjps.2005.12.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Plast Reconstr Aesthet Surg"
                        "fecha" => "2006"
                        "volumen" => "59"
                        "paginaInicial" => "775"
                        "paginaFinal" => "778"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16782578"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Undifferentiated high grade pleomorphic sarcoma&#47;malignant fibrous histiocytoma associated a gouty tophus&#46; A case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Szlabi"
                            1 => "J&#46;O&#46; Flores"
                            2 => "A&#46;L&#46; Diller"
                            3 => "M&#46; Cabrera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Fac Cien Med Univ Nac Cordoba"
                        "fecha" => "2012"
                        "volumen" => "69"
                        "paginaInicial" => "224"
                        "paginaFinal" => "227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23751790"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1134282X09000694"
                          "estado" => "S300"
                          "issn" => "1134282X"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous angiosarcoma arising in a gouty tophus&#58; report of a unique case and a review of foreign material-associated angiosarcomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;L&#46; Folpe"
                            1 => "C&#46;A&#46; Johnston"
                            2 => "S&#46;W&#46; Weiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "2000"
                        "volumen" => "22"
                        "paginaInicial" => "418"
                        "paginaFinal" => "421"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11048977"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Associated giant cell tumor and tophaceous deposits in a finger pulp&#58; a case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46;A&#46; Schuind"
                            1 => "B&#46; Stallenberg"
                            2 => "M&#46; Remmelink"
                            3 => "J&#46;L&#46; Pasteels"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hand Surg Am"
                        "fecha" => "2003"
                        "volumen" => "28"
                        "paginaInicial" => "871"
                        "paginaFinal" => "874"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14507521"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibrosarcoma arising from gouty tophi&#58; report of a unique case and review of literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;J&#46; Wang"
                            1 => "H&#46;Y&#46; Wang"
                            2 => "K&#46; Cheng"
                            3 => "X&#46; Wang"
                            4 => "B&#46; Yu"
                            5 => "S&#46;S&#46; Shi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Clin Exp Pathol"
                        "fecha" => "2015"
                        "volumen" => "8"
                        "paginaInicial" => "4227"
                        "paginaFinal" => "4232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26097616"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new complication of retained surgical gauze&#58; development of malignant fibrous histiocytoma-report of a case with a literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Kaplan"
                            1 => "H&#46;&#304;&#46; &#304;yik&#246;&#351;ker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1477-7819-10-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "World J Surg Oncol"
                        "fecha" => "2012"
                        "volumen" => "10"
                        "paginaInicial" => "1"
                        "paginaFinal" => "5"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22214417"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack295643"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0035" class="elsevierStylePara elsevierViewall">To the Pathology and Medical Oncology Departments of Grupo HM Hospitales&#44; Madrid&#44; Spain&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001300000005/v1_201708230012/S2173574317300965/v1_201708230012/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8400"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001300000005/v1_201708230012/S2173574317300965/v1_201708230012/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300965?idApp=UINPBA00004M"
]
Article information
ISSN: 21735743
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 12 11 23
2024 October 118 36 154
2024 September 126 17 143
2024 August 141 36 177
2024 July 93 32 125
2024 June 126 31 157
2024 May 184 36 220
2024 April 118 16 134
2024 March 123 29 152
2024 February 94 19 113
2024 January 79 19 98
2023 December 74 17 91
2023 November 95 16 111
2023 October 76 24 100
2023 September 67 30 97
2023 August 42 15 57
2023 July 56 30 86
2023 June 64 20 84
2023 May 68 23 91
2023 April 36 10 46
2023 March 114 30 144
2023 February 67 21 88
2023 January 57 22 79
2022 December 83 41 124
2022 November 91 28 119
2022 October 81 31 112
2022 September 74 46 120
2022 August 95 51 146
2022 July 67 63 130
2022 June 61 21 82
2022 May 56 41 97
2022 April 70 58 128
2022 March 71 41 112
2022 February 73 36 109
2022 January 72 49 121
2021 December 43 42 85
2021 November 38 52 90
2021 October 72 51 123
2021 September 50 43 93
2021 August 39 47 86
2021 July 34 36 70
2021 June 66 24 90
2021 May 56 36 92
2021 April 114 101 215
2021 March 62 35 97
2021 February 45 26 71
2021 January 46 22 68
2020 December 35 29 64
2020 November 41 24 65
2020 October 48 10 58
2020 September 59 25 84
2020 August 33 26 59
2020 July 28 16 44
2020 June 30 18 48
2020 May 24 25 49
2020 April 31 12 43
2020 March 14 6 20
2020 February 1 0 1
2020 January 2 0 2
2019 December 1 0 1
2019 November 3 0 3
2019 October 2 0 2
2019 August 1 0 1
2019 July 4 0 4
2019 June 3 0 3
2019 May 5 0 5
2019 April 1 0 1
2019 March 5 0 5
2019 February 1 0 1
2019 January 1 0 1
2018 December 2 0 2
2018 May 4 0 4
2018 April 69 9 78
2018 March 94 5 99
2018 February 31 9 40
2018 January 65 6 71
2017 December 30 10 40
2017 November 37 8 45
2017 October 57 30 87
2017 September 57 27 84
2017 August 26 21 47
2017 July 4 7 11
Show all

Follow this link to access the full text of the article

Idiomas
Reumatología Clínica (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?