was read the article
array:24 [ "pii" => "S2173574319300218" "issn" => "21735743" "doi" => "10.1016/j.reumae.2017.11.005" "estado" => "S300" "fechaPublicacion" => "2019-11-01" "aid" => "1164" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología" "copyrightAnyo" => "2017" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Reumatol Clin. 2019;15:360-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 4 "formatos" => array:2 [ "HTML" => 2 "PDF" => 2 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S1699258X17303017" "issn" => "1699258X" "doi" => "10.1016/j.reuma.2017.11.013" "estado" => "S300" "fechaPublicacion" => "2019-11-01" "aid" => "1164" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Reumatol Clin. 2019;15:360-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1877 "formatos" => array:3 [ "EPUB" => 73 "HTML" => 1422 "PDF" => 382 ] ] "es" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original breve</span>" "titulo" => "Relación de calprotectina fecal y anti saccharomyces antisacaromices con otros marcadores de actividad en pacientes con espondiloartritis" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "360" "paginaFinal" => "362" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Relationship between fecal calprotectin, anti-<span class="elsevierStyleItalic">Saccharomyces cerevisiae</span> antibodies and other markers of disease activity in patients with spondyloarthritis" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María José Moreno Martínez, Manuel José Moreno Ramos, Luis Francisco Linares Ferrando" "autores" => array:3 [ 0 => array:2 [ "nombre" => "María José" "apellidos" => "Moreno Martínez" ] 1 => array:2 [ "nombre" => "Manuel José" "apellidos" => "Moreno Ramos" ] 2 => array:2 [ "nombre" => "Luis Francisco" "apellidos" => "Linares Ferrando" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173574319300218" "doi" => "10.1016/j.reumae.2017.11.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574319300218?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X17303017?idApp=UINPBA00004M" "url" => "/1699258X/0000001500000006/v1_201911200727/S1699258X17303017/v1_201911200727/es/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S2173574319301571" "issn" => "21735743" "doi" => "10.1016/j.reumae.2017.11.009" "estado" => "S300" "fechaPublicacion" => "2019-11-01" "aid" => "1154" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Reumatol Clin. 2019;15:363-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief report</span>" "titulo" => "Clinical Significance of Neutrophil/lymphocyte Ratio in Patients With Granulomatosis With Polyangiitis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "363" "paginaFinal" => "367" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Significación clínica del ratio neutrófilos/linfocitos en pacientes con granulomatosis con poliangeítis" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1838 "Ancho" => 1179 "Tamanyo" => 52921 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Neutrophil-to-lymphocyte Ratio in Patients With Granulomatosis With Polyangiitis and Controls.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Nouran M. Abaza, Eiman M. Abd El-Latif, Tamer A. Gheita" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Nouran M." "apellidos" => "Abaza" ] 1 => array:2 [ "nombre" => "Eiman M. Abd" "apellidos" => "El-Latif" ] 2 => array:2 [ "nombre" => "Tamer A." "apellidos" => "Gheita" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574319301571?idApp=UINPBA00004M" "url" => "/21735743/0000001500000006/v1_201911250632/S2173574319301571/v1_201911250632/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S217357431830176X" "issn" => "21735743" "doi" => "10.1016/j.reumae.2017.10.004" "estado" => "S300" "fechaPublicacion" => "2019-11-01" "aid" => "1151" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2019;15:355-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Characteristics and Disease Course in a Cohort of Children With PFAPA Syndrome in the Community of Madrid, Spain" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "355" "paginaFinal" => "359" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Características y evolución de una cohorte de niños con síndrome PFAPA en la Comunidad de Madrid" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2276 "Ancho" => 2344 "Tamanyo" => 200556 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">(A) Observed frequency of the signs included in the diagnostic criteria of Thomas. (B) Frequency of associated symptoms.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María de las Mercedes Ibáñez Alcalde, Laura Caldevilla Asenjo, Cristina Calvo Rey, Fernando García-Mon Marañés, Daniel Blázquez Gamero, Jesús Saavedra Lozano, María Luisa Navarro Gómez, Teresa Hernández-Sampelayo Matos, Mar Santos Sebastián" "autores" => array:9 [ 0 => array:2 [ "nombre" => "María de las Mercedes" "apellidos" => "Ibáñez Alcalde" ] 1 => array:2 [ "nombre" => "Laura" "apellidos" => "Caldevilla Asenjo" ] 2 => array:2 [ "nombre" => "Cristina" "apellidos" => "Calvo Rey" ] 3 => array:2 [ "nombre" => "Fernando" "apellidos" => "García-Mon Marañés" ] 4 => array:2 [ "nombre" => "Daniel" "apellidos" => "Blázquez Gamero" ] 5 => array:2 [ "nombre" => "Jesús" "apellidos" => "Saavedra Lozano" ] 6 => array:2 [ "nombre" => "María Luisa" "apellidos" => "Navarro Gómez" ] 7 => array:2 [ "nombre" => "Teresa" "apellidos" => "Hernández-Sampelayo Matos" ] 8 => array:2 [ "nombre" => "Mar" "apellidos" => "Santos Sebastián" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1699258X17302747" "doi" => "10.1016/j.reuma.2017.10.015" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X17302747?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357431830176X?idApp=UINPBA00004M" "url" => "/21735743/0000001500000006/v1_201911250632/S217357431830176X/v1_201911250632/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief Report</span>" "titulo" => "Relationship Between Fecal Calprotectin, Anti-<span class="elsevierStyleItalic">Saccharomyces</span><span class="elsevierStyleItalic">cerevisiae</span> Antibodies and Other Markers of Disease Activity in Patients With Spondyloarthritis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "360" "paginaFinal" => "362" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "María José Moreno Martínez, Manuel José Moreno Ramos, Luis Francisco Linares Ferrando" "autores" => array:3 [ 0 => array:4 [ "nombre" => "María José" "apellidos" => "Moreno Martínez" "email" => array:1 [ 0 => "mjmorenomartinez@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Manuel José" "apellidos" => "Moreno Ramos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Luis Francisco" "apellidos" => "Linares Ferrando" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Reumatología, Hospital Rafael Méndez, Lorca, Murcia, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Reumatología, Hospital Virgen de la Arrixaca, Murcia, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Relación de calprotectina fecal y anticuerpos anti saccharomyces con otros marcadores de actividad en pacientes con espondiloartritis" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Ankylosing spondylitis (AS) is a chronic inflammatory disease that may be associated with extra-skeletal manifestations such as inflammatory intestinal disease (IID), among others. There is a high incidence of IID in patients with AS. There is even a theory that AS and Crohn's disease share the same etiopathogenesis.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> 25%–50% of AS patients without IID symptoms have an intestinal histology with inflammation, according to some works.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Increased intestinal permeability has been found in IID as well as in AS, shown by the presence of certain markers such as anti-<span class="elsevierStyleItalic">Saccharomyces cerevisiae</span> antibodies (ASCA) and calprotectin, among others.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Faecal and serum calprotectin is used to differentiate between IID and functional intestinal disease.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3,4</span></a> A rise in serum calprotectin has been observed in patients with spondyloarthritis (Spa), with a good correlation with other markets (PCR and VSG, among others), disease progression<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> with response to treatment.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3,5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">There are doubts as to whether the concentration of faecal calprotectin in AS patients is linked to taking non-steroid anti-inflammatory drugs (NSAID). In some series patients with AS who do not take NSAID have similar concentrations of calprotectin to patients with IID.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In other diseases, such as rheumatoid arthritis and psoriatic arthropathy, faecal calprotectin may act as an independent predictor of joint injury,<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">4,6</span></a> and it is associated with vascular alterations.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Objectives</span><p id="par0030" class="elsevierStylePara elsevierViewall">To discover whether the rise in faecal calprotectin and ASCA is associated with activity and physical function markers in patients with Spa.</p><p id="par0035" class="elsevierStylePara elsevierViewall">We will also analyse the association of calprotectin and ASCA with taking NSAID and with other relevant parameters (HLA-B27 positivity or treatments, among others).</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material and Methods</span><p id="par0040" class="elsevierStylePara elsevierViewall">The patients, who were over the age of 18 years old, were recruited in the dedicated spondyloarthritis department of the University Hospital Virgen de la Arrixaca, Murcia, sequentially in the order of their visits. Patients diagnosed non-radiographic axial spondyloarthritis were included, according to ASAS criteria, as were those diagnosed AS according to the modified New York criteria.</p><p id="par0045" class="elsevierStylePara elsevierViewall">BASDAI and ASDAS-PCR were included as disease activity variables, together with others for physical functioning (BASFI) and to evaluate the disease. Analytical variables were included, such as sedimentation velocity, reactive C protein, the presence of HLA-B27, blood levels of ASCA and faecal calprotectin levels (microgram/gram). ELISA technique was used to detect faecal calprotectin, and 50<span class="elsevierStyleHsp" style=""></span>μg/g stool was considered to be the upper limit of normality.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Patients under the age of 18 years old were excluded, as were those who found it difficult to fill out the questionnaires and those without a definitive diagnosis and/or with another type of spondyloarthritis, including psoriatic arthropathy.</p><p id="par0055" class="elsevierStylePara elsevierViewall">A descriptive analysis was carried out, together with a correlation study and comparison of averages for non-parametric variables (SPSS 15.0). We performed a lineal regression analysis to evaluate the predictive capacity of the variables regarding faecal calprotectin levels.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">Thirty-three patients were included (22 men). 54.8% were AS and the others were cases of non-radiographic axial spondyloarthritis.</p><p id="par0065" class="elsevierStylePara elsevierViewall">The average age was 46.5 (±<span class="elsevierStyleHsp" style=""></span>13.6) years old, and 80% of the patients were HLA B27 positive.</p><p id="par0070" class="elsevierStylePara elsevierViewall">51.5% of the patients took an NSAID every day. 39.4% were only taking NSAID, while 6% were taking non-biological immunosupressors, 30.3% were taking biological anti-TNF alpha drugs and 21.2% were untreated.</p><p id="par0075" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the other characteristics of the patients.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">All of the patients except one had normal ASCA levels.</p><p id="par0085" class="elsevierStylePara elsevierViewall">84.4% of the patients had levels<span class="elsevierStyleHsp" style=""></span>≥<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>μg/g of faecal calprotectin, and 47% had levels<span class="elsevierStyleHsp" style=""></span>≥<span class="elsevierStyleHsp" style=""></span>100<span class="elsevierStyleHsp" style=""></span>μg/g.</p><p id="par0090" class="elsevierStylePara elsevierViewall">We found no differences in levels of faecal calprotectin according to the diagnosis (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.43). This was also the case with the activity parameters, including acute phase reagents (PCR and VSG).</p><p id="par0095" class="elsevierStylePara elsevierViewall">The faecal calprotectin level was only statistically correlated with PCR (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.001; <span class="elsevierStyleItalic">r</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">s</span></span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.55) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">No relationship was found between calprotectin levels and the diagnosis or HLA B27 positivity.</p><p id="par0105" class="elsevierStylePara elsevierViewall">We found no association between PCR levels and NSAID administration (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>.05).</p><p id="par0110" class="elsevierStylePara elsevierViewall">The lineal regression study included the level of calprotectin as a dependent variable, and the predictive variables were the BASDAI, PCR, VSG, sex, age and diagnosis. We obtained a corrected <span class="elsevierStyleItalic">R</span><span class="elsevierStyleSup">2</span> determination coefficient<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.04, and none of the variables were statistically significant.</p><p id="par0115" class="elsevierStylePara elsevierViewall">We wanted to see whether the increase in calprotectin could be secondary to NSAID administration. For this purpose, a subgroup of 13 patients (8 men) who were taking a NSAID and had a high level of calprotectin<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>μg/g were subjected to a second determination of calprotectin as well as the other variables, after one month without taking a NSAID:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">•</span><p id="par0120" class="elsevierStylePara elsevierViewall">Their average age was 47 years old (±<span class="elsevierStyleHsp" style=""></span>10.25).</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">•</span><p id="par0125" class="elsevierStylePara elsevierViewall">No significant differences were detected between the levels of acute phase reagents, BASDAI, BASFI and the overall evaluation of the patient (EVA), before and after the withdrawal of the NSAID.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">•</span><p id="par0130" class="elsevierStylePara elsevierViewall">After the withdrawal of the NSAID we found no significant differences in the average levels of calprotectin (92 vs 110, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.9) or in the other parameters.</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">•</span><p id="par0135" class="elsevierStylePara elsevierViewall">We found no differences in the percentage of patients with calprotectin<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>μg/g before and after.</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">•</span><p id="par0140" class="elsevierStylePara elsevierViewall">Nine patients were assessed by a digestive system specialist using colonoscopy. One patient was diagnosed with irritable bowel syndrome and probable enteropathy caused by a NSAID.</p></li></ul></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0145" class="elsevierStylePara elsevierViewall">In rheumatology, several studies associate disease activity in patients with Spa with microscopic inflammatory digestive pathology.</p><p id="par0150" class="elsevierStylePara elsevierViewall">In this work we found a positive correlation between faecal calprotectin and PCR in our spondyloarthritis series. The association with other inflammation or activity markers was not confirmed.</p><p id="par0155" class="elsevierStylePara elsevierViewall">Practically 100% of the patients had normal levels of ASCA, so that it can be deduced that this marker would not be useful as an activity indicator.</p><p id="par0160" class="elsevierStylePara elsevierViewall">Raised calprotectin level has been associated in some spondyloarthritis patient cohorts with NSAID administration. In this work we analysed calprotectin levels following NSAID withdrawal in a subgroup of patients, and we found that there was no significant change in the said levels. Nor were alterations found in the colonoscopy of these patients. Disease activity may be a reason for the association between calprotectin and NSAID administration: patients with inflammation and pain take NSAID to control it. The lack of a relationship between treatment with a NSAID and PCR may be due to the rarity of this marker rising in disease of this type.</p><p id="par0165" class="elsevierStylePara elsevierViewall">The small number of patients in this study should be taken into account as a source of distortion. This may be the reason why there is a lack of correlation between calprotectin and other activity parameters such as the BASDAI.</p><p id="par0170" class="elsevierStylePara elsevierViewall">Another distortion that we can analyse is the time without NSAID administration in the 13-patient subgroup. According to some other studies,<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> some calprotectin analysis tests recommend not taking NSAID during the two days prior to taking the sample. A recent study<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> which analyses the possible influence of NSAIDs on levels of faecal calprotectin, suggests that two weeks without NSAID are sufficient for levels of faecal calprotectin to be unaltered by these drugs.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusions</span><p id="par0175" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">•</span><p id="par0180" class="elsevierStylePara elsevierViewall">Faecal calprotectin levels are raised in patients with spondyloarthritis, correlating positively with PCR.</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">•</span><p id="par0185" class="elsevierStylePara elsevierViewall">Raised levels of faecal calprotectin are not modified by taking an NSAID or not.</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">•</span><p id="par0190" class="elsevierStylePara elsevierViewall">ASCA levels in blood neither vary nor show any relationship with clinical parameters in the population studied.</p></li></ul></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of Interests</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres1268363" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1173964" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1268364" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1173963" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Objectives" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Material and Methods" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Results" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Discussion" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Conclusions" ] 10 => array:2 [ "identificador" => "sec0035" "titulo" => "Conflict of Interests" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-07-09" "fechaAceptado" => "2017-11-26" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1173964" "palabras" => array:4 [ 0 => "Spondyloarthritis" 1 => "Anti-inflammatory drugs" 2 => "Calprotectin" 3 => "Inflammation" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1173963" "palabras" => array:4 [ 0 => "Espondiloartritis" 1 => "Antiinflamatorios" 2 => "Calprotectina" 3 => "Inflamación" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To assess the relationship between the increase of faecal calprotectin, anti-<span class="elsevierStyleItalic">Saccharomyces cerevisiae</span> antibodies (ASCA) and disease markers in a group of patients with spondyloarthritis.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We evaluated patients who were at least 18 years old and met the Assessment in Spondyloarthritis International Society (ASAS) criteria for spondyloarthritis or the New York modified criteria. We analysed activity criteria, physical function, analytical criteria (human leucocyte antigen [HLA] B27, faecal calprotectin, presence of ASCA, among others) and demographic data.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We included 33 patients. All but one patient had normal ASCA values. We found statistical significance in the correlation of calprotectin with <span class="elsevierStyleSmallCaps">C</span>-reactive protein (CRP) but not with other parameters. We also found a relationship between calprotectin levels and nonsteroidal anti-inflammatory drug (NSAID) intake (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.001). We found no relationship between CRP levels and NSAID use. After discontinuation of NSAIDs for one month, we found no significant differences in calprotectin levels (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.9).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Faecal calprotectin is elevated in patients with spondyloarthritis and correlates positively with CRP. Level of faecal calprotectin is not altered by NSAID use. The amount of ASCA present does not change and does not correlate with any clinical parameters in the study population.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Valorar la relación entre la calprotectina fecal, ASCA y marcadores de enfermedad en espondiloartritis (Spa).</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se evaluaron pacientes<span class="elsevierStyleHsp" style=""></span>≥<span class="elsevierStyleHsp" style=""></span>18 años que cumplían criterios ASAS o criterios modificados de Nueva York. Se analizan criterios de actividad, función física, analíticos y datos demográficos.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 33 pacientes. Todos excepto uno tenían valores normales de ASCA. Encontramos correlación significativa entre calprotectina y PCR pero no con otros parámetros, ni entre los niveles de calprotectina y la toma de AINE (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,001). Tampoco entre los niveles de PCR y el uso de AINE. Después de retirar los AINE no encontramos diferencias en los niveles de calprotectina (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,9).</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La calprotectina fecal está elevada en pacientes con Spa y se correlaciona positivamente con la PCR. La elevación de la calprotectina fecal no se ve alterada por el uso de AINE. La cantidad de ASCA no cambia y no se correlaciona con ningún parámetro clínico en el estudio poblacional.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as: Moreno Martínez MJ, Moreno Ramos MJ, Linares Ferrando LF. Relación de calprotectina fecal y anticuerpos antisacaromices con otros marcadores de actividad en pacientes con espondiloartritis. Reumatol Clin. 2019;15:360–362.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Average (± standard deviation) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Faecal calprotectin (μg/g stool) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">136.75 (± 146.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Reactive C protein (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.47 (± .7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sedimentation rate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.43 (± 10.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BASDAI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.78 (± 2. 4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BASFI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.60 (± 2. 8) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2169547.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Average and Standard Deviation of Activity and Physical Function Markers.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Correlation \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">r</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">s</span></span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> (significance) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Calprotectin/VSG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.29 (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.11) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Calprotectin/BASDAI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.16 (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.94) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Calprotectin/BASFI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.15 (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.50) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Calprotectin/AGE \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.02 (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.91) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Calprotectin/PCR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.55 (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.001) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2169548.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Spearman's correlation coefficient.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Correlation Between Calprotectin and BASDAI, BASFI, Age and PCR.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0045" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Marker of intestinal inflammation in patients with ankylosing spondylitis: a pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.G. Matzkies" 1 => "S.R. Targan" 2 => "D. Berel" 3 => "C.J. Landers" 4 => "J.D. Reveille" 5 => "D. McGovern" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/ar4106" "Revista" => array:5 [ "tituloSerie" => "Arthritis Res Ther" "fecha" => "2012" "volumen" => "14" "paginaInicial" => "R261" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23194008" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0050" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Calprotectin serum level is an independent marker for radiographic spinal progression in axial spondyloarthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.C. Turina" 1 => "J. Sieper" 2 => "N. Yeremenko" 3 => "K. Conrad" 4 => "H. Haibel" 5 => "M. Rudwaleit" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/annrheumdis-2014-205506" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2014" "volumen" => "73" "paginaInicial" => "1746" "paginaFinal" => "1748" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24845387" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0055" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Calprotectin (S100A8/9) as serum biomarker for clinical response in proof-of-concept trials in axial and peripheral spondyloarthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Turina" 1 => "N. Yeremenko" 2 => "J. Paramarta" 3 => "L. Rycke" 4 => "D. Baeten" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s13075-014-0413-4" "Revista" => array:5 [ "tituloSerie" => "Arthritis Res Ther" "fecha" => "2014" "volumen" => "16" "paginaInicial" => "413" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25135077" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0060" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of fecal calprotectin in gastrointestinal disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Montalto" 1 => "A. Gallo" 2 => "L. Santoro" 3 => "F. d’Onofrio" 4 => "R. Landolfi" 5 => "A. Gasbarrini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Rev Med Pharmacol Sci" "fecha" => "2013" "volumen" => "17" "paginaInicial" => "1569" "paginaFinal" => "1582" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23832721" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0065" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Calprotectin in rheumatoid arthritis: association with disease activity in a cross-sectional and a longitudinal cohort" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Garcia-Arias" 1 => "D. Pascual-Salcedo" 2 => "S. Ramiro" 3 => "M.E. Ueberschlag" 4 => "T.M. Jermann" 5 => "E. Martin-Mola" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s40291-013-0016-9" "Revista" => array:6 [ "tituloSerie" => "Mol Diagn Ther" "fecha" => "2013" "volumen" => "17" "paginaInicial" => "49" "paginaFinal" => "56" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23329363" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0070" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "S100 proteins calprotectin and S100A12 are related to radiographic changes rather than disease activity in psoriatic arthritis with low disease activity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T.M. Madiand" 1 => "A. Larsen" 2 => "J.G. Brun" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2007" "volumen" => "34" "paginaInicial" => "2089" "paginaFinal" => "2092" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17787039" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0075" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of 1-year anti-TNF-α therapy on aortic stiffness, carotid atherosclerosis, and calprotectin in inflammatory arthropathies: a controlled study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K. Angel" 1 => "S. Provan" 2 => "M. Fagerhol" 3 => "P. Mowinckel" 4 => "T. Kvien" 5 => "D. Atar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Hypertens" "fecha" => "2012" "volumen" => "25" "paginaInicial" => "644" "paginaFinal" => "650" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0080" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of oral diclofenac intake on faecal calprotectin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Z. Rendek" 1 => "M. Falk" 2 => "E. Grodzinsky" 3 => "K. Wahlin" 4 => "S. Kechagias" 5 => "R. Svernlöv" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/00365521.2015.1066421" "Revista" => array:6 [ "tituloSerie" => "Scand J Gastroenterol" "fecha" => "2016" "volumen" => "51" "paginaInicial" => "28" "paginaFinal" => "32" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26200803" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000001500000006/v1_201911250632/S2173574319300218/v1_201911250632/en/main.assets" "Apartado" => array:4 [ "identificador" => "43294" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001500000006/v1_201911250632/S2173574319300218/v1_201911250632/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574319300218?idApp=UINPBA00004M" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 6 | 5 | 11 |
2024 October | 86 | 27 | 113 |
2024 September | 110 | 18 | 128 |
2024 August | 126 | 48 | 174 |
2024 July | 123 | 38 | 161 |
2024 June | 100 | 35 | 135 |
2024 May | 120 | 48 | 168 |
2024 April | 90 | 28 | 118 |
2024 March | 101 | 41 | 142 |
2024 February | 90 | 41 | 131 |
2024 January | 67 | 33 | 100 |
2023 December | 43 | 24 | 67 |
2023 November | 78 | 48 | 126 |
2023 October | 92 | 28 | 120 |
2023 September | 142 | 47 | 189 |
2023 August | 98 | 21 | 119 |
2023 July | 57 | 29 | 86 |
2023 June | 52 | 31 | 83 |
2023 May | 64 | 22 | 86 |
2023 April | 44 | 12 | 56 |
2023 March | 88 | 20 | 108 |
2023 February | 57 | 27 | 84 |
2023 January | 76 | 15 | 91 |
2022 December | 110 | 24 | 134 |
2022 November | 94 | 28 | 122 |
2022 October | 99 | 27 | 126 |
2022 September | 94 | 29 | 123 |
2022 August | 89 | 68 | 157 |
2022 July | 86 | 62 | 148 |
2022 June | 65 | 35 | 100 |
2022 May | 70 | 48 | 118 |
2022 April | 52 | 35 | 87 |
2022 March | 54 | 44 | 98 |
2022 February | 61 | 28 | 89 |
2022 January | 83 | 27 | 110 |
2021 December | 76 | 38 | 114 |
2021 November | 89 | 50 | 139 |
2021 October | 103 | 50 | 153 |
2021 September | 83 | 42 | 125 |
2021 August | 54 | 38 | 92 |
2021 July | 37 | 27 | 64 |
2021 June | 56 | 28 | 84 |
2021 May | 65 | 49 | 114 |
2021 April | 170 | 54 | 224 |
2021 March | 71 | 30 | 101 |
2021 February | 55 | 23 | 78 |
2021 January | 69 | 26 | 95 |
2020 December | 71 | 25 | 96 |
2020 November | 49 | 21 | 70 |
2020 October | 44 | 20 | 64 |
2020 September | 61 | 24 | 85 |
2020 August | 54 | 19 | 73 |
2020 July | 37 | 16 | 53 |
2020 June | 42 | 2 | 44 |
2020 May | 54 | 21 | 75 |
2020 January | 1 | 0 | 1 |
2019 April | 1 | 2 | 3 |