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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Twenty to 71&#37; of patients with Sj&#246;gren&#39;s syndrome &#40;SS&#41; will develop systemic manifestations&#46;</p> <span class="elsevierStyleSectionTitle">Objetive</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To characterize the clinical-serological presentation and the frequency of systemic manifestations in patients with primary SS&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Retrospective study including patients with SS visited in &#8220;Hospital Brit&#225;nico de Buenos Aires&#8221; during the period from January 2000 to August 2008&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Forty-one patients fulfilled the 2002 American-European classification criteria for SS&#46; All patients were women&#46; Mean age at enrollment was 57&#44;85&#177;12&#44;42 years &#40;range 26&#8211;79&#41;&#46; Mean duration of the disease was 9&#44;28 years &#40;range 0&#44;08&#8211;24&#41;&#46; Thirty-three &#40;80&#46;49&#37;&#41; developed systemic manifestations&#46; The most frequent were arthritis&#44; cutaneous vasculitis and polyneuropathy&#46; This group featured more frequently ANA titles &#8805;1&#47;640 and hypocomplementemia&#59; although no statistical significance was found&#46; The frequency of systemic manifestations found was greater than reported in the literature&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A multidisciplinary approach focusing also on systemic manifestations should be the new standard for management of SS&#46;</p>"
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        "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Del 20&#8211;71&#37; de los pacientes con s&#237;ndrome de Sj&#246;gren &#40;SS&#41; desarrolla manifestaciones sist&#233;micas&#46;</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El objetivo fue evaluar las caracter&#237;sticas clinicoserol&#243;gicas y frecuencia de manifestaciones sist&#233;micas en pacientes con SS primario&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0530" class="elsevierStyleSimplePara elsevierViewall">Material y m&#233;todos&#58; Estudio retrospectivo con revisi&#243;n de historias cl&#237;nicas de pacientes con Sd de Sj&#246;gren primario visitados en el Hospital Brit&#225;nico de Buenos Aires en el per&#237;odo desde Enero de 2000 a Agosto de 2008&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 41 pacientes que cumplian criterios de clasificacion Europeoamericanos 2002 para SS&#44; todos de sexo femenino&#46; La edad media fue 57&#44;85<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;42 anos &#40;rango 26&#8211;79&#41;&#46; El tiempo de evolucion fue de 9&#44;28 anos &#40;rango 0&#44;08&#8211;24&#41;&#46; Treinta y tres &#40;80&#44;49&#37;&#41; presentaron manifestaciones sistemicas&#46; Las mas frecuentes fueron artritis&#44; vasculitis cutanea y polineuropatia&#46; Este grupo presento mas frecuentemente titulos de AAN &#8805;<span class="elsevierStyleHsp" style=""></span>1&#47;640 e hipocomplementemia&#59; aunque no estadisticamente significativas&#46; La frecuencia de manifestaciones sistemicas halladas fue mayor a la reportada en otras series&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Un abordaje multidisciplinario enfocado en las manifestaciones sist&#233;micas deber&#237;a ser el nuevo est&#225;ndar para el manejo del SS&#46;</p>"
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Vol. 6. Issue 6.
Pages 299-302 (November - December 2010)
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Vol. 6. Issue 6.
Pages 299-302 (November - December 2010)
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Frequency of systemic manifestations in patients with primary Sjögren's syndrome in Argentina
Frecuencia de manifestaciones sistémicas en pacientes con síndrome de Sjögren primario en Argentina
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Federico Zazzettia,
Corresponding author
reumatologia@hbritanico.com.ar

Corresponding author.
, Mariano Adolfo Riveroa, Damián Elvio Duartes Noéa, Alberto Gallachera, Amalia Schielb, Marina Claudia Khouryc, Hugo Armando Labordea, Juan Carlos Barreiraa
a Servicio de Reumatología, Buenos Aires, Argentina
b Sección Laboratorio de Inmunología, Buenos Aires, Argentina
c Departamento de Estadística, Hospital Británico de Buenos Aires, Buenos Aires, Argentina
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Article information
Abstract

Twenty to 71% of patients with Sjögren's syndrome (SS) will develop systemic manifestations.

Objetive

To characterize the clinical-serological presentation and the frequency of systemic manifestations in patients with primary SS.

Methods

Retrospective study including patients with SS visited in “Hospital Británico de Buenos Aires” during the period from January 2000 to August 2008.

Results

Forty-one patients fulfilled the 2002 American-European classification criteria for SS. All patients were women. Mean age at enrollment was 57,85±12,42 years (range 26–79). Mean duration of the disease was 9,28 years (range 0,08–24). Thirty-three (80.49%) developed systemic manifestations. The most frequent were arthritis, cutaneous vasculitis and polyneuropathy. This group featured more frequently ANA titles ≥1/640 and hypocomplementemia; although no statistical significance was found. The frequency of systemic manifestations found was greater than reported in the literature.

Conclusions

A multidisciplinary approach focusing also on systemic manifestations should be the new standard for management of SS.

Keywords:
Sjögren's Syndrome
Autoimmunity
Connective Tissue Diseases
Xerostomia
Resumen

Del 20–71% de los pacientes con síndrome de Sjögren (SS) desarrolla manifestaciones sistémicas.

Objetivos

El objetivo fue evaluar las características clinicoserológicas y frecuencia de manifestaciones sistémicas en pacientes con SS primario.

Material y métodos

Material y métodos: Estudio retrospectivo con revisión de historias clínicas de pacientes con Sd de Sjögren primario visitados en el Hospital Británico de Buenos Aires en el período desde Enero de 2000 a Agosto de 2008.

Resultados

Se incluyeron 41 pacientes que cumplian criterios de clasificacion Europeoamericanos 2002 para SS, todos de sexo femenino. La edad media fue 57,85±12,42 anos (rango 26–79). El tiempo de evolucion fue de 9,28 anos (rango 0,08–24). Treinta y tres (80,49%) presentaron manifestaciones sistemicas. Las mas frecuentes fueron artritis, vasculitis cutanea y polineuropatia. Este grupo presento mas frecuentemente titulos de AAN ≥1/640 e hipocomplementemia; aunque no estadisticamente significativas. La frecuencia de manifestaciones sistemicas halladas fue mayor a la reportada en otras series.

Conclusiones

Un abordaje multidisciplinario enfocado en las manifestaciones sistémicas debería ser el nuevo estándar para el manejo del SS.

Palabras clave:
Síndrome de Sjögren
Autoinmunidad
Enfermedades del tejido conectivo
Xerostomía
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Copyright © 2010. Sociedad Española de Reumatología and Colegio Mexicano de Reumatología
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