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                        "paginaFinal" => "3190"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7593424"
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                      "doi" => "10.1186/s13075-015-0524-6"
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Res Ther&#46;"
                        "fecha" => "2010"
                        "volumen" => "17"
                        "paginaInicial" => "12"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25600705"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cumulative childhood stress and autoimmune diseases in adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;R&#46; Dube"
                            1 => "D&#46; Fairweather"
                            2 => "W&#46;S&#46; Pearson"
                            3 => "V&#46;J&#46; Felitti"
                            4 => "R&#46;F&#46; Anda"
                            5 => "J&#46;B&#46; Croft"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/PSY.0b013e3181907888"
                      "Revista" => array:6 [
                        "tituloSerie" => "Psychosom Med&#46;"
                        "fecha" => "2009"
                        "volumen" => "71"
                        "paginaInicial" => "243"
                        "paginaFinal" => "250"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19188532"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sex hormones and risks of rheumatoid arthritis and developmental or environmental influences"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;T&#46; Masi"
                            1 => "J&#46;C&#46; Aldag"
                            2 => "R&#46;T&#46; Chatterton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1196/annals.1351.020"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann N Y Acad Sci&#46;"
                        "fecha" => "2006"
                        "volumen" => "1069"
                        "paginaInicial" => "223"
                        "paginaFinal" => "235"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16855149"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Breast-feeding and the onset of rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Brennan"
                            1 => "A&#46; Silman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum&#46;"
                        "fecha" => "1994"
                        "volumen" => "37"
                        "paginaInicial" => "808"
                        "paginaFinal" => "813"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8003052"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of female hormonal factors&#44; in relation to autoantibodies and genetic markers&#44; on the development of rheumatoid arthritis in northern Sweden&#58; a case-control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Berglin"
                            1 => "H&#46; Kokkonen"
                            2 => "E&#46; Einarsdottir"
                            3 => "A&#46; Agren"
                            4 => "S&#46; Rantap&#228;&#228; Dahlqvist"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/03009741003742763"
                      "Revista" => array:6 [
                        "tituloSerie" => "Scand J Rheumatol&#46;"
                        "fecha" => "2010"
                        "volumen" => "39"
                        "paginaInicial" => "454"
                        "paginaFinal" => "460"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20560812"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The influence of early life factors on the risk of developing rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;N&#46; Colebatch"
                            1 => "C&#46;J&#46; Edwards"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2249.2010.04263.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Immunol&#46;"
                        "fecha" => "2011"
                        "volumen" => "163"
                        "paginaInicial" => "11"
                        "paginaFinal" => "16"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20964640"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Roles of prolactin and gonadotropin-releasing hormone in rheumatic diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;E&#46; Walker"
                            1 => "J&#46;D&#46; Jacobson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheum Dis Clin North Am&#46;"
                        "fecha" => "2000"
                        "volumen" => "26"
                        "paginaInicial" => "713"
                        "paginaFinal" => "736"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11084941"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enfermedades endocrinol&#243;gicas y metab&#243;licas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;J&#46; Jara Quezada"
                            1 => "M&#46;A&#46; Saavedra Salinas"
                            2 => "O&#46; Vera Lastra"
                            3 => "Marquez&#46; Alcal&#225;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:7 [
                        "editores" => "D&#46;Alarc&#243;n SegoviaJ&#46;Molina"
                        "paginaInicial" => "1285"
                        "paginaFinal" => "1299"
                        "edicion" => "1st ed"
                        "serieVolumen" => "II"
                        "serieTitulo" => "Tratado Hispanoamericano de Reumatologia"
                        "serieFecha" => "2007"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypothalamic-pituitary-adrenocortical and gonadal functions in rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Cutolo"
                            1 => "A&#46; Sulli"
                            2 => "C&#46; Pizzorni"
                            3 => "C&#46; Craviotto"
                            4 => "R&#46;H&#46; Straub"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann NY Acad Sci&#46;"
                        "fecha" => "2003"
                        "volumen" => "992"
                        "paginaInicial" => "107"
                        "paginaFinal" => "117"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12794051"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inadequately low serum levels of steroid hormones in relation to IL-6 and TNF in untreated patients with early rheumatoid arthritis and reactive arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;H&#46; Straub"
                            1 => "L&#46; Paimela"
                            2 => "R&#46; Peltomaa"
                            3 => "J&#46; Sch&#246;lmerich"
                            4 => "M&#46; Leirisalo-Repo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.10177"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum&#46;"
                        "fecha" => "2002"
                        "volumen" => "46"
                        "paginaInicial" => "654"
                        "paginaFinal" => "662"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11920401"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of cytokines and growth factors on distinct steroidogenic enzymes in vitro&#58; a short tubular data collection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Herrmann"
                            1 => "J&#46; Sch&#246;lmerich"
                            2 => "R&#46;H&#46; Straub"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann NY Acad Sci&#46;"
                        "fecha" => "2002"
                        "volumen" => "966"
                        "paginaInicial" => "166"
                        "paginaFinal" => "186"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12114270"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term anti-tumor necrosis factor antibody therapy in rheumatoid arthritis patients sensitizes the pituitary gland and favors adrenal androgen secretion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;H&#46; Straub"
                            1 => "G&#46; Pongratz"
                            2 => "J&#46; Sch&#246;lmerich"
                            3 => "F&#46; Kees"
                            4 => "T&#46;F&#46; Schaible"
                            5 => "C&#46; Antoni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.11036"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum&#46;"
                        "fecha" => "2003"
                        "volumen" => "48"
                        "paginaInicial" => "1504"
                        "paginaFinal" => "1512"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12794817"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improvement of ACTH response to insulin tolerance test in female patients with rheumatoid arthritis due to tumor necrosis factor inhibition"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Daza"
                            1 => "R&#46; Mart&#237;n-Jim&#233;nez"
                            2 => "P&#46; de la Torre"
                            3 => "E&#46; Hern&#225;ndez"
                            4 => "B&#46; Murillo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1530/EJE-06-0644"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Endocrinol&#46;"
                        "fecha" => "2007"
                        "volumen" => "157"
                        "paginaInicial" => "47"
                        "paginaFinal" => "51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17609401"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased cortisol relative to adrenocorticotropic hormone predicts improvement during anti-tumor necrosis factor therapy in rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;H&#46; Straub"
                            1 => "G&#46; Pongratz"
                            2 => "M&#46; Cutolo"
                            3 => "C&#46;A&#46; Wijbrandts"
                            4 => "D&#46; Baeten"
                            5 => "M&#46; Fleck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.23385"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum&#46;"
                        "fecha" => "2008"
                        "volumen" => "58"
                        "paginaInicial" => "976"
                        "paginaFinal" => "984"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18383357"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New roles for estrogens in rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Cutolo"
                            1 => "S&#46; Capellino"
                            2 => "P&#46; Montagna"
                            3 => "B&#46; Villaggio"
                            4 => "A&#46; Sulli"
                            5 => "B&#46; Seriolo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Rheumatol&#46;"
                        "fecha" => "2003"
                        "volumen" => "21"
                        "paginaInicial" => "687"
                        "paginaFinal" => "689"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14740444"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Castagnetta"
                            1 => "G&#46; Carruba"
                            2 => "M&#46; Cutolo"
                            3 => "R&#46; Stefano"
                            4 => "M&#46; Miele"
                            5 => "M&#46; Schmidt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol&#46;"
                        "fecha" => "2003"
                        "volumen" => "30"
                        "paginaInicial" => "2597"
                        "paginaFinal" => "2605"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14719200"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hydroxylated estrogen metabolites influence the proliferation of cultured human monocytes&#58; possible role in synovial tissue hyperplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Capellino"
                            1 => "P&#46; Montagna"
                            2 => "B&#46; Villaggio"
                            3 => "S&#46; Soldano"
                            4 => "R&#46;H&#46; Straub"
                            5 => "M&#46; Cutolo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Rheumatol&#46;"
                        "fecha" => "2008"
                        "volumen" => "26"
                        "paginaInicial" => "903"
                        "paginaFinal" => "909"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19032826"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sex hormones&#44; the immune system and autoimmune diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Cutolo"
                            1 => "S&#46; Capellino"
                            2 => "R&#46;H&#46; Straub"
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                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:7 [
                        "editores" => "S&#46;E&#46;WalkerL&#46;J&#46;Jara"
                        "paginaInicial" => "13"
                        "paginaFinal" => "19"
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                        "serieVolumen" => "9"
                        "serieTitulo" => "Endocrine manifestations of systemic autoimmune diseases&#46; Handbook of Systemic Autoimmune Diseases"
                        "serieFecha" => "2008"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quantitative determination of steroid hormone receptor positive cells in synovium of RA and OA patients&#58; is there a link to inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "B&#46; Riepl"
                            2 => "L&#46; Raucn"
                            3 => "P&#46; Angele"
                            4 => "M&#46; Cutolo"
                            5 => "R&#46;H&#46; Straub"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2006.055483"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis&#46;"
                        "fecha" => "2007"
                        "volumen" => "66"
                        "paginaInicial" => "53"
                        "paginaFinal" => "68"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16815861"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased DHEAS levels in patients with rheumatoid arthritis after treatment with tumor necrosis factor antagonists&#58; evidence for improved adrenal function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Ernestam"
                            1 => "I&#46; Hafstr&#246;m"
                            2 => "S&#46; Werner"
                            3 => "K&#46; Carlstr&#246;m"
                            4 => "B&#46; Tengstrand"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol&#46;"
                        "fecha" => "2007"
                        "volumen" => "34"
                        "paginaInicial" => "1451"
                        "paginaFinal" => "1458"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17477470"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disrupted brain-immune system-joint communication during experimental arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "A&#46; Del Rey"
                            1 => "C&#46; Wolff"
                            2 => "J&#46; Wildmann"
                            3 => "A&#46; Randolf"
                            4 => "A&#46; Hahnel"
                            5 => "H&#46;O&#46; Besedovsky"
                            6 => "R&#46;H&#46; Straub"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.23869"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum&#46;"
                        "fecha" => "2008"
                        "volumen" => "58"
                        "paginaInicial" => "3090"
                        "paginaFinal" => "3099"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18821705"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The autonomic nervous system and the immune system in juvenile rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46; Kuis"
                            1 => "C&#46;E&#46; de Jong-de Vos van Steenwijk"
                            2 => "G&#46; Sinnema"
                            3 => "A&#46; Kavelaars"
                            4 => "B&#46; Prakken"
                            5 => "P&#46;J&#46; Helders"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Brain Behav Immune&#46;"
                        "fecha" => "1996"
                        "volumen" => "10"
                        "paginaInicial" => "387"
                        "paginaFinal" => "398"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Elevated sympathetic nervous system activity in patients with recently diagnosed rheumatoid arthritis with active disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;C&#46; Dekkers"
                            1 => "R&#46; Geenen"
                            2 => "G&#46;L&#46; Godaert"
                            3 => "J&#46;W&#46; Bijlsma"
                            4 => "L&#46;J&#46; Van Doornen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Rheumatol&#46;"
                        "fecha" => "2004"
                        "volumen" => "22"
                        "paginaInicial" => "63"
                        "paginaFinal" => "70"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15005006"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neuroendocrine immune control mechanisms&#44; their influence on autoimmune diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Capellino"
                            1 => "R&#46;H&#46; Straub"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:7 [
                        "editores" => "S&#46;E&#46;WalkerL&#46;J&#46;Jara"
                        "paginaInicial" => "3"
                        "paginaFinal" => "12"
                        "edicion" => "1st ed"
                        "serieVolumen" => "9"
                        "serieTitulo" => "Endocrine manifestations of systemic autoimmune diseases&#46; Handbook of Systemic Autoimmune Diseases"
                        "serieFecha" => "2008"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Altered function of the hypothalamic stress axes in patients with moderately active systemic lupus erythematosus II Dissociation between androstenedione&#44; cortisol&#44; or dehydroepiandrosterone and interleukin 6 or tumor necrosis factor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; Zietz"
                            1 => "T&#46; Reber"
                            2 => "M&#46; Oertel"
                            3 => "T&#46; Gl&#252;ck"
                            4 => "J&#46; Sch&#246;lmerich"
                            5 => "R&#46;H&#46; Straub"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol&#46;"
                        "fecha" => "2000"
                        "volumen" => "27"
                        "paginaInicial" => "911"
                        "paginaFinal" => "918"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10782815"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased 16 alpha-hydroxylation of estradiol in systemic lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;G&#46; Lahita"
                            1 => "H&#46;L&#46; Bradlow"
                            2 => "H&#46;G&#46; Kunkel"
                            3 => "J&#46; Fishman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem-53-1-174"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Clin Endocrinol Metab&#46;"
                        "fecha" => "1981"
                        "volumen" => "53"
                        "paginaInicial" => "174"
                        "paginaFinal" => "178"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7240374"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109701017132"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estradiol targets T cell signaling pathways in human systemic lupus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Walters"
                            1 => "V&#46; Rider"
                            2 => "N&#46;I&#46; Abdou"
                            3 => "C&#46; Greenwell"
                            4 => "S&#46; Svojanovsky"
                            5 => "P&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clim.2009.09.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Immunol&#46;"
                        "fecha" => "2009"
                        "volumen" => "133"
                        "paginaInicial" => "428"
                        "paginaFinal" => "436"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19793680"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutting Edge&#58; Hormonal milieu&#44; not antigenic specificity&#44; determines the mature phenotype of autoreactive B cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Venkatesh"
                            1 => "E&#46; Peeva"
                            2 => "X&#46; Xu"
                            3 => "B&#46; Diamond"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol&#46;"
                        "fecha" => "2006"
                        "volumen" => "176"
                        "paginaInicial" => "3311"
                        "paginaFinal" => "3314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16517697"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prolactin and autoimmunity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46;J&#46; Jara"
                            1 => "G&#46; Medina"
                            2 => "M&#46;A&#46; Saavedra"
                            3 => "O&#46; Vera-Lastra"
                            4 => "C&#46; Navarro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s12016-009-8185-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Rev Allergy Immunol&#46;"
                        "fecha" => "2011"
                        "volumen" => "40"
                        "paginaInicial" => "50"
                        "paginaFinal" => "59"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19911311"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
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Vol. 7. Issue 2.
Pages 85-87 (March - April 2011)
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Vol. 7. Issue 2.
Pages 85-87 (March - April 2011)
Editorial
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Neuroimmunoendocrine interaction in autoimmune rheumatic diseases: a new challenge for the rheumatologist
La interacción inmuno-neuro-endocrina en enfermedades reumáticas autoinmunes: un nuevo desafío para el reumatólogo
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Luis J. Jara
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reuma2003@Yahoo.Com

Corresponding author.
Dirección de Educación e Investigación, Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico La Raza, IMSS. Universidad Nacional Autónoma de México, Mexico City, Mexico
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References
[1.]
H.O. Besedovsky, A. Del Rey.
Immune-neuro-endocrine interactions: facts and hypotheses.
Endocr Rev., 17 (1996), pp. 64-102
[2.]
L.J. Jara, C. Navarro, G. Medina, O. Vera-Lastra, F. Blanco.
Immune-neuroendocrine. interactions and autoimmune diseases.
Clin Dev Immunol., 13 (2006), pp. 109-123
[3.]
A.S. Tait, C.L. Butts, E.M. Sternberg.
The role of glucocorticoids and progestins in inflammatory, autoimmune, and infectious disease.
J Leukoc Biol., 84 (2008), pp. 924-931
[4.]
P. Lakatos, A. Blumsohn, R. Eastell, G. Tarjan, H. Shinoda, P.H. Stern.
Circadian rhythm of in vitro bone-resorbing activity in human serum.
J Clin Endocrinol Metab., 80 (1995), pp. 3185-3190
[5.]
J.C. O’Connor, R.H. McCusker, K. Strle, R.W. Johnson, R. Dantzer, K.W. Kelley.
Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology.
Cell Immunol., 252 (2008), pp. 91-110
[6.]
W.A. Banks, M.A. Erickson.
The blood-brain barrier and immune function and dysfunction.
Neurobiol Dis., 37 (2010), pp. 26-32
[7.]
R. Dantzer, K.W. Kelley.
Twenty years of research on cytokine-induced sickness behavior.
Brain Behav Immun., 21 (2007), pp. 153-160
[8.]
R.H. Straub, H.O. Besedovsky.
Integrated evolutionary immunological neuroendocrine framework for the pathogenesis of chronic disabling inflammatory F diseases.
FASEBJ, 17 (2003), pp. 2176-2183
[9.]
M. Jafarian-Tehrani, E.M. Sternberg.
Neuroendocrine-immune modulation of autoimmune/inflammatory diseases.
Front Horm Res., 29 (2002), pp. 69-82
[10.]
O. Vera-Lastra, L.J. Jara, G. Medina, J.L. Rojas, F. Veláquez, R. Ariza, et al.
Functional hyperprolactinemia and hypophyseal microadenoma in systemic sclerosis.
J Rheumatol., 33 (2006), pp. 1108-1112
[11.]
L. Stojanovich, D. Marisavljevich.
Stress as a trigger of autoimmune disease.
Autoimmun Rev., 7 (2008), pp. 209-213
[12.]
S.J. De Brouwer, F.W. Kraaimaat, F.C. Sweep, M.C. Creemers, T.R. Radstake, A.I. Van Laarhoven, et al.
Experimental stress in inflammatory rheumatic diseases: a review of psychophysiological stress responses.
Arthritis Res Ther., 17 (2010), pp. 12
[13.]
S.R. Dube, D. Fairweather, W.S. Pearson, V.J. Felitti, R.F. Anda, J.B. Croft.
Cumulative childhood stress and autoimmune diseases in adults.
Psychosom Med., 71 (2009), pp. 243-250
[14.]
A.T. Masi, J.C. Aldag, R.T. Chatterton.
Sex hormones and risks of rheumatoid arthritis and developmental or environmental influences.
Ann N Y Acad Sci., 1069 (2006), pp. 223-235
[15.]
P. Brennan, A. Silman.
Breast-feeding and the onset of rheumatoid arthritis.
Arthritis Rheum., 37 (1994), pp. 808-813
[16.]
E. Berglin, H. Kokkonen, E. Einarsdottir, A. Agren, S. Rantapää Dahlqvist.
Influence of female hormonal factors, in relation to autoantibodies and genetic markers, on the development of rheumatoid arthritis in northern Sweden: a case-control study.
Scand J Rheumatol., 39 (2010), pp. 454-460
[17.]
A.N. Colebatch, C.J. Edwards.
The influence of early life factors on the risk of developing rheumatoid arthritis.
Clin Exp Immunol., 163 (2011), pp. 11-16
[18.]
S.E. Walker, J.D. Jacobson.
Roles of prolactin and gonadotropin-releasing hormone in rheumatic diseases.
Rheum Dis Clin North Am., 26 (2000), pp. 713-736
[19.]
L.J. Jara Quezada, M.A. Saavedra Salinas, O. Vera Lastra, Marquez. Alcalá.
Enfermedades endocrinológicas y metabólicas.
1st ed, pp. 1285-1299
[20.]
M. Cutolo, A. Sulli, C. Pizzorni, C. Craviotto, R.H. Straub.
Hypothalamic-pituitary-adrenocortical and gonadal functions in rheumatoid arthritis.
Ann NY Acad Sci., 992 (2003), pp. 107-117
[21.]
R.H. Straub, L. Paimela, R. Peltomaa, J. Schölmerich, M. Leirisalo-Repo.
Inadequately low serum levels of steroid hormones in relation to IL-6 and TNF in untreated patients with early rheumatoid arthritis and reactive arthritis.
Arthritis Rheum., 46 (2002), pp. 654-662
[22.]
M. Herrmann, J. Schölmerich, R.H. Straub.
Influence of cytokines and growth factors on distinct steroidogenic enzymes in vitro: a short tubular data collection.
Ann NY Acad Sci., 966 (2002), pp. 166-186
[23.]
R.H. Straub, G. Pongratz, J. Schölmerich, F. Kees, T.F. Schaible, C. Antoni, et al.
Long-term anti-tumor necrosis factor antibody therapy in rheumatoid arthritis patients sensitizes the pituitary gland and favors adrenal androgen secretion.
Arthritis Rheum., 48 (2003), pp. 1504-1512
[24.]
L. Daza, R. Martín-Jiménez, P. de la Torre, E. Hernández, B. Murillo.
Improvement of ACTH response to insulin tolerance test in female patients with rheumatoid arthritis due to tumor necrosis factor inhibition.
Eur J Endocrinol., 157 (2007), pp. 47-51
[25.]
R.H. Straub, G. Pongratz, M. Cutolo, C.A. Wijbrandts, D. Baeten, M. Fleck, et al.
Increased cortisol relative to adrenocorticotropic hormone predicts improvement during anti-tumor necrosis factor therapy in rheumatoid arthritis.
Arthritis Rheum., 58 (2008), pp. 976-984
[26.]
M. Cutolo, S. Capellino, P. Montagna, B. Villaggio, A. Sulli, B. Seriolo, et al.
New roles for estrogens in rheumatoid arthritis.
Clin Exp Rheumatol., 21 (2003), pp. 687-689
[27.]
L. Castagnetta, G. Carruba, M. Cutolo, R. Stefano, M. Miele, M. Schmidt, et al.
Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis.
J Rheumatol., 30 (2003), pp. 2597-2605
[28.]
S. Capellino, P. Montagna, B. Villaggio, S. Soldano, R.H. Straub, M. Cutolo.
Hydroxylated estrogen metabolites influence the proliferation of cultured human monocytes: possible role in synovial tissue hyperplasia.
Clin Exp Rheumatol., 26 (2008), pp. 903-909
[29.]
M. Cutolo, S. Capellino, R.H. Straub.
Sex hormones, the immune system and autoimmune diseases.
1st ed, pp. 13-19
[30.]
S. Capellino, B. Riepl, L. Raucn, P. Angele, M. Cutolo, R.H. Straub.
Quantitative determination of steroid hormone receptor positive cells in synovium of RA and OA patients: is there a link to inflammation.
Ann Rheum Dis., 66 (2007), pp. 53-68
[31.]
S. Ernestam, I. Hafström, S. Werner, K. Carlström, B. Tengstrand.
Increased DHEAS levels in patients with rheumatoid arthritis after treatment with tumor necrosis factor antagonists: evidence for improved adrenal function.
J Rheumatol., 34 (2007), pp. 1451-1458
[32.]
A. Del Rey, C. Wolff, J. Wildmann, A. Randolf, A. Hahnel, H.O. Besedovsky, R.H. Straub.
Disrupted brain-immune system-joint communication during experimental arthritis.
Arthritis Rheum., 58 (2008), pp. 3090-3099
[33.]
W. Kuis, C.E. de Jong-de Vos van Steenwijk, G. Sinnema, A. Kavelaars, B. Prakken, P.J. Helders, et al.
The autonomic nervous system and the immune system in juvenile rheumatoid arthritis.
Brain Behav Immune., 10 (1996), pp. 387-398
[34.]
J.C. Dekkers, R. Geenen, G.L. Godaert, J.W. Bijlsma, L.J. Van Doornen.
Elevated sympathetic nervous system activity in patients with recently diagnosed rheumatoid arthritis with active disease.
Clin Exp Rheumatol., 22 (2004), pp. 63-70
[35.]
S. Capellino, R.H. Straub.
Neuroendocrine immune control mechanisms, their influence on autoimmune diseases.
1st ed, pp. 3-12
[36.]
B. Zietz, T. Reber, M. Oertel, T. Glück, J. Schölmerich, R.H. Straub.
Altered function of the hypothalamic stress axes in patients with moderately active systemic lupus erythematosus II Dissociation between androstenedione, cortisol, or dehydroepiandrosterone and interleukin 6 or tumor necrosis factor.
J Rheumatol., 27 (2000), pp. 911-918
[37.]
R.G. Lahita, H.L. Bradlow, H.G. Kunkel, J. Fishman.
Increased 16 alpha-hydroxylation of estradiol in systemic lupus erythematosus.
J Clin Endocrinol Metab., 53 (1981), pp. 174-178
[38.]
E. Walters, V. Rider, N.I. Abdou, C. Greenwell, S. Svojanovsky, P. Smith, et al.
Estradiol targets T cell signaling pathways in human systemic lupus.
Clin Immunol., 133 (2009), pp. 428-436
[39.]
J. Venkatesh, E. Peeva, X. Xu, B. Diamond.
Cutting Edge: Hormonal milieu, not antigenic specificity, determines the mature phenotype of autoreactive B cells.
J Immunol., 176 (2006), pp. 3311-3314
[40.]
L.J. Jara, G. Medina, M.A. Saavedra, O. Vera-Lastra, C. Navarro.
Prolactin and autoimmunity.
Clin Rev Allergy Immunol., 40 (2011), pp. 50-59
Copyright © 2011. Sociedad Española de Reumatología and Colegio Mexicano de Reumatología
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?