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shown by the presence of certain markers such as anti-<span class="elsevierStyleItalic">Saccharomyces cerevisiae</span> antibodies &#40;ASCA&#41; and calprotectin&#44; among others&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Faecal and serum calprotectin is used to differentiate between IID and functional intestinal disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3&#44;4</span></a> A rise in serum calprotectin has been observed in patients with spondyloarthritis &#40;Spa&#41;&#44; with a good correlation with other markets &#40;PCR and VSG&#44; among others&#41;&#44; disease progression<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> with response to treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">There are doubts as to whether the concentration of faecal calprotectin in AS patients is linked to taking non-steroid anti-inflammatory drugs &#40;NSAID&#41;&#46; In some series patients with AS who do not take NSAID have similar concentrations of calprotectin to patients with IID&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In other diseases&#44; such as rheumatoid arthritis and psoriatic arthropathy&#44; faecal calprotectin may act as an independent predictor of joint injury&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">4&#44;6</span></a> and it is associated with vascular alterations&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Objectives</span><p id="par0030" class="elsevierStylePara elsevierViewall">To discover whether the rise in faecal calprotectin and ASCA is associated with activity and physical function markers in patients with Spa&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">We will also analyse the association of calprotectin and ASCA with taking NSAID and with other relevant parameters &#40;HLA-B27 positivity or treatments&#44; among others&#41;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material and Methods</span><p id="par0040" class="elsevierStylePara elsevierViewall">The patients&#44; who were over the age of 18 years old&#44; were recruited in the dedicated spondyloarthritis department of the University Hospital Virgen de la Arrixaca&#44; Murcia&#44; sequentially in the order of their visits&#46; Patients diagnosed non-radiographic axial spondyloarthritis were included&#44; according to ASAS criteria&#44; as were those diagnosed AS according to the modified New York criteria&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">BASDAI and ASDAS-PCR were included as disease activity variables&#44; together with others for physical functioning &#40;BASFI&#41; and to evaluate the disease&#46; Analytical variables were included&#44; such as sedimentation velocity&#44; reactive C protein&#44; the presence of HLA-B27&#44; 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54&#46;8&#37; were AS and the others were cases of non-radiographic axial spondyloarthritis&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The average age was 46&#46;5 &#40;&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;6&#41; years old&#44; and 80&#37; of the patients were HLA B27 positive&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">51&#46;5&#37; of the patients took an NSAID every day&#46; 39&#46;4&#37; were only taking NSAID&#44; while 6&#37; were taking non-biological immunosupressors&#44; 30&#46;3&#37; were taking biological anti-TNF alpha drugs and 21&#46;2&#37; were untreated&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the other characteristics of the patients&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">All of the patients except one had normal ASCA levels&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">84&#46;4&#37; of the patients had levels<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;g of faecal calprotectin&#44; and 47&#37; had levels<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>100<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;g&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">We found no differences in levels of faecal calprotectin according to the diagnosis &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;43&#41;&#46; This was also the case with the activity parameters&#44; including acute phase reagents &#40;PCR and VSG&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The faecal calprotectin level was only statistically correlated with PCR &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;001&#59; <span class="elsevierStyleItalic">r</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">s</span></span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;55&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">No relationship was found between calprotectin levels and the diagnosis or HLA B27 positivity&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">We found no association between PCR levels and NSAID administration &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">The lineal regression study included the level of calprotectin as a dependent variable&#44; and the predictive variables were the BASDAI&#44; PCR&#44; VSG&#44; sex&#44; age and diagnosis&#46; We obtained a corrected <span class="elsevierStyleItalic">R</span><span class="elsevierStyleSup">2</span> determination coefficient<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;04&#44; and none of the variables were statistically significant&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">We wanted to see whether the increase in calprotectin could be secondary to NSAID administration&#46; For this purpose&#44; a subgroup of 13 patients &#40;8 men&#41; who were taking a NSAID and had a high level of calprotectin<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;g were subjected to a second determination of calprotectin as well as the other variables&#44; after one month without taking a NSAID&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0120" class="elsevierStylePara elsevierViewall">Their average age was 47 years old &#40;&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;25&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0125" class="elsevierStylePara elsevierViewall">No significant differences were detected between the levels of acute phase reagents&#44; BASDAI&#44; BASFI and the overall evaluation of the patient &#40;EVA&#41;&#44; before and after the withdrawal of the NSAID&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0130" class="elsevierStylePara elsevierViewall">After the withdrawal of the NSAID we found no significant differences in the average levels of calprotectin &#40;92 vs 110&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;9&#41; or in the other parameters&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0135" class="elsevierStylePara elsevierViewall">We found no differences in the percentage of patients with calprotectin<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;g before and after&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0140" class="elsevierStylePara elsevierViewall">Nine patients were assessed by a digestive system specialist using colonoscopy&#46; One patient was diagnosed with irritable bowel syndrome and probable enteropathy caused by a NSAID&#46;</p></li></ul></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0145" class="elsevierStylePara elsevierViewall">In rheumatology&#44; several studies associate disease activity in patients with Spa with microscopic inflammatory digestive pathology&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In this work we found a positive correlation between faecal calprotectin and PCR in our spondyloarthritis series&#46; The association with other inflammation or activity markers was not confirmed&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Practically 100&#37; of the patients had normal levels of ASCA&#44; so that it can be deduced that this marker would not be useful as an activity indicator&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Raised calprotectin level has been associated in some spondyloarthritis patient cohorts with NSAID administration&#46; In this work we analysed calprotectin levels following NSAID withdrawal in a subgroup of patients&#44; and we found that there was no significant change in the said levels&#46; Nor were alterations found in the colonoscopy of these patients&#46; Disease activity may be a reason for the association between calprotectin and NSAID administration&#58; patients with inflammation and pain take NSAID to control it&#46; The lack of a relationship between treatment with a NSAID and PCR may be due to the rarity of this marker rising in disease of this type&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The small number of patients in this study should be taken into account as a source of distortion&#46; This may be the reason why there is a lack of correlation between calprotectin and other activity parameters such as the BASDAI&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Another distortion that we can analyse is the time without NSAID administration in the 13-patient subgroup&#46; According to some other studies&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> some calprotectin analysis tests recommend not taking NSAID during the two days prior to taking the sample&#46; A recent study<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> which analyses the possible influence of NSAIDs on levels of faecal calprotectin&#44; suggests that two weeks without NSAID are sufficient for levels of faecal calprotectin to be unaltered by these drugs&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusions</span><p id="par0175" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8226;</span><p id="par0180" class="elsevierStylePara elsevierViewall">Faecal calprotectin levels are raised in patients with spondyloarthritis&#44; correlating positively with PCR&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0185" class="elsevierStylePara elsevierViewall">Raised levels of faecal calprotectin are not modified by taking an NSAID or not&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">&#8226;</span><p id="par0190" class="elsevierStylePara elsevierViewall">ASCA levels in blood neither vary nor show any relationship with clinical parameters in the population studied&#46;</p></li></ul></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of Interests</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare&#46;</p></span></span>"
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              "identificador" => "abst0005"
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          "titulo" => "Resumen"
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          "titulo" => "Introduction"
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          "titulo" => "Objectives"
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    "fechaRecibido" => "2017-07-09"
    "fechaAceptado" => "2017-11-26"
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          "clase" => "keyword"
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          "palabras" => array:4 [
            0 => "Spondyloarthritis"
            1 => "Anti-inflammatory drugs"
            2 => "Calprotectin"
            3 => "Inflammation"
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      ]
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1173963"
          "palabras" => array:4 [
            0 => "Espondiloartritis"
            1 => "Antiinflamatorios"
            2 => "Calprotectina"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To assess the relationship between the increase of faecal calprotectin&#44; anti-<span class="elsevierStyleItalic">Saccharomyces cerevisiae</span> antibodies &#40;ASCA&#41; and disease markers in a group of patients with spondyloarthritis&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We evaluated patients who were at least 18 years old and met the Assessment in Spondyloarthritis International Society &#40;ASAS&#41; criteria for spondyloarthritis or the New York modified criteria&#46; We analysed activity criteria&#44; physical function&#44; analytical criteria &#40;human leucocyte antigen &#91;HLA&#93; B27&#44; faecal calprotectin&#44; presence of ASCA&#44; among others&#41; and demographic data&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We included 33 patients&#46; All but one patient had normal ASCA values&#46; We found statistical significance in the correlation of calprotectin with <span class="elsevierStyleSmallCaps">C</span>-reactive protein &#40;CRP&#41; but not with other parameters&#46; We also found a relationship between calprotectin levels and nonsteroidal anti-inflammatory drug &#40;NSAID&#41; intake &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; We found no relationship between CRP levels and NSAID use&#46; After discontinuation of NSAIDs for one month&#44; we found no significant differences in calprotectin levels &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;9&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Faecal calprotectin is elevated in patients with spondyloarthritis and correlates positively with CRP&#46; Level of faecal calprotectin is not altered by NSAID use&#46; The amount of ASCA present does not change and does not correlate with any clinical parameters in the study population&#46;</p></span>"
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          1 => array:2 [
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Valorar la relaci&#243;n entre la calprotectina fecal&#44; ASCA y marcadores de enfermedad en espondiloartritis &#40;Spa&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se evaluaron pacientes<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>18 a&#241;os que cumpl&#237;an criterios ASAS o criterios modificados de Nueva York&#46; Se analizan criterios de actividad&#44; funci&#243;n f&#237;sica&#44; anal&#237;ticos y datos demogr&#225;ficos&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 33 pacientes&#46; Todos excepto uno ten&#237;an valores normales de ASCA&#46; Encontramos correlaci&#243;n significativa entre calprotectina y PCR pero no con otros par&#225;metros&#44; ni entre los niveles de calprotectina y la toma de AINE &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Tampoco entre los niveles de PCR y el uso de AINE&#46; Despu&#233;s de retirar los AINE no encontramos diferencias en los niveles de calprotectina &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;9&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La calprotectina fecal est&#225; elevada en pacientes con Spa y se correlaciona positivamente con la PCR&#46; La elevaci&#243;n de la calprotectina fecal no se ve alterada por el uso de AINE&#46; La cantidad de ASCA no cambia y no se correlaciona con ning&#250;n par&#225;metro cl&#237;nico en el estudio poblacional&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Moreno Mart&#237;nez MJ&#44; Moreno Ramos MJ&#44; Linares Ferrando LF&#46; Relaci&#243;n de calprotectina fecal y anticuerpos antisacaromices con otros marcadores de actividad en pacientes con espondiloartritis&#46; Reumatol Clin&#46; 2019&#59;15&#58;360&#8211;362&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Faecal calprotectin &#40;&#956;g&#47;g stool&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Sedimentation rate&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">BASDAI&nbsp;\t\t\t\t\t\t\n
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          "identificador" => "bibs0015"
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            0 => array:3 [
              "identificador" => "bib0045"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Marker of intestinal inflammation in patients with ankylosing spondylitis&#58; a pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;G&#46; Matzkies"
                            1 => "S&#46;R&#46; Targan"
                            2 => "D&#46; Berel"
                            3 => "C&#46;J&#46; Landers"
                            4 => "J&#46;D&#46; Reveille"
                            5 => "D&#46; McGovern"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/ar4106"
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2012"
                        "volumen" => "14"
                        "paginaInicial" => "R261"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23194008"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Calprotectin serum level is an independent marker for radiographic spinal progression in axial spondyloarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;C&#46; Turina"
                            1 => "J&#46; Sieper"
                            2 => "N&#46; Yeremenko"
                            3 => "K&#46; Conrad"
                            4 => "H&#46; Haibel"
                            5 => "M&#46; Rudwaleit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/annrheumdis-2014-205506"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2014"
                        "volumen" => "73"
                        "paginaInicial" => "1746"
                        "paginaFinal" => "1748"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24845387"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Calprotectin &#40;S100A8&#47;9&#41; as serum biomarker for clinical response in proof-of-concept trials in axial and peripheral spondyloarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Turina"
                            1 => "N&#46; Yeremenko"
                            2 => "J&#46; Paramarta"
                            3 => "L&#46; Rycke"
                            4 => "D&#46; Baeten"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s13075-014-0413-4"
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2014"
                        "volumen" => "16"
                        "paginaInicial" => "413"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25135077"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of fecal calprotectin in gastrointestinal disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Montalto"
                            1 => "A&#46; Gallo"
                            2 => "L&#46; Santoro"
                            3 => "F&#46; d&#8217;Onofrio"
                            4 => "R&#46; Landolfi"
                            5 => "A&#46; Gasbarrini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Rev Med Pharmacol Sci"
                        "fecha" => "2013"
                        "volumen" => "17"
                        "paginaInicial" => "1569"
                        "paginaFinal" => "1582"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23832721"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Calprotectin in rheumatoid arthritis&#58; association with disease activity in a cross-sectional and a longitudinal cohort"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Garcia-Arias"
                            1 => "D&#46; Pascual-Salcedo"
                            2 => "S&#46; Ramiro"
                            3 => "M&#46;E&#46; Ueberschlag"
                            4 => "T&#46;M&#46; Jermann"
                            5 => "E&#46; Martin-Mola"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s40291-013-0016-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Diagn Ther"
                        "fecha" => "2013"
                        "volumen" => "17"
                        "paginaInicial" => "49"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23329363"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "S100 proteins calprotectin and S100A12 are related to radiographic changes rather than disease activity in psoriatic arthritis with low disease activity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46;M&#46; Madiand"
                            1 => "A&#46; Larsen"
                            2 => "J&#46;G&#46; Brun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2007"
                        "volumen" => "34"
                        "paginaInicial" => "2089"
                        "paginaFinal" => "2092"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17787039"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of 1-year anti-TNF-&#945; therapy on aortic stiffness&#44; carotid atherosclerosis&#44; and calprotectin in inflammatory arthropathies&#58; a controlled study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46; Angel"
                            1 => "S&#46; Provan"
                            2 => "M&#46; Fagerhol"
                            3 => "P&#46; Mowinckel"
                            4 => "T&#46; Kvien"
                            5 => "D&#46; Atar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Hypertens"
                        "fecha" => "2012"
                        "volumen" => "25"
                        "paginaInicial" => "644"
                        "paginaFinal" => "650"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of oral diclofenac intake on faecal calprotectin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Z&#46; Rendek"
                            1 => "M&#46; Falk"
                            2 => "E&#46; Grodzinsky"
                            3 => "K&#46; Wahlin"
                            4 => "S&#46; Kechagias"
                            5 => "R&#46; Svernl&#246;v"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/00365521.2015.1066421"
                      "Revista" => array:6 [
                        "tituloSerie" => "Scand J Gastroenterol"
                        "fecha" => "2016"
                        "volumen" => "51"
                        "paginaInicial" => "28"
                        "paginaFinal" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26200803"
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Brief Report
Relationship Between Fecal Calprotectin, Anti-Saccharomycescerevisiae Antibodies and Other Markers of Disease Activity in Patients With Spondyloarthritis
Relación de calprotectina fecal y anticuerpos anti saccharomyces con otros marcadores de actividad en pacientes con espondiloartritis
María José Moreno Martíneza,
Corresponding author
mjmorenomartinez@gmail.com

Corresponding author.
, Manuel José Moreno Ramosb, Luis Francisco Linares Ferrandoa,b
a Reumatología, Hospital Rafael Méndez, Lorca, Murcia, Spain
b Reumatología, Hospital Virgen de la Arrixaca, Murcia, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Ankylosing spondylitis &#40;AS&#41; is a chronic inflammatory disease that may be associated with extra-skeletal manifestations such as inflammatory intestinal disease &#40;IID&#41;&#44; among others&#46; There is a high incidence of IID in patients with AS&#46; There is even a theory that AS and Crohn&#39;s disease share the same etiopathogenesis&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> 25&#37;&#8211;50&#37; of AS patients without IID symptoms have an intestinal histology with inflammation&#44; according to some works&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Increased intestinal permeability has been found in IID as well as in AS&#44; shown by the presence of certain markers such as anti-<span class="elsevierStyleItalic">Saccharomyces cerevisiae</span> antibodies &#40;ASCA&#41; and calprotectin&#44; among others&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Faecal and serum calprotectin is used to differentiate between IID and functional intestinal disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3&#44;4</span></a> A rise in serum calprotectin has been observed in patients with spondyloarthritis &#40;Spa&#41;&#44; with a good correlation with other markets &#40;PCR and VSG&#44; among others&#41;&#44; disease progression<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> with response to treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">There are doubts as to whether the concentration of faecal calprotectin in AS patients is linked to taking non-steroid anti-inflammatory drugs &#40;NSAID&#41;&#46; In some series patients with AS who do not take NSAID have similar concentrations of calprotectin to patients with IID&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In other diseases&#44; such as rheumatoid arthritis and psoriatic arthropathy&#44; faecal calprotectin may act as an independent predictor of joint injury&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">4&#44;6</span></a> and it is associated with vascular alterations&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Objectives</span><p id="par0030" class="elsevierStylePara elsevierViewall">To discover whether the rise in faecal calprotectin and ASCA is associated with activity and physical function markers in patients with Spa&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">We will also analyse the association of calprotectin and ASCA with taking NSAID and with other relevant parameters &#40;HLA-B27 positivity or treatments&#44; among others&#41;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material and Methods</span><p id="par0040" class="elsevierStylePara elsevierViewall">The patients&#44; who were over the age of 18 years old&#44; were recruited in the dedicated spondyloarthritis department of the University Hospital Virgen de la Arrixaca&#44; Murcia&#44; sequentially in the order of their visits&#46; Patients diagnosed non-radiographic axial spondyloarthritis were included&#44; according to ASAS criteria&#44; as were those diagnosed AS according to the modified New York criteria&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">BASDAI and ASDAS-PCR were included as disease activity variables&#44; together with others for physical functioning &#40;BASFI&#41; and to evaluate the disease&#46; Analytical variables were included&#44; such as sedimentation velocity&#44; reactive C protein&#44; the presence of HLA-B27&#44; blood levels of ASCA and faecal calprotectin levels &#40;microgram&#47;gram&#41;&#46; ELISA technique was used to detect faecal calprotectin&#44; and 50<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;g stool was considered to be the upper limit of normality&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Patients under the age of 18 years old were excluded&#44; as were those who found it difficult to fill out the questionnaires and those without a definitive diagnosis and&#47;or with another type of spondyloarthritis&#44; including psoriatic arthropathy&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">A descriptive analysis was carried out&#44; together with a correlation study and comparison of averages for non-parametric variables &#40;SPSS 15&#46;0&#41;&#46; We performed a lineal regression analysis to evaluate the predictive capacity of the variables regarding faecal calprotectin levels&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">Thirty-three patients were included &#40;22 men&#41;&#46; 54&#46;8&#37; were AS and the others were cases of non-radiographic axial spondyloarthritis&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The average age was 46&#46;5 &#40;&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;6&#41; years old&#44; and 80&#37; of the patients were HLA B27 positive&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">51&#46;5&#37; of the patients took an NSAID every day&#46; 39&#46;4&#37; were only taking NSAID&#44; while 6&#37; were taking non-biological immunosupressors&#44; 30&#46;3&#37; were taking biological anti-TNF alpha drugs and 21&#46;2&#37; were untreated&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the other characteristics of the patients&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">All of the patients except one had normal ASCA levels&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">84&#46;4&#37; of the patients had levels<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;g of faecal calprotectin&#44; and 47&#37; had levels<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>100<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;g&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">We found no differences in levels of faecal calprotectin according to the diagnosis &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;43&#41;&#46; This was also the case with the activity parameters&#44; including acute phase reagents &#40;PCR and VSG&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The faecal calprotectin level was only statistically correlated with PCR &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;001&#59; <span class="elsevierStyleItalic">r</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">s</span></span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;55&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">No relationship was found between calprotectin levels and the diagnosis or HLA B27 positivity&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">We found no association between PCR levels and NSAID administration &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">The lineal regression study included the level of calprotectin as a dependent variable&#44; and the predictive variables were the BASDAI&#44; PCR&#44; VSG&#44; sex&#44; age and diagnosis&#46; We obtained a corrected <span class="elsevierStyleItalic">R</span><span class="elsevierStyleSup">2</span> determination coefficient<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;04&#44; and none of the variables were statistically significant&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">We wanted to see whether the increase in calprotectin could be secondary to NSAID administration&#46; For this purpose&#44; a subgroup of 13 patients &#40;8 men&#41; who were taking a NSAID and had a high level of calprotectin<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;g were subjected to a second determination of calprotectin as well as the other variables&#44; after one month without taking a NSAID&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0120" class="elsevierStylePara elsevierViewall">Their average age was 47 years old &#40;&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;25&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0125" class="elsevierStylePara elsevierViewall">No significant differences were detected between the levels of acute phase reagents&#44; BASDAI&#44; BASFI and the overall evaluation of the patient &#40;EVA&#41;&#44; before and after the withdrawal of the NSAID&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0130" class="elsevierStylePara elsevierViewall">After the withdrawal of the NSAID we found no significant differences in the average levels of calprotectin &#40;92 vs 110&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;9&#41; or in the other parameters&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0135" class="elsevierStylePara elsevierViewall">We found no differences in the percentage of patients with calprotectin<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;g before and after&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0140" class="elsevierStylePara elsevierViewall">Nine patients were assessed by a digestive system specialist using colonoscopy&#46; One patient was diagnosed with irritable bowel syndrome and probable enteropathy caused by a NSAID&#46;</p></li></ul></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0145" class="elsevierStylePara elsevierViewall">In rheumatology&#44; several studies associate disease activity in patients with Spa with microscopic inflammatory digestive pathology&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In this work we found a positive correlation between faecal calprotectin and PCR in our spondyloarthritis series&#46; The association with other inflammation or activity markers was not confirmed&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Practically 100&#37; of the patients had normal levels of ASCA&#44; so that it can be deduced that this marker would not be useful as an activity indicator&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Raised calprotectin level has been associated in some spondyloarthritis patient cohorts with NSAID administration&#46; In this work we analysed calprotectin levels following NSAID withdrawal in a subgroup of patients&#44; and we found that there was no significant change in the said levels&#46; Nor were alterations found in the colonoscopy of these patients&#46; Disease activity may be a reason for the association between calprotectin and NSAID administration&#58; patients with inflammation and pain take NSAID to control it&#46; The lack of a relationship between treatment with a NSAID and PCR may be due to the rarity of this marker rising in disease of this type&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The small number of patients in this study should be taken into account as a source of distortion&#46; This may be the reason why there is a lack of correlation between calprotectin and other activity parameters such as the BASDAI&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Another distortion that we can analyse is the time without NSAID administration in the 13-patient subgroup&#46; According to some other studies&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> some calprotectin analysis tests recommend not taking NSAID during the two days prior to taking the sample&#46; A recent study<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> which analyses the possible influence of NSAIDs on levels of faecal calprotectin&#44; suggests that two weeks without NSAID are sufficient for levels of faecal calprotectin to be unaltered by these drugs&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusions</span><p id="par0175" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8226;</span><p id="par0180" class="elsevierStylePara elsevierViewall">Faecal calprotectin levels are raised in patients with spondyloarthritis&#44; correlating positively with PCR&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0185" class="elsevierStylePara elsevierViewall">Raised levels of faecal calprotectin are not modified by taking an NSAID or not&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">&#8226;</span><p id="par0190" class="elsevierStylePara elsevierViewall">ASCA levels in blood neither vary nor show any relationship with clinical parameters in the population studied&#46;</p></li></ul></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of Interests</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare&#46;</p></span></span>"
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              "identificador" => "abst0005"
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          "titulo" => "Keywords"
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          "titulo" => "Resumen"
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              "identificador" => "abst0025"
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              "titulo" => "M&#233;todos"
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              "titulo" => "Resultados"
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              "titulo" => "Conclusi&#243;n"
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          "identificador" => "xpalclavsec1173963"
          "titulo" => "Palabras clave"
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          "identificador" => "sec0005"
          "titulo" => "Introduction"
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          "identificador" => "sec0010"
          "titulo" => "Objectives"
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          "titulo" => "References"
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    "fechaRecibido" => "2017-07-09"
    "fechaAceptado" => "2017-11-26"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1173964"
          "palabras" => array:4 [
            0 => "Spondyloarthritis"
            1 => "Anti-inflammatory drugs"
            2 => "Calprotectin"
            3 => "Inflammation"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1173963"
          "palabras" => array:4 [
            0 => "Espondiloartritis"
            1 => "Antiinflamatorios"
            2 => "Calprotectina"
            3 => "Inflamaci&#243;n"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To assess the relationship between the increase of faecal calprotectin&#44; anti-<span class="elsevierStyleItalic">Saccharomyces cerevisiae</span> antibodies &#40;ASCA&#41; and disease markers in a group of patients with spondyloarthritis&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We evaluated patients who were at least 18 years old and met the Assessment in Spondyloarthritis International Society &#40;ASAS&#41; criteria for spondyloarthritis or the New York modified criteria&#46; We analysed activity criteria&#44; physical function&#44; analytical criteria &#40;human leucocyte antigen &#91;HLA&#93; B27&#44; faecal calprotectin&#44; presence of ASCA&#44; among others&#41; and demographic data&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We included 33 patients&#46; All but one patient had normal ASCA values&#46; We found statistical significance in the correlation of calprotectin with <span class="elsevierStyleSmallCaps">C</span>-reactive protein &#40;CRP&#41; but not with other parameters&#46; We also found a relationship between calprotectin levels and nonsteroidal anti-inflammatory drug &#40;NSAID&#41; intake &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; We found no relationship between CRP levels and NSAID use&#46; After discontinuation of NSAIDs for one month&#44; we found no significant differences in calprotectin levels &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;9&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Faecal calprotectin is elevated in patients with spondyloarthritis and correlates positively with CRP&#46; Level of faecal calprotectin is not altered by NSAID use&#46; The amount of ASCA present does not change and does not correlate with any clinical parameters in the study population&#46;</p></span>"
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            "identificador" => "abst0005"
            "titulo" => "Objective"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
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            "identificador" => "abst0015"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Valorar la relaci&#243;n entre la calprotectina fecal&#44; ASCA y marcadores de enfermedad en espondiloartritis &#40;Spa&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se evaluaron pacientes<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>18 a&#241;os que cumpl&#237;an criterios ASAS o criterios modificados de Nueva York&#46; Se analizan criterios de actividad&#44; funci&#243;n f&#237;sica&#44; anal&#237;ticos y datos demogr&#225;ficos&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 33 pacientes&#46; Todos excepto uno ten&#237;an valores normales de ASCA&#46; Encontramos correlaci&#243;n significativa entre calprotectina y PCR pero no con otros par&#225;metros&#44; ni entre los niveles de calprotectina y la toma de AINE &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Tampoco entre los niveles de PCR y el uso de AINE&#46; Despu&#233;s de retirar los AINE no encontramos diferencias en los niveles de calprotectina &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;9&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La calprotectina fecal est&#225; elevada en pacientes con Spa y se correlaciona positivamente con la PCR&#46; La elevaci&#243;n de la calprotectina fecal no se ve alterada por el uso de AINE&#46; La cantidad de ASCA no cambia y no se correlaciona con ning&#250;n par&#225;metro cl&#237;nico en el estudio poblacional&#46;</p></span>"
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            "titulo" => "Resultados"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Moreno Mart&#237;nez MJ&#44; Moreno Ramos MJ&#44; Linares Ferrando LF&#46; Relaci&#243;n de calprotectina fecal y anticuerpos antisacaromices con otros marcadores de actividad en pacientes con espondiloartritis&#46; Reumatol Clin&#46; 2019&#59;15&#58;360&#8211;362&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Average &#40;&#177; standard deviation&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Faecal calprotectin &#40;&#956;g&#47;g stool&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">136&#46;75 &#40;&#177; 146&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reactive C protein &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;47 &#40;&#177; &#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sedimentation rate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;43 &#40;&#177; 10&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BASDAI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">2&#46;78 &#40;&#177; 2&#46; 4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">BASFI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;60 &#40;&#177; 2&#46; 8&#41;&nbsp;\t\t\t\t\t\t\n
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                  <table border="0" frame="\n
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Correlation&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">r</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">s</span></span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;significance&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Calprotectin&#47;VSG&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;29 &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;11&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Calprotectin&#47;BASDAI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#46;16 &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Calprotectin&#47;BASFI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#46;15 &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;50&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Calprotectin&#47;AGE&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#46;02 &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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              "identificador" => "bib0045"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Marker of intestinal inflammation in patients with ankylosing spondylitis&#58; a pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;G&#46; Matzkies"
                            1 => "S&#46;R&#46; Targan"
                            2 => "D&#46; Berel"
                            3 => "C&#46;J&#46; Landers"
                            4 => "J&#46;D&#46; Reveille"
                            5 => "D&#46; McGovern"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/ar4106"
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2012"
                        "volumen" => "14"
                        "paginaInicial" => "R261"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23194008"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Calprotectin serum level is an independent marker for radiographic spinal progression in axial spondyloarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;C&#46; Turina"
                            1 => "J&#46; Sieper"
                            2 => "N&#46; Yeremenko"
                            3 => "K&#46; Conrad"
                            4 => "H&#46; Haibel"
                            5 => "M&#46; Rudwaleit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/annrheumdis-2014-205506"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2014"
                        "volumen" => "73"
                        "paginaInicial" => "1746"
                        "paginaFinal" => "1748"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24845387"
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                          ]
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                  ]
                ]
              ]
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              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Calprotectin &#40;S100A8&#47;9&#41; as serum biomarker for clinical response in proof-of-concept trials in axial and peripheral spondyloarthritis"
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                        0 => array:2 [
                          "etal" => false
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                            2 => "J&#46; Paramarta"
                            3 => "L&#46; Rycke"
                            4 => "D&#46; Baeten"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1186/s13075-014-0413-4"
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2014"
                        "volumen" => "16"
                        "paginaInicial" => "413"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25135077"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0060"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of fecal calprotectin in gastrointestinal disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Montalto"
                            1 => "A&#46; Gallo"
                            2 => "L&#46; Santoro"
                            3 => "F&#46; d&#8217;Onofrio"
                            4 => "R&#46; Landolfi"
                            5 => "A&#46; Gasbarrini"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Rev Med Pharmacol Sci"
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                        "paginaInicial" => "1569"
                        "paginaFinal" => "1582"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23832721"
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                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0065"
              "etiqueta" => "5"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Calprotectin in rheumatoid arthritis&#58; association with disease activity in a cross-sectional and a longitudinal cohort"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Garcia-Arias"
                            1 => "D&#46; Pascual-Salcedo"
                            2 => "S&#46; Ramiro"
                            3 => "M&#46;E&#46; Ueberschlag"
                            4 => "T&#46;M&#46; Jermann"
                            5 => "E&#46; Martin-Mola"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1007/s40291-013-0016-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Diagn Ther"
                        "fecha" => "2013"
                        "volumen" => "17"
                        "paginaInicial" => "49"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23329363"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "S100 proteins calprotectin and S100A12 are related to radiographic changes rather than disease activity in psoriatic arthritis with low disease activity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46;M&#46; Madiand"
                            1 => "A&#46; Larsen"
                            2 => "J&#46;G&#46; Brun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2007"
                        "volumen" => "34"
                        "paginaInicial" => "2089"
                        "paginaFinal" => "2092"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17787039"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "etiqueta" => "7"
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                    0 => array:2 [
                      "titulo" => "Effect of 1-year anti-TNF-&#945; therapy on aortic stiffness&#44; carotid atherosclerosis&#44; and calprotectin in inflammatory arthropathies&#58; a controlled study"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46; Angel"
                            1 => "S&#46; Provan"
                            2 => "M&#46; Fagerhol"
                            3 => "P&#46; Mowinckel"
                            4 => "T&#46; Kvien"
                            5 => "D&#46; Atar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Hypertens"
                        "fecha" => "2012"
                        "volumen" => "25"
                        "paginaInicial" => "644"
                        "paginaFinal" => "650"
                      ]
                    ]
                  ]
                ]
              ]
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            7 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of oral diclofenac intake on faecal calprotectin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Z&#46; Rendek"
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                            2 => "E&#46; Grodzinsky"
                            3 => "K&#46; Wahlin"
                            4 => "S&#46; Kechagias"
                            5 => "R&#46; Svernl&#246;v"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.3109/00365521.2015.1066421"
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                        "tituloSerie" => "Scand J Gastroenterol"
                        "fecha" => "2016"
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                        "paginaInicial" => "28"
                        "paginaFinal" => "32"
                        "link" => array:1 [
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ISSN: 21735743
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