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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Patients with juvenile idiopathic arthritis &#40;JIA&#41; are at increased risk for developing inflammatory bowel disease &#40;IBD&#41;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#44; although their association with systemic-onset JIAs is exceptional<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a>&#44; Mutations in genes causing immune deficiency due to immune dysregulation&#44; common to both entities<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#44; or the role of anti-IL1 treatments are hypothesised<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a>&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical case report</span><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of an 8-year old girl with fever of one month&#8217;s duration&#44; anorexia&#44; sweating&#44; and weight loss&#46; Physical examination revealed no abnormalities&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Laboratory tests revealed leukocytosis &#40;25&#44;000&#47;mm<span class="elsevierStyleSup">3</span>&#41; with a shift to the left&#44; thrombocytosis &#40;528&#44;000&#47;mm<span class="elsevierStyleSup">3</span>&#41;&#44; CRP 163&#8239;mg&#47;l&#44; ESR 92&#8239;mm&#44; ferritin 737&#8239;ng&#47;mL&#44; and hypergammaglobulinaemia &#40;IgG 2&#44;650&#8239;mg&#47;dl&#41;&#46; The rest of the biochemical study failed to exhibit any further alterations&#46; The infectious screening&#44; which included tuberculosis&#44; was negative&#46; ANA and rheumatoid factor were similarly negative&#46; Faecal calprotectin &#40;FC&#41; was 58&#8239;ng&#47;g&#46; Chest X-ray&#44; abdominal ultrasound&#44; thoracoabdominal CT&#44; echocardiography&#44; MRI&#44; and bone scan displayed no pathological findings&#46; The fundus examination was normal and the bone marrow biopsy exhibited no abnormalities&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">After one week she developed right axillary adenopathy&#44; hypoechoic on ultrasound&#44; and with pathological uptake on the PET-CT scan&#46; After surgical excision&#44; the anatomopathological and microbiological study showed no alterations&#46; Subsequently&#44; he developed swelling and limitation of the left knee&#44; with joint effusion with no synovial hypertrophy&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">With a diagnosis of JIA &#40;ILAR 2001 criteria&#41;&#44; oral prednisone &#40;1&#46;5&#8239;mg&#47; kg&#47; day&#41; was started&#44; to which subcutaneous anakinra &#40;2&#8239;mg&#47; kg&#47; day&#41; had to added after 3 weeks&#44; due to relapse after decreasing the corticosteroids&#46; One month later&#44; it was substituted for subcutaneous canakinumab &#40;4&#8239;mg&#47; kg&#47; 4weeks&#41;&#44; making it possible to administer doses every 6 weeks&#44; without incident&#44; and she remained asymptomatic for 3 years&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">After this&#44; the patient once again began to have fever&#44; arthralgias&#44; and an increase in CRP&#46; Given her incomplete clinical and analytical response to oral prednisone &#40;1&#8239;mg&#47; kg&#47; day&#41;&#44; intravenous tocilizumab &#40;8&#8239;mg&#47; kg&#47; 2 weeks&#41; was initiated&#44; with partial improvement&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">One month later she was readmitted for abdominal pain and haematochezia&#46; Laboratory tests yielded haemoglobin values of 7&#46;6&#8239;g&#47; dl and CF 3132 ug&#47; g&#46; After ultrasound evidence of ileocolitis&#44; upper and lower gastrointestinal endoscopy was performed and a diagnosis of Crohn&#8217;s disease &#40;CD&#41; was established according to the Oporto criteria<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and the Paris classification<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46; The genetic panel for autoinflammatory diseases resulted in a probably benign mutation &#40;pR702W&#41; and a mutation of uncertain significance &#40;p1007finsC&#41;&#44; both in heterozygosis&#44; of the NOD2 gene&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Tocilizumab was discontinued&#44; and subcutaneous adalimumab &#40;160-80-40&#8239;mg&#47; 2 weeks&#41; and oral prednisone &#40;1&#46;5&#8239;mg&#47; kg&#47; day&#41; were started&#44; requiring combo therapy with azathioprine&#46; She is currently asymptomatic on adalimumab monotherapy&#44; with CF&#8239;&#60;&#8239;15&#46;6 ug&#47; g&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">IBD very rarely develops as an extra-articular manifestation of JIA<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a>&#46; Although some authors propose that pharmacological blockade of IL-1 would favour the phenotypic change of JIA to IBD<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a>&#44; this evolution has also been detected in individuals with other treatments &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> in whom this hypothesis is not supported&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">The JIA-IBD overlap is an alternative to be considered&#44; with good response to treatment based on anti-TNF drugs and even disappearance of systemic symptoms in patients with JIA who subsequently progress to CD<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46; The description of mutations of the LACC1 gene&#44; associated with both entities&#44; would support this possibility<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The detection of mutations in the NOD2 gene associated with CD in our patient poses the alternative that the initial symptoms&#44; compatible with JIAs&#44; were the set of extraintestinal manifestations of the onset of an underlying CD&#44; although the normal CF and imaging tests allowed this diagnosis to be ruled out&#46; We do not know the role that anti-IL1 treatment played in lengthening the latency period until the development of classic CD symptoms<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0060" class="elsevierStylePara elsevierViewall">As this is a single case&#44; and given the absence of genetic studies in the published series<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a>&#44; it is not possible to extrapolate conclusions&#44; and further studies are needed to prove or disprove these hypotheses&#46; Be that as it may&#44; in diseases with a diagnosis of exclusion&#44; such as JIA&#44; other diagnostic alternatives or the association with other diseases due to immune dysregulation should be assessed in the event of the appearance of atypical manifestations or loss of effectiveness of the usual treatment&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Funding</span><p id="par0065" class="elsevierStylePara elsevierViewall">This work has not received any funding of any kind&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conflict of interests</span><p id="par0070" class="elsevierStylePara elsevierViewall">None&#46;</p></span></span>"
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        ]
        2 => array:3 [
          "identificador" => "xres1793044"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1569759"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Clinical case report"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Conclusions"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Funding"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Conflict of interests"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2021-05-07"
    "fechaAceptado" => "2021-06-10"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1569758"
          "palabras" => array:3 [
            0 => "Crohn&#8217;s disease"
            1 => "Systemic-onset juvenile idiopathic arthritis"
            2 => "Paediatrics"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1569759"
          "palabras" => array:3 [
            0 => "Enfermedad de Crohn"
            1 => "Artritis idiop&#225;tica juvenil de inicio sist&#233;mico"
            2 => "Pediatr&#237;a"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The progression of systemic-onset juvenile idiopathic arthritis &#40;JIAs&#41; to the different forms of presentation of inflammatory bowel disease is extremely rare&#46; We present the first report of a patient with SJIA that progressed to Crohn&#8217;s disease in which mutations have been detected in genes responsible for the adequate regulation of the innate immune system&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La evoluci&#243;n de la artritis idiop&#225;tica juvenil de inicio sist&#233;mico &#40;AIJs&#41; hacia las diferentes formas de presentaci&#243;n de enfermedad inflamatoria intestinal es extremadamente infrecuente&#46; Presentamos la que&#44; hasta ahora&#44; es la primera comunicaci&#243;n de un paciente con AIJs con evoluci&#243;n a enfermedad de Crohn en el que se han detectado mutaciones en genes responsables de la adecuada regulaci&#243;n del sistema inmune innato&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Mart&#237;n Pedraz L&#44; Galindo Zavala R&#44; Blasco Alonso J&#44; Navas L&#243;pez VM&#44; N&#250;&#241;ez Cuadros E&#46; Enfermedad de Crohn en paciente con artritis idiop&#225;tica juvenil de inicio sist&#233;mico&#58; &#191;asociaci&#243;n o complicaci&#243;n asociada al tratamiento&#63; Reumatol Clin&#46; 2022&#59;18&#58;557&#8211;559&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">CD&#58; Crohn&#8217;s disease&#59; IBD&#58; Inflammatory bowel disease&#59; JIAs&#58; Systemic-onset juvenile idiopathic arthritis&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Sample size&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Maller et al&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#44; 2020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col"><span class="elsevierStyleItalic">H&#252;gle B</span> et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#44; 2017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Van Dijken et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#44; 2011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&#8239;&#61;&#8239;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n&#8239;&#61;&#8239;3</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&#8239;&#61;&#8239;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sex &#40;male&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mean age at diagnosis of JIAs</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;9 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;5 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;5 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;range 1&#46;5-16&#46;1 years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;range 6&#46;8-15&#46;8 years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;range 5-14 years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Most common clinical manifestations at the onset of JIAs</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Arthritis 100&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Arthritis 100&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fever 94&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fever 100&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Exanthema 69&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Exanthema 100&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mean time of evolution of JIA at the time of IBD diagnosis</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;3 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;7 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;range 1&#46;5-9 years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;range 0&#46;9-4&#46;7 years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;range 5&#46;2-12&#46;3 years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Most common clinical manifestations at the onset of IBD</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diarrhoea 75&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diarrhoea 100&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Abdominal pain 69&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hematochezia 33&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Weight loss 63&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IBD subtype</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CD 81&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CD 66&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CD 100&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Undetermined colitis 19&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colitis ulcerosa 33&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Type of biological treatment prior to onset of IBD</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti IL-1 &#40;anakinra or canakinumab&#41; 50&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti IL-1 100&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti TNF-&#945; &#40;etanercept&#41; 100&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti TNF-&#945; &#40;etanercept&#41; 31&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anakinra 66&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti IL-6 &#40;tocilizumab&#41; 12&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Canakinumab 33&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mean time since biological treatment initiation to onset of IBD</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;5 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;6 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;range 0&#46;9-4&#46;4 years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;range &#46;3-3&#46;0 years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Type of biological treatment following onset of IBD</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti TNF-&#945; &#40;adalimumab or infliximab&#41; 75&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti TNF-&#945; &#40;infliximab&#41; 66&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti TNF-&#945; &#40;infliximab&#41; 50&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti-IL1 6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti IL-1 &#40;anakinra&#41; 33&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti IL-6 &#40;tocilizumab&#41; 6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evolution following onset of IBD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">JIAs&#58; 77&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">JIAs&#58; 100&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IBD&#58; 100&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#37; inactive disease&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IBD&#58; 23&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EII&#58; 66&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Paediatric series of JIAs with subsequent development of IBD&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
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                  ]
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Journal Information
Vol. 18. Issue 9.
Pages 557-559 (November 2022)
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Vol. 18. Issue 9.
Pages 557-559 (November 2022)
Case Report
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Crohn’s disease in a patient with systemic onset juvenile idiopathic arthritis. Association or associated side effect of treatment?
Enfermedad de Crohn en paciente con artritis idiopática juvenil de inicio sistémico: ¿asociación o complicación asociada al tratamiento?
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Laura Martín Pedraza,
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pedraz88@hotmail.com

Corresponding author.
, Rocío Galindo Zavalaa, Javier Blasco Alonsob, Víctor Manuel Navas Lópezb, Esmeralda Núñez Cuadrosa
a Sección de Reumatología Pediátrica, UGC Pediatría, Hospital Regional Universitario de Málaga, Málaga, Spain
b Sección de Gastroenterología y Nutrición Infantil, UGC Pediatría, Hospital Regional Universitario de Málaga, Málaga, Spain
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Abstract

The progression of systemic-onset juvenile idiopathic arthritis (JIAs) to the different forms of presentation of inflammatory bowel disease is extremely rare. We present the first report of a patient with SJIA that progressed to Crohn’s disease in which mutations have been detected in genes responsible for the adequate regulation of the innate immune system.

Keywords:
Crohn’s disease
Systemic-onset juvenile idiopathic arthritis
Paediatrics
Resumen

La evolución de la artritis idiopática juvenil de inicio sistémico (AIJs) hacia las diferentes formas de presentación de enfermedad inflamatoria intestinal es extremadamente infrecuente. Presentamos la que, hasta ahora, es la primera comunicación de un paciente con AIJs con evolución a enfermedad de Crohn en el que se han detectado mutaciones en genes responsables de la adecuada regulación del sistema inmune innato.

Palabras clave:
Enfermedad de Crohn
Artritis idiopática juvenil de inicio sistémico
Pediatría
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Introduction

Patients with juvenile idiopathic arthritis (JIA) are at increased risk for developing inflammatory bowel disease (IBD)1, although their association with systemic-onset JIAs is exceptional2–4, Mutations in genes causing immune deficiency due to immune dysregulation, common to both entities5, or the role of anti-IL1 treatments are hypothesised2,3.

Clinical case report

We present the case of an 8-year old girl with fever of one month’s duration, anorexia, sweating, and weight loss. Physical examination revealed no abnormalities.

Laboratory tests revealed leukocytosis (25,000/mm3) with a shift to the left, thrombocytosis (528,000/mm3), CRP 163 mg/l, ESR 92 mm, ferritin 737 ng/mL, and hypergammaglobulinaemia (IgG 2,650 mg/dl). The rest of the biochemical study failed to exhibit any further alterations. The infectious screening, which included tuberculosis, was negative. ANA and rheumatoid factor were similarly negative. Faecal calprotectin (FC) was 58 ng/g. Chest X-ray, abdominal ultrasound, thoracoabdominal CT, echocardiography, MRI, and bone scan displayed no pathological findings. The fundus examination was normal and the bone marrow biopsy exhibited no abnormalities.

After one week she developed right axillary adenopathy, hypoechoic on ultrasound, and with pathological uptake on the PET-CT scan. After surgical excision, the anatomopathological and microbiological study showed no alterations. Subsequently, he developed swelling and limitation of the left knee, with joint effusion with no synovial hypertrophy.

With a diagnosis of JIA (ILAR 2001 criteria), oral prednisone (1.5 mg/ kg/ day) was started, to which subcutaneous anakinra (2 mg/ kg/ day) had to added after 3 weeks, due to relapse after decreasing the corticosteroids. One month later, it was substituted for subcutaneous canakinumab (4 mg/ kg/ 4weeks), making it possible to administer doses every 6 weeks, without incident, and she remained asymptomatic for 3 years.

After this, the patient once again began to have fever, arthralgias, and an increase in CRP. Given her incomplete clinical and analytical response to oral prednisone (1 mg/ kg/ day), intravenous tocilizumab (8 mg/ kg/ 2 weeks) was initiated, with partial improvement.

One month later she was readmitted for abdominal pain and haematochezia. Laboratory tests yielded haemoglobin values of 7.6 g/ dl and CF 3132 ug/ g. After ultrasound evidence of ileocolitis, upper and lower gastrointestinal endoscopy was performed and a diagnosis of Crohn’s disease (CD) was established according to the Oporto criteria6 and the Paris classification7. The genetic panel for autoinflammatory diseases resulted in a probably benign mutation (pR702W) and a mutation of uncertain significance (p1007finsC), both in heterozygosis, of the NOD2 gene.

Tocilizumab was discontinued, and subcutaneous adalimumab (160-80-40 mg/ 2 weeks) and oral prednisone (1.5 mg/ kg/ day) were started, requiring combo therapy with azathioprine. She is currently asymptomatic on adalimumab monotherapy, with CF < 15.6 ug/ g.

Discussion

IBD very rarely develops as an extra-articular manifestation of JIA2–4. Although some authors propose that pharmacological blockade of IL-1 would favour the phenotypic change of JIA to IBD2,3, this evolution has also been detected in individuals with other treatments (Table 1)3,4 in whom this hypothesis is not supported.

Table 1.

Paediatric series of JIAs with subsequent development of IBD.

Sample size  Maller et al.3, 2020  Hügle B et al.2, 2017  Van Dijken et al.4, 2011 
  n = 16  n = 3  n = 2 
Sex (male)  50.0%  66.7%  – 
Mean age at diagnosis of JIAs9.9 years  12.5 years  9.5 years 
(range 1.5-16.1 years)  (range 6.8-15.8 years)  (range 5-14 years) 
Most common clinical manifestations at the onset of JIAsArthritis 100%  Arthritis 100%  – 
Fever 94%  Fever 100%   
Exanthema 69%  Exanthema 100%   
Mean time of evolution of JIA at the time of IBD diagnosis3 years  3.3 years  8.7 years 
(range 1.5-9 years)  (range 0.9-4.7 years)  (range 5.2-12.3 years) 
Most common clinical manifestations at the onset of IBDDiarrhoea 75%  Diarrhoea 100%  – 
Abdominal pain 69%  Hematochezia 33.3%   
Weight loss 63%     
IBD subtypeCD 81%  CD 66.7%  CD 100% 
Undetermined colitis 19%  Colitis ulcerosa 33.3%   
Type of biological treatment prior to onset of IBDAnti IL-1 (anakinra or canakinumab) 50%  Anti IL-1 100%  Anti TNF-α (etanercept) 100% 
Anti TNF-α (etanercept) 31%  Anakinra 66.7%   
Anti IL-6 (tocilizumab) 12.5%  Canakinumab 33.3%   
Mean time since biological treatment initiation to onset of IBD–  2.5 years  1.6 years 
  (range 0.9-4.4 years)  (range .3-3.0 years) 
Type of biological treatment following onset of IBDAnti TNF-α (adalimumab or infliximab) 75%  Anti TNF-α (infliximab) 66.7%  Anti TNF-α (infliximab) 50% 
Anti-IL1 6%  Anti IL-1 (anakinra) 33.3%   
Anti IL-6 (tocilizumab) 6%     
Evolution following onset of IBD  JIAs: 77%  JIAs: 100%  IBD: 100% 
(% inactive disease)  IBD: 23%  EII: 66.7%   

CD: Crohn’s disease; IBD: Inflammatory bowel disease; JIAs: Systemic-onset juvenile idiopathic arthritis.

The JIA-IBD overlap is an alternative to be considered, with good response to treatment based on anti-TNF drugs and even disappearance of systemic symptoms in patients with JIA who subsequently progress to CD3. The description of mutations of the LACC1 gene, associated with both entities, would support this possibility5.

The detection of mutations in the NOD2 gene associated with CD in our patient poses the alternative that the initial symptoms, compatible with JIAs, were the set of extraintestinal manifestations of the onset of an underlying CD, although the normal CF and imaging tests allowed this diagnosis to be ruled out. We do not know the role that anti-IL1 treatment played in lengthening the latency period until the development of classic CD symptoms8.

Conclusions

As this is a single case, and given the absence of genetic studies in the published series2–4, it is not possible to extrapolate conclusions, and further studies are needed to prove or disprove these hypotheses. Be that as it may, in diseases with a diagnosis of exclusion, such as JIA, other diagnostic alternatives or the association with other diseases due to immune dysregulation should be assessed in the event of the appearance of atypical manifestations or loss of effectiveness of the usual treatment.

Funding

This work has not received any funding of any kind.

Conflict of interests

None.

References
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Z. Gündüz, R. Düşünsel, D. Aslan, B. Sözeri, A.P. Kısaarslan.
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Please cite this article as: Martín Pedraz L, Galindo Zavala R, Blasco Alonso J, Navas López VM, Núñez Cuadros E. Enfermedad de Crohn en paciente con artritis idiopática juvenil de inicio sistémico: ¿asociación o complicación asociada al tratamiento? Reumatol Clin. 2022;18:557–559.

Copyright © 2021. Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
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