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Vol. 17. Issue 9.
Pages 521-524 (November 2021)
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Vol. 17. Issue 9.
Pages 521-524 (November 2021)
Brief Report
Anti-phosphatidylserine/prothrombin antibodies in patients with polyarteritis nodosa
Anticuerpos antifosfatidilserina/protrombina en pacientes con poliarteritis nodosa
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Susy Marcela Sánchez-Cubíasa,1, Eduardo Martín-Naresa,1, Gabriela Hernández-Molinaa, Carlos A. Nuñez-Alvareza, Manuel Antonio Sedano-Montoyaa, Angel Gabriel Vargas-Ruizb, Andrea Hinojosa-Azaolaa,
Corresponding author
andreaha@yahoo.com

Corresponding author.
a Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
b Departamento de Hematología y Oncología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
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Table 1. Comparative analysis of patients with PAN and control group with other forms of vasculitis.
Abstract
Introduction

Anti-phospatidylserine/prothrombin (aPS/PT) antibodies have been described in cutaneous Polyarteritis Nodosa (PAN) in association with specific manifestations.

Objectives

To determine aPS/PT antibodies in patients with PAN and its correlation with clinical manifestations.

Methods

Cross-sectional comparative study including PAN patients and 20 controls (10 Microscopic Polyangiitis [MPA] and 10 Behçet’s disease [BD]). Clinical and demographic variables, treatment, serologic markers, prognosis, activity and damage indexes were evaluated. aPS/PT, anti-cardiolipin (aCL), anti-beta 2 glycoprotein 1 (anti-B2GP1) antibodies, and lupus anticoagulant (LA) were determined.

Results

Fourteen patients with PAN were included, 11 (79%) women, with disease duration of 207 months, and mostly inactive disease. Only one patient with PAN and one with BD were positive for aPS/PT IgG. LA was the most frequent antibody identified. One patient with MPA and one with BD were positive for aCL IgM; one with MPA for anti-B2GP1 IgG, and one with PAN for anti-B2GP1 IgM.

Conclusions

aPS/PT antibodies are not frequent in patients with longstanding inactive PAN.

Keywords:
Anti-phospatidylserine/prothrombin
Anti-phospholipid antibodies
Polyarteritis nodosa
Vasculitis
Resumen
Antecedentes

Anticuerpos anti-fosfatidilserina/protrombina (aPS/PT) han sido descritos en Poliarteritis Nodosa (PAN) cutánea, en asociación con manifestaciones específicas.

Objetivos

Determinar anticuerpos aPS/PT en pacientes con PAN y analizar correlación con manifestaciones clínicas.

Métodos

Estudio transversal comparativo de pacientes con PAN y 20 controles (10 con Poliangeítis Microscópica [PAM] y 10 con Enfermedad de Behçet [EB]). Se evaluaron variables demográficas, clínicas, serológicas y tratamiento; índices de pronóstico, actividad y daño. Se determinaron anticuerpos aPS/PT, anti-cardiolipina (aCL), anti-beta 2 glicoproteína 1 (anti-B2GP1) y anticoagulante lúpico (AL).

Resultados

Catorce pacientes con PAN fueron incluidos, 11 (79%) mujeres, con duración de la enfermedad de 207 meses, y principalmente enfermedad inactiva. Sólo un paciente con PAN y uno con EB fueron positivos para aPS/PT IgG. El anticuerpo antifosfolípido más frecuente fue AL. Un paciente con PAM y uno con EB fueron positivos para aCL IgM; uno con PAM para anti-B2GP1 IgG, uno con PAN para anti-B2GP1 IgM.

Conclusiones

Los anticuerpos aPS/PT son infrecuentes en pacientes con PAN inactiva de larga evolución.

Palabras clave:
Anti-fosfatidilserina/protrombina
Anticuerpos antifosfolípidos
Poliarteritis nodosa
Vasculitis

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