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Nótese la presencia de un sutil engrosamiento bibasal del intersticio pulmonar. B) Imagen axial de la TC de tórax en la que se confirma la presencia de masas pulmonares derechas (asteriscos). C) Imagen axial de la TC de tórax (proyección de intensidad mínima) en la que se visualiza una reticulación del intersticio pulmonar bibasal (flechas) en relación con la neumopatía intersticial del paciente. 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Note the presence of a subtle bibasal enlargement of the lung interstitium. (B) Axial image of chest CT which confirms the presence of right lung masses (asterisks). (C) Axial image of chest CT (minimum intensity projection) in which a bibasal lung interstitium reticulation (arrows) may be observed in relation to the patient's interstitial lung disease. Note the presence of small traction bronchiectasis.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We present the case of a 66 year-old patient who presented at surgery with dyspnoea. A chest X-ray revealed multiple opacities in the right lung (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). Of note in the patient's medical history was high blood pressure, type 1 diabetes mellitus (both controlled), and nonspecific interstitial pneumonia (NSIP) which had been confirmed several years previously by means of a biopsy. Computerised tomography (CT) of the chest confirmed the presence of multiple right lung masses (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B), with aerial bronchogram, with no pleural or lymph node effusion, and with interstitial involvement (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a><span class="elsevierStyleSmallCaps">C</span>). Transbronchial biopsy confirmed high grade diffuse large B-cell non-Hodgkin lymphoma (DLBCL). Positron emission tomography/CT (PET/CT) ruled out other tumours. The patient was treated with chemotherapy (R-CHOP regimen), with complete response after 6 cycles.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Lung DLBCL is a rare subtype of primary lung lymphoma (PLL) which may be associated with states of immunosuppression (infection by human immunodeficiency virus, common variable immunodeficiency), a tobacco habit and autoimmune diseases.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> Of the latter, Sjögren's syndrome and rheumatoid arthritis are the most common. Our case is interesting since none of the described associations presented, but NSIP did. NSIP may be idiopathic or secondary (among other causes) to autoimmune diseases. In order of frequency the following are of note: systemic sclerosis, polymiosytis/dermatomyositis and mixed connective tissue disease. Interstitial lung diseases which may be complicated with cancer are the usual interstitial penumonitis<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a> (bronchogenic carcinoma) and lymphoid interstitial pneumonitis<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> (PLL, particularly in patients with Sjögren syndrome), but no descriptions of lung DLBCL associated with an NSIP have been found.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethical Disclosures</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Protection of human and animal subjects</span><p id="par0015" class="elsevierStylePara elsevierViewall">The authors declare that for this research no experimentation has been carried out on human beings or animals.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Confidentiality of data</span><p id="par0020" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Right to privacy and informed consent</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflict of Interests</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interests to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:3 [ "identificador" => "sec0005" "titulo" => "Ethical Disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0015" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0020" "titulo" => "Right to privacy and informed consent" ] ] ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflict of Interests" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-06-17" "fechaAceptado" => "2017-07-13" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Gorospe Sarasúa L, Arrieta P, Chinea-Rodríguez A, de la Puente-Bujidos C. Linfoma difuso de células B grandes pulmonar en paciente con neumonía intersticial no específica. Reumatol Clin. 2019;15:e151–e152.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1530 "Ancho" => 2020 "Tamanyo" => 227072 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Posteroanterior X-ray of the chest in which several nodular opacities are observed in the right lung (arrow). Note the presence of a subtle bibasal enlargement of the lung interstitium. (B) Axial image of chest CT which confirms the presence of right lung masses (asterisks). (C) Axial image of chest CT (minimum intensity projection) in which a bibasal lung interstitium reticulation (arrows) may be observed in relation to the patient's interstitial lung disease. Note the presence of small traction bronchiectasis.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0020" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary pulmonary lymphomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Piña-Oviedo" 1 => "A. Weissferdt" 2 => "N. Kalhor" 3 => "C.A. Moran" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/PAP.0000000000000090" "Revista" => array:6 [ "tituloSerie" => "Adv Anat Pathol" "fecha" => "2015" "volumen" => "22" "paginaInicial" => "355" "paginaFinal" => "375" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26452211" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0025" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Usual interstitial pneumonia with lung cancer: clinicopathological analysis of 43 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.H. Song" 1 => "I.H. Choi" 2 => "S.Y. Ha" 3 => "K.M. Han" 4 => "J.J. Lee" 5 => "M.E. Hong" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4132/KoreanJPathol.2014.48.1.10" "Revista" => array:6 [ "tituloSerie" => "Korean J Pathol" "fecha" => "2014" "volumen" => "48" "paginaInicial" => "10" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24627689" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0030" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary involvement in Sjögren syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Kokosi" 1 => "E.C. Riemer" 2 => "K.B. Highland" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ccm.2010.05.007" "Revista" => array:6 [ "tituloSerie" => "Clin Chest Med" "fecha" => "2010" "volumen" => "31" "paginaInicial" => "489" "paginaFinal" => "500" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20692541" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000001500000006/v1_201911250632/S2173574318301564/v1_201911250632/en/main.assets" "Apartado" => array:4 [ "identificador" => "5795" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in Clinical Rheumatology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001500000006/v1_201911250632/S2173574318301564/v1_201911250632/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574318301564?idApp=UINPBA00004M" ]
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2022 April | 33 | 35 | 68 |
2022 March | 44 | 38 | 82 |
2022 February | 38 | 32 | 70 |
2022 January | 43 | 29 | 72 |
2021 December | 30 | 36 | 66 |
2021 November | 28 | 41 | 69 |
2021 October | 48 | 40 | 88 |
2021 September | 31 | 41 | 72 |
2021 August | 16 | 34 | 50 |
2021 July | 20 | 25 | 45 |
2021 June | 25 | 26 | 51 |
2021 May | 33 | 41 | 74 |
2021 April | 65 | 78 | 143 |
2021 March | 51 | 32 | 83 |
2021 February | 24 | 21 | 45 |
2021 January | 47 | 20 | 67 |
2020 December | 27 | 15 | 42 |
2020 November | 29 | 17 | 46 |
2020 October | 27 | 19 | 46 |
2020 September | 21 | 20 | 41 |
2020 August | 25 | 15 | 40 |
2020 July | 19 | 24 | 43 |
2020 June | 26 | 9 | 35 |
2020 May | 31 | 14 | 45 |