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Vol. 5. Issue 2.
Pages 83-87 (March - April 2009)
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Vol. 5. Issue 2.
Pages 83-87 (March - April 2009)
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Follow-up and prognostic value using magnetic resonance imaging in patients with spondyloarthritis treated with biologic agents
Monitorización y valor pronóstico por resonancia magnética de los tratamientos biológicos en las espondiloartritis
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José María Martos Becerraa,
Corresponding author
martakos@hotmail.com

Corresponding author.
, José Antonio Carrasco Fernándezb, Antonio Cano Sánchezc
a Department of Radiodiagnostics, Hospital de Alta Resolución de Puente Genil, Córdoba, Spain
b Department of Rheumatology, Centro Hospitalario La Mancha Centro, Ciudad Real, Spain
c Department of Radiodiagnostics, Hospital Universitario Reina Sofía, Córdoba, Spain
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Article information
Abstract

Early diagnosis and assessment of the response to treatment in patients suffering from spondyloarthritis have always been challenging due to the lack of imaging techniques able to demonstrate spinal and sacroiliac inflammation.

The last 2 years have seen important advances in the use of magnetic resonance imaging (MRI) for the study of spondyloarthritis. The possibility of quantification of inflammatory lesions using different scoring systems allows not only an early diagnosis, but the assessment of the response to several therapeutic agents, especially those known as “biological therapies.”

A number of randomized controlled trials of anti-tumor necrosis factor agents have been published showing regression of inflammatory lesions in MRI. This review discusses briefly the techniques and scoring systems used and all the evidences that exist about assessing treatment in spondyloarthritis.

Keywords:
MRI
Spondyloarthritis
Treatment
Resumen

El diagnóstico precoz y la respuesta al tratamiento en los pacientes con espondiloartritis han supuesto, desde siempre, un reto dada la escasez de técnicas de imagen que demostrasen, de manera cuantitativa, la inflamación en columna y articulaciones sacroilíacas.

Durante los últimos 2 años se han llevado a cabo importantes avances en el uso de la resonancia magnética (RM) para el estudio de las espondiloartritis. La posibilidad de cuantificar la inflamación que ocurre en estos pacientes mediante la utilización de diferentes sistemas de puntuación permite no sólo llevar a cabo el diagnóstico de forma precoz, sino además valorar la respuesta de los pacientes con espondiloartritis a diferentes agentes terapéuticos, en especial a las nuevas terapias biológicas.

Se han publicado varios ensayos controlados con dichos fármacos que muestran la disminución de las lesiones inflamatorias en RM. Esta revisión se centra, brevemente, en las técnicas y los sistemas de puntuación de RM utilizados, así como en los datos aportados por dichos estudios, que valoran la respuesta al tratamiento con terapias biológicas mediante las imágenes de RM.

Palabras clave:
Resonancia magnética
Espondiloartritis
Tratamiento
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