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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Some patients with thrombocytopenia due SLE fail to respond to conventional therapies&#46; Rituximab has been reported to be an alternative for patient treatment&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To evaluate the response of thrombocytopenia due to Systemic Lupus Erythematosus to the use of Rituximab and patient relapse time at our hospital&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We analyzed patients with SLE than received a 2 gram rituximab treatment for thrombocytopenia&#46; We analyzed the rate of patients that achieved complete remission &#40;CR&#41;&#44; defined as a platelet count over 100 mil&#47;mm3&#44; partial remission &#40;PR&#41; described as platelets within 50&#8211;100 mil&#47;mm3 and no response &#40;NR&#41; if platelets remained unchanged and the time the remission was sustained&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Sixteen treatments were applied to 13 patients&#44; aged 28<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 years of age and SLE mean duration time of 68<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>44 months with a mean platelet count of 38<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29 mil&#46; In 14 treatments &#40;87&#37;&#41; remission was achieved after 5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2 weeks where 2 patients &#40;12&#46;5&#37;&#41; were non respondent&#46; One of them died due to a massive hemorrhage&#46; The mean response time without relapse was 15&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6 months&#46; Follow up of three patients was not possible and 3 other died due to infections&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Rituximab is an alternative for treatment of thrombocytopenia due to Systemic Lupus Erythematosus&#46;</p>"
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        "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">En algunos casos la trombocitopenia secundaria a lupus eritematoso sist&#233;mico &#40;LES&#41; no responde al tratamiento convencional&#46; En los &#250;ltimos a&#241;os se ha reportado que el rituximab es una alternativa para estos pacientes&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Evaluar la respuesta de la trombocitopenia &#40;T&#41; secundaria a LES con el uso de rituximab y determinar el tiempo que se mantiene el efecto libre de reca&#237;da&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se revisaron los expedientes de los pacientes con diagn&#243;stico de LES con T que recibieron tratamiento con rituximab &#40;2<span class="elsevierStyleHsp" style=""></span>g&#41; para conocer la proporci&#243;n de pacientes que lograron remisi&#243;n completa &#40;RC&#41;&#58; definida como una cuenta plaquetaria &#62;<span class="elsevierStyleHsp" style=""></span>100&#46;000&#47;mm3&#59; remisi&#243;n parcial &#40;RP&#41;&#58; cuenta plaquetaria entre 50&#46;000 y 100&#46;000&#47;mm3 y los no respondedores &#40;NR&#41;&#59; as&#237; como el tiempo que se mantiene el paciente sin reca&#237;da&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se aplicaron 16 tratamientos en 13 pacientes&#44; en una paciente 3 y en otra 2 ciclos&#46; Fueron 12 mujeres y 1 hombre con edad media de 28<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 a&#241;os y tiempo medio de duraci&#243;n del LES de 68<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>44 meses&#44; con una cuenta media plaquetaria de 38&#46;000<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#46;000&#46; En 14 tratamientos &#40;87&#37;&#41; se logr&#243; RC despu&#233;s de 5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2 semanas y 2 pacientes &#40;12&#46;5&#37;&#41; fueron NR&#46; Una de ellas muri&#243; por hemorragia masiva&#46; El tiempo medio de respuesta sin reca&#237;da fue de 15&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6 meses&#46; Tres pacientes perdieron el seguimiento y 3 murieron de infecciones&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">El rituximab es una alternativa de tratamiento en pacientes con T secundaria a LES&#46;</p>"
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Journal Information
Vol. 6. Issue 2.
Pages 82-85 (March - April 2010)
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Vol. 6. Issue 2.
Pages 82-85 (March - April 2010)
Original article
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Treatment with rituximab for thrombocytopenia due to systemic lupus erythematosus
Tratamiento con rituximab para la trombocitopenia secundaria a lupus eritematoso sistémico
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Rosa Elena Calderón Saldierna
Corresponding author
edra.rosa.calderon@hotmail.com

Corresponding author.
, María Azucena Ramos Sánchez, Yadhira Mejía Holguín, Laura Elena Aranda Baca, María Josefina Sauza del Pozo, Ariana Maia Becerra Márquez
Unidad Médica de Alta Especialidad N.° 25 del IMSS, Monterrey, Mexico
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Abstract

Some patients with thrombocytopenia due SLE fail to respond to conventional therapies. Rituximab has been reported to be an alternative for patient treatment.

Objective

To evaluate the response of thrombocytopenia due to Systemic Lupus Erythematosus to the use of Rituximab and patient relapse time at our hospital.

Patients and methods

We analyzed patients with SLE than received a 2 gram rituximab treatment for thrombocytopenia. We analyzed the rate of patients that achieved complete remission (CR), defined as a platelet count over 100 mil/mm3, partial remission (PR) described as platelets within 50–100 mil/mm3 and no response (NR) if platelets remained unchanged and the time the remission was sustained.

Results

Sixteen treatments were applied to 13 patients, aged 28±9 years of age and SLE mean duration time of 68±44 months with a mean platelet count of 38±29 mil. In 14 treatments (87%) remission was achieved after 5±2 weeks where 2 patients (12.5%) were non respondent. One of them died due to a massive hemorrhage. The mean response time without relapse was 15.6±6 months. Follow up of three patients was not possible and 3 other died due to infections.

Conclusions

Rituximab is an alternative for treatment of thrombocytopenia due to Systemic Lupus Erythematosus.

Keywords:
Rituximab
Anti CD20
Systemic lupus erythematosus
Thrombocytopenia
Resumen

En algunos casos la trombocitopenia secundaria a lupus eritematoso sistémico (LES) no responde al tratamiento convencional. En los últimos años se ha reportado que el rituximab es una alternativa para estos pacientes.

Objetivo

Evaluar la respuesta de la trombocitopenia (T) secundaria a LES con el uso de rituximab y determinar el tiempo que se mantiene el efecto libre de recaída.

Material y métodos

Se revisaron los expedientes de los pacientes con diagnóstico de LES con T que recibieron tratamiento con rituximab (2g) para conocer la proporción de pacientes que lograron remisión completa (RC): definida como una cuenta plaquetaria >100.000/mm3; remisión parcial (RP): cuenta plaquetaria entre 50.000 y 100.000/mm3 y los no respondedores (NR); así como el tiempo que se mantiene el paciente sin recaída.

Resultados

Se aplicaron 16 tratamientos en 13 pacientes, en una paciente 3 y en otra 2 ciclos. Fueron 12 mujeres y 1 hombre con edad media de 28±9 años y tiempo medio de duración del LES de 68±44 meses, con una cuenta media plaquetaria de 38.000±29.000. En 14 tratamientos (87%) se logró RC después de 5±2 semanas y 2 pacientes (12.5%) fueron NR. Una de ellas murió por hemorragia masiva. El tiempo medio de respuesta sin recaída fue de 15,6±6 meses. Tres pacientes perdieron el seguimiento y 3 murieron de infecciones.

Conclusiones

El rituximab es una alternativa de tratamiento en pacientes con T secundaria a LES.

Palabras clave:
Rituximab
Anti CD20
Lupus eritematoso sistémico
Trombocitopenia
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Copyright © 2010. Sociedad Española de Reumatología and Colegio Mexicano de Reumatología
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