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Vol. 20. Issue 6.
Pages 287-290 (June - July 2024)
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Vol. 20. Issue 6.
Pages 287-290 (June - July 2024)
Original article
Serum leukemia inhibitory factor (LIF) levels in patients with Takayasu's and Giant cell arteritis: A cross-sectional study
Niveles séricos del factor inhibidor de la leucemia en pacientes con arteritis de Takayasu y de células gigantes, un estudio transversal
Rahime Aksoya,
Corresponding author

Corresponding author.
, Tahsin Murat Turgayb, Recep Yilmazb, Serdar Sezerb, Müçteba Enes Yaylab, Emine Uslu Yurterib
a Department of Hematology, Faculty of Medicine, Ankara University, Ankara, Turkey
b Department of Rheumatology, Faculty of Medicine, Ankara University, Ankara, Turkey
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Tables (4)
Table 1. Clinical, laboratory and demographic characteristics of Takayasu and Giant cell arteritis patients and healthy controls.
Table 2. Comparison of acute phase reactants and LIF values of active and inactive patients.a
Table 3. Factors associated with active disease.
Table 4. Possible clinical and demographic characteristics that may affect the LIF value.
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Introduction and objectives

In this study, we aimed to evaluate LIF levels and its possible relationship with disease activity in patients with Takayasu's (TAK) and Giant cell arteritis (GCA) patients.

Materials and methods

23 Takayasu's arteritis, 9 Giant cell arteritis patients and 25 healthy volunteers were included in the study. Serum LIF levels were measured ELISA.


The mean age of Giant cell arteritis patients was statistically significantly higher than the other groups (p<0.001). The rate of women was found to be higher in Takayasu's arteritis (p=0.021). When healthy control, patients with GCA and Takayasu arteritis were compared, there was a difference in LIF values (p=0.018). In subgroup analyzes, LIF values were found to be higher in GCA patients compared to healthy controls (p<0.05). There was no statistically significant correlation between LIF and CRP (Rho=−0.038, p=0.778), ESR (Rho=0.114, p=0.399) and ITAS (Rho=−0.357, p=0.094). While CRP was statistically significantly higher in patients with disease activity (p=0.003), there was no statistically significant difference between patients in terms of ESR and LIF values. While there was a statistically significant relationship between CRP (OR=1.19 [1.03–1.37], p=0.018) and disease activity in univariate analyses, no statistically significant variable was found in multivariable analyses.


LIF values were significantly higher in patients with Giant cell arteritis compared to healthy controls.

Takayasu's arteritis
Giant cell arteritis
Leukemia inhibitory factor
Introducción y objetivos

En este estudio nos propusimos evaluar los niveles de factor inhibidor de la leucemia (LIF) y su posible relación con la actividad de la enfermedad en pacientes con Takayasu (TAK) y arteritis de células gigantes (ACG).

Materiales y métodos

En el estudio se incluyeron 23 pacientes con arteritis de TAK, nueve con ACG y 25 voluntarios sanos. Los niveles séricos de LIF se midieron mediante ELISA.


La edad media de los pacientes con ACG fue significativamente superior a la de los demás grupos (p<0,001). Se observó que la tasa de mujeres era superior en la arteritis de TAK (p=0,021). Cuando se compararon controles sanos, pacientes con ACG y arteritis de TAK, se observaron diferencias en los valores de LIF (p=0,018). En los análisis de subgrupos, se observó que los valores de LIF eran más elevados en los pacientes con ACG que en los controles sanos (p<0,05). No hubo correlación estadísticamente significativa entre el LIF y la reacción en cadena de la polimerasa (PCR) (Rho=-0,038, p=0,778), la velocidad de sedimentación globular (VSG) (Rho=0,114, p=0,399) y el ITAS (Rho=-0,357, p=0,094). Aunque la PCR fue estadísticamente significativa en los pacientes con actividad de la enfermedad (p=0,003), no hubo diferencias estadísticamente significativas entre estos en cuanto a los valores de VSG y LIF. Aunque hubo una relación estadísticamente significativa entre la PCR (odds ratio [OR]=1,19 [1,03-1,37], p=0,018) y la actividad de la enfermedad en los análisis univariantes, no se encontró ninguna variable estadísticamente significativa en los multivariantes.


Los valores de LIF fueron significativamente más elevados en los pacientes con arteritis de células gigantes en comparación con los controles sanos.

Palabras clave:
Arteritis de Takayasu
Arteritis de células gigantes
Factor inhibidor de la leucemia


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