Letter to the Editor
Interstitial Granulomatous Dermatitis Associated With Lupus: A Case Report
Dermatitis intersticial granulomatosa asociada al lupus: a propósito de un caso
Marta Arévalo
, Mireia Moreno, Jordi Gratacós
Corresponding author
Servicio de Reumatología, Hospital Universitari Parc Taulí de Sabadell, Sabadell, Barcelona, Spain
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The interstitial lymphohistiocytic infiltrate can be observed in superficial and deep dermis, with the presence of mucin deposits surrounding the collagen fibers. Histopathological view of interstitial granulomatous dermatitis.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Recently, we treated a patient with interstitial granulomatous dermatitis (IGD) associated with systemic lupus erythematosus (SLE). Given the refractoriness of the condition to standard therapy, treatment with belimumab was begun, and the response was satisfactory. In view of the absence of data in the literature on the efficacy of belimumab in IGD associated with SLE, the report of this case was considered to be interesting, as it would enable us to examine new therapeutic lines in refractory IGD.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 40-year-old white man who had been diagnosed with SLE at the age of 35 on the basis of leukopenia, oral and nasal ulcers, arthritis of the hands, myositis and cutaneous involvement in the form of diffuse alopecia. He was also positive for immunological markers (antinuclear, anti-Smith, anti-Ro and anti-double-stranded DNA antibodies) and had decreased complement levels. Given the predominance of joint involvement, at first, he was treated with prednisone at 10<span class="elsevierStyleHsp" style=""></span>mg/day and hydroxychloroquine at 400<span class="elsevierStyleHsp" style=""></span>mg/day. There was a partial response in the joints, but none with respect to the skin. He had a substantial deterioration of the cutaneous manifestations, developing patches of alopecia areata, palpebral edema and nonpruritic, erythematous violaceous macular lesions on his face, torso and proximal portion of extremities, producing a serious physical and psychological distress for the patient. In addition, he had constitutional symptoms, with fever and an elevation of serum markers of lupus activity. A biopsy of the skin lesions revealed an interstitial lymphohistiocytic infiltrate in superficial and deep dermis, with the presence of mucin deposits arranged around collagen fibers, corresponding histopathologically to IGD (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). It was decided to treat the patient with high-dose corticosteroids (1<span class="elsevierStyleHsp" style=""></span>mg/kg body weight [bw]/day of prednisone), to which he responded only partially. His response to the association of metronidazole (250<span class="elsevierStyleHsp" style=""></span>mg/8<span class="elsevierStyleHsp" style=""></span>h) and mycophenolate mofetil (1<span class="elsevierStyleHsp" style=""></span>g/12<span class="elsevierStyleHsp" style=""></span>h) was not satisfactory either, and he did not tolerate methotrexate. Given the high clinical activity and extension of the lesions, we decided to start treatment with intravenous belimumab (10<span class="elsevierStyleHsp" style=""></span>mg/kg bw each month), associated with hydroxychloroquine. The patient showed an evident satisfactory response after 1 month of treatment, with resolution of the skin lesions and alopecia, as well as clinical remission and normalization of the biological parameters. Four years after the start of this approach, he remains in remission.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Interstitial granulomatous dermatitis is an uncommon skin condition, that is occasionally associated with autoimmune diseases (rheumatoid arthritis, SLE, vasculitis, thyroiditis or diabetes), lymphoproliferative disorders and even certain drugs like anti-tumor necrosis factor agents.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,2</span></a> The skin lesions usually develop in patients with SLE although, in some cases, they can also be the presenting sign of the disease.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Its treatment has not been well established. In the case of IGD associated with drugs, it seems to be necessary to discontinue the causative agent and assess introducing treatment with corticosteroids. In general lines, these are the primary therapeutic options for IGD. In cases of IGD associated with an autoimmune disease, it may be necessary to combine corticosteroids with the treatment of the underlying disease. For this, we utilize immunosuppressive drugs, like methotrexate, mycophenolate, hydroxychloroquine, dapsone and even metronidazole (the latter indicated in granulomatous diseases). Our patient did not tolerate methotrexate or respond to other treatments. With respect to biological therapy, there are reports of cases of IGD associated with arthritis in which there was a good cutaneous response to infliximab,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> etanercept,<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> tocilizumab,<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> ustekinumab<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> and immunoglobulins,<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> treatments that were not indicated in our patient. Belimumab has been seen to be effective in individuals with SLE and with cutaneous and joint involvement that is refractory to standard immunosuppressive agents.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> There is no evidence of its efficacy in IGD. It is a fully humanized monoclonal antibody against B lymphocyte stimulator (BlyS), the action of which focuses on the indirect depletion of B lymphocytes and plasma cells, thus reducing the production of antibodies. Given the elevated clinical and serum activity, considering the extension, severity and refractoriness of the skin lesions, we began treatment with belimumab, which achieved complete resolution of IGD. These results are surprising, considering that the mechanism of action of this drug does not appear to be related to the pathophysiology of the granulomatous lesion. The literature provides cases in which the development of IGD associated with autoimmune diseases was related to the presence of autoantibodies and immune complex deposition.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> This suggests that the depletion of these elements would impede the perpetuation of the inflammatory cascade causing the granuloma.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In short, the development of IGD during the course of SLE is an uncommon cutaneous condition, with no established treatment, and it may be resistant to different therapeutic strategies. The case we report is the first in which belimumab was found to be effective in IGD associated with SLE.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Arévalo M, Moreno M, Gratacós J. Dermatitis intersticial granulomatosa asociada al lupus: a propósito de un caso. Reumatol Clin. 2017;13:367–368.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1536 "Ancho" => 2047 "Tamanyo" => 898199 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Histological image of a skin biopsy. The interstitial lymphohistiocytic infiltrate can be observed in superficial and deep dermis, with the presence of mucin deposits surrounding the collagen fibers. Histopathological view of interstitial granulomatous dermatitis.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interstitial granulomatous dermatitis associated with the use of tumor necrosis factor alpha inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Deng" 1 => "V. Harvey" 2 => "B. Sina" 3 => "D. Strobel" 4 => "A. Badros" 5 => "J.M. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 15 | 12 | 27 |
| 2024 October | 132 | 42 | 174 |
| 2024 September | 163 | 55 | 218 |
| 2024 August | 144 | 60 | 204 |
| 2024 July | 136 | 45 | 181 |
| 2024 June | 120 | 34 | 154 |
| 2024 May | 108 | 38 | 146 |
| 2024 April | 121 | 38 | 159 |
| 2024 March | 101 | 39 | 140 |
| 2024 February | 87 | 27 | 114 |
| 2024 January | 118 | 30 | 148 |
| 2023 December | 94 | 28 | 122 |
| 2023 November | 85 | 22 | 107 |
| 2023 October | 149 | 28 | 177 |
| 2023 September | 136 | 40 | 176 |
| 2023 August | 122 | 18 | 140 |
| 2023 July | 128 | 35 | 163 |
| 2023 June | 121 | 23 | 144 |
| 2023 May | 131 | 35 | 166 |
| 2023 April | 116 | 18 | 134 |
| 2023 March | 192 | 32 | 224 |
| 2023 February | 162 | 34 | 196 |
| 2023 January | 112 | 17 | 129 |
| 2022 December | 154 | 49 | 203 |
| 2022 November | 143 | 41 | 184 |
| 2022 October | 145 | 32 | 177 |
| 2022 September | 154 | 49 | 203 |
| 2022 August | 101 | 45 | 146 |
| 2022 July | 84 | 43 | 127 |
| 2022 June | 92 | 43 | 135 |
| 2022 May | 86 | 38 | 124 |
| 2022 April | 138 | 56 | 194 |
| 2022 March | 108 | 57 | 165 |
| 2022 February | 137 | 41 | 178 |
| 2022 January | 120 | 45 | 165 |
| 2021 December | 69 | 43 | 112 |
| 2021 November | 90 | 47 | 137 |
| 2021 October | 84 | 69 | 153 |
| 2021 September | 85 | 89 | 174 |
| 2021 August | 91 | 52 | 143 |
| 2021 July | 51 | 34 | 85 |
| 2021 June | 57 | 37 | 94 |
| 2021 May | 79 | 63 | 142 |
| 2021 April | 191 | 142 | 333 |
| 2021 March | 77 | 67 | 144 |
| 2021 February | 82 | 54 | 136 |
| 2021 January | 54 | 70 | 124 |
| 2020 December | 60 | 48 | 108 |
| 2020 November | 59 | 33 | 92 |
| 2020 October | 30 | 17 | 47 |
| 2020 September | 54 | 36 | 90 |
| 2020 August | 33 | 25 | 58 |
| 2020 July | 27 | 21 | 48 |
| 2020 June | 54 | 24 | 78 |
| 2020 May | 39 | 20 | 59 |
| 2020 April | 33 | 25 | 58 |
| 2020 March | 8 | 4 | 12 |
| 2020 February | 1 | 0 | 1 |
| 2018 December | 6 | 0 | 6 |
| 2018 July | 1 | 0 | 1 |
| 2018 May | 5 | 1 | 6 |
| 2018 April | 3 | 1 | 4 |
| 2018 March | 41 | 5 | 46 |
| 2018 February | 73 | 19 | 92 |
| 2018 January | 93 | 27 | 120 |
| 2017 December | 73 | 34 | 107 |
| 2017 November | 88 | 41 | 129 |
| 2017 October | 18 | 18 | 36 |
| 2017 September | 3 | 13 | 16 |
| 2017 August | 6 | 16 | 22 |
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