array:23 [
  "pii" => "S2173574313000336"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2012.09.003"
  "estado" => "S300"
  "fechaPublicacion" => "2013-05-01"
  "aid" => "522"
  "copyright" => "Elsevier España, S.L.. All rights reserved"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2013;9:198"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2917
    "formatos" => array:3 [
      "EPUB" => 55
      "HTML" => 2245
      "PDF" => 617
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X13000089"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2012.09.010"
      "estado" => "S300"
      "fechaPublicacion" => "2013-05-01"
      "aid" => "522"
      "copyright" => "Elsevier España, S.L."
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Reumatol Clin. 2013;9:198"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 6920
        "formatos" => array:3 [
          "EPUB" => 140
          "HTML" => 5471
          "PDF" => 1309
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "S&#237;ndrome de Brown adquirido en una paciente con artritis psori&#225;sica"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:1 [
            "paginaInicial" => "198"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Acquired Brown&#39;s syndrome in a patient with psoriatic arthritis"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Walter Alberto Sifuentes Giraldo, Jos&#233; Luis Morell Hita, Javier Bachiller Corral, Elia Brito Brito"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Walter Alberto"
                "apellidos" => "Sifuentes Giraldo"
              ]
              1 => array:2 [
                "nombre" => "Jos&#233; Luis"
                "apellidos" => "Morell Hita"
              ]
              2 => array:2 [
                "nombre" => "Javier"
                "apellidos" => "Bachiller Corral"
              ]
              3 => array:2 [
                "nombre" => "Elia"
                "apellidos" => "Brito Brito"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574313000336"
          "doi" => "10.1016/j.reumae.2012.09.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574313000336?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X13000089?idApp=UINPBA00004M"
      "url" => "/1699258X/0000000900000003/v1_201305061538/S1699258X13000089/v1_201305061538/es/main.assets"
    ]
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574313000506"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2013.04.003"
    "estado" => "S300"
    "fechaPublicacion" => "2013-05-01"
    "aid" => "525"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2013;9:197"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 4216
      "formatos" => array:3 [
        "EPUB" => 66
        "HTML" => 3545
        "PDF" => 605
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Mesenteric Panniculitis in a Patient With Ankylosing Spondylitis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "197"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Paniculitis mesent&#233;rica en un paciente con espondilitis anquilosante"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 835
              "Ancho" => 900
              "Tamanyo" => 113176
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">CT scan of the abdomen and pelvis&#58; marked thickening of mesenteric fat and displacement of the small intestine&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Patricia Tej&#243;n Men&#233;ndez, Sara Alonso, Mercedes Alperi, Javier Ballina"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Patricia"
              "apellidos" => "Tej&#243;n Men&#233;ndez"
            ]
            1 => array:2 [
              "nombre" => "Sara"
              "apellidos" => "Alonso"
            ]
            2 => array:2 [
              "nombre" => "Mercedes"
              "apellidos" => "Alperi"
            ]
            3 => array:2 [
              "nombre" => "Javier"
              "apellidos" => "Ballina"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X13000119"
        "doi" => "10.1016/j.reuma.2012.10.014"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X13000119?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574313000506?idApp=UINPBA00004M"
    "url" => "/21735743/0000000900000003/v1_201307311407/S2173574313000506/v1_201307311407/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Acquired Brown&#39;s Syndrome in a Patient With Psoriatic Arthritis"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">Dear Editor</span>&#44;"
    "paginas" => array:1 [
      0 => array:1 [
        "paginaInicial" => "198"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Walter Alberto Sifuentes Giraldo, Jos&#233; Luis Morell Hita, Javier Bachiller Corral, Elia Brito Brito"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Walter Alberto"
            "apellidos" => "Sifuentes Giraldo"
            "email" => array:1 [
              0 => "albertosifuentesg&#64;gmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Jos&#233; Luis"
            "apellidos" => "Morell Hita"
          ]
          2 => array:2 [
            "nombre" => "Javier"
            "apellidos" => "Bachiller Corral"
          ]
          3 => array:2 [
            "nombre" => "Elia"
            "apellidos" => "Brito Brito"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Reumatolog&#237;a&#44; Hospital Universitario Ram&#243;n y Cajal&#44; Madrid&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "S&#237;ndrome de Brown adquirido en una paciente con artritis psori&#225;sica"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Brown&#39;s syndrome &#40;SB&#41; is an ocular motility disorder characterized by the inability to fully elevate the affected eye in complete adduction&#46; It can be congenital or acquired&#44; the latter being caused by a mechanical restriction of the movement of the superior oblique muscle tendon as it passes through the trochlea&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It has been described as a rare ocular complication in various rheumatic diseases&#44; including rheumatoid arthritis&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> JIA&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> adult Still&#39;s disease&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> lupus erythematosus&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Sj&#246;gren&#39;s syndrome&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> poststreptococcal reactive arthritis<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and arthritis associated with Crohn&#39;s disease&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Patients with psoriasis and psoriatic arthritis &#40;PsA&#41; frequently develop inflammatory processes&#44; including conjunctivitis&#44; uveitis and keratoconjunctivitis sicca&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> but so far there is only one described case of associated PsA and BS&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A 24-year-old woman&#44; with personal and family history of psoriasis&#44; was diagnosed in November 2006 with PsA based on asymmetric oligoarthritis&#44; dactylitis&#44; and thoracic and lumbar inflammatory pain presenting a year later&#46; She had elevated acute phase reactants &#40;C reactive protein 21<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#44; erythrocyte sedimentation rate 35<span class="elsevierStyleHsp" style=""></span>mm&#47;h&#41;&#44; but rheumatoid factor&#44; anti-CCP antibodies and antinuclear antibodies were negative&#46; The HLA-B27 I and Cw&#42;06 were negative&#46; Lumbosacral spine X-rays showed no signs of sacroiliitis and spinal involvement&#44; and changes in the hands and feet were not significant&#46; She was treated with indomethacin 150<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; methotrexate 15<span class="elsevierStyleHsp" style=""></span>mg&#47;week&#44; sulfasalazine 2<span class="elsevierStyleHsp" style=""></span>g&#47;day and prednisone 5<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; yet maintained a significant inflammatory activity&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In November 2007 she came to the emergency room presenting diplopia and pain triggered by right eye movement&#46; There was limitation in raising her right eye in adduction&#44; with elevation preserved in abduction and diplopia on upper left version&#46; The motility of the left eye was normal&#46; The fundus examination and magnetic resonance imaging &#40;MRI&#41; showed no orbital abnormalities&#46; She was diagnosed with acquired BS and treatment intensified &#40;prednisone 10<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; methotrexate 20<span class="elsevierStyleHsp" style=""></span>mg&#47;week&#41;&#44; with no improvement&#46; In January 2008 there was an infiltration in the right superior oblique trochlea&#44; with complete recovery within 2 weeks&#46; Because of persistent activity of arthritis she later began treatment with adalimumab&#44; achieving clinical remission within a few months&#46; There has been no recurrence of BS during a follow up period of 55 months&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">It has been suggested that the pathophysiology of rheumatic diseases associated to BS is a superior oblique impingement secondary to stenosing tenosynovitis&#44; similar to trigger finger&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> Its appearance usually coincides with periods of high activity of the underlying disease&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;7&#44;8</span></a> but has also been described in patients undergoing remission&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;10</span></a> The diagnosis is mainly clinical and imaging tests such as MRI may show inflammation of the superior oblique tendon or trochlea&#46; However&#44; this finding is not always present&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The differential diagnosis includes isolated paralysis of the iv pair&#44; traumatic injury&#44; sinusitis and trochlear metastasis&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;8</span></a> The course of acquired BS is usually self-limiting&#44; but in persistent cases the efficacy of corticosteroid treatment&#44; both systemic and local&#44; has been demonstrated&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In conclusion&#44; although BS is a rare disorder&#44; it should be considered in patients with rheumatic diseases who develop diplopia or ocular dismotility&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Sifuentes Giraldo WA&#44; et al&#46; S&#237;ndrome de Brown adquirido en una paciente con artritis psori&#225;sica&#46; Reumatol Clin&#46; 2013&#46; <span class="elsevierStyleInterRef" id="intr0005" href="doi:10.1016/j.reuma.2012.09.010">http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;reuma&#46;2012&#46;09&#46;010</span>&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "True and simulated superior oblique tendon sheath syndromes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46;W&#46; Brown"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Doc Ophthalmol"
                        "fecha" => "1973"
                        "volumen" => "34"
                        "paginaInicial" => "123"
                        "paginaFinal" => "136"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4706084"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Brown&#39;s syndrome&#58; an unusual ocular complication of rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Cooper"
                            1 => "J&#46;R&#46; Kirwan"
                            2 => "N&#46;W&#46; McGill"
                            3 => "P&#46;A&#46; Dieppe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "1990"
                        "volumen" => "49"
                        "paginaInicial" => "188"
                        "paginaFinal" => "189"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2091616"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0300289609734945"
                          "estado" => "S300"
                          "issn" => "03002896"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Juvenile idiopathic arthritis-associated uveitis complicated by glaucoma and Brown&#39;s syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46; Tejada"
                            1 => "E&#46; Enriquez"
                            2 => "J&#46; Maria Rodriguez Del Valle"
                            3 => "A&#46; Barcelo"
                            4 => "E&#46; Gutierrez"
                            5 => "J&#46; de Inocencio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2012"
                        "volumen" => "51"
                        "paginaInicial" => "1729"
                        "paginaFinal" => "1730"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Superior oblique tenosynovitis &#40;Brown&#39;s syndrome&#41; as a manifestation of adult Still&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;D&#46; Kaufman"
                            1 => "P&#46;A&#46; Sibony"
                            2 => "A&#46;K&#46; Anand"
                            3 => "B&#46;L&#46; Gruber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1987"
                        "volumen" => "14"
                        "paginaInicial" => "625"
                        "paginaFinal" => "627"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3625648"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0300289608704265"
                          "estado" => "S300"
                          "issn" => "03002896"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acquired Brown&#39;s syndrome in a patient with systemic lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;L&#46; Alonso-Valdivielso"
                            1 => "B&#46; Alvarez Lario"
                            2 => "J&#46; Alegre Lopez"
                            3 => "M&#46;J&#46; Sedano Tous"
                            4 => "A&#46; Buitrago Gomez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "1993"
                        "volumen" => "52"
                        "paginaInicial" => "63"
                        "paginaFinal" => "64"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8427518"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acquired Brown&#39;s syndrome and primary Sjogren&#39;s syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;K&#46; Brahma"
                            1 => "E&#46; Hay"
                            2 => "D&#46;A&#46; Sturgess"
                            3 => "L&#46;H&#46; Morgan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Ophthalmol"
                        "fecha" => "1995"
                        "volumen" => "79"
                        "paginaInicial" => "89"
                        "paginaFinal" => "90"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7880800"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674908014942"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acquired Brown&#39;s syndrome in a child with poststreptococcal reactive arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;O&#46; Faust"
                            1 => "J&#46;M&#46; Gillenwater"
                            2 => "F&#46;T&#46; Saulsbury"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2001"
                        "volumen" => "28"
                        "paginaInicial" => "2748"
                        "paginaFinal" => "2749"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11764228"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acquired Brown syndrome associated with enteropathic arthropathy&#58; a case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46;J&#46; Bradshaw"
                            1 => "V&#46;J&#46; Bray"
                            2 => "R&#46;W&#46; Enzenauer"
                            3 => "R&#46;J&#46; Enzenauer"
                            4 => "C&#46;L&#46; Truwit"
                            5 => "T&#46;R&#46; Damiano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Ophthalmol Strabismus"
                        "fecha" => "1994"
                        "volumen" => "31"
                        "paginaInicial" => "118"
                        "paginaFinal" => "119"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7912268"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of eye disease in Brazilian patients with psoriatic arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;B&#46; De Lima"
                            1 => "M&#46;F&#46; Abalem"
                            2 => "D&#46;G&#46; Ruiz"
                            3 => "B&#46;de&#46; A&#46; F&#46; Gomes"
                            4 => "M&#46;N&#46; de Azevedo"
                            5 => "H&#46;V&#46; Moraes Jr&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clinics &#40;Sao Paulo&#41;"
                        "fecha" => "2012"
                        "volumen" => "67"
                        "paginaInicial" => "249"
                        "paginaFinal" => "253"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Magnetic resonance imaging of acquired Brown syndrome in a patient with psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;E&#46; Thorne"
                            1 => "N&#46;J&#46; Volpe"
                            2 => "G&#46;T&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Ophthalmol"
                        "fecha" => "1999"
                        "volumen" => "127"
                        "paginaInicial" => "233"
                        "paginaFinal" => "235"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10030581"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000000900000003/v1_201307311407/S2173574313000336/v1_201307311407/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8400"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000900000003/v1_201307311407/S2173574313000336/v1_201307311407/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574313000336?idApp=UINPBA00004M"
]
Share
Journal Information
Vol. 9. Issue 3.
Pages 198 (May - June 2013)
Vol. 9. Issue 3.
Pages 198 (May - June 2013)
Letter to the Editor
Full text access
Acquired Brown's Syndrome in a Patient With Psoriatic Arthritis
Síndrome de Brown adquirido en una paciente con artritis psoriásica
Visits
6983
Walter Alberto Sifuentes Giraldo
Corresponding author
albertosifuentesg@gmail.com

Corresponding author.
, José Luis Morell Hita, Javier Bachiller Corral, Elia Brito Brito
Servicio de Reumatología, Hospital Universitario Ramón y Cajal, Madrid, Spain
This item has received
Article information
Full Text
Bibliography
Download PDF
Statistics
Full Text
Dear Editor,

Brown's syndrome (SB) is an ocular motility disorder characterized by the inability to fully elevate the affected eye in complete adduction. It can be congenital or acquired, the latter being caused by a mechanical restriction of the movement of the superior oblique muscle tendon as it passes through the trochlea.1 It has been described as a rare ocular complication in various rheumatic diseases, including rheumatoid arthritis,2 JIA,3 adult Still's disease,4 lupus erythematosus,5 Sjögren's syndrome,6 poststreptococcal reactive arthritis7 and arthritis associated with Crohn's disease.8 Patients with psoriasis and psoriatic arthritis (PsA) frequently develop inflammatory processes, including conjunctivitis, uveitis and keratoconjunctivitis sicca,9 but so far there is only one described case of associated PsA and BS.10

A 24-year-old woman, with personal and family history of psoriasis, was diagnosed in November 2006 with PsA based on asymmetric oligoarthritis, dactylitis, and thoracic and lumbar inflammatory pain presenting a year later. She had elevated acute phase reactants (C reactive protein 21mg/l, erythrocyte sedimentation rate 35mm/h), but rheumatoid factor, anti-CCP antibodies and antinuclear antibodies were negative. The HLA-B27 I and Cw*06 were negative. Lumbosacral spine X-rays showed no signs of sacroiliitis and spinal involvement, and changes in the hands and feet were not significant. She was treated with indomethacin 150mg/day, methotrexate 15mg/week, sulfasalazine 2g/day and prednisone 5mg/day, yet maintained a significant inflammatory activity.

In November 2007 she came to the emergency room presenting diplopia and pain triggered by right eye movement. There was limitation in raising her right eye in adduction, with elevation preserved in abduction and diplopia on upper left version. The motility of the left eye was normal. The fundus examination and magnetic resonance imaging (MRI) showed no orbital abnormalities. She was diagnosed with acquired BS and treatment intensified (prednisone 10mg/day, methotrexate 20mg/week), with no improvement. In January 2008 there was an infiltration in the right superior oblique trochlea, with complete recovery within 2 weeks. Because of persistent activity of arthritis she later began treatment with adalimumab, achieving clinical remission within a few months. There has been no recurrence of BS during a follow up period of 55 months.

It has been suggested that the pathophysiology of rheumatic diseases associated to BS is a superior oblique impingement secondary to stenosing tenosynovitis, similar to trigger finger.6,7 Its appearance usually coincides with periods of high activity of the underlying disease,2,7,8 but has also been described in patients undergoing remission.5,10 The diagnosis is mainly clinical and imaging tests such as MRI may show inflammation of the superior oblique tendon or trochlea. However, this finding is not always present.6 The differential diagnosis includes isolated paralysis of the iv pair, traumatic injury, sinusitis and trochlear metastasis.6,8 The course of acquired BS is usually self-limiting, but in persistent cases the efficacy of corticosteroid treatment, both systemic and local, has been demonstrated.6 In conclusion, although BS is a rare disorder, it should be considered in patients with rheumatic diseases who develop diplopia or ocular dismotility.

References
[1]
H.W. Brown.
True and simulated superior oblique tendon sheath syndromes.
Doc Ophthalmol, 34 (1973), pp. 123-136
[2]
C. Cooper, J.R. Kirwan, N.W. McGill, P.A. Dieppe.
Brown's syndrome: an unusual ocular complication of rheumatoid arthritis.
Ann Rheum Dis, 49 (1990), pp. 188-189
[3]
P. Tejada, E. Enriquez, J. Maria Rodriguez Del Valle, A. Barcelo, E. Gutierrez, J. de Inocencio.
Juvenile idiopathic arthritis-associated uveitis complicated by glaucoma and Brown's syndrome.
Rheumatology (Oxford), 51 (2012), pp. 1729-1730
[4]
L.D. Kaufman, P.A. Sibony, A.K. Anand, B.L. Gruber.
Superior oblique tenosynovitis (Brown's syndrome) as a manifestation of adult Still's disease.
J Rheumatol, 14 (1987), pp. 625-627
[5]
J.L. Alonso-Valdivielso, B. Alvarez Lario, J. Alegre Lopez, M.J. Sedano Tous, A. Buitrago Gomez.
Acquired Brown's syndrome in a patient with systemic lupus erythematosus.
Ann Rheum Dis, 52 (1993), pp. 63-64
[6]
A.K. Brahma, E. Hay, D.A. Sturgess, L.H. Morgan.
Acquired Brown's syndrome and primary Sjogren's syndrome.
Br J Ophthalmol, 79 (1995), pp. 89-90
[7]
A.O. Faust, J.M. Gillenwater, F.T. Saulsbury.
Acquired Brown's syndrome in a child with poststreptococcal reactive arthritis.
J Rheumatol, 28 (2001), pp. 2748-2749
[8]
D.J. Bradshaw, V.J. Bray, R.W. Enzenauer, R.J. Enzenauer, C.L. Truwit, T.R. Damiano.
Acquired Brown syndrome associated with enteropathic arthropathy: a case report.
J Pediatr Ophthalmol Strabismus, 31 (1994), pp. 118-119
[9]
F.B. De Lima, M.F. Abalem, D.G. Ruiz, B.de. A. F. Gomes, M.N. de Azevedo, H.V. Moraes Jr., et al.
Prevalence of eye disease in Brazilian patients with psoriatic arthritis.
Clinics (Sao Paulo), 67 (2012), pp. 249-253
[10]
J.E. Thorne, N.J. Volpe, G.T. Liu.
Magnetic resonance imaging of acquired Brown syndrome in a patient with psoriasis.
Am J Ophthalmol, 127 (1999), pp. 233-235

Please cite this article as: Sifuentes Giraldo WA, et al. Síndrome de Brown adquirido en una paciente con artritis psoriásica. Reumatol Clin. 2013. http://dx.doi.org/10.1016/j.reuma.2012.09.010.

Copyright © 2012. Elsevier España, S.L.. All rights reserved
Download PDF
Idiomas
Reumatología Clínica (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?