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Original Article
Available online 25 February 2025
Rheumatological diseases in patients with autoimmune hepatitis in a fourth level hospital in Bogotá between 2013 and 2023
Enfermedades reumatológicas en pacientes con hepatitis autoinmune en un hospital de cuarto nivel de Bogotá entre el 2013 al 2023
Juan Sebastián Almánzar Cortésa,
Corresponding author
sebastian_almanzar@hotmail.com

Corresponding author.
, Cathalina Vergara Cabraa, María Paula Uchima-Verab, Gerardo Quintanaa, Fernando Sierraa
a Departamento de Medicina Interna, Fundación Santa Fe de Bogotá, Bogotá, Colombia
b Facultad de Medicina, Universidad de Los Andes, Bogotá, Colombia
Received 04 November 2024. Accepted 14 November 2024
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Tables (9)
Table 1. Simplified autoimmune hepatitis diagnostic criteria.
Table 2. Sociodemographic characteristics (n = 66).
Table 3. Presence of cirrhosis at diagnosis and Child-Pugh classification (n = 66).
Table 4. Clinical characteristics of patients with AIH (n = 66).
Table 5. Hepatic autoimmune profile and histopathological findings (n = 66).
Table 6. Types of autoimmune disease in patients with autoimmune hepatitis (n = 66).
Table 7. Statistical analysis for the association between histology and antibodies.
Table 8. Statistical analysis for the association between histology and type of autoimmune disease.
Table 9. Statistical analysis for the association between cirrhosis and type of autoimmune disease.
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Abstract
Introduction

Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease with low prevalence worldwide. The coexistence of this entity with rheumatic diseases has been evaluated in multiple studies and is highly variable. The objective of this study is to identify the frequency of coexistence of rheumatic diseases and autoimmune hepatitis in adults who have been treated for 10 years in a fourth-level hospital in Bogota, Colombia.

Materials and methods

Analytical, observational, cross-sectional study in a single center that included patients over 18 years of age of both sexes with a diagnosis of AIH by simplified score ≥7 points, with a medical history registered at the Fundacion Santa Fe de Bogota in Bogota, Colombia between January 2013 and December 2023.

Results

A total of 66 patients met inclusion criteria. 36.4% of patients had a concomitant autoimmune disease, with Sjögren's syndrome, systemic lupus erythematosus and autoimmune thyroid disease being the most prevalent.

Conclusion

The frequency of coexistence of autoimmune hepatitis with rheumatic diseases in adult patients is 36.4% for the cohort studied, which is within the range of what has already been reported globally, where a prevalence of 14 to 44% has been described.

Keywords:
Autoinmune hepatitis
Inmune system diseases
Autoantibodies
Prevalence
Coexistent disease
Resumen
Introducción

La hepatitis autoinmune (HAI) es una enfermedad crónica inflamatoria del hígado de baja prevalencia a nivel global. En múltiples estudios se ha evaluado la coexistencia de esta entidad con enfermedades reumatológicas la cual es muy variable. El objetivo de este estudio es identificar la frecuencia de la coexistencia de enfermedades reumatológicas y hepatitis autoinmune en adultos que han sido atendidos durante 10 años en un hospital de cuarto nivel en Bogotá, Colombia.

Materiales y métodos

Estudio observacional analítico de corte transversal en un único centro que incluyó pacientes mayores de 18 años de ambos sexos con diagnóstico de HAI por “score” simplificado ≥7 puntos, con historia clínica registrada en el Hospital Fundación Santa Fe de Bogotá entre enero de 2013 y diciembre 2023.

Resultados

Un total de 66 pacientes cumplieron criterios de inclusión. El 36.4% de los pacientes presentaban una enfermedad autoinmune concomitante, siendo el síndrome de Sjögren, el lupus eritematoso sistémico y la enfermedad tiroidea autoinmune las de mayor prevalencia.

Conclusión

La frecuencia de la coexistencia de hepatitis autoinmune con enfermedades reumatológicas en pacientes adultos es del 36.4% para la cohorte estudiada, encontrándose en el rango de lo ya reportado a nivel global, donde se ha descrito una prevalencia del 14 al 44%.

Palabras clave:
Hepatitis autoinmune
Enfermedades reumatológicas
Perfil inmunoserológico
Frecuencia
Coexistencia

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