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                        "link" => array:1 [
                          0 => array:2 [
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                        "paginaFinal" => "440"
                        "link" => array:1 [
                          0 => array:2 [
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17560310"
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                        "paginaFinal" => "674"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4592903"
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                        "tituloSerie" => "Arch Pathol Lab Med"
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              "etiqueta" => "9&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunodeficiency and the pathogenesis of lymphoma and leukemia"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Louie"
                            1 => "R&#46;S&#46; Schwartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Semin Hematol"
                        "fecha" => "1978"
                        "volumen" => "15"
                        "paginaInicial" => "117"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/349695"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between sarcoidosis and lymphoma revisited"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Karakantza"
                            1 => "E&#46; Matutes"
                            2 => "K&#46; McLennan"
                            3 => "N&#46;T&#46;J&#46; O&#8217;Connor"
                            4 => "P&#46;C&#46; Srivastava"
                            5 => "D&#46; Catovsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Pathol"
                        "fecha" => "1996"
                        "volumen" => "49"
                        "paginaInicial" => "208"
                        "paginaFinal" => "212"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8675730"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The &#8220;sarcoidosis-lymphoma syndrome&#8221; &#8212;A lymphocyte dysregulation&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;S&#46; Linnenberg"
                            1 => "T&#46;C&#46; Medici"
                            2 => "K&#46; Rhyner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pneumologie"
                        "fecha" => "1992"
                        "volumen" => "46"
                        "paginaInicial" => "229"
                        "paginaFinal" => "235"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1495911"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Non-Hodgkin&#39;s lymphoma associated with hypercalcemia and increased activity of serum angiotensin-converting enzyme"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;A&#46; De Remee"
                            1 => "P&#46;M&#46; Banks"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "1986"
                        "volumen" => "61"
                        "paginaInicial" => "714"
                        "paginaFinal" => "718"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3018390"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Two cases of sarcoidosis-lymphoma syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; Suvajdzic"
                            1 => "B&#46; Milenkovic"
                            2 => "M&#46; Perunicic"
                            3 => "J&#46; Stojsic"
                            4 => "S&#46; Jankovic"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Oncol"
                        "fecha" => "2007"
                        "volumen" => "24"
                        "paginaInicial" => "469"
                        "paginaFinal" => "471"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17917102"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Dermatosis eosinof&#237;lica asociada a leucemia linf&#225;tica cr&#243;nica&#58; estudio cl&#237;nico&#44; microsc&#243;pico e inmunoshistoqu&#237;mico de 5 casos"
                      "autores" => array:1 [
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                            1 => "I&#46; Bielsa"
                            2 => "J&#46;L&#46; Mate"
                            3 => "M&#46;T&#46; Fern&#225;ndez-Figueras"
                            4 => "M&#46; Ribera"
                            5 => "C&#46; Ferr&#225;ndiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                      ]
                    ]
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Vol. 5. Núm. 1.
Páginas 31-33 (febrero - febrero 2009)
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Vol. 5. Núm. 1.
Páginas 31-33 (febrero - febrero 2009)
Caso clínico
Acceso a texto completo
Síndrome sarcoidosis-linfoma
Sarcoidosis-lymphoma syndrome
Visitas
17427
Elisabet García Casaresa,
Autor para correspondencia
37710egc@comb.es

Autor para correspondencia.
, Lourdes Mateo Soriaa, Emma García Melchora, Sonia Mínguez Blascoa, Ferran Vall-Llobera Calmetb, Gerónima Cañellas Olivera, Susana Holgado Péreza
a Sección de Reumatología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España
b Servicio de Hematología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España
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Resumen

La combinación de sarcoidosis y linfoma (síndrome sarcoidosis-linfoma) es poco frecuente pero bien conocida. Algunas manifestaciones pueden ser comunes y es un reto para el clínico establecer el diagnóstico diferencial entre ambas entidades o de su verdadera coexistencia. En estos casos ni la presentación clínica ni los parámetros de laboratorio son específicos, por lo que es esencial el estudio anatomopatológico de una adenopatía para llegar al diagnóstico definitivo. El síndrome sarcoidosis-linfoma podría aparecer como consecuencia de algunas alteraciones inmunitarias que acontecen en la sarcoidosis y en algunos pacientes con una neoplasia sólida o hemática que reciben quimioterapia. Se presenta un caso de síndrome sarcoidosis-linfoma y se analizan los aspectos clave en el diagnóstico de esta forma clínica.

Palabras clave:
Adenopatía
Granuloma
Sarcoidosis
Abstract

Sarcoidosis may occur in association with lymphoma (sarcoidosis-lymphoma syndrome), it is an uncommon but well-known association. Some clinical features can be similar and clinicians have the challenge to differentiate between these two diseases or prove their co-existence. Clinical and laboratory data are not characteristic in any of them, and an anatomopathological study of lymphadenopathy is necessary to establish the diagnosis. The sarcoidosis-lymphoma syndrome could occur as a result of a disturbance in the host immune system in sarcoidosis and in some patients with solid tumors or hematologic malignancies who have received chemotherapy. We present a case report of a patient with sarcoidosis-lymphoma syndrome.

Keywords:
Granuloma
Sarcoidosis
Lymphoma
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Bibliografía
[1.]
H. Brincker.
The sarcoidosis-lymphoma síndrome.
Br J Cancer, 54 (1986), pp. 467-473
[2.]
S. Simsek, F. Van Leuven, W. Bronsveld, G.H. Ooms, A.B.J. Groeneveld, C.S. Graaff.
Unusual association of Hodgkin's disease and sarcoidosis.
Neth J Med, 60 (2002), pp. 438-440
[3.]
P.R. Cohen, R. Krzrock.
Sarcoidosis and malignancy.
Clin Dermatol, 25 (2007), pp. 326-333
[4.]
M. Kornacher, A. Kraemer, E. Leo, A.D. Ho.
Ocurrence of sarcoidosis subsequent to chemotherapy for non-Hodgkin's lymphoma: report of two cases.
Ann Hematol, 81 (2002), pp. 103-105
[5.]
H. Kim, R.F. Dorfman.
Morphological studies of 84 untreated patients subjected to laparotomy for the staging of non-Hodgkin's lymphomas.
Cancer, 33 (1974), pp. 657-674
[6.]
C.H. Dunphy, M.J. Panella, L.E. Grosso.
Low-grade B-cell lymphoma and concomitant extensive sarcoidlike granulomas.
Arch Pathol Lab Med, 124 (2000), pp. 152-156
[7.]
J.M. Reich, J.P. Mullooly, R.E. Johnson.
Linkage analysis of malignancy-associated sarcoidosis.
Chest, 105 (1995), pp. 605-613
[8.]
R.P. Daniele, J.H. Dauber, M.D. Rossman.
Immunologic abnormalities in sarcoidosis.
Ann Int Med, 92 (1980), pp. 406
[9.]
S. Louie, R.S. Schwartz.
Immunodeficiency and the pathogenesis of lymphoma and leukemia.
Semin Hematol, 15 (1978), pp. 117
[10.]
M. Karakantza, E. Matutes, K. McLennan, N.T.J. O’Connor, P.C. Srivastava, D. Catovsky.
Association between sarcoidosis and lymphoma revisited.
J Clin Pathol, 49 (1996), pp. 208-212
[11.]
H.S. Linnenberg, T.C. Medici, K. Rhyner.
The “sarcoidosis-lymphoma syndrome” —A lymphocyte dysregulation?.
Pneumologie, 46 (1992), pp. 229-235
[12.]
R.A. De Remee, P.M. Banks.
Non-Hodgkin's lymphoma associated with hypercalcemia and increased activity of serum angiotensin-converting enzyme.
Mayo Clin Proc, 61 (1986), pp. 714-718
[13.]
N. Suvajdzic, B. Milenkovic, M. Perunicic, J. Stojsic, S. Jankovic.
Two cases of sarcoidosis-lymphoma syndrome.
Med Oncol, 24 (2007), pp. 469-471
[14.]
C. Mangas, I. Bielsa, J.L. Mate, M.T. Fernández-Figueras, M. Ribera, C. Ferrándiz.
Dermatosis eosinofílica asociada a leucemia linfática crónica: estudio clínico, microscópico e inmunoshistoquímico de 5 casos.
Actas Dermosifiliogr, 95 (2004), pp. 165-170
Copyright © 2009. Elsevier España S.L. Barcelona
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