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Vol. 15. Issue 6.
Pages 360-362 (November - December 2019)
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Vol. 15. Issue 6.
Pages 360-362 (November - December 2019)
Brief Report
DOI: 10.1016/j.reumae.2017.11.005
Relationship Between Fecal Calprotectin, Anti-Saccharomycescerevisiae Antibodies and Other Markers of Disease Activity in Patients With Spondyloarthritis
Relación de calprotectina fecal y anticuerpos anti saccharomyces con otros marcadores de actividad en pacientes con espondiloartritis
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María José Moreno Martíneza,
Corresponding author
mjmorenomartinez@gmail.com

Corresponding author.
, Manuel José Moreno Ramosb, Luis Francisco Linares Ferrandoa,b
a Reumatología, Hospital Rafael Méndez, Lorca, Murcia, Spain
b Reumatología, Hospital Virgen de la Arrixaca, Murcia, Spain
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Tables (2)
Table 1. Average and Standard Deviation of Activity and Physical Function Markers.
Table 2. Correlation Between Calprotectin and BASDAI, BASFI, Age and PCR.
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Abstract
Objective

To assess the relationship between the increase of faecal calprotectin, anti-Saccharomyces cerevisiae antibodies (ASCA) and disease markers in a group of patients with spondyloarthritis.

Methods

We evaluated patients who were at least 18 years old and met the Assessment in Spondyloarthritis International Society (ASAS) criteria for spondyloarthritis or the New York modified criteria. We analysed activity criteria, physical function, analytical criteria (human leucocyte antigen [HLA] B27, faecal calprotectin, presence of ASCA, among others) and demographic data.

Results

We included 33 patients. All but one patient had normal ASCA values. We found statistical significance in the correlation of calprotectin with C-reactive protein (CRP) but not with other parameters. We also found a relationship between calprotectin levels and nonsteroidal anti-inflammatory drug (NSAID) intake (P=.001). We found no relationship between CRP levels and NSAID use. After discontinuation of NSAIDs for one month, we found no significant differences in calprotectin levels (P=.9).

Conclusion

Faecal calprotectin is elevated in patients with spondyloarthritis and correlates positively with CRP. Level of faecal calprotectin is not altered by NSAID use. The amount of ASCA present does not change and does not correlate with any clinical parameters in the study population.

Keywords:
Spondyloarthritis
Anti-inflammatory drugs
Calprotectin
Inflammation
Resumen
Objetivo

Valorar la relación entre la calprotectina fecal, ASCA y marcadores de enfermedad en espondiloartritis (Spa).

Métodos

Se evaluaron pacientes18 años que cumplían criterios ASAS o criterios modificados de Nueva York. Se analizan criterios de actividad, función física, analíticos y datos demográficos.

Resultados

Se incluyeron 33 pacientes. Todos excepto uno tenían valores normales de ASCA. Encontramos correlación significativa entre calprotectina y PCR pero no con otros parámetros, ni entre los niveles de calprotectina y la toma de AINE (p=0,001). Tampoco entre los niveles de PCR y el uso de AINE. Después de retirar los AINE no encontramos diferencias en los niveles de calprotectina (p=0,9).

Conclusión

La calprotectina fecal está elevada en pacientes con Spa y se correlaciona positivamente con la PCR. La elevación de la calprotectina fecal no se ve alterada por el uso de AINE. La cantidad de ASCA no cambia y no se correlaciona con ningún parámetro clínico en el estudio poblacional.

Palabras clave:
Espondiloartritis
Antiinflamatorios
Calprotectina
Inflamación

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