Mario García-Carrasco graduated from medicine and surgery at the Universidad Autónoma de Puebla, México. He trained as a resident of rheumatology at the Centro Nacional de Lucha contra Enfermedades Reumáticas in Barcelona. He then performed research in rheumatology for 3 years at the Hospital Lariboisiére in París, France.

Through the Universidad Autónoma de Puebla he obtained a scholarship to obtain his masters and doctorate degrees at the Hospital Clínic in Barcelona and obtained a PhD in 1997 from the Universidad de Barcelona with the doctoral thesis: Viral, hormonal and immunomodulatory factors in the ethiopathogenesis of primary Sjögren's syndrome. Since 1986 he is the head research professor of Rheumatology and Immunology at the Faculty of Medicine of the Benemérita Universidad Autónoma de Puebla. He is currently the head of the Systemic Autoimmune Disease Unit at the Hospital General Regional número 36 of the Instituto Mexicano del Seguro Social. He belongs to the National Researchers System of México, attaining the top level, level III. He is a member of the International Editorial Board of the Brazilian Journal of Rheumatology, has received different awards and distinctions, among others the State Award for Science and Technology 2005 in the area of Medical Technology and Science given by the Consejo de Ciencia y Tecnología of the state of Puebla as well as the annual award in municipal health in the category “Dr. Mariano Joaquín de Anzurez y Zeballos” in 2007.

He has published numerous articles in international journals on different topics of rheumatology, such as Sjögren's syndrome, systemic lupus erythematosus, antiphospholipid syndrome and osteoporosis. He has been the coeditor of different rheumatology and autoimmune diseases texts. He has participated as head researcher in several clinical trials related to systemic lupus erythematosus and osteoporosis, financed by the Instituto Mexicano del Seguro Social, the Consejo Nacional de Ciencia y Tecnología, and the Benemérita Universidad Autónoma de Puebla.