Statistics

 array:24 [
  "pii" => "S2173574320300654"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2020.06.001"
  "estado" => "S300"
  "fechaPublicacion" => "2021-08-01"
  "aid" => "1400"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2020"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2021;17:427-8"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X20300243"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2020.02.001"
      "estado" => "S300"
      "fechaPublicacion" => "2021-08-01"
      "aid" => "1400"
      "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Reumatol Clin. 2021;17:427-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "Dos enfermedades autoinmunes de dif&#237;cil manejo"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "427"
            "paginaFinal" => "428"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Two Difficult Management Autoinmune Diseases"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1181
                "Ancho" => 900
                "Tamanyo" => 116343
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erupci&#243;n generalizada&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Carola Baliu-Piqu&#233;, F&#46;J&#46; Narvaez-Garcia, Alexandra Retamero, Dolors Grados"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Carola"
                "apellidos" => "Baliu-Piqu&#233;"
              ]
              1 => array:2 [
                "nombre" => "F&#46;J&#46;"
                "apellidos" => "Narvaez-Garcia"
              ]
              2 => array:2 [
                "nombre" => "Alexandra"
                "apellidos" => "Retamero"
              ]
              3 => array:2 [
                "nombre" => "Dolors"
                "apellidos" => "Grados"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574320300654"
          "doi" => "10.1016/j.reumae.2020.06.001"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320300654?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X20300243?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001700000007/v1_202107270524/S1699258X20300243/v1_202107270524/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173574321001325"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2020.02.008"
    "estado" => "S300"
    "fechaPublicacion" => "2021-08-01"
    "aid" => "1401"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2021;17:428-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Exposure to belimumab in the first trimester of pregnancy in a young woman with systemic lupus erythematosus"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "428"
          "paginaFinal" => "429"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Exposici&#243;n a belimumab en el primer trimestre de embarazo en una mujer joven con lupus eritematoso sist&#233;mico"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ignacio Javier Gandino, Sophia Lutgen, Mar&#237;a Cristina Basta, Sebasti&#225;n Andr&#233;s Mu&#241;oz"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Ignacio Javier"
              "apellidos" => "Gandino"
            ]
            1 => array:2 [
              "nombre" => "Sophia"
              "apellidos" => "Lutgen"
            ]
            2 => array:2 [
              "nombre" => "Mar&#237;a Cristina"
              "apellidos" => "Basta"
            ]
            3 => array:2 [
              "nombre" => "Sebasti&#225;n Andr&#233;s"
              "apellidos" => "Mu&#241;oz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574321001325?idApp=UINPBA00004M"
    "url" => "/21735743/0000001700000007/v1_202107210817/S2173574321001325/v1_202107210817/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574321000204"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2020.05.006"
    "estado" => "S300"
    "fechaPublicacion" => "2021-08-01"
    "aid" => "1440"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Reumatol Clin. 2021;17:425-6"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>"
      "titulo" => "Periprosthetic osteolysis by microparticles mimicking a tumour process in the right hip in <span class="elsevierStyleSup">18</span>F-FDG PET&#47;CT study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "425"
          "paginaFinal" => "426"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Oste&#243;lisis periprot&#233;sica por micropart&#237;culas que simula un proceso tumoral en cadera derecha en estudio <span class="elsevierStyleSup">18</span>F-FDG PET&#47;TC"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1751
              "Ancho" => 2500
              "Tamanyo" => 273207
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0025"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">PET-CT performed 60<span class="elsevierStyleHsp" style=""></span>min following intravenous administration of 200&#46;14<span class="elsevierStyleHsp" style=""></span>MBq <span class="elsevierStyleSup">18</span>F-FDG&#46; Emission and attenuation-corrected images with low-dose CT&#44; from skull vault to upper third of the thighs &#40;whole body protocol&#41;&#46; A hypermetabolic mass in the right iliac region&#44; multi-lobed&#44; of approximately 15<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>13<span class="elsevierStyleHsp" style=""></span>cm and high uptake intensity &#40;SUVmax 14&#46;64&#41;&#46; It encompasses the prosthetic material of the hip and extends cranially towards the iliac muscle&#44; causing bone destruction of the iliac wing&#44; the coxofemoral joint and the ischium &#40;arrow&#41;&#46; Ametabolic zones are associated indicative of a necrotic&#47;cystic component &#40;star&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Elena Espinosa Mu&#241;oz, Antonio Luis Guti&#233;rrez Cardo, Carmen Puentes Zarzuela"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "Espinosa Mu&#241;oz"
            ]
            1 => array:2 [
              "nombre" => "Antonio Luis"
              "apellidos" => "Guti&#233;rrez Cardo"
            ]
            2 => array:2 [
              "nombre" => "Carmen"
              "apellidos" => "Puentes Zarzuela"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X20301406"
        "doi" => "10.1016/j.reuma.2020.05.011"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X20301406?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574321000204?idApp=UINPBA00004M"
    "url" => "/21735743/0000001700000007/v1_202107210817/S2173574321000204/v1_202107210817/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Two difficult management autoimmune diseases"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "427"
        "paginaFinal" => "428"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Carola Baliu-Piqu&#233;, F&#46;J&#46; Narvaez-Garcia, Alexandra Retamero, Dolors Grados"
        "autores" => array:4 [
          0 => array:3 [
            "nombre" => "Carola"
            "apellidos" => "Baliu-Piqu&#233;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "F&#46;J&#46;"
            "apellidos" => "Narvaez-Garcia"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Alexandra"
            "apellidos" => "Retamero"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:4 [
            "nombre" => "Dolors"
            "apellidos" => "Grados"
            "email" => array:1 [
              0 => "dgrados@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Unidad de Dermatolog&#237;a&#44; Hospital de Igualada-Consorci Sanitari Anoia&#44; Igualada&#44; Barcelona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Reumatolog&#237;a&#44; Hospital de Bellvitge&#44; Hospitalet de Llobregat&#44; Barcelona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Farmacia&#44; Hospital de Igualada-Consorci Sanitari Anoia&#44; Igualada&#44; Barcelona&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Unidad de Reumatolog&#237;a&#44; Hospital de Igualada-Consorci Sanitari Anoia&#44; Igualada&#44; Barcelona&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Dos enfermedades autoinmunes de dif&#237;cil manejo"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 984
            "Ancho" => 750
            "Tamanyo" => 85188
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">General outbreak&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We present the case of a 56-year-old male patient&#44; allergic to penicillin&#44; with a history of hypercholesterolaemia&#44; diabetes mellitus and seropositive&#44; nodular&#44; and erosive rheumatoid arthritis&#44; diagnosed in 2009&#46; He had received several biological treatments &#40;etanercept&#44; adalimumab&#44; tocilizumab&#44; rituximab&#44; abatacept&#44; which were withdrawn due to inefficacy or adverse effects&#41; and was currently being treated with 25<span class="elsevierStyleHsp" style=""></span>mg methotrexate weekly&#44; 5<span class="elsevierStyleHsp" style=""></span>mg of celecoxib and tofacitinib every 12<span class="elsevierStyleHsp" style=""></span>h&#44; without incident and with the rheumatic disease in remission&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">He presented at the emergency department on 3 occasions due to the presentation of a generalized&#44; very itchy&#44; wheal-like rash of more than 24<span class="elsevierStyleHsp" style=""></span>h onset&#44; which left hyperpigmentation and on occasions purpura where the wheals were located &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The rash was accompanied by a general feeling of malaise&#44; a tightening of the chest&#44; glottic and uvula labial edema&#46; The patient was administered with intravenous glucocorticoids and antihistamines in the emergency department&#44; with rapid improvement of symptoms&#46; During one visit adrenaline was required&#46; Despite the treatment with high doses of systemic glucocorticoids&#44; maximum doses of second-generation antihistamines&#44; sedating antihistamines and ranitidine&#44; the patient continued having extremely itchy general lesions&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Analysis revealed high acute phase reactants&#44; leucocytosis with neutrophilia&#44; <span class="elsevierStyleSmallCaps">d</span>-dimer of 1080<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; normal complement&#44; negative antinuclear antibodies and IgE 383<span class="elsevierStyleHsp" style=""></span>KU&#47;l with specific IgE negative to <span class="elsevierStyleItalic">Anisakis</span> and <span class="elsevierStyleItalic">Ascaris</span>&#46; A punch skin biopsy was performed on an acute lesion which showed mild neutrophilic vasculitis in the superficial and deep dermis with an absence of eosinophils&#44; compatible with urticarial vasculitis &#40;UV&#41;&#46; Computerized tomography of the chest was performed&#44; together with an echocardiogram&#44; which were both normal&#46;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0020" class="elsevierStylePara elsevierViewall">Once the diagnosis of normocomplementemic UV &#40;NUV&#41; had been established we considered whether the cutaneous symptoms were toxicoderma from the new immunosuppressants &#40;Janus kinase inhibitor&#41; or some other autoimmune process associated with the patient&#39;s rheumatoid arthritis&#46; We ruled out the first option because the patient had been treated with tofacitinib for months without complications and because although the treatment was temporarily suspended&#44; the skin lesions persisted&#46; Symptoms were not controlled&#44; and we therefore considered treatment with omalizumab&#46; Other therapeutic options were ruled out &#40;colchicine&#44; sulphone or cyclosporine&#41; due to the patient&#39;s immunosuppression&#46; Several published cases have reported on the use of omalizumab in UV<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#8211;5</span></a> aside from specification sheet usage&#46; The article by De Brito et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> reviewed cases published until 2018 in patients with UV and comparing the efficacy of omalizumab&#44; observed that the NUV responded better to omalizumab than the hypocomplementemics &#40;HUV&#41;&#46; This led them to believe that there could be 2 diseases with different physio pathological mechanisms&#46; In NUV the IgE and mastocytary cells would play a more important role whilst the endothelial damage from immunocomplex deposits would be more involved in the HUV&#44; which would therefore not respond so well to omalizumab&#46;</p></li></ul></p><p id="par0025" class="elsevierStylePara elsevierViewall">The case was presented and approved by the committee of special hospital uses and the patient signed an informed consent form&#46; Treatment was initiated with omalizumab at a dose of 300<span class="elsevierStyleHsp" style=""></span>mg&#47;every 4 weeks&#44; maintaining the antihistamines for several weeks and withdrawing the glucocorticoids&#46; The skin lesions disappeared after the first administration of therapy&#46; The patient has to date received 6 cycles of omalizumab at a dose of 300<span class="elsevierStyleHsp" style=""></span>mg&#47;every 4 weeks and continues to be asymptomatic&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Both the acute phase reactants and the <span class="elsevierStyleSmallCaps">d</span>-dimer reached normal levels&#46; It was possible to withdraw the glucocorticoids maintaining just 5<span class="elsevierStyleHsp" style=""></span>mg&#47;day &#40;arthritis control&#41;&#46; Treatment with tofacitinib was re-started 2 weeks after treatment with omalizumab&#44; without incident&#46; On re-initiation of methotrexate the patient presented with an episode of transaminitis which was resolved on dose reduction&#46; No interactions or infections occurred during combined treatment&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">This is the first case to be described in the literature of a patient with rheumatoid arthritis and NUV&#44; both autoimmune diseases with difficult management&#46; The patient presented with an extremely rapid and effective response to omalizumab with total disappearance of the skin lesions&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Baliu-Piqu&#233; C&#44; Narvaez-Garcia FJ&#44; Retamero A&#44; Grados D&#46; Dos enfermedades autoinmunes de dif&#237;cil manejo&#46; Reumatol Clin&#46; 2021&#59;17&#58;427&#8211;428&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 984
            "Ancho" => 750
            "Tamanyo" => 85188
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">General outbreak&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effectiveness of omalizumab in a case of urticarial vasculitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Fueyo-Casado"
                            1 => "L&#46; Campos-Mu&#241;oz"
                            2 => "E&#46; Gonz&#225;lez-Guerra"
                            3 => "J&#46; Pedraz-Mu&#241;oz"
                            4 => "J&#46;A&#46; Cort&#233;s-Toro"
                            5 => "E&#46; L&#243;pez-Bran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ced.13076"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2017"
                        "volumen" => "42"
                        "paginaInicial" => "403"
                        "paginaFinal" => "405"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28247460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Successful treatment of normocomplementemic urticarial&#46; vasculitis with omalizumab&#58; a report of three cases and literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Rattananukrom"
                            1 => "P&#46; Svetvilas"
                            2 => "K&#46; Chanprapaph"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.12932/AP-050918-0402"
                      "Revista" => array:3 [
                        "tituloSerie" => "Asian Pac J Allergy Immunol"
                        "fecha" => "2019"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12744626"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Normocomplementaemic urticarial vasculitis&#58; effective treatment with omalizumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "De Brito M&#46;"
                            1 => "G&#46; Huebner"
                            2 => "D&#46; Murrell"
                            3 => "P&#46; Bullpitt"
                            4 => "K&#46; Hartmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s13601-018-0222-y"
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Transl Allergy"
                        "fecha" => "2018"
                        "volumen" => "8"
                        "paginaInicial" => "37"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30258566"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improvement in quality of life impairment followed by relapse with 6-monthly periodic administration of omalizumab for severe treatment-refractory chronic urticaria and urticarial vasculitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;C&#46; Kai"
                            1 => "C&#46; Flohr"
                            2 => "C&#46;E&#46; Grattan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ced.12320"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2014"
                        "volumen" => "39"
                        "paginaInicial" => "651"
                        "paginaFinal" => "652"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24758481"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patient-reported outcomes in urticarial vasculitis treated with omalizumab&#58; case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "I&#46; Cherrez-Ojeda"
                            1 => "Vanegas E&#46;"
                            2 => "M&#46; Felix"
                            3 => "V&#46;L&#46; Mata"
                            4 => "A&#46; Cherrez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12895-018-0077-x"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Dermatol"
                        "fecha" => "2018"
                        "volumen" => "18"
                        "paginaInicial" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30359231"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001700000007/v1_202107210817/S2173574320300654/v1_202107210817/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8400"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001700000007/v1_202107210817/S2173574320300654/v1_202107210817/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320300654?idApp=UINPBA00004M"
]