Letter to the Editor
Miescher Syndrome: An Uncommon Cause of Recurrent Swelling of the Lips
Síndrome de Miescher: una causa poco frecuente de tumefacción labial
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It is included in the spectrum of orofacial granulomatosis, the paradigm of which is Melkersson–Rosenthal syndrome, in the cases in which it is accompanied by involvement of the facial nerve together with fissured tongue.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 45-year-old woman with a history of hypertension who had been treated for several years with atenolol. She presented complaining of recurrent episodes of labial edema accompanied by burning pain. The patient explained that she felt generally unwell, in the absence of fever or chills. She did not have constitutional symptoms, diarrhea or abdominal pain, and denied exposure to toxic agents and was unable to provide epidemiological data of interest. She had not begun to take any new drugs.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Physical examination revealed the presence of lip swelling, in the absence of ulcers or other associated lesions. It also found that her facial nerve and tongue morphology were absolutely normal. The results of cardiopulmonary evaluation were also normal. A biopsy of the upper lip showed the presence of granulomatous dermatitis with a mixed component of predominantly superficial and deep perivascular infiltrate. In the biopsy, the findings with stains for acid–alcohol-resistant bacilli and fungi were negative.</p><p id="par0020" class="elsevierStylePara elsevierViewall">We performed the intradermal Mantoux test and the result was negative. The findings were the same for the syphilis test (Venereal Disease Research Laboratory [VDRL]) and for serological tests for hepatitis B and C viruses, and for human immunodeficiency virus. The systemic study was accompanied by analyses to determine angiotensin-converting enzyme, antinuclear antibodies, nucleolar antibodies, total extractable nuclear antibodies, antineutrophil cytoplasmic antibodies, immunoglobulins and erythrocyte sedimentation rate, in which all of the results were normal or negative. A chest radiograph showed a normal mediastinal silhouette, and the absence of lymphadenopathy.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The response to glucocorticoids was very favorable, and resulted in the disappearance of swelling and episodes of labial edema. However, 6 weeks later, the patient came back with similar clinical signs, that coincided with the decrease in steroid dose. Treatment was begun with dapsone, followed by an improvement in the symptoms.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Miescher syndrome appears to be an incomplete form of Melkersson–Rosenthal syndrome in 28% of the patients.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> In general, MS is an uncommon disease with special predilection for the second or third decades of life, although cases have been reported at any age.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> It characteristically affects the upper lip and has a lesser effect on the lower lip, although there have been anecdotal reports of the involvement of other regions of the oral cavity. The most frequent presentation is acute and symptomatic swelling of the lips that lasts for hours or days. The confirmation of the diagnosis is the discovery of non-necrotizing granulomas and perivascular lymphocyte infiltration in the biopsy of the affected region.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> Other diseases with a granulomatous etiology, such as sarcoidosis, tuberculosis and inflammatory bowel disease, should be taken into account in the differential diagnosis and must be ruled out.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">There is no ideal treatment for this disease. A number of therapeutic strategies have been proposed, including intralesional or systemic glucocorticoids, as well as other options such as oral tetracyclines, thalidomide, dapsone or biological therapy (anti-tumor necrosis factor <span class="elsevierStyleItalic">α</span>), with differing results.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Although it is rare, MS should be taken into account in the differential diagnosis of recurrent edema of the lips. A histological study is essential for the definitive diagnosis of the disease. Treatment with corticosteroids is highly effective. However, as occurs with other immune-mediated diseases, treatment of the underlying disease should be included. Despite the few cases in which the use of dapsone is reported, this drug at a dose of 50<span class="elsevierStyleHsp" style=""></span>mg a day, may prove to be a useful alternative in MS, as is illustrated by the experience we report here.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: González-García A, Barbolla Díaz I, Sifuentes Giraldo WA, Patier-de la Peña JL. Síndrome de Miescher: una causa poco frecuente de tumefacción labial. 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Faura Berruga" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2012.02.005" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2012" "volumen" => "103" "paginaInicial" => "718" "paginaFinal" => "724" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22657098" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000001300000006/v1_201710250854/S2173574317301302/v1_201710250854/en/main.assets" "Apartado" => array:4 [ "identificador" => "8400" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001300000006/v1_201710250854/S2173574317301302/v1_201710250854/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317301302?idApp=UINPBA00004M" ]
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| 2022 November | 284 | 38 | 322 |
| 2022 October | 220 | 53 | 273 |
| 2022 September | 195 | 39 | 234 |
| 2022 August | 168 | 48 | 216 |
| 2022 July | 188 | 36 | 224 |
| 2022 June | 145 | 43 | 188 |
| 2022 May | 170 | 40 | 210 |
| 2022 April | 220 | 45 | 265 |
| 2022 March | 184 | 61 | 245 |
| 2022 February | 188 | 44 | 232 |
| 2022 January | 223 | 43 | 266 |
| 2021 December | 174 | 56 | 230 |
| 2021 November | 267 | 45 | 312 |
| 2021 October | 206 | 66 | 272 |
| 2021 September | 136 | 43 | 179 |
| 2021 August | 162 | 44 | 206 |
| 2021 July | 195 | 34 | 229 |
| 2021 June | 183 | 25 | 208 |
| 2021 May | 187 | 51 | 238 |
| 2021 April | 390 | 102 | 492 |
| 2021 March | 206 | 34 | 240 |
| 2021 February | 137 | 26 | 163 |
| 2021 January | 156 | 31 | 187 |
| 2020 December | 134 | 25 | 159 |
| 2020 November | 129 | 18 | 147 |
| 2020 October | 144 | 17 | 161 |
| 2020 September | 140 | 36 | 176 |
| 2020 August | 142 | 14 | 156 |
| 2020 July | 89 | 17 | 106 |
| 2020 June | 83 | 37 | 120 |
| 2020 May | 74 | 23 | 97 |
| 2020 April | 73 | 20 | 93 |
| 2020 March | 16 | 9 | 25 |
| 2018 July | 1 | 0 | 1 |
| 2018 May | 6 | 0 | 6 |
| 2018 April | 1 | 1 | 2 |
| 2018 March | 29 | 1 | 30 |
| 2018 February | 43 | 16 | 59 |
| 2018 January | 61 | 25 | 86 |
| 2017 December | 62 | 31 | 93 |
| 2017 November | 59 | 32 | 91 |
| 2017 October | 18 | 21 | 39 |
Show all
