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Vol. 18. Issue 6.
Pages 343-348 (June - July 2022)
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Vol. 18. Issue 6.
Pages 343-348 (June - July 2022)
Original Article
Evaluation of thiol-disulfide homeostasis in active ankylosing spondylitis patients
Evaluación de la homeostasis de tiol-disulfuro en pacientes con espondilitis anquilosante activa
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Medeni Arpaa,
Corresponding author
drmedeniarpa@gmail.com

Corresponding author.
, Bayram Şenb, Münevver Serdaroğlu Beyazalc, Özcan Ereld
a Department of Medical Biochemistry, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey
b Department of Medical Biochemistry, Recep Tayyip Erdogan University Training and Research Hospital, Rize, Turkey
c Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey
d Department of Medical Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University Ankara, Turkey
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Abstract
Introduction and objectives

The etiopathogenesis of ankylosing spondylitis (AS), which is a chronic, progressive, inflammatory, systemic disease, has not been fully elucidated yet. Thiol-disulfide homeostasis, a component of antioxidant defense, is thought to play a role in the etiology of inflammatory diseases. We aimed to evaluate the existence of oxidative stress in active AS patients with thiol-disulfide homeostasis.

Materials and methods

Patients who were found to have high (n: 27) and very-high (n: 18) activity levels with ASDAS-ESR and 40 healthy controls participated in the study. Serum native-thiol (NT), total-thiol (TT), and disulfide levels were analyzed by an automated colorimetric method.

Results

While TT and NT levels were significantly decreased in patients compared to the control group, the disulfide levels were increased. There was a significant negative correlation between ESR, and NT, TT in both groups and also between hsCRP and NT, TT in very-high active AS patients.TT and NT levels were significantly higher in the nonsteroidal anti-inflammatory drug (NSAID) users compared to those using biological agents.

Conclusions

The deterioration of thiol-disulfide homeostasis in favor of disulfide; correlations between ESR, CRP, and NT, TT support the use of thiol-disulfide variables in determining the disease activity level.

Keywords:
Ankylosing spondylitis
Disulfide
Oxidative stress
Thiol
Resumen
Introducción y objetivos

La etiopatogenia de la espondilitis anquilosante (EA), que es una enfermedad crónica, progresiva, inflamatoria y sistémica, aún no se ha dilucidado por completo. Se cree que la homeostasis del tiol-disulfuro, un componente de la defensa antioxidante, desempeña un papel en la etiología de las enfermedades inflamatorias. Nuestro objetivo fue evaluar la existencia de estrés oxidativo en pacientes con EA activa con homeostasis de tiol-disulfuro.

Materiales y métodos

Participaron en el estudio pacientes que tenían niveles de actividad altos (n: 27) y muy altos (n: 18) con ASDAS-ESR y 40 controles sanos. Los niveles séricos de tiol nativo (NT), tiol total (TT) y disulfuro se analizaron mediante un método colorimétrico automático.

Resultados

Si bien los niveles de TT y NT disminuyeron significativamente en los pacientes en comparación con el grupo de control, los de disulfuro aumentaron. Hubo una correlación negativa significativa entre ESR y NT, TT en ambos grupos y también entre hsCRP y NT, TT en pacientes con EA muy alta activa. Los niveles de TT y NT fueron significativamente más altos en los usuarios de medicamentos antiinflamatorios no esteroideos (AINE) en comparación con los que utilizan agentes biológicos.

Conclusiones

El deterioro de la homeostasis tiol-disulfuro a favor del disulfuro y las correlaciones entre ESR, CRP y NT, TT apoyan el uso de variables de tiol-disulfuro para determinar el nivel de actividad de la enfermedad.

Palabras clave:
Espondilitis anquilosante
Disulfuro
Estrés oxidativo
Tiol

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