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albumin&#58; 4<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#59; globulin&#58; 4<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#59; immunoglobulin &#40;Ig&#41; G&#58; 1669&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; IgM&#58; 473&#46;0<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; antinuclear antibodies positive&#58; 1&#47;400&#44; homogeneous pattern&#59; native SS-A<span class="elsevierStyleSup">&#43;&#43;&#43;</span>&#59; single-stranded DNA<span class="elsevierStyleSup">&#43;&#43;</span>&#59; RNP&#58; positive&#59; RNP A&#58; negative&#59; RNP C&#58; negative&#59; Scl 70&#58; negative&#59; PM-Scl&#58; negative&#59; Jo-1&#58; negative&#59; centromere protein B&#58; negative&#59; serum complement C3-C4 level&#58; low&#59; lupus anticoagulant &#40;kaolin&#41;&#58; 0&#46;83 &#40;&#8722;&#41;&#59; IgG anticardiolipin&#58; 12 &#40;&#43;&#41;&#59; IgM anticardiolipin&#58; 19 &#40;&#43;&#41;&#59; and beta 2 glycoprotein I&#58; not determined&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Total bilirubin&#58;</span> 1&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;0&#46;4&#8211;1&#46;2<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#59; direct bilirubin&#58; 1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;0&#8211;0&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; aspartate aminotransferase&#58; 31<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#59; alanine aminotransferase&#58; 25<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#59; gamma-glutamyltransferase&#58; 61<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#59; prothrombin time&#58; 13&#46;9<span class="elsevierStyleHsp" style=""></span>s&#59; international normalized ratio &#40;INR&#41;&#58; 1&#46;22&#59; Australian antigen &#40;HBsAg&#41;&#58; negative&#59; anti-hepatitis C virus&#58; negative&#59; anti-hepatitis A virus &#40;HAV&#41; IgM&#58; negative&#59; rheumatoid factor&#58; 21<span class="elsevierStyleHsp" style=""></span>IU&#47;mL&#59; erythrocyte sedimentation rate&#58; 66<span class="elsevierStyleHsp" style=""></span>mm&#47;h&#59; anti-smooth muscle antibodies &#40;&#43;&#41;&#59; and anti-liver-kidney microsomal &#40;LKM&#41; antibody&#58; negative&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Abdominal ultrasound&#58;</span> chronic diffuse liver disease and hepatomegaly&#44; right diffuse renal disease and nephromegaly&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Soft tissue ultrasound&#58;</span> capsular distension with effusion&#44; synovitis in proximal metacarpophalangeal joints compatible with RA&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Liver biopsy&#58; changes in liver architecture&#44; with portal spaces widened by the chronic mononuclear lymphocytic inflammatory process that damaged the limiting plate&#46; Presence of piecemeal necrosis&#44; or interface hepatitis&#44; necroinflammatory foci&#44; mild plasmacytosis&#44; binucleated reactive hepatocytes&#44; disarranged trabeculae &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The findings were consistent with chronic active liver disease&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Symptoms suggestive of SLE were manifest&#46; Thus&#44; we requested an immunological profile that subsequently would corroborate the diagnosis&#44; together with the history of RA and evidence from the soft tissue ultrasound&#44; pointed to the diagnosis of <span class="elsevierStyleItalic">rhupus</span>&#46; Patients with <span class="elsevierStyleItalic">rhupus</span> often present with a diagnosis of RA and&#44; later&#44; develop secondary signs of SLE&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> The clinical symptoms and signs associated with SLE in <span class="elsevierStyleItalic">rhupus</span> are cutaneous photosensitivity&#44; malar rash&#44; alopecia&#44; and hematologic changes such as leukopenia and thrombocytopenia&#46; Renal and neurological involvement are uncommon&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Diffuse liver disease&#44; hypergammaglobulinemia and the presence of anti-smooth muscle antibodies were noteworthy and&#44; given the suspicion of AIH&#44; we requested a liver biopsy&#46; The findings were consistent with interface hepatitis with mononuclear infiltrate&#44; and the simplified criteria for AIH were evaluated<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> and the result was positive&#44; with a score of 7&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The presence of antiphospholipid &#40;aPL&#41; antibodies pointed to the suspicion of aPL syndrome&#46; However&#44; the absence of clinical manifestations or obstetric history ruled it out&#46; Another study found that up to 3&#37; of the patients with autoimmune liver disease had aPL&#44; although this result was not significant&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; the overlap of <span class="elsevierStyleItalic">rhupus</span> and autoimmune hepatitis is an uncommon condition that requires suspicion on the part of the clinician and multidisciplinary management for appropriate treatment&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authorship</span><p id="par0065" class="elsevierStylePara elsevierViewall">EZF and DLO participated in the conception of the article&#44; 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Letter to the Editor
Rhupus and Autoimmune Hepatitis: A Rare Association
Rupus y hepatitis autoinmune: una asociación infrecuente
Ernesto Zavala-Floresa,
Corresponding author
ernestozav123@gmail.com

Corresponding author.
, David Loja-Oropezab
a Universidad San Martin de Porres, Lima, Peru
b Hospital Nacional Arzobispo Loayza, Lima, Peru
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Overlap syndromes are uncommon conditions in which the diagnostic criteria of more than one systemic autoimmune disease are met in a single patient&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> In contrast to mixed connective tissue diseases &#40;MCTD&#41;&#44; in which certain clinical or serological characteristics are identified&#44; they do not fulfill the diagnostic criteria in order to be categorized as a defined disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">&#8220;<span class="elsevierStyleItalic">Rhupus</span>&#8221; is an entity in which there is an overlap of systemic lupus erythematosus &#40;SLE&#41; and rheumatoid arthritis &#40;RA&#41;&#44; and the incidence involves less than 1&#37; of the SLE population&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;2</span></a> Autoimmune hepatitis &#40;AIH&#41; is a chronic progressive liver disease&#46; Its prevalence is relatively low&#44; as it affects around 16&#46;9 individuals in population of 100&#44;000&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We report the case of a 30-year-old woman&#44; with a history of RA&#44; who came to the hospital with acute pyelonephritis&#46; Therapy was begun with antibiotics and symptomatic treatment&#44; and the patient responded favorably&#46; Four days later&#44; she presented with pain in hypogastrium and right hypochondriac region&#44; nausea&#44; vomiting&#44; paleness&#44; pain and stiffness in the metacarpophalangeal joint &#40;with synovitis&#41; and bilateral coxofemoral joint&#44; red eye syndrome&#44; malar erythema and photosensitivity&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Ancillary tests</span>&#58; albumin&#58; 4<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#59; globulin&#58; 4<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#59; immunoglobulin &#40;Ig&#41; G&#58; 1669&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; IgM&#58; 473&#46;0<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; antinuclear antibodies positive&#58; 1&#47;400&#44; homogeneous pattern&#59; native SS-A<span class="elsevierStyleSup">&#43;&#43;&#43;</span>&#59; single-stranded DNA<span class="elsevierStyleSup">&#43;&#43;</span>&#59; RNP&#58; positive&#59; RNP A&#58; negative&#59; RNP C&#58; negative&#59; Scl 70&#58; negative&#59; PM-Scl&#58; negative&#59; Jo-1&#58; negative&#59; centromere protein B&#58; negative&#59; serum complement C3-C4 level&#58; low&#59; lupus anticoagulant &#40;kaolin&#41;&#58; 0&#46;83 &#40;&#8722;&#41;&#59; IgG anticardiolipin&#58; 12 &#40;&#43;&#41;&#59; IgM anticardiolipin&#58; 19 &#40;&#43;&#41;&#59; and beta 2 glycoprotein I&#58; not determined&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Total bilirubin&#58;</span> 1&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;0&#46;4&#8211;1&#46;2<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#59; direct bilirubin&#58; 1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;0&#8211;0&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; aspartate aminotransferase&#58; 31<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#59; alanine aminotransferase&#58; 25<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#59; gamma-glutamyltransferase&#58; 61<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#59; prothrombin time&#58; 13&#46;9<span class="elsevierStyleHsp" style=""></span>s&#59; international normalized ratio &#40;INR&#41;&#58; 1&#46;22&#59; Australian antigen &#40;HBsAg&#41;&#58; negative&#59; anti-hepatitis C virus&#58; negative&#59; anti-hepatitis A virus &#40;HAV&#41; IgM&#58; negative&#59; rheumatoid factor&#58; 21<span class="elsevierStyleHsp" style=""></span>IU&#47;mL&#59; erythrocyte sedimentation rate&#58; 66<span class="elsevierStyleHsp" style=""></span>mm&#47;h&#59; anti-smooth muscle antibodies &#40;&#43;&#41;&#59; and anti-liver-kidney microsomal &#40;LKM&#41; antibody&#58; negative&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Abdominal ultrasound&#58;</span> chronic diffuse liver disease and hepatomegaly&#44; right diffuse renal disease and nephromegaly&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Soft tissue ultrasound&#58;</span> capsular distension with effusion&#44; synovitis in proximal metacarpophalangeal joints compatible with RA&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Liver biopsy&#58; changes in liver architecture&#44; with portal spaces widened by the chronic mononuclear lymphocytic inflammatory process that damaged the limiting plate&#46; Presence of piecemeal necrosis&#44; or interface hepatitis&#44; necroinflammatory foci&#44; mild plasmacytosis&#44; binucleated reactive hepatocytes&#44; disarranged trabeculae &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The findings were consistent with chronic active liver disease&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Symptoms suggestive of SLE were manifest&#46; Thus&#44; we requested an immunological profile that subsequently would corroborate the diagnosis&#44; together with the history of RA and evidence from the soft tissue ultrasound&#44; pointed to the diagnosis of <span class="elsevierStyleItalic">rhupus</span>&#46; Patients with <span class="elsevierStyleItalic">rhupus</span> often present with a diagnosis of RA and&#44; later&#44; develop secondary signs of SLE&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> The clinical symptoms and signs associated with SLE in <span class="elsevierStyleItalic">rhupus</span> are cutaneous photosensitivity&#44; malar rash&#44; alopecia&#44; and hematologic changes such as leukopenia and thrombocytopenia&#46; Renal and neurological involvement are uncommon&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Diffuse liver disease&#44; hypergammaglobulinemia and the presence of anti-smooth muscle antibodies were noteworthy and&#44; given the suspicion of AIH&#44; we requested a liver biopsy&#46; The findings were consistent with interface hepatitis with mononuclear infiltrate&#44; and the simplified criteria for AIH were evaluated<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> and the result was positive&#44; with a score of 7&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The presence of antiphospholipid &#40;aPL&#41; antibodies pointed to the suspicion of aPL syndrome&#46; However&#44; the absence of clinical manifestations or obstetric history ruled it out&#46; Another study found that up to 3&#37; of the patients with autoimmune liver disease had aPL&#44; although this result was not significant&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; the overlap of <span class="elsevierStyleItalic">rhupus</span> and autoimmune hepatitis is an uncommon condition that requires suspicion on the part of the clinician and multidisciplinary management for appropriate treatment&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authorship</span><p id="par0065" class="elsevierStylePara elsevierViewall">EZF and DLO participated in the conception of the article&#44; in its writing and in the critical review of the text&#46; All of the authors approved the article for publication&#46;</p></span></span>"
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Article information
ISSN: 21735743
Original language: English
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2024 September 95 27 122
2024 August 117 50 167
2024 July 107 46 153
2024 June 92 35 127
2024 May 105 30 135
2024 April 98 33 131
2024 March 98 44 142
2024 February 71 24 95
2024 January 85 27 112
2023 December 71 25 96
2023 November 71 31 102
2023 October 66 26 92
2023 September 94 44 138
2023 August 47 13 60
2023 July 67 38 105
2023 June 84 19 103
2023 May 67 22 89
2023 April 59 14 73
2023 March 83 25 108
2023 February 88 20 108
2023 January 81 12 93
2022 December 70 28 98
2022 November 84 26 110
2022 October 93 24 117
2022 September 62 39 101
2022 August 74 33 107
2022 July 63 37 100
2022 June 83 34 117
2022 May 77 45 122
2022 April 90 55 145
2022 March 109 54 163
2022 February 89 30 119
2022 January 46 40 86
2021 December 63 44 107
2021 November 62 51 113
2021 October 67 49 116
2021 September 60 37 97
2021 August 54 40 94
2021 July 62 38 100
2021 June 75 22 97
2021 May 57 50 107
2021 April 186 147 333
2021 March 103 22 125
2021 February 65 30 95
2021 January 75 23 98
2020 December 72 18 90
2020 November 95 19 114
2020 October 80 14 94
2020 September 40 23 63
2020 August 39 21 60
2020 July 28 15 43
2020 June 44 16 60
2020 May 33 13 46
2020 April 27 21 48
2020 March 24 4 28
2018 December 2 0 2
2018 July 1 0 1
2018 May 6 0 6
2018 April 3 1 4
2018 March 26 2 28
2018 February 78 15 93
2018 January 63 27 90
2017 December 79 29 108
2017 November 58 33 91
2017 October 20 20 40
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