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Vol. 18. Issue 4.
Pages 227-230 (April 2022)
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Vol. 18. Issue 4.
Pages 227-230 (April 2022)
Brief report
Familial mediterranean fever patients may have unmet needs for the treatments of exertional leg pain and enthesitis
Los pacientes con fiebre mediterránea familiar podrían tener necesidades no satisfechas de tratamiento del dolor en piernas con el esfuerzo y entesitis
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Mehmet Engin Tezcana,
Corresponding author
engintez@yahoo.com

Corresponding author.
, Omur Volkana, Ridvan Mercanb, Nesrin Sena, Sibel Yilmaz-Onera
a Kartal Dr. Lutfi Kirdar Training and Research Hospital, Department of Rheumatology, Istanbul, Turkey
b Namik Kemal University, School of Medicine, Department of Internal Medicine, Section of Rheumatology, Tekirdag, Turkey
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Tables (2)
Table 1. Demographic and disease related features of the FMF patients.
Table 2. Treatments effect on the FMF attacks’ features.
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Abstract
Introduction

Exertional leg pain (ELP) and enthesitis are musculoskeletal findings in familial Mediterranean fever (FMF). They are not accepted as principal treatment targets. In this study, we assessed the effectiveness of treatments on ELP and enthesitis.

Material and methods

We have included 218 FMF patients to the study. We retrospectively compared the FMF attacks’ frequency, duration and intensity (FMF attack VAS score) and levels of ELP VAS and enthesitis VAS scores between pre-treatment stage and while patients were on treatment at the last visit.

Results

Forty-nine (22.5%) and 52 (23.9%) of the patients had enthesitis and ELP respectively. All patients were on colchicine treatment. Serositis attacks respond the treatments significantly. Moreover, both ELP VAS scores (p=0.002) and enthesis VAS scores (p=0.17) were improved with treatment. But only improvement in ELP VAS scores was significant.

Conclusion

FMF treatments had favourable effect on ELP and enthesitis in FMF patients. However, the response rates would be inadequate. Therefore, there would be unmet need for treatment of both conditions.

Keywords:
Familial Mediterranean fever
Enthesitis
Exertional leg pain
Visual analog score
Resumen
Introducción

El dolor en piernas con el esfuerzo (ELP) y la entesitis son hallazgos musculoesqueléticos en la fiebre mediterránea familiar (FMF), no aceptados como dianas de tratamiento principales. En este estudio evaluamos la efectividad de los tratamientos para ELP y entesitis.

Material y métodos

Incluimos en el estudio a 218 pacientes con FMF. Comparamos retrospectivamente la frecuencia de los ataques de FMF, su duración e intensidad (escala analógica visual [VAS] del ataque de FMF) y los niveles VAS para ELP y las puntuaciones VAS para entesitis entre la etapa previa al tratamiento y la etapa en que los pacientes estaban siendo tratados en la última visita.

Resultados

Cuarenta y nueve (22,5%) y 52 (23,9%) pacientes tuvieron entesitis y ELP, respectivamente. Todos los pacientes recibieron colchicina. Los ataques de serositis respondieron significativamente a los tratamientos. Además, tanto las puntuaciones VAS para ELP (p=0,002) como para entesis (p=0,17) mejoraron con el tratamiento, pero únicamente fueron significativas las puntuaciones VAS para ELP.

Conclusión

Los tratamientos para FMF tuvieron un efecto favorable para ELP y entesitis en los pacientes con FMF. Sin embargo, las tasas de respuesta serían inadecuadas. Por tanto, existiría una necesidad no satisfecha de tratamiento de ambas situaciones.

Palabras clave:
Fiebre mediterránea familiar
Entesitis
Dolor en piernas con el esfuerzo
Escala analógica visual

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