Reactivation of hepatitis B in a patient with spondyloarthritis after the suspension of methotrexate and efficacy of treatment with antivirals in association to adalimumab

Cobeta García, Juan Carlos; Medrano, Marta

doi:10.1016/S2173-5743(11)70041-7

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Full recovery after therapy with lamivudine and adefovir allowed treatment with adalimumab which was well tolerated.Reactivation of hepatitis B after MTX withdrawal is a very rare complication, which can also occur in association with anti-TNF agents. In patients with positive serology for HBV prophylactic antiviral therapy is recommended." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Comunicamos el caso de un varón portador crónico de virus de hepatitis B (VHB) con espondiloartritis B27 positivo que desarrolló una hepatitis fulminante tras la suspensión del tratamiento con metotrexato (MTX). Una total recuperación tras terapia con lamivudina y adefovir permitió un tratamiento con adalimumab sin otras complicaciones y buena tolerancia.La reactivación de hepatitis B tras suspensión de MTX es una complicación muy poco frecuente, que también puede ocurrir con los anti-TNF. En pacientes con serología positiva de VHB se recomienda tratamiento profiláctico con antivirales." ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Screening, prevention and treatment of viral hepatitis B reactivation in patients with haematological malignancies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Lalazar" 1 => "D. Rund" 2 => "D. Shouval" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2141.2006.06465.x" "Revista" => array:6 [ "tituloSerie" => "Br J Haematol" "fecha" => "2007" "volumen" => "136" "paginaInicial" => "699" "paginaFinal" => "712" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17338776" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fulminant hepatitis as a consequence of reactivation of Hepatitis B virus infection after discontinuation of low-dose methotrexate therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.A. Flowers" 1 => "J. Heathcote" 2 => "I.R. Wanless" 3 => "M. Sherman" 4 => "W.J. Reynolds" 5 => "R.G. Cameron" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1990" "volumen" => "112" "paginaInicial" => "381" "paginaFinal" => "382" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2306066" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "13135260" "estado" => "S300" "issn" => "11301406" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severe hepatitis linked to B Virus infection after withdrawal of low dose methotrexate therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Narváez" 1 => "J. Rodríguez-Moreno" 2 => "M.D. Martínez-Aguilá" 3 => "M.T. Clavaguera" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1998" "volumen" => "25" "paginaInicial" => "2037" "paginaFinal" => "2038" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9779869" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of fulminant hepatitis B (precore variant mutant type) after the discontinuation of low-dose methotrexate therapy in a rheumatoid arthritis patient" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Ito" 1 => "K. Nakazono" 2 => "A. Murasawa" 3 => "Y. Mita" 4 => "K. Hata" 5 => "N. Saito" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arthrtis Rheumatism" "fecha" => "2001" "volumen" => "44" "paginaInicial" => "339" "paginaFinal" => "342" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fulminant hepatitis in an asymptomatic chronic carrier of hepatitis B virus mutant after withdrawal of low-dose methotrexate therapy for rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Hagiyama" 1 => "T. Kubota" 2 => "Y. Komano" 3 => "M. Kurosaki" 4 => "M. Watanabe" 5 => "N. Miyasaka" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2004" "volumen" => "22" "paginaInicial" => "375" "paginaFinal" => "376" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15144137" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety of antitumour necrosis factor (anti-TNF) therapy in patients with chronic viral infections: hepatitis C, hepatitis B and HIV infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.H. Calabrese" 1 => "N. Zein" 2 => "D. Vassilopoulos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2004" "volumen" => "63" "numero" => "Suppl 2" "paginaInicial" => "18" "paginaFinal" => "24" "itemHostRev" => array:3 [ "pii" => "S0163445307008134" "estado" => "S300" "issn" => "01634453" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fatal hepatic failure associated with hepatits B virus reactivation in a hepatitis B surface antigen-negative patient with rheumatoid arthritis receiving low dose methotrexate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G.Y. Gwak" 1 => "K.C. Koh" 2 => "H.Y. Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2007" "volumen" => "25" "paginaInicial" => "888" "paginaFinal" => "889" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18173926" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1130140609000047" "estado" => "S300" "issn" => "11301406" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prophylaxis and therapy of HBV infection in 20 patients treated with disease modifying antirheumatic drugs or with biological agents for rheumatic diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Zingarelli" 1 => "P. Airò" 2 => "M. Frassi" 3 => "C. Bazzani" 4 => "M. Scarsi" 5 => "M. Puoti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Reumatismo" "fecha" => "2008" "volumen" => "60" "paginaInicial" => "22" "paginaFinal" => "27" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18432322" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of tumor necrosis factor-α- blocking agents in hepatitis B virus-positive patients: reports of 3 cases and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Zingarelli" 1 => "M. Frassi" 2 => "C. Bazzani" 3 => "M. Scarsi" 4 => "M. Puoti" 5 => "P. Airò" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3899/jrheum.081246" "Revista" => array:7 [ "tituloSerie" => "J Rheumatol" "fecha" => "2009" "volumen" => "36" "paginaInicial" => "1188" "paginaFinal" => "1194" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19447932" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "13135265" "estado" => "S300" "issn" => "11301406" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatitis B virus (HBV) reactivation with immunosuppresive therapy in rheumatic diseases: assesment and preventive strategies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.H. Calabrese" 1 => "N.N. Zein" 2 => "D. Vassilopolos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2005.043257" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2006" "volumen" => "65" "paginaInicial" => "983" "paginaFinal" => "989" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16627542" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tratamiento de situaciones clínicas difíciles en pacientes que presentan artritis reumatoide con hepatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Ibáñez Bosch" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.reuma.2008.11.006" "Revista" => array:7 [ "tituloSerie" => "Reumatol Clin" "fecha" => "2009" "volumen" => "5" "numero" => "Suppl 1" "paginaInicial" => "53" "paginaFinal" => "60" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21794644" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "How I treat and monitor viral hepatitis B infection in patients receiving intensive immunosuppressive therapies or undergoing hematopoietic stem cell transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Lang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1182/blood-2008-10-163493" "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "2009" "volumen" => "113" "paginaInicial" => "3147" "paginaFinal" => "3153" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19144986" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spondyloarthropathy and chronic B hepatitis Effect of anti-TNF therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Wendling" 1 => "V. Di Martino" 2 => "C. Prati" 3 => "E. Toussirot" 4 => "G. Herbein" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jbspin.2008.11.005" "Revista" => array:6 [ "tituloSerie" => "Joint Bone Spine" "fecha" => "2009" "volumen" => "76" "paginaInicial" => "308" "paginaFinal" => "311" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19346146" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "AASLD Practice Guidelines Chronic Hepatitis B: Update 2009" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.S.F. Lok" 1 => "B.J. McMahon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.22943" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2009" "volumen" => "50" "paginaInicial" => "1" "paginaFinal" => "36" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19554618" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000700000003/v1_201305061622/S2173574311700417/v1_201305061622/en/main.assets" "Apartado" => array:4 [ "identificador" => "17376" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Case Report" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000700000003/v1_201305061622/S2173574311700417/v1_201305061622/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574311700417?idApp=UINPBA00004M"]

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Abstract

We report the case of a male chronic hepatitis B virus (HBV) carrier with HLA-B27 spondyloarthrititis who developed fulminant hepatitis after discontinuation of methotrexate (MTX). Full recovery after therapy with lamivudine and adefovir allowed treatment with adalimumab which was well tolerated.

Reactivation of hepatitis B after MTX withdrawal is a very rare complication, which can also occur in association with anti-TNF agents. In patients with positive serology for HBV prophylactic antiviral therapy is recommended.

Keywords:

Hepatitis B virus

Spondyloarthritis

Methotrexate

Anti-TNF

Antivirals

Resumen

Comunicamos el caso de un varón portador crónico de virus de hepatitis B (VHB) con espondiloartritis B27 positivo que desarrolló una hepatitis fulminante tras la suspensión del tratamiento con metotrexato (MTX). Una total recuperación tras terapia con lamivudina y adefovir permitió un tratamiento con adalimumab sin otras complicaciones y buena tolerancia.

La reactivación de hepatitis B tras suspensión de MTX es una complicación muy poco frecuente, que también puede ocurrir con los anti-TNF. En pacientes con serología positiva de VHB se recomienda tratamiento profiláctico con antivirales.

Palabras clave:

Virus hepatitis B

Espondiloartritis

Metotrexato

Anti-TNF

Antivirales

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References

[1.]

G. Lalazar, D. Rund, D. Shouval.

Screening, prevention and treatment of viral hepatitis B reactivation in patients with haematological malignancies.

Br J Haematol, 136 (2007), pp. 699-712

http://dx.doi.org/10.1111/j.1365-2141.2006.06465.x | Medline

[2.]

M.A. Flowers, J. Heathcote, I.R. Wanless, M. Sherman, W.J. Reynolds, R.G. Cameron, et al.

Fulminant hepatitis as a consequence of reactivation of Hepatitis B virus infection after discontinuation of low-dose methotrexate therapy.

Ann Intern Med, 112 (1990), pp. 381-382

Article | Medline

[3.]

J. Narváez, J. Rodríguez-Moreno, M.D. Martínez-Aguilá, M.T. Clavaguera.

Severe hepatitis linked to B Virus infection after withdrawal of low dose methotrexate therapy.

J Rheumatol, 25 (1998), pp. 2037-2038

Medline

[4.]

S. Ito, K. Nakazono, A. Murasawa, Y. Mita, K. Hata, N. Saito, et al.

Development of fulminant hepatitis B (precore variant mutant type) after the discontinuation of low-dose methotrexate therapy in a rheumatoid arthritis patient.

Arthrtis Rheumatism, 44 (2001), pp. 339-342

[5.]

H. Hagiyama, T. Kubota, Y. Komano, M. Kurosaki, M. Watanabe, N. Miyasaka.

Fulminant hepatitis in an asymptomatic chronic carrier of hepatitis B virus mutant after withdrawal of low-dose methotrexate therapy for rheumatoid arthritis.

Clin Exp Rheumatol, 22 (2004), pp. 375-376

Medline

[6.]

L.H. Calabrese, N. Zein, D. Vassilopoulos.

Safety of antitumour necrosis factor (anti-TNF) therapy in patients with chronic viral infections: hepatitis C, hepatitis B and HIV infection.

Ann Rheum Dis, 63 (2004), pp. 18-24

[7.]

G.Y. Gwak, K.C. Koh, H.Y. Kim.

Fatal hepatic failure associated with hepatits B virus reactivation in a hepatitis B surface antigen-negative patient with rheumatoid arthritis receiving low dose methotrexate.

Clin Exp Rheumatol, 25 (2007), pp. 888-889

Article | Medline

[8.]

S. Zingarelli, P. Airò, M. Frassi, C. Bazzani, M. Scarsi, M. Puoti.

Prophylaxis and therapy of HBV infection in 20 patients treated with disease modifying antirheumatic drugs or with biological agents for rheumatic diseases.

Reumatismo, 60 (2008), pp. 22-27

Medline

[9.]

S. Zingarelli, M. Frassi, C. Bazzani, M. Scarsi, M. Puoti, P. Airò.

Use of tumor necrosis factor-α- blocking agents in hepatitis B virus-positive patients: reports of 3 cases and review of the literature.

J Rheumatol, 36 (2009), pp. 1188-1194

http://dx.doi.org/10.3899/jrheum.081246Article | Medline

[10.]

L.H. Calabrese, N.N. Zein, D. Vassilopolos.

Hepatitis B virus (HBV) reactivation with immunosuppresive therapy in rheumatic diseases: assesment and preventive strategies.

Ann Rheum Dis, 65 (2006), pp. 983-989

http://dx.doi.org/10.1136/ard.2005.043257 | Medline

[11.]

R. Ibáñez Bosch.

Tratamiento de situaciones clínicas difíciles en pacientes que presentan artritis reumatoide con hepatitis.

Reumatol Clin, 5 (2009), pp. 53-60

http://dx.doi.org/10.1016/j.reuma.2008.11.006 | Medline

[12.]

R. Lang.

How I treat and monitor viral hepatitis B infection in patients receiving intensive immunosuppressive therapies or undergoing hematopoietic stem cell transplantation.

Blood, 113 (2009), pp. 3147-3153

http://dx.doi.org/10.1182/blood-2008-10-163493 | Medline

[13.]

D. Wendling, V. Di Martino, C. Prati, E. Toussirot, G. Herbein.

Spondyloarthropathy and chronic B hepatitis Effect of anti-TNF therapy.

Joint Bone Spine, 76 (2009), pp. 308-311

http://dx.doi.org/10.1016/j.jbspin.2008.11.005 | Medline

[14.]

A.S.F. Lok, B.J. McMahon.

AASLD Practice Guidelines Chronic Hepatitis B: Update 2009.

Hepatology, 50 (2009), pp. 1-36

http://dx.doi.org/10.1002/hep.22943 | Medline