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Vol. 5. Issue 2.
Pages 83-87 (March - April 2009)
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Vol. 5. Issue 2.
Pages 83-87 (March - April 2009)
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Follow-up and prognostic value using magnetic resonance imaging in patients with spondyloarthritis treated with biologic agents
Monitorización y valor pronóstico por resonancia magnética de los tratamientos biológicos en las espondiloartritis
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José María Martos Becerraa,
Corresponding author
martakos@hotmail.com

Corresponding author.
, José Antonio Carrasco Fernándezb, Antonio Cano Sánchezc
a Department of Radiodiagnostics, Hospital de Alta Resolución de Puente Genil, Córdoba, Spain
b Department of Rheumatology, Centro Hospitalario La Mancha Centro, Ciudad Real, Spain
c Department of Radiodiagnostics, Hospital Universitario Reina Sofía, Córdoba, Spain
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Abstract

Early diagnosis and assessment of the response to treatment in patients suffering from spondyloarthritis have always been challenging due to the lack of imaging techniques able to demonstrate spinal and sacroiliac inflammation.

The last 2 years have seen important advances in the use of magnetic resonance imaging (MRI) for the study of spondyloarthritis. The possibility of quantification of inflammatory lesions using different scoring systems allows not only an early diagnosis, but the assessment of the response to several therapeutic agents, especially those known as “biological therapies.”

A number of randomized controlled trials of anti-tumor necrosis factor agents have been published showing regression of inflammatory lesions in MRI. This review discusses briefly the techniques and scoring systems used and all the evidences that exist about assessing treatment in spondyloarthritis.

Keywords:
MRI
Spondyloarthritis
Treatment
Resumen

El diagnóstico precoz y la respuesta al tratamiento en los pacientes con espondiloartritis han supuesto, desde siempre, un reto dada la escasez de técnicas de imagen que demostrasen, de manera cuantitativa, la inflamación en columna y articulaciones sacroilíacas.

Durante los últimos 2 años se han llevado a cabo importantes avances en el uso de la resonancia magnética (RM) para el estudio de las espondiloartritis. La posibilidad de cuantificar la inflamación que ocurre en estos pacientes mediante la utilización de diferentes sistemas de puntuación permite no sólo llevar a cabo el diagnóstico de forma precoz, sino además valorar la respuesta de los pacientes con espondiloartritis a diferentes agentes terapéuticos, en especial a las nuevas terapias biológicas.

Se han publicado varios ensayos controlados con dichos fármacos que muestran la disminución de las lesiones inflamatorias en RM. Esta revisión se centra, brevemente, en las técnicas y los sistemas de puntuación de RM utilizados, así como en los datos aportados por dichos estudios, que valoran la respuesta al tratamiento con terapias biológicas mediante las imágenes de RM.

Palabras clave:
Resonancia magnética
Espondiloartritis
Tratamiento
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References
[1.]
X. Baraliakos, J. Braun.
Magnetic resonance imaging in spondyloarthropathies.
Joint Bone Spine, 73 (2006), pp. 1-3
[2.]
J. Braun, W. Golder, M. Bollow, J. Sieper, D. van der Heide.
Imaging and scoring in ankylosing spondylitis.
Clin Exp Rheumatol, 20 (2002), pp. 178-184
[3.]
J.M. Martos, J.A. Carrasco, A. Cano, M. Martínez.
Diagnóstico y valoración de la respuesta al tratamiento mediante resonancia magnética en la espondilitis anquilosante.
Radiología, 493 (2007), pp. 177-181
[4.]
W.P. Maksymowych, R. Landewé.
Imaging in ankylosing spondylitis.
Best Pract Res Clin Rheumatol, 20 (2006), pp. 507-519
[5.]
J. Zochling, X. Baraliakos, K.G. Hermann, J. Braun.
Magnetic resonance imaging in ankylosing spondylitis.
Curr Opin Rheumatol, 19 (2007), pp. 346-352
[6.]
D. van der Heijde, R. Landewé, K.G.A. Hermann, A.G. Jurik, W.P. Maksymowych, M. Rudwaleit.
Application of the OMERACT filter to scoring methods for magnetic resonance imaging of the sacroiliac joints and the spine. Recommendations for a research agenda at OMERACT 7.
J Rheumatol, 32 (2005), pp. 2042-2047
[7.]
W.P. Maksymowych, R.D. Inman, D. Salonen, S.S. Dhillon, M. Williams, M. Stone.
Spondyloarthritis research Consortium of Canada magnetic resonance imaging index for assessment of spinal inflammation in ankylosing spondylitis.
Arthritis Rheum, 53 (2005), pp. 703-709
[8.]
J. Braun, X. Baraliakos, W. Golder, J. Brandt, M. Rudwaleit, J. Listing.
MRI examinations of the spine in patients with ankylosing spondylitis, before and alter successful therapy with infliximab. Evaluation of a new scoring system.
Arthritis Rheum, 48 (2003), pp. 1126-1136
[9.]
A.M. Manadan, N. James, J.A. Block.
New therapeutic approaches for spondyloarthritis.
Curr Opin Rheumatol, 19 (2007), pp. 259-264
[10.]
J. Brandt, H. Haibel, D. Cornely, W. Golder, J. Gonzalez, J. Reddig.
Succesful treatment of active ankylosing spondylitis with the anti-tumor necrosis factor alpha monoclonal antibody infliximab.
[11.]
J. Brandt, A. Khariouzov, J. Listing, H. Haibel, H. Sörensen, L. Grassnickel.
Six-month results of a double-blind placebo-controlled trial of etanercept treatment in patients with active ankylosing spondylitis.
Arthritis Rheum, 48 (2003), pp. 1667-1675
[12.]
D. van der Heijde, A. Kivitz, M.H. Schiff, J. Sieper, B.A. Dijkmans, J. Braun, ATLAS Study Group.
Efficacy and safety of adalimumab in patients with ankylosing spondylitis: results of a multicenter, randomized, double-blind, placebo-controlled trial.
Arthritis Rheum, 54 (2006), pp. 2136-2146
[13.]
S.N. Nikas, Y. Alamanos, P.V. Voulgari, X.I. Pliakou, C.G. Papadopoulos, A.A. Drosos.
Infliximab treatment in ankylosing spondylitis: an observational study.
Ann Rheum Dis, 64 (2005), pp. 940-942
[14.]
X. Baraliakos, J. Listing, M. Rudwaleit, J. Brandt, J. Sieper, J. Braun.
Radiographic progression in patients with ankylosing spondylitis after 2 years of treatment with the tumor necrosis factor alpha antibody infliximab.
Ann Rheum Dis, 64 (2005), pp. 1462-1466
[15.]
J. Braun, J. Brandt, J. Listing, A. Zink, R. Alten, W. Golder.
Treatment of active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial.
Lancet, 359 (2002), pp. 1187-1193
[16.]
J. Sieper, X. Baraliakos, J. Listing, J. Brandt, H. Haibel, M. Rudwaleit.
Persistent reduction of spinal inflammation as assessed by magnetic resonance imaging in patients with ankylosing spondylitis after 2 years of treatment with the anti-tumor necrosis factor infliximab.
Rheumatology (Oxford), 44 (2005), pp. 1525-1530
[17.]
H. Marzo-Ortega, D. McGonagle, S. Jarrett, G. Haugeberg, E. Hensar, P. O’Connor.
Infliximab in combination with methotrexate in active ankylosing spondylitis: a clinical and imaging study.
Ann Rheum Dis, 64 (2005), pp. 1568-1575
[18.]
H. Marzo-Ortega, D. McGonagle, P. O’Connor, P. Emery.
Efficacy of etanercept in the treatment of entheseal patology in resistant spondyloarthropathy: a clinical and magnetic resonance imaging study.
[19.]
R. Fleischmann, S.W. Baumgartner, M.H. Weisman, T. Liu, B. White, P. Peloso.
Long term safety of etanercept in elderly subjects with rheumatic diseases.
Ann Rheum Dis, 65 (2006), pp. 379-384
[20.]
X. Baraliakos, J. Davis, W. Tsuji, J. Braun.
Magnetic resonance imaging examinations of the spine in patients with ankylosing spondylitis before and after therapy with the tumor necrosis factor alpha receptor fusion protein etanercept.
Arthritis Rheum, 52 (2005), pp. 1216-1223
[21.]
M. Rudwaleit, X. Baraliakos, J. Listing, J. Brandt, J. Sieper, J. Braun.
Magnetic resonance imaging of the spine and sacroiliac joints in ankylosing spondylitis and undifferentiated spondyloartrhtis during treatment with etanercept.
Ann Rheum Dis, 64 (2005), pp. 1305-1310
[22.]
H. Haibel, M. Rudwaleit, H.C. Brandt, Z. Grozdanovic, J. Listing, H. Kupper.
Adalimumab reduces spinal symptoms in active ankylosing spondylitis: clinical and magnetic resonance imaging results of a fifty-two-week open label trial.
Arthritis Rheum, 54 (2006), pp. 678-681
[23.]
J. Oostven, R. Prevo, J. Den Boer, M. van de Laar.
Early detection of sacroiliitis on magnetic resonance imaging and subsequent development of sacroiliitis on plain radiography. A prospective, longitudinal study.
J Rheumatol, 26 (1999), pp. 1953-1958
[24.]
J. Zochling, J. Brandt, J. Braun.
The current concept of spondyloarthritis with special emphasis on undifferentiated spondyloarthritis.
Rheumatology (Oxford), 44 (2005), pp. 1483-1491
Copyright © 2009. Sociedad Española de Reumatología and Colegio Mexicano de Reumatología
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