array:23 [
  "pii" => "S2173574318301631"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2018.11.008"
  "estado" => "S300"
  "fechaPublicacion" => "2019-09-01"
  "aid" => "1136"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2017"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2019;15:e78-e79"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1
    "HTML" => 1
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X17302474"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2017.09.009"
      "estado" => "S300"
      "fechaPublicacion" => "2019-09-01"
      "aid" => "1136"
      "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Reumatol Clin. 2019;15:e78-e79"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 611
        "formatos" => array:3 [
          "EPUB" => 52
          "HTML" => 268
          "PDF" => 291
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "Infecci&#243;n de pr&#243;tesis articular por <span class="elsevierStyleItalic">Streptococcus mutans</span>"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "e78"
            "paginaFinal" => "e79"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Joint prosthesis infection by <span class="elsevierStyleItalic">Streptococcus mutans</span>"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 745
                "Ancho" => 1500
                "Tamanyo" => 121924
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#41; Tinci&#243;n de Gram directa de la muestra&#46; B&#41; Cultivo en agar chocolate&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "M&#243;nica Parra-Grande, Pedro Hern&#225;ndez-Ros, Ivan Prats-S&#225;nchez, Pilar L&#243;pez-Garc&#237;a"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "M&#243;nica"
                "apellidos" => "Parra-Grande"
              ]
              1 => array:2 [
                "nombre" => "Pedro"
                "apellidos" => "Hern&#225;ndez-Ros"
              ]
              2 => array:2 [
                "nombre" => "Ivan"
                "apellidos" => "Prats-S&#225;nchez"
              ]
              3 => array:2 [
                "nombre" => "Pilar"
                "apellidos" => "L&#243;pez-Garc&#237;a"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574318301631"
          "doi" => "10.1016/j.reumae.2018.11.008"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574318301631?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X17302474?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001500000005/v1_201910230648/S1699258X17302474/v1_201910230648/es/main.assets"
    ]
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574318301692"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2018.12.001"
    "estado" => "S300"
    "fechaPublicacion" => "2019-09-01"
    "aid" => "1138"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2019;15:e75-e77"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2
      "HTML" => 2
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Study of Apoptosis and Intercellular Adhesion in Oral Mucosa of Patients With Osteonecrosis Induced by Biphosphonates"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "e75"
          "paginaFinal" => "e77"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Estudio de apoptosis y adhesi&#243;n intercelular en mucosa oral de pacientes con osteonecrosis inducida por bifosfonatos"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1340
              "Ancho" => 1500
              "Tamanyo" => 515122
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Immunohistochemical apoptosis profile of oral mucosa in patients with osteonecrosis induced by BP&#46; &#40;A&#41; Microphotographs &#40;40&#215;&#41; showing nuclear expression of Bax in epithelium&#44; mainly in the basal and parabasal layer&#46; &#40;B&#41; Microphotographs &#40;40&#215;&#41; showing nuclear expression of Bax in spiny epithelium strata&#46; &#40;C and D&#41; Absence of the expression of Bcl-2 &#40;C&#41; and survivin &#40;D&#41; in oral mucosa epithelium&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Mariana Villarroel-Dorrego, Mar&#237;a Elena Romero, Orlando Reyes, Vanesa Pereira-Prado, Ronell Bologna-Molina"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Mariana"
              "apellidos" => "Villarroel-Dorrego"
            ]
            1 => array:2 [
              "nombre" => "Mar&#237;a Elena"
              "apellidos" => "Romero"
            ]
            2 => array:2 [
              "nombre" => "Orlando"
              "apellidos" => "Reyes"
            ]
            3 => array:2 [
              "nombre" => "Vanesa"
              "apellidos" => "Pereira-Prado"
            ]
            4 => array:2 [
              "nombre" => "Ronell"
              "apellidos" => "Bologna-Molina"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X1730253X"
        "doi" => "10.1016/j.reuma.2017.10.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X1730253X?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574318301692?idApp=UINPBA00004M"
    "url" => "/21735743/0000001500000005/v1_201910260908/S2173574318301692/v1_201910260908/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Joint Prosthesis Infection by <span class="elsevierStyleItalic">Streptococcus mutans</span>"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "e78"
        "paginaFinal" => "e79"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#243;nica Parra-Grande, Pedro Hern&#225;ndez-Ros, Ivan Prats-S&#225;nchez, Pilar L&#243;pez-Garc&#237;a"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "M&#243;nica"
            "apellidos" => "Parra-Grande"
            "email" => array:1 [
              0 => "monicaparra88@hotmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Pedro"
            "apellidos" => "Hern&#225;ndez-Ros"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Ivan"
            "apellidos" => "Prats-S&#225;nchez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Pilar"
            "apellidos" => "L&#243;pez-Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Microbiolog&#237;a&#44; Hospital General Universitario de Elche&#44; Elche&#44; Alicante&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Traumatolog&#237;a&#44; Hospital General Universitario de Elche&#44; Elche&#44; Alicante&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Infecci&#243;n de pr&#243;tesis articular por <span class="elsevierStyleItalic">Streptococcus mutans</span>"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 745
            "Ancho" => 1500
            "Tamanyo" => 121924
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Gram stain direct from the sample&#46; &#40;B&#41; Agar chocolate culture&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Streptococcus mutans &#40;Sm&#41;</span> is a microorganism of oral microbiota&#44; which causes dental decay&#44; bacteriaemia and endocarditis&#46; Only a single case report of arthritis from this microorganism<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> has been published&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present a case of joint prosthesis infection by <span class="elsevierStyleItalic">Sm</span>&#46; A 73 year-old male presented with distal oedemas and cellulite in the lower left limb &#40;LLL&#41;&#46; The patient had a history of morbid obesity&#44; high blood pressure&#44; dyslipidemia&#44; type 2 diabetes mellitus and chronic renal disorder&#46; Total right and left hip replacements had been performed &#40;1998&#8211;1999&#41;&#59; left knee replacement &#40;2014&#41; due to medial tibiofemoral compartment gonarthrosis in varus knee&#46; He had non complicated cellulite in LLL 2 years previously&#46; There was no history of oral treatment&#46; Findings from Venus Doppler Ultrasound were&#58; oedema of the subcutaneous cell tissue in LLL&#44; with joint effusion in the anterior compartment of the knee&#46; Possible infection of the total prosthesis was diagnosed and cellulite of the left knee&#59; an extraction of the cement spacer with extraction of the tibial and femoral component was performed&#46; The patella polyethylene was removed and the fragmented external side was extracted&#46; The cemented knee prosthesis was positioned&#44; with semi-constrained&#44; fixed plates&#44; SAMO trecking&#59; with no patella prosthesis&#46; There were no clinical signs or laboratory analysis compatible with sepsis or bacteriaemia&#46; No clinical or radiological signs were compatible with osteomyelitis&#46; One hundred cc of seropurulent liquid was obtained by evacuative arthrocentesis&#46; Inoculated synovial fluid was sent in blood culture bottles to the microbiology laboratory&#46; Antibiotic therapy with intravenous vancomycin and rifampin was initiated&#46; After 30<span class="elsevierStyleHsp" style=""></span>h of incubation in Bactec 9240 &#40;BD&#41; <span class="elsevierStyleItalic">Sm</span> was identified directly from aerobic bottle&#44; using mass spectrometry &#40;MALDI-TOF&#174;&#44; Bruker&#41;&#46; In Gram &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41; staining&#44; pleomorphic variable gran bacilli were observed&#46; The appearance of the colonies is represented in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#46; The direct bottle phenotype identification &#40;panel WalkAway&#174;&#44; Beckman&#41; the following 48<span class="elsevierStyleHsp" style=""></span>h was compatible with the identification of MALDI-TOF&#174;&#46; Antibiotic sensitivity was undertaken in addition to micro dilution &#40;panel WalkAway&#174;&#41;&#44; using concentration gradient &#40;E-test&#174;&#44; Bio-Merieux&#41;&#44; following the directives of EUCAST version 6&#46;0 2016-01-01&#46; The microorganism was sensitive to penicillin&#44; cefotaxime&#44; clindamycin and vancomycin&#46; Minimum inhibitory concentration &#40;MIC&#41;&#44; levofloxacin<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>1&#44; linezolid<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>1 and daptomycin<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#46;5&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Twelve days after hospital admittance surgery was performed&#44; with synovial fluid being taken again and the re-identification of <span class="elsevierStyleItalic">Sm&#46;</span></p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient&#39;s evolution was favourable with obvious clinical improvement compared with his pre-surgical status and after 18 days the patient was discharged from hospital with an outpatient antibiotic treatment &#40;levofloxacin&#58; 500<span class="elsevierStyleHsp" style=""></span>mg&#47;12<span class="elsevierStyleHsp" style=""></span>h oral administration for 42 days&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Sm</span> is a pleomorphic streptococcus &#40;bacillary in an acidic medium and coccus in a neutral or alkaline medium&#41;&#46; Described by Clarke in 1924 &#40;tooth decay&#41; and later its capacity to produce endocarditis was observed&#46; The <span class="elsevierStyleItalic">Sm</span> group includes isolated species in humans &#40;<span class="elsevierStyleItalic">mutans</span>&#44; <span class="elsevierStyleItalic">sobrinus</span>&#44; <span class="elsevierStyleItalic">criceti</span>&#44; <span class="elsevierStyleItalic">ratti</span> and <span class="elsevierStyleItalic">downei</span>&#41; and other isolated species in animals&#46; The <span class="elsevierStyleItalic">mutans</span> species is the producer of caries and the mother&#8211;child transmission is probably through oral secretions&#44; with this species being the one most frequently associated with bacteriaemia&#46; It may be confused with other streptococci and enterococci&#46; Its isolation and identification may be difficult&#44; as was corroborated by Emmerson and Eykyn&#44; and also by Schelenz and Cois&#44; reporting cases of endocarditis in which the agent had been erroneously determined as diphtheroid&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#8211;3</span></a> It is resistant to phagocytosis by polymorphonuclear leukocytes<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> and may participate in the pathogenesis of atherosclerosis&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> Many reports have been published associating <span class="elsevierStyleItalic">Sm</span> with the production of <span class="elsevierStyleItalic">biofilm</span> in dental plaque and in materials used in odontology&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> but there are few or no studies regarding Sm adherence to material used in prostheses or osteoarticular tissues&#46; It has been suggested that the bacteria wall could contribute to the inducement of arthritis in animal models&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> The bacterial protein <span class="elsevierStyleSmallCaps">I</span>&#47;<span class="elsevierStyleSmallCaps">II</span> &#40;pathogen-associated molecular pattern &#91;PAMP&#93;&#41; could contribute to adverse evolution in osteoarthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> It has been described that non C serotypes are prone to extra-oral translocation&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> It has been associated with conditions such as Beh&#231;et&#39;s disease&#44; Sj&#246;gren syndrome and rheumatoid arthritis&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4&#44;8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Few infections of the joints have been reported&#46; Before molecular identification techniques &#40;sequencing&#41; and proteomic techniques were available &#40;MALDI-TOF&#174;&#41;&#44; identification posed a diagnostic challenge due to <span class="elsevierStyleItalic">Sm&#39;s</span> ability to present as a &#8220;gram positive bacillus&#8221; to Gram stain and its possible confusion with other microorganisms&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Parra-Grande M&#44; Hern&#225;ndez-Ros P&#44; Prats-S&#225;nchez I&#44; L&#243;pez-Garc&#237;a P&#46; Infecci&#243;n de pr&#243;tesis articular por <span class="elsevierStyleItalic">Streptococcus mutans</span>&#46; Reumatol Clin&#46; 2019&#59;15&#58;e78&#8211;e79&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 745
            "Ancho" => 1500
            "Tamanyo" => 121924
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Gram stain direct from the sample&#46; &#40;B&#41; Agar chocolate culture&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Streptococcus mutans</span>&#58; una bacteria que hace honor a su nombre"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Lorena Porte"
                            1 => "J&#46; Stephanie Braun"
                            2 => "P&#46; Jeannette Dabanch"
                            3 => "A&#46; Ega&#241;a"
                            4 => "D&#46; Andrighetti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Rev Chil Infectol"
                        "fecha" => "2009"
                        "volumen" => "26"
                        "paginaInicial" => "571"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estreptococos viridans&#44; estreptococos de los grupos C y G y g&#233;nero Gemella"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Sinner"
                            1 => "A&#46; Tunkel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "Mandell, Douglas, Bennett"
                        "titulo" => "Enfermedades infecciosas&#58; principios y pr&#225;cticas"
                        "paginaInicial" => "2674"
                        "paginaFinal" => "2688"
                        "serieFecha" => "2012"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Streptococcus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46; Spellerberg"
                            1 => "C&#46; Brandt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "J&#46;Versalovic, K&#46;Carroll, G&#46;Funke, J&#46;Jorgensen, M&#46;Landry, D&#46;Warnock"
                        "titulo" => "Manual of clinical microbiology"
                        "paginaInicial" => "331"
                        "paginaFinal" => "349"
                        "serieFecha" => "2011"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Repeated bacteraemia caused by <span class="elsevierStyleItalic">Streptococcus mutans</span> in a patient with Sjogren&#39;s syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Nomura"
                            1 => "M&#46; Hamada"
                            2 => "K&#46; Nakano"
                            3 => "H&#46; Nemoto"
                            4 => "K&#46; Fujimoto"
                            5 => "T&#46; Ooshima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1099/jmm.0.47186-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Microbiol"
                        "fecha" => "2007"
                        "volumen" => "56"
                        "paginaInicial" => "988"
                        "paginaFinal" => "992"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17577066"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Invasion of human aortic endothelial cells by oral viridans group streptococci and induction of inflammatory cytokine production"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Nagata"
                            1 => "A&#46; de Toledo"
                            2 => "T&#46; Oho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.2041-1014.2010.00597.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Oral Microbiol"
                        "fecha" => "2011"
                        "volumen" => "26"
                        "paginaInicial" => "78"
                        "paginaFinal" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21214874"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An analytical tool-box for comprehensive biochemical&#44; structural and transcriptome evaluation of oral biofilms mediated by mutans streptococci"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;I&#46; Klein"
                            1 => "J&#46; Xiao"
                            2 => "A&#46; Heydorn"
                            3 => "H&#46; Koo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Vis Exp"
                        "fecha" => "2011"
                        "volumen" => "47"
                        "paginaInicial" => "e2512"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Arthritogenicity in rats of cell walls from several streptococci staphylococci and two other bacteria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46; Kohashi"
                            1 => "C&#46;M&#46; Pearson"
                            2 => "F&#46;W&#46; Beck"
                            3 => "T&#46; Narita"
                            4 => "S&#46; Kotani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3181/00379727-152-39360"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Soc Exp Biol Med"
                        "fecha" => "1976"
                        "volumen" => "152"
                        "paginaInicial" => "199"
                        "paginaFinal" => "203"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/819936"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "MMP-3 expression and release by rheumatoid arthritis fibroblast-like synoviocytes induced with a bacterial ligand of integrin &#945;5&#946;1"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;B&#46; Zeisel"
                            1 => "V&#46;A&#46; Druet"
                            2 => "D&#46; Wachsmann"
                            3 => "J&#46; Sibilia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/ar1745"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2005"
                        "volumen" => "7"
                        "paginaInicial" => "118"
                        "paginaFinal" => "126"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15899062"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "V Mobile microbiome&#58; oral bacteria in extra-oral infections and inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Y&#46;W&#46; Han"
                            1 => "X&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Dent Res"
                        "fecha" => "2013"
                        "volumen" => "92"
                        "paginaInicial" => "485"
                        "paginaFinal" => "491"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001500000005/v1_201910260908/S2173574318301631/v1_201910260908/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8400"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001500000005/v1_201910260908/S2173574318301631/v1_201910260908/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574318301631?idApp=UINPBA00004M"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Letter to the Editor
Joint Prosthesis Infection by Streptococcus mutans
Infección de prótesis articular por Streptococcus mutans
Mónica Parra-Grandea,
Corresponding author
monicaparra88@hotmail.com

Corresponding author.
, Pedro Hernández-Rosb, Ivan Prats-Sáncheza, Pilar López-Garcíaa
a Servicio de Microbiología, Hospital General Universitario de Elche, Elche, Alicante, Spain
b Servicio de Traumatología, Hospital General Universitario de Elche, Elche, Alicante, Spain
Read
4379
Times
was read the article
1590
Total PDF
2789
Total HTML
Share statistics
 array:23 [
  "pii" => "S2173574318301631"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2018.11.008"
  "estado" => "S300"
  "fechaPublicacion" => "2019-09-01"
  "aid" => "1136"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
  "copyrightAnyo" => "2017"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2019;15:e78-e79"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1
    "HTML" => 1
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X17302474"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2017.09.009"
      "estado" => "S300"
      "fechaPublicacion" => "2019-09-01"
      "aid" => "1136"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Reumatol Clin. 2019;15:e78-e79"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 611
        "formatos" => array:3 [
          "EPUB" => 52
          "HTML" => 268
          "PDF" => 291
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "Infecci&#243;n de pr&#243;tesis articular por <span class="elsevierStyleItalic">Streptococcus mutans</span>"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "e78"
            "paginaFinal" => "e79"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Joint prosthesis infection by <span class="elsevierStyleItalic">Streptococcus mutans</span>"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 745
                "Ancho" => 1500
                "Tamanyo" => 121924
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#41; Tinci&#243;n de Gram directa de la muestra&#46; B&#41; Cultivo en agar chocolate&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "M&#243;nica Parra-Grande, Pedro Hern&#225;ndez-Ros, Ivan Prats-S&#225;nchez, Pilar L&#243;pez-Garc&#237;a"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "M&#243;nica"
                "apellidos" => "Parra-Grande"
              ]
              1 => array:2 [
                "nombre" => "Pedro"
                "apellidos" => "Hern&#225;ndez-Ros"
              ]
              2 => array:2 [
                "nombre" => "Ivan"
                "apellidos" => "Prats-S&#225;nchez"
              ]
              3 => array:2 [
                "nombre" => "Pilar"
                "apellidos" => "L&#243;pez-Garc&#237;a"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574318301631"
          "doi" => "10.1016/j.reumae.2018.11.008"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574318301631?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X17302474?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001500000005/v1_201910230648/S1699258X17302474/v1_201910230648/es/main.assets"
    ]
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574318301692"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2018.12.001"
    "estado" => "S300"
    "fechaPublicacion" => "2019-09-01"
    "aid" => "1138"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2019;15:e75-e77"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2
      "HTML" => 2
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Study of Apoptosis and Intercellular Adhesion in Oral Mucosa of Patients With Osteonecrosis Induced by Biphosphonates"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "e75"
          "paginaFinal" => "e77"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Estudio de apoptosis y adhesi&#243;n intercelular en mucosa oral de pacientes con osteonecrosis inducida por bifosfonatos"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1340
              "Ancho" => 1500
              "Tamanyo" => 515122
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Immunohistochemical apoptosis profile of oral mucosa in patients with osteonecrosis induced by BP&#46; &#40;A&#41; Microphotographs &#40;40&#215;&#41; showing nuclear expression of Bax in epithelium&#44; mainly in the basal and parabasal layer&#46; &#40;B&#41; Microphotographs &#40;40&#215;&#41; showing nuclear expression of Bax in spiny epithelium strata&#46; &#40;C and D&#41; Absence of the expression of Bcl-2 &#40;C&#41; and survivin &#40;D&#41; in oral mucosa epithelium&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Mariana Villarroel-Dorrego, Mar&#237;a Elena Romero, Orlando Reyes, Vanesa Pereira-Prado, Ronell Bologna-Molina"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Mariana"
              "apellidos" => "Villarroel-Dorrego"
            ]
            1 => array:2 [
              "nombre" => "Mar&#237;a Elena"
              "apellidos" => "Romero"
            ]
            2 => array:2 [
              "nombre" => "Orlando"
              "apellidos" => "Reyes"
            ]
            3 => array:2 [
              "nombre" => "Vanesa"
              "apellidos" => "Pereira-Prado"
            ]
            4 => array:2 [
              "nombre" => "Ronell"
              "apellidos" => "Bologna-Molina"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X1730253X"
        "doi" => "10.1016/j.reuma.2017.10.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X1730253X?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574318301692?idApp=UINPBA00004M"
    "url" => "/21735743/0000001500000005/v1_201910260908/S2173574318301692/v1_201910260908/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Joint Prosthesis Infection by <span class="elsevierStyleItalic">Streptococcus mutans</span>"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "e78"
        "paginaFinal" => "e79"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#243;nica Parra-Grande, Pedro Hern&#225;ndez-Ros, Ivan Prats-S&#225;nchez, Pilar L&#243;pez-Garc&#237;a"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "M&#243;nica"
            "apellidos" => "Parra-Grande"
            "email" => array:1 [
              0 => "monicaparra88@hotmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Pedro"
            "apellidos" => "Hern&#225;ndez-Ros"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Ivan"
            "apellidos" => "Prats-S&#225;nchez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Pilar"
            "apellidos" => "L&#243;pez-Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Microbiolog&#237;a&#44; Hospital General Universitario de Elche&#44; Elche&#44; Alicante&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Traumatolog&#237;a&#44; Hospital General Universitario de Elche&#44; Elche&#44; Alicante&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Infecci&#243;n de pr&#243;tesis articular por <span class="elsevierStyleItalic">Streptococcus mutans</span>"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 745
            "Ancho" => 1500
            "Tamanyo" => 121924
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Gram stain direct from the sample&#46; &#40;B&#41; Agar chocolate culture&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Streptococcus mutans &#40;Sm&#41;</span> is a microorganism of oral microbiota&#44; which causes dental decay&#44; bacteriaemia and endocarditis&#46; Only a single case report of arthritis from this microorganism<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> has been published&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present a case of joint prosthesis infection by <span class="elsevierStyleItalic">Sm</span>&#46; A 73 year-old male presented with distal oedemas and cellulite in the lower left limb &#40;LLL&#41;&#46; The patient had a history of morbid obesity&#44; high blood pressure&#44; dyslipidemia&#44; type 2 diabetes mellitus and chronic renal disorder&#46; Total right and left hip replacements had been performed &#40;1998&#8211;1999&#41;&#59; left knee replacement &#40;2014&#41; due to medial tibiofemoral compartment gonarthrosis in varus knee&#46; He had non complicated cellulite in LLL 2 years previously&#46; There was no history of oral treatment&#46; Findings from Venus Doppler Ultrasound were&#58; oedema of the subcutaneous cell tissue in LLL&#44; with joint effusion in the anterior compartment of the knee&#46; Possible infection of the total prosthesis was diagnosed and cellulite of the left knee&#59; an extraction of the cement spacer with extraction of the tibial and femoral component was performed&#46; The patella polyethylene was removed and the fragmented external side was extracted&#46; The cemented knee prosthesis was positioned&#44; with semi-constrained&#44; fixed plates&#44; SAMO trecking&#59; with no patella prosthesis&#46; There were no clinical signs or laboratory analysis compatible with sepsis or bacteriaemia&#46; No clinical or radiological signs were compatible with osteomyelitis&#46; One hundred cc of seropurulent liquid was obtained by evacuative arthrocentesis&#46; Inoculated synovial fluid was sent in blood culture bottles to the microbiology laboratory&#46; Antibiotic therapy with intravenous vancomycin and rifampin was initiated&#46; After 30<span class="elsevierStyleHsp" style=""></span>h of incubation in Bactec 9240 &#40;BD&#41; <span class="elsevierStyleItalic">Sm</span> was identified directly from aerobic bottle&#44; using mass spectrometry &#40;MALDI-TOF&#174;&#44; Bruker&#41;&#46; In Gram &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41; staining&#44; pleomorphic variable gran bacilli were observed&#46; The appearance of the colonies is represented in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#46; The direct bottle phenotype identification &#40;panel WalkAway&#174;&#44; Beckman&#41; the following 48<span class="elsevierStyleHsp" style=""></span>h was compatible with the identification of MALDI-TOF&#174;&#46; Antibiotic sensitivity was undertaken in addition to micro dilution &#40;panel WalkAway&#174;&#41;&#44; using concentration gradient &#40;E-test&#174;&#44; Bio-Merieux&#41;&#44; following the directives of EUCAST version 6&#46;0 2016-01-01&#46; The microorganism was sensitive to penicillin&#44; cefotaxime&#44; clindamycin and vancomycin&#46; Minimum inhibitory concentration &#40;MIC&#41;&#44; levofloxacin<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>1&#44; linezolid<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>1 and daptomycin<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#46;5&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Twelve days after hospital admittance surgery was performed&#44; with synovial fluid being taken again and the re-identification of <span class="elsevierStyleItalic">Sm&#46;</span></p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient&#39;s evolution was favourable with obvious clinical improvement compared with his pre-surgical status and after 18 days the patient was discharged from hospital with an outpatient antibiotic treatment &#40;levofloxacin&#58; 500<span class="elsevierStyleHsp" style=""></span>mg&#47;12<span class="elsevierStyleHsp" style=""></span>h oral administration for 42 days&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Sm</span> is a pleomorphic streptococcus &#40;bacillary in an acidic medium and coccus in a neutral or alkaline medium&#41;&#46; Described by Clarke in 1924 &#40;tooth decay&#41; and later its capacity to produce endocarditis was observed&#46; The <span class="elsevierStyleItalic">Sm</span> group includes isolated species in humans &#40;<span class="elsevierStyleItalic">mutans</span>&#44; <span class="elsevierStyleItalic">sobrinus</span>&#44; <span class="elsevierStyleItalic">criceti</span>&#44; <span class="elsevierStyleItalic">ratti</span> and <span class="elsevierStyleItalic">downei</span>&#41; and other isolated species in animals&#46; The <span class="elsevierStyleItalic">mutans</span> species is the producer of caries and the mother&#8211;child transmission is probably through oral secretions&#44; with this species being the one most frequently associated with bacteriaemia&#46; It may be confused with other streptococci and enterococci&#46; Its isolation and identification may be difficult&#44; as was corroborated by Emmerson and Eykyn&#44; and also by Schelenz and Cois&#44; reporting cases of endocarditis in which the agent had been erroneously determined as diphtheroid&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#8211;3</span></a> It is resistant to phagocytosis by polymorphonuclear leukocytes<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> and may participate in the pathogenesis of atherosclerosis&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> Many reports have been published associating <span class="elsevierStyleItalic">Sm</span> with the production of <span class="elsevierStyleItalic">biofilm</span> in dental plaque and in materials used in odontology&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> but there are few or no studies regarding Sm adherence to material used in prostheses or osteoarticular tissues&#46; It has been suggested that the bacteria wall could contribute to the inducement of arthritis in animal models&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> The bacterial protein <span class="elsevierStyleSmallCaps">I</span>&#47;<span class="elsevierStyleSmallCaps">II</span> &#40;pathogen-associated molecular pattern &#91;PAMP&#93;&#41; could contribute to adverse evolution in osteoarthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> It has been described that non C serotypes are prone to extra-oral translocation&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> It has been associated with conditions such as Beh&#231;et&#39;s disease&#44; Sj&#246;gren syndrome and rheumatoid arthritis&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4&#44;8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Few infections of the joints have been reported&#46; Before molecular identification techniques &#40;sequencing&#41; and proteomic techniques were available &#40;MALDI-TOF&#174;&#41;&#44; identification posed a diagnostic challenge due to <span class="elsevierStyleItalic">Sm&#39;s</span> ability to present as a &#8220;gram positive bacillus&#8221; to Gram stain and its possible confusion with other microorganisms&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Parra-Grande M&#44; Hern&#225;ndez-Ros P&#44; Prats-S&#225;nchez I&#44; L&#243;pez-Garc&#237;a P&#46; Infecci&#243;n de pr&#243;tesis articular por <span class="elsevierStyleItalic">Streptococcus mutans</span>&#46; Reumatol Clin&#46; 2019&#59;15&#58;e78&#8211;e79&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 745
            "Ancho" => 1500
            "Tamanyo" => 121924
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Gram stain direct from the sample&#46; &#40;B&#41; Agar chocolate culture&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Streptococcus mutans</span>&#58; una bacteria que hace honor a su nombre"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Lorena Porte"
                            1 => "J&#46; Stephanie Braun"
                            2 => "P&#46; Jeannette Dabanch"
                            3 => "A&#46; Ega&#241;a"
                            4 => "D&#46; Andrighetti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Rev Chil Infectol"
                        "fecha" => "2009"
                        "volumen" => "26"
                        "paginaInicial" => "571"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estreptococos viridans&#44; estreptococos de los grupos C y G y g&#233;nero Gemella"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Sinner"
                            1 => "A&#46; Tunkel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "Mandell, Douglas, Bennett"
                        "titulo" => "Enfermedades infecciosas&#58; principios y pr&#225;cticas"
                        "paginaInicial" => "2674"
                        "paginaFinal" => "2688"
                        "serieFecha" => "2012"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Streptococcus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46; Spellerberg"
                            1 => "C&#46; Brandt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "J&#46;Versalovic, K&#46;Carroll, G&#46;Funke, J&#46;Jorgensen, M&#46;Landry, D&#46;Warnock"
                        "titulo" => "Manual of clinical microbiology"
                        "paginaInicial" => "331"
                        "paginaFinal" => "349"
                        "serieFecha" => "2011"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Repeated bacteraemia caused by <span class="elsevierStyleItalic">Streptococcus mutans</span> in a patient with Sjogren&#39;s syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Nomura"
                            1 => "M&#46; Hamada"
                            2 => "K&#46; Nakano"
                            3 => "H&#46; Nemoto"
                            4 => "K&#46; Fujimoto"
                            5 => "T&#46; Ooshima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1099/jmm.0.47186-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Microbiol"
                        "fecha" => "2007"
                        "volumen" => "56"
                        "paginaInicial" => "988"
                        "paginaFinal" => "992"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17577066"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Invasion of human aortic endothelial cells by oral viridans group streptococci and induction of inflammatory cytokine production"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Nagata"
                            1 => "A&#46; de Toledo"
                            2 => "T&#46; Oho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.2041-1014.2010.00597.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Oral Microbiol"
                        "fecha" => "2011"
                        "volumen" => "26"
                        "paginaInicial" => "78"
                        "paginaFinal" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21214874"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An analytical tool-box for comprehensive biochemical&#44; structural and transcriptome evaluation of oral biofilms mediated by mutans streptococci"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;I&#46; Klein"
                            1 => "J&#46; Xiao"
                            2 => "A&#46; Heydorn"
                            3 => "H&#46; Koo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Vis Exp"
                        "fecha" => "2011"
                        "volumen" => "47"
                        "paginaInicial" => "e2512"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Arthritogenicity in rats of cell walls from several streptococci staphylococci and two other bacteria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46; Kohashi"
                            1 => "C&#46;M&#46; Pearson"
                            2 => "F&#46;W&#46; Beck"
                            3 => "T&#46; Narita"
                            4 => "S&#46; Kotani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3181/00379727-152-39360"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Soc Exp Biol Med"
                        "fecha" => "1976"
                        "volumen" => "152"
                        "paginaInicial" => "199"
                        "paginaFinal" => "203"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/819936"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "MMP-3 expression and release by rheumatoid arthritis fibroblast-like synoviocytes induced with a bacterial ligand of integrin &#945;5&#946;1"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;B&#46; Zeisel"
                            1 => "V&#46;A&#46; Druet"
                            2 => "D&#46; Wachsmann"
                            3 => "J&#46; Sibilia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/ar1745"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2005"
                        "volumen" => "7"
                        "paginaInicial" => "118"
                        "paginaFinal" => "126"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15899062"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "V Mobile microbiome&#58; oral bacteria in extra-oral infections and inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Y&#46;W&#46; Han"
                            1 => "X&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Dent Res"
                        "fecha" => "2013"
                        "volumen" => "92"
                        "paginaInicial" => "485"
                        "paginaFinal" => "491"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001500000005/v1_201910260908/S2173574318301631/v1_201910260908/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8400"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001500000005/v1_201910260908/S2173574318301631/v1_201910260908/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574318301631?idApp=UINPBA00004M"
]
Article information
ISSN: 21735743
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 5 5 10
2024 October 50 46 96
2024 September 60 48 108
2024 August 75 59 134
2024 July 55 31 86
2024 June 70 26 96
2024 May 60 46 106
2024 April 65 22 87
2024 March 52 29 81
2024 February 38 16 54
2024 January 33 16 49
2023 December 51 22 73
2023 November 52 34 86
2023 October 47 27 74
2023 September 86 39 125
2023 August 45 13 58
2023 July 54 27 81
2023 June 51 21 72
2023 May 51 21 72
2023 April 38 7 45
2023 March 77 19 96
2023 February 69 27 96
2023 January 49 19 68
2022 December 75 35 110
2022 November 47 27 74
2022 October 69 33 102
2022 September 47 45 92
2022 August 45 44 89
2022 July 33 38 71
2022 June 46 25 71
2022 May 38 50 88
2022 April 48 36 84
2022 March 63 33 96
2022 February 65 26 91
2022 January 91 31 122
2021 December 49 38 87
2021 November 38 37 75
2021 October 67 44 111
2021 September 41 38 79
2021 August 33 30 63
2021 July 40 22 62
2021 June 40 28 68
2021 May 52 33 85
2021 April 112 72 184
2021 March 48 27 75
2021 February 60 21 81
2021 January 53 17 70
2020 December 57 14 71
2020 November 34 16 50
2020 October 26 21 47
2020 September 32 18 50
2020 August 18 21 39
2020 July 20 10 30
2020 June 27 12 39
2020 May 20 9 29
2020 April 19 19 38
2020 March 2 0 2
2019 November 1 0 1
Show all

Follow this link to access the full text of the article

Idiomas
Reumatología Clínica (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?