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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To determine whether an association exists between the presence of rheumatoid nodules and thickening of the intima-media and plaque of the carotid artery&#44; which is evidence of atherosclerosis&#46; Materials and methods&#58; Observational&#44; cross-sectional study of 124 patients with rheumatoid arthritis from a University Hospital clinic from 2005 to 2006&#46; We divided the patients into 2 groups&#44; 62 with rheumatoid nodules and 62 without rheumatoid nodules&#44; matched for age and sex&#46; Medical history&#44; erythrocyte sedimentation rate&#44; anti-cyclic citrullinated peptide&#44; rheumatoid factor&#44; and a high resolution doppler ultrasound of the carotid arteries were performed&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Results</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Women comprised 89&#46;5&#37; of the patients&#46; The prevalence of a carotid plaque was 57&#37; in our population&#46; The presence of a plaque was associated with age&#44; arterial hypertension and abdominal circumference&#46; Average intima-media thickness &#40;IMT&#41; in patients with a plaque was 0&#46;085<span class="elsevierStyleHsp" style=""></span>cm &#40;&#177;0&#46;02&#41;&#46; There was no correlation between laboratory parameters and thickening of the intima-media of the carotid artery&#46; Subcutaneous nodules were present in 33 &#40;47&#37;&#41; of the 70 patients with a carotid plaque and in 29 &#40;54&#37;&#41; of patients without a carotid plaque &#40;p &#61; &#46;471&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Conclusions</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We did not &#64257;nd an association between rheumatoid nodules and the presence of a carotid plaque and thickening of the intima-media of the carotid in patients with rheumatoid arthritis&#46;</p>"
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        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0030">Objetivo</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Determinar si existe una asociaci&#243;n entre la presencia de n&#243;dulos reumatoides y el engrosamiento de la &#237;ntima-media y de placa de las arterias car&#243;tidas&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0035">Materiales y m&#233;todos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional&#44; transversal de 124 pacientes con artritis reumatoide del Servicio de Reumatolog&#237;a de un Hospital Universitario desde 2005 a 2006&#46; Se dividieron los pacientes en 2 grupos&#44; 62 con n&#243;dulos reumatoide y 62 sin n&#243;dulos reumatoides&#44; pareados por edad y sexo&#46; Se realiz&#243; una historia cl&#237;nica completa&#44; velocidad de sedimentaci&#243;n globular&#44; medici&#243;n de anticuerpos antip&#233;ptidos c&#237;clicos citrulinados&#44; factor reumatoide y una ecograf&#237;a doppler de alta resoluci&#243;n de las arterias car&#243;tidas&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">Resultados</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Las mujeres comprendieron el 89&#44;5&#37; de los pacientes&#46; La prevalencia de al menos una placa en las car&#243;tidas fue del 57&#37; en nuestra poblaci&#243;n&#46; La presencia de placa carot&#237;dea estuvo asociada a la edad&#44; hipertensi&#243;n arterial y circunferencia abdominal&#46; El grosor promedio de la &#237;ntima-media en pacientes con placa carot&#237;dea fue 0&#46;085<span class="elsevierStyleHsp" style=""></span>cm &#40;&#177; 0&#46;02&#41;&#46; No hubo ninguna correlaci&#243;n entre los par&#225;metros de laboratorio y el engrosamiento de &#237;ntima-media de la arteria car&#243;tida&#46; Los n&#243;dulos subcut&#225;neos estuvieron presentes en 33 &#40;47&#37;&#41; de los 70 pacientes con placas de car&#243;tida y 29 &#40;54&#37;&#41; de los pacientes sin una placa car&#243;tida &#40;p &#61; 0&#46;471&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Conclusiones</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">No hemos encontrado una asociaci&#243;n entre n&#243;dulos reumatoides y la presencia de placa y&#47;o el engrosamiento de la &#237;ntima-media de car&#243;tidas en pacientes con artritis reumatoide&#46;</p>"
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Journal Information
Vol. 9. Issue 3.
Pages 136-141 (May - June 2013)
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Vol. 9. Issue 3.
Pages 136-141 (May - June 2013)
Original article
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Carotid atherosclerosis in patients with rheumatoid arthritis and rheumatoid nodules
Aterosclerosis carotídea en pacientes con artritis reumatoide y nódulos reumatoides
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Dionicio Angel Galarza-Delgadoa,c,
Corresponding author
, Jorge Antonio Esquivel-Valerioa,c, Mario Alberto Garza-Elizondoa, Fernando Góngora-Riverab,c, Jorge Luis Muñoz-De Hoyosa, Griselda Serna-Peñac
a Rheumatology Service, Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico
b Neurology Service, Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico
c Internal Medicine Service, Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico
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Article information
Abstract
Objective

To determine whether an association exists between the presence of rheumatoid nodules and thickening of the intima-media and plaque of the carotid artery, which is evidence of atherosclerosis. Materials and methods: Observational, cross-sectional study of 124 patients with rheumatoid arthritis from a University Hospital clinic from 2005 to 2006. We divided the patients into 2 groups, 62 with rheumatoid nodules and 62 without rheumatoid nodules, matched for age and sex. Medical history, erythrocyte sedimentation rate, anti-cyclic citrullinated peptide, rheumatoid factor, and a high resolution doppler ultrasound of the carotid arteries were performed.

Results

Women comprised 89.5% of the patients. The prevalence of a carotid plaque was 57% in our population. The presence of a plaque was associated with age, arterial hypertension and abdominal circumference. Average intima-media thickness (IMT) in patients with a plaque was 0.085cm (±0.02). There was no correlation between laboratory parameters and thickening of the intima-media of the carotid artery. Subcutaneous nodules were present in 33 (47%) of the 70 patients with a carotid plaque and in 29 (54%) of patients without a carotid plaque (p = .471).

Conclusions

We did not find an association between rheumatoid nodules and the presence of a carotid plaque and thickening of the intima-media of the carotid in patients with rheumatoid arthritis.

Keywords:
Atherosclerosis
Rheumatoid arthritis
Carotid plaque
Intima media thickness
Cardiovascular disease
Resumen
Objetivo

Determinar si existe una asociación entre la presencia de nódulos reumatoides y el engrosamiento de la íntima-media y de placa de las arterias carótidas.

Materiales y métodos

Estudio observacional, transversal de 124 pacientes con artritis reumatoide del Servicio de Reumatología de un Hospital Universitario desde 2005 a 2006. Se dividieron los pacientes en 2 grupos, 62 con nódulos reumatoide y 62 sin nódulos reumatoides, pareados por edad y sexo. Se realizó una historia clínica completa, velocidad de sedimentación globular, medición de anticuerpos antipéptidos cíclicos citrulinados, factor reumatoide y una ecografía doppler de alta resolución de las arterias carótidas.

Resultados

Las mujeres comprendieron el 89,5% de los pacientes. La prevalencia de al menos una placa en las carótidas fue del 57% en nuestra población. La presencia de placa carotídea estuvo asociada a la edad, hipertensión arterial y circunferencia abdominal. El grosor promedio de la íntima-media en pacientes con placa carotídea fue 0.085cm (± 0.02). No hubo ninguna correlación entre los parámetros de laboratorio y el engrosamiento de íntima-media de la arteria carótida. Los nódulos subcutáneos estuvieron presentes en 33 (47%) de los 70 pacientes con placas de carótida y 29 (54%) de los pacientes sin una placa carótida (p = 0.471).

Conclusiones

No hemos encontrado una asociación entre nódulos reumatoides y la presencia de placa y/o el engrosamiento de la íntima-media de carótidas en pacientes con artritis reumatoide.

Palabras clave:
Aterosclerosis Artritis reumatoide Placa carotídea Espesor íntima media Enfermedad cardiovascular
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