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Vol. 11. Issue 4.
Pages 232-236 (July - August 2015)
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Vol. 11. Issue 4.
Pages 232-236 (July - August 2015)
Review Article
DOI: 10.1016/j.reumae.2014.12.006
Bone Health, Vitamin D and Lupus
Salud ósea, vitamina D y lupus
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Clara Sangüesa Gómez, Bryan Josué Flores Robles, José Luis Andréu
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jlandreu@arrakis.es

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Sección de Enfermedades Autoinmunes Sistémicas, Servicio de Reumatología, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain
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Abstract

The prevalence of vitamin D deficiency and insufficiency among patients with systemic lupus erythematosus is high. This is likely due to photoprotection measures in addition to intrinsic factors of the disease. Low levels of vitamin D increase the risk of low bone mineral density and fracture. Vitamin D deficiency could also have undesirable effects on patients’ immune response, enhancing mechanisms of loss of tolerance and autoimmunity. Vitamin D levels should be periodically monitored and patients should be treated with the objective of reaching vitamin D levels higher than 30–40ng/ml.

Keywords:
Systemic lupus erythematosus
Vitamin D
Osteoporosis
Resumen

Los pacientes con lupus eritematoso sistémico presentan una prevalencia elevada de deficiencia e insuficiencia de vitamina D. Esto se debe probablemente a las medidas de fotoprotección y a factores intrínsecos de la enfermedad. Los niveles bajos de vitamina D aumentan el riesgo de presentar una densidad mineral ósea reducida y de fractura. El déficit de vitamina D podría también tener efectos no deseados sobre la respuesta inmune de los pacientes, potenciando mecanismos de pérdida de tolerancia y autoinmunidad. Los niveles de vitamina D deberían ser monitorizados periódicamente y los pacientes deberían ser tratados con el objetivo de alcanzar unos niveles de vitamina D superiores a 30–40ng/ml.

Palabras clave:
Lupus eritematoso sistémico
Vitamina D
Osteoporosis

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