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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To compare the costs of treating osteoarthritis &#40;OA&#41; pain using combination tramadol&#47;paracetamol tablets&#44; Non-Steroidal Anti-Inflammatory Agents &#40;NSAID&#41; alone or NSAID plus proton pump inhibitors &#40;PPI&#41; from the perspective of the Spanish National Health System&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A decision-analytical model was constructed to analyze the cost associated with three treatment strategies over 6 months&#46; A cost-minimization approach was used&#44; which considered data related to resource use&#44; medication costs and costs for the treatment of adverse events&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In the base-case analysis&#44; costs for 6 months of treatment of OA pain using tramadol&#47;paracetamol were &#8364;232&#46;86&#44; compared with &#8364;274&#46;60 for NSAID &#43; PPI and &#8364;133&#46;75 for NSAID alone&#46; This provided a savings of &#8364;41&#46;74 per patient over 6 months for tramadol&#47;paracetamol compared with NSAID &#43; PPI and a cost increase of &#8364;99&#46;11 compared with NSAID alone&#46; When renal adverse events associated with NSAID were considered&#44; tramadol&#47;paracetamol was cost saving compared with all NSAID-based regimens &#40;saving &#8364;140&#46;02 vs NSAID alone&#44; &#8364;280&#46;86 vs NSAID &#43; PPI&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Based on the results of a theoretical decision-analytic model&#44; the data obtained may suggest that tramadol&#47;paracetamol is cost saving compared with NSAID &#43; PPI for the treatment of OA pain over a period of 6 months&#46; Tramadol&#47;paracetamol is also cost saving compared with treatment with NSAID alone if considering renal adverse events</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Comparar el coste del tratamiento del dolor en la osteoartrosis &#40;OA&#41; con tramadol&#47;paracetamol frente a los antiinflamatorios no esteroideos &#40;AINE&#41; solos o en combinaci&#243;n con un inhibidor de la bomba de protones &#40;IBP&#41; desde el punto de vista del Sistema Nacional de Salud de Espa&#241;a&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un modelo anal&#237;tico de decisiones que evalu&#243; los costes derivados de las tres estrategias de tratamiento durante 6 meses&#46; Se utiliz&#243; un an&#225;lisis de minimizaci&#243;n de costes considerando datos referentes al uso de recursos&#44; costes farmacol&#243;gicos y costes derivados del tratamiento de los acontecimientos adversos &#40;AE&#41; de la medicaci&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En el an&#225;lisis del caso base&#44; el coste del tratamiento del dolor de la OA durante 6 meses con tramadol&#47;paracetamol fue de 232&#44;86 &#8364;&#44; comparado con 274&#44;60 &#8364; con los AINE &#43; IBP y 133&#44;75 &#8364; con los AINE solos&#46; Por tanto&#44; el tratamiento con tramadol&#47;paracetamol produce un ahorro de 41&#44;74 &#8364; por paciente durante 6 meses respecto a AINE &#43; IBP y un coste adicional de 99&#44;11 &#8364; respecto a los AINE solos&#46; Al considerar los AE renales&#44; tramadol&#47;paracetamol produce un ahorro comparado con los tratamientos que contienen AINE &#40;140&#44;02 &#8364; respecto de los AINE solos y 280&#44;86 &#8364; respecto de los AINE &#43; IBP&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Bas&#225;ndose en los resultados de un modelo te&#243;rico anal&#237;tico de decisiones&#44; los datos sugieren que tramadol&#47;paracetamol produce ahorros comparado con los AINE &#43; IBP en el tratamiento del dolor de la OA durante 6 meses&#46; Tramadol&#47;paracetamol tambi&#233;n produce ahorros comparado con los AINE solos si se consideran los AE renales&#46;</p>"
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Vol. 7. Issue 4.
Pages 241-247 (July - August 2011)
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Vol. 7. Issue 4.
Pages 241-247 (July - August 2011)
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Economic evaluation of tramadol/paracetamol in the management of pain in patients with osteoarthritis in Spain
Evaluación económica de tramadol/paracetamol en el manejo del dolor en pacientes con osteoartrosis en España
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Javier Vidala, Pere Benitob, Anna Manresac, Domingo Ly-Pend, Enrique Batllee, Francisco J. Blancof, Max Brosag, Diana Nievesg,
Corresponding author
diana.nieves@oblikue.com

Corresponding author. Oblikue Consulting, C/Josep Irla i Bosch, 5–7, 1.ª planta, 08034 Barcelona. Spain.
a Servicio de Reumatología, Hospital General Universitario de Guadalajara, Guadalajara, Spain
b Servicio de Reumatología, Hospital del Mar-IMAS, Barcelona, Spain
c CAP Nou Tarraco, Tarragona, Spain
d Centro de Salud Gandhi, Madrid, Spain
e Servicio de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain
f Servicio de Reumatología, Hospital Universitario A Coruña, A Coruña, Spain
g Oblikue Consulting, Barcelona, Spain
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Abstract
Objective

To compare the costs of treating osteoarthritis (OA) pain using combination tramadol/paracetamol tablets, Non-Steroidal Anti-Inflammatory Agents (NSAID) alone or NSAID plus proton pump inhibitors (PPI) from the perspective of the Spanish National Health System.

Methods

A decision-analytical model was constructed to analyze the cost associated with three treatment strategies over 6 months. A cost-minimization approach was used, which considered data related to resource use, medication costs and costs for the treatment of adverse events.

Results

In the base-case analysis, costs for 6 months of treatment of OA pain using tramadol/paracetamol were €232.86, compared with €274.60 for NSAID + PPI and €133.75 for NSAID alone. This provided a savings of €41.74 per patient over 6 months for tramadol/paracetamol compared with NSAID + PPI and a cost increase of €99.11 compared with NSAID alone. When renal adverse events associated with NSAID were considered, tramadol/paracetamol was cost saving compared with all NSAID-based regimens (saving €140.02 vs NSAID alone, €280.86 vs NSAID + PPI).

Conclusion

Based on the results of a theoretical decision-analytic model, the data obtained may suggest that tramadol/paracetamol is cost saving compared with NSAID + PPI for the treatment of OA pain over a period of 6 months. Tramadol/paracetamol is also cost saving compared with treatment with NSAID alone if considering renal adverse events

Keywords:
Cost-minimisation analysis
Tramadol/paracetamol
Non-Steroidal Anti-Inflammatory Agents
Osteoarthritis
Resumen
Objetivo

Comparar el coste del tratamiento del dolor en la osteoartrosis (OA) con tramadol/paracetamol frente a los antiinflamatorios no esteroideos (AINE) solos o en combinación con un inhibidor de la bomba de protones (IBP) desde el punto de vista del Sistema Nacional de Salud de España.

Métodos

Se realizó un modelo analítico de decisiones que evaluó los costes derivados de las tres estrategias de tratamiento durante 6 meses. Se utilizó un análisis de minimización de costes considerando datos referentes al uso de recursos, costes farmacológicos y costes derivados del tratamiento de los acontecimientos adversos (AE) de la medicación.

Resultados

En el análisis del caso base, el coste del tratamiento del dolor de la OA durante 6 meses con tramadol/paracetamol fue de 232,86 €, comparado con 274,60 € con los AINE + IBP y 133,75 € con los AINE solos. Por tanto, el tratamiento con tramadol/paracetamol produce un ahorro de 41,74 € por paciente durante 6 meses respecto a AINE + IBP y un coste adicional de 99,11 € respecto a los AINE solos. Al considerar los AE renales, tramadol/paracetamol produce un ahorro comparado con los tratamientos que contienen AINE (140,02 € respecto de los AINE solos y 280,86 € respecto de los AINE + IBP).

Conclusiones

Basándose en los resultados de un modelo teórico analítico de decisiones, los datos sugieren que tramadol/paracetamol produce ahorros comparado con los AINE + IBP en el tratamiento del dolor de la OA durante 6 meses. Tramadol/paracetamol también produce ahorros comparado con los AINE solos si se consideran los AE renales.

Palabras clave:
Análisis de minimización de costes
Tramadol/paracetamol
Antiinflamatorios no esteroideos
Osteoartrosis
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